22 recruiting, 15 completed, 14 not yet recruiting, 2 enrolling by invitation. 20 Not applicable, 8 Phase 2, 2 Phase 1, 2 Phase 3, 1 Early Phase 1.
Follow ARDS (Acute Respiratory Distress Syndrome): new trials by email Literature Review of ARDS (Acute Respiratory Distress Syndrome) trials Research Report on ARDS (Acute Respiratory Distress Syndrome)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Variable Ventilation Trial (Part A) Variable Ventilation, Conventional Ventilation - ARDS (Acute Respiratory Distress Syndrome) | Not applicable | Not yet recruiting | Brigham and Women's Hospital | 20 | 2027-02-01 | 2026-08-27 |
| Continuous vs Bolus Neuromuscular Blockade Regimens in Moderate to Severe Hypoxemic Respiratory Failure and ARDS (COBRA) Neuromuscular Blocking Agent - Bolus Dosing, Neuromuscular Blocking Agent - Continuous Infusion - ARDS (Acute Respiratory Distress Syndrome) | Phase 2 | Not yet recruiting | University of Calgary | 100 | 2027-01-01 | 2026-05-14 |
| The Effect of Catheter Size on the Efficacy of Ultralow-flow Extracorporeal Carbon Dioxide Removal System in Acute Respiratory Distress Syndrome 12F Catheter, 13F Catheter, 15F Catheter - ARDS (Acute Respiratory Distress Syndrome) | Not applicable | Not yet recruiting | Chulalongkorn University | 30 | 2026-12-01 | 2026-10-08 |
| Safety and Efficacy Study of GKL-006RTU in Moderate to Severe Acute Respiratory Distress Syndrome (ARDS) GKL-006RTU injection, Placebo - ARDS (Acute Respiratory Distress Syndrome) | Phase 1 / Phase 2 | Not yet recruiting | Beijing Gene Key Life Technology Co., Ltd | 52 | 2026-11-10 | 2026-09-30 |
| EARLY-SARDS: Early AlveolaR Lung biologY Underling Sepsis-Associated ARDS Serial bronchoalveolar lavage and biological-physiological assessment - Acute Hypoxemic Respiratory Failure, Sepsis | Not yet recruiting | Hospital Universitari Vall d'Hebron Research Institute | 145 | 2026-10-15 | 2026-08-28 | |
| Ondansetron for the Prevention of Patient Self-Inflicted Lung Injury in Patients With ARDS - Pilot RCT Ondansetron hydrochloride 8 mg IV Q8H, 0.9 % Normal Saline 10 ml - ARDS (Acute Respiratory Distress Syndrome), Invasive Mechanical Ventilation | Phase 2 / Phase 3 | Not yet recruiting | Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal | 76 | 2026-10-01 | 2026-05-14 |
| Time-controlled Adaptive Ventilation (TCAV) Compared With Conventional Ventilation in Patients With Moderate-to-severe Acute Respiratory Distress Syndrome (ARDS) Secondary to Community-acquired Pneumonia Invasive ventilation with the Time-controlled Adaptative Ventilation settings applied to the Airway Pressure Release Ventilation mode, Volume Control - ARDS (Acute Respiratory Distress Syndrome) | Not applicable | Not yet recruiting | Central Hospital, Nancy, France | 56 | 2026-10-01 | 2026-07-01 |
| Observational, Non-interventional Biomarker and Endotyping Study ARDS (Acute Respiratory Distress Syndrome) | Recruiting | Prenosis, Inc. | 1200 | 2026-09-14 | 2026-09-28 | |
| Precision Medicine Adaptive Network Platform Trial in Hypoxemic Acute Respiratory Failure Simvastatin, Baricitinib - ARDS (Acute Respiratory Distress Syndrome), Acute Hypoxic Respiratory Failure | Phase 2 | Not yet recruiting | University of Colorado, Denver | 300 | 2026-09-01 | 2026-10-08 |
| Trial of Total Lung Protective Ventilation in Adult VV-ECMO Patients With Severe ARDS Mechanical Power Targeted Ventilation - ARDS (Acute Respiratory Distress Syndrome), VV ECMO | Not applicable | Not yet recruiting | University of Virginia | 24 | 2026-09-01 | 2026-09-01 |
| The Impact of Low Versus High Positive End-expiratory Pressure on Diaphragm Function, Ventilation Efficiency, and Lung Mechanics Low positive end-expiratory pressure, Medium positive end-expiratory pressure, High positive end-expiratory pressure - Respiratory Failure, ARDS (Acute Respiratory Distress Syndrome) | Not applicable | Recruiting | Vastra Gotaland Region | 25 | 2026-08-31 | 2026-09-02 |
| BALance: ARDS Deconvolution by Bronchoalveolar Lavage Multiomics and Radiomics sampling blood, Lavage with physiologic saline solution - ARDS (Acute Respiratory Distress Syndrome) | Recruiting | Medical University of Vienna | 130 | 2026-07-01 | 2026-07-10 | |
| EIT Evaluation of the Impact of Inhaled Nitric Oxide on Ventilation/Perfusion Mismatch in ARDS Patients Receiving Noninvasive Respiratory Support Inhale different doses of nitric oxide - ARDS (Acute Respiratory Distress Syndrome) | Not yet recruiting | Ming Zhong | 40 | 2026-06-30 | 2026-06-01 | |
| Influence of Lung Recruitment Potential on Positive End-Expiratory Pressure (PEEP) Titration Strategies in Acute Respiratory Distress Syndrome (ARDS) Patients. Positive End-Expiratory Pressure (PEEP) Titration guided by Static Compliance, Positive End-Expiratory Pressure (PEEP) Titration guided by Transpulmonary Pressure - ARDS (Acute Respiratory Distress Syndrome) | Not applicable | Recruiting | Hospital Dr. Franco Ravera Zunino | 52 | 2026-06-01 | 2026-07-10 |
| Clinical Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of HT31-1 for Treating ARDS HT31-1, Saline (0.9%, sterile, for infusion) - ARDS (Acute Respiratory Distress Syndrome) | Phase 1 | Recruiting | HTIC, Inc | 24 | 2026-05-28 | 2026-09-16 |
| A Single Dose, Dose Escalation Clinical Trial on the Safety, Tolerability and Efficacy of Lyophilized Powder for Inhalation of Recombinant Human Keratinocyte Growth Factor-2 (Rh-KGF-2) in The Treatment of Patients With Acute Respiratory Distress Syndrome Recombinant Human Keratinocyte Growth Factor-2 for Inhalation (Lyophilized Powder) - ARDS (Moderate or Severe), ARDS (Acute Respiratory Distress Syndrome) | Early Phase 1 | Recruiting | Shanghai Zhongshan Hospital | 24 | 2026-05-14 | 2026-06-11 |
| Lung EIT Image Guide Ventilation in ARDS Recruitment maneuver and PEEP setting guided by EIT, PEEP setting according to routine practice, Prone positioning guided by EIT - ARDS (Acute Respiratory Distress Syndrome) | Not applicable | Recruiting | Peking Union Medical College Hospital | 574 | 2026-03-24 | 2026-07-09 |
| RECOMMEND Platform Trial Liberal RBC Transfusion, Restrictive RBC Transfusion - Extracorporeal Membrane Oxygenation Complication, ARDS (Acute Respiratory Distress Syndrome) | Phase 3 | Recruiting | Australian and New Zealand Intensive Care Research Centre | 600 | 2026-03-23 | 2026-05-13 |
| Effect of EIT-guided PEEP in ARDS Patients EIT-guided PEEP - ARDS (Acute Respiratory Distress Syndrome) | Not applicable | Recruiting | Southeast University, China | 2400 | 2026-03-13 | 2026-07-10 |
| The Caribbean Registry of Extracorporeal Membrane Oxygenation (ECMO) From the University Hospital in Martinique Cardiogenic Shock, Malignant Arrhythmias | Not yet recruiting | University of Genova | 1200 | 2026-02-01 | 2026-01-20 |
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Acute Lung Injury (54) · Respiratory Distress Syndrome (8) · Respiratory Insufficiency (5) · Ventilator-Induced Lung Injury (4) · Acute Kidney Injury (3) · COVID-19 (3) · Pneumonia (3) · Sepsis (3) · Critical Illness (2) · Heart Arrest (2) · Pulmonary Disease, Chronic Obstructive (2) · Shock, Cardiogenic (2) · Acidosis, Respiratory (1) · Bronchiectasis (1) · Coinfection (1)
Lung Diseases (54) · Lung Injury (54) · Respiratory Tract Diseases (54) · Respiration Disorders (15) · Pathologic Processes (9) · Pathological Conditions, Signs and Symptoms (9) · Infections (8) · Respiratory Tract Infections (5) · Disease Attributes (4) · Cardiovascular Diseases (3) · Coronaviridae Infections (3) · Coronavirus Infections (3) · Female Urogenital Diseases (3) · Female Urogenital Diseases and Pregnancy Complications (3) · Heart Diseases (3)
Prone Position (2) · (2-(1R)-1-cyclopropyl)ethyl-6-isopropyl-phenol (1) · Bronchoscopy (1) · Continuous Positive Airway Pressure (1) · Cordocentesis (1) · Inhalation (1) · Midazolam (1) · Observation (1) · Ondansetron (1) · Positive-Pressure Respiration (1) · Saline Solution (1) · Simvastatin (1) · Sodium Bicarbonate (1) · Sodium Chloride (1) · Tomography, X-Ray Computed (1)
Peking Union Medical College Hospital (5) · PPD Development, LP (4) · Ain Shams University (2) · Bakirkoy Dr. Sadi Konuk Research and Training Hospital (2) · First Affiliated Hospital of Wannan Medical College (2) · Ming Zhong (2) · Shanghai Zhongshan Hospital (2) · Southeast University, China (2) · University Hospital, Ghent (2) · Assistance Publique Hopitaux De Marseille (1) · Australian and New Zealand Intensive Care Research Centre (1) · Beijing Gene Key Life Technology Co., Ltd (1) · Brigham and Women's Hospital (1) · Central Hospital, Nancy, France (1) · Centre Hospitalier Saint Joseph Saint Luc de Lyon (1)
China (15) · United States (9) · France (5) · Egypt (3) · Turkey (Türkiye) (3) · Belgium (2) · Japan (2) · South Korea (2) · Australia (1) · Austria (1) · Canada (1) · Chile (1) · Poland (1) · Spain (1) · Sweden (1)
Zafer Cukurova, M.D (2) · Asad Usman, MD (1) · Carlos Pellegrini, MD. (1) · Carol Hodgson, PhD FACP FAHMS (1) · Christian Bermudez, MD (1) · Dang Xinya Xinya Dang, bachelor (1) · David Williamson, BPharm, PhD (1) · Dr. Tarekahmed Abdelgawad (1) · Esteban Santis, RT. (1) · Francisco Cerda, RT. (1) · Hannes Widing (1) · Huaiwu He, MD (1) · Javier Astudillo, MD. (1) · Jennifer Ayuso, RT. (1)
PMID 37487152, PMID 11719313, PMID 15753733, PMID 15812622, PMID 16044083, PMID 16690982, PMID 21297069, PMID 21809107, PMID 22797452, PMID 22990871, PMID 26903337, PMID 27875408, PMID 28040987, PMID 28252536, PMID 28828358, PMID 29135617, PMID 30921400, PMID 31463251, PMID 31570096, PMID 31576250, PMID 31592346, PMID 31856056, PMID 32204716, PMID 32646771, PMID 32825837, PMID 33905798, PMID 34090669, PMID 34957747, PMID 35771774, PMID 36070788, PMID 36836113, PMID 37564041, PMID 37907946, PMID 38035100, PMID 38256439, PMID 38432698, PMID 39055813, PMID 39787604, PMID 39905371, PMID 40028879, PMID 41180101, PMID 41318642, PMID 41738148, PMID 42401979, PMID 788524
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