94 completed, 35 unknown, 14 recruiting, 12 terminated. 176 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 176 | Completed 94, Unknown 35, Recruiting 14, Terminated 12, Not yet recruiting 11, Active not recruiting 5, Withdrawn 3, Enrolling by invitation 1, Suspended 1 |
Follow Appendicitis: new trials by email Literature Review of Appendicitis trials Research Report on Appendicitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Perforated Appendicitis and Postoperative Antibiotics Pilot Trial Postoperative antibiotico-prophylaxis, No postoperative antibiotics - Perforated Appendicitis | Not applicable | Not yet recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 100 | 2027-01-01 | 2026-09-17 |
| Comparative Study Between Laparoscopic and Open Appendectomy of Complicated Appendicitis Laparoscopic Appendectomy, Open Appendectomy - Appendicitis, Perforated Appendicitis | Not applicable | Not yet recruiting | Assiut University | 100 | 2026-11-01 | 2026-10-16 |
| Laparoscopic vs Open Appendectomy in Obese Patients Open Appendectomy, Laparoscopic Appendectomy - Acute Appendicitis, Appendicitis (Diagnosis) | Not applicable | Not yet recruiting | University of Health Sciences Lahore | 166 | 2026-10-02 | 2026-09-16 |
| Immediate Laparoscopic Appendectomy Versus Interval Laparoscopic Appendectomy for Early Appendicular Mass Immediate Laparoscopic Appendectomy, Interval Laparoscopic Appendectomy - Appendicular Mass, Acute Appendicitis | Not applicable | Not yet recruiting | Assiut University | 100 | 2026-10-01 | 2026-09-23 |
| Laparoscopic Appendectomy: Outcomes of 10 mmHg Versus 15 mmHg Intra-abdominal Pressure Laparoscopic appendectomy with 10 mmHg pneumoperitoneum, Laparoscopic appendectomy with 15 mmHg pneumoperitoneum - Appendectomy, Laparoscopic, Intra Abdominal Pressure | Not applicable | Not yet recruiting | Ankara Etlik City Hospital | 150 | 2026-07-27 | 2026-07-27 |
| Primary Versus Delayed Wound Closure in Complicated Appendectomy (The HIEDI-Yemen Trial) Primary Closure with HIEDI, Delayed Primary Closure with HIEDI - Appendicitis, Surgical Wound Infection | Not applicable | Not yet recruiting | Sana'a University | 200 | 2026-07-01 | 2026-07-07 |
| Effect of Endotracheal Tube Cuff Pressure Management on Postoperative Sore Throat in Pediatric Laparoscopic Appendectomy Pressure Transducer, Traditional Palpation Method - Appendicitis Acute, Postoperative Sore Throat, Cough, Hoarseness | Not applicable | Recruiting | Ankara Etlik City Hospital | 60 | 2026-06-30 | 2026-07-07 |
| Feasibility and Safety of a Pediatric ERAS Protocol for Laparoscopic Appendectomy Comprehensive 20-Item Pediatric ERAS Protocol - Appendectomy, Laparoscopic, Acute Appendicitis | Not applicable | Recruiting | Ahmet Burak Doğan, MD | 100 | 2026-06-15 | 2026-10-15 |
| TACTILE : Validation of a Teleconsultation-Based Predictive Score for the Diagnosis of Acute Appendicitis in Children Using Artificial Intelligence Methods Score-based appendicitis risk classification in teleconsultation - Acute Appendicitis | Not applicable | Not yet recruiting | University Hospital, Angers | 1500 | 2026-06-01 | 2026-03-18 |
| Effect Of Specimen Extraction Site And Local Anesthesia On Postoperative Pain In Laparoscopic Appendectomy Port-site local anesthesia infiltration, Port-Site Saline Infiltration (Placebo) - Appendectomy, Laparoscopic, Appendicitis Acute | Not applicable | Recruiting | YUNUS YÜKSEL | 300 | 2026-04-24 | 2026-09-17 |
| First Appendectomy Using Revolve Surgical Robotic Arm Revolve Surgical System - RSS - Appendicitis Acute | Not applicable | Not yet recruiting | Unity Health Toronto | 3 | 2026-04-01 | 2026-03-06 |
| Laparoscopic vs Open Appendectomy Laparoscopic appendectomy, Open Appendectomy - Acute Appendicitis, Superficial SSI | Not applicable | Completed | Quaid-e-Azam Medical College | 276 | 2026-01-24 | 2026-09-25 |
| Direct Visualization ERAT Versus Laparoscopic Appendectomy in Adults With Acute Uncomplicated Appendicitis Direct Visualization Endoscopic Retrograde Appendicitis Therapy, Laparoscopic appendectomy - Acute Uncomplicated Appendicitis | Not applicable | Recruiting | Changhai Hospital | 376 | 2025-12-10 | 2026-09-04 |
| Out-patiente Management for Gangrenous Acute Appendicitis: The PENDI-CSI II Randomized Clinical Trial. outpatient surgery, Hospitalization - Appendicitis Acute, Gangrenous Appendicitis | Not applicable | Recruiting | Fundación Pública Andaluza para la gestión de la Investigación en Sevilla | 122 | 2025-11-01 | 2026-04-21 |
| Effects of Cartoons and Mobile Games on Preoperative Anxiety and Fear in Children With Appendicitis: An RCT Cartoon-Assisted Distraction (Şüko Ameliyat Oluyor), Mobile Game - Preoperative Anxiety, Children | Not applicable | Recruiting | Ankara City Hospital Bilkent | 69 | 2025-10-10 | 2026-06-10 |
| Differences In Microbiota Profiles Of Pediatric Appendicitis Cases Appendectomy - Appendicitis Acute, Disbiosis | Not applicable | Completed | Istanbul University | 50 | 2025-08-18 | 2026-10-06 |
| Comparison Between Metallic Clip Ligation and Suture Ligation of Appendicular Stump in Laparoscopic Appendectomy Metallic clip ligation of the appendicular stump, Suture ligation of appendicular stump - Laparoscopic Appendectomy | Not applicable | Not yet recruiting | Jinnah Hospital | 10 | 2025-08-15 | 2025-08-19 |
| Effect of Probiotic's Consumption on Several Markers in Perforated Appendix Patients With Diffuse Peritonitis Lactobacillus plantarum sp Probiotic, Placebo Group - Appendicitis With Perforation, Appendectomy | Not applicable | Active not recruiting | Universitas Padjadjaran | 50 | 2025-08-01 | 2026-03-31 |
| Results of Laparoscopic Appendectomy With Application of Clips Versus Ligature for Stump Closure Laparoscopic Appendectomy with application of clips for stump closure, Laparoscopic Appendectomy with ligature for stump closure - Appendicitis | Not applicable | Recruiting | Sohag University | 80 | 2025-07-14 | 2025-08-11 |
| Evaluating the Outcome of Surgical Clip Versus Ligatures in Securing Base of Appendix in Laparoscopic Appendicectomy. single polymeric clip (XXL Click'aV Plus, Grena), suture ligature - Appendicitis (Diagnosis) | Not applicable | Completed | Universiti Sains Malaysia | 64 | 2025-07-01 | 2026-07-08 |
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Pain (9) · Agnosia (5) · Disease (5) · Pain, Postoperative (5) · Surgical Wound Infection (5) · Abdominal Abscess (3) · Abscess (3) · Acute Disease (3) · Infections (3) · Peritonitis (3) · Abdomen, Acute (2) · Cholecystitis (2) · Cholelithiasis (2) · Gallstones (2)
Digestive System Diseases (176) · Gastroenteritis (176) · Intestinal Diseases (176) · Cecal Diseases (175) · Gastrointestinal Diseases (174) · Intraabdominal Infections (174) · Infections (173) · Pathological Conditions, Signs and Symptoms (43) · Pathologic Processes (25) · Signs and Symptoms (23) · Neurologic Manifestations (22) · Pain (9) · Postoperative Complications (9) · Biliary Tract Diseases (7) · Nervous System Diseases (6)
Appendectomy (15) · Metronidazole (8) · Ertapenem (5) · Anti-Bacterial Agents (4) · Amoxicillin-Potassium Clavulanate Combination (3) · Drainage (3) · Hospitalization (3) · Levofloxacin (3) · Moxifloxacin (3) · Observation (3) · Therapeutic Irrigation (3) · Cefazolin (2) · Cefotaxime (2) · Ceftriaxone (2) · Ciprofloxacin (2)
Assiut University (7) · Turku University Hospital (7) · Children's Mercy Hospital Kansas City (6) · Mansoura University (5) · Helsinki University Central Hospital (3) · Ankara City Hospital Bilkent (2) · Ankara Etlik City Hospital (2) · Bakirkoy Dr. Sadi Konuk Research and Training Hospital (2) · Centre Hospitalier Universitaire de Nice (2) · Children's National Research Institute (2) · Fatih Sultan Mehmet Training and Research Hospital (2) · Fundación Pública Andaluza para la gestión de la Investigación en Sevilla (2) · HJ23 (2) · HaEmek Medical Center, Israel (2) · Hallym University Medical Center (2)
United States (37) · Turkey (Türkiye) (21) · Finland (10) · Egypt (9) · China (7) · France (7) · South Korea (7) · Spain (5) · Canada (4) · Israel (4) · Pakistan (4) · Croatia (3) · Malaysia (3) · Netherlands (3) · Sweden (3)
Paulina Salminen, MD, PhD (5) · Shawn D St. Peter, MD (4) · David R Flum, MD, MPH (2) · Abut Kebudi, Prof. (1) · Ahmed Nasr, MD (1) · Ahmet Burak Erdem, Assoc. Prof. (1) · Alexander V Sazhin, Prof. (1) · Andrew Kepner, MD (1) · Anupam B Kharbanda, MD, MSc (1) · Arnold Hill (1) · Arnold K Hill (1) · Arthur Rawlings, MD (1) · Arun Jayaraman, PT, PhD (1) · Asmaa S.A. El Malah, PhD (1)
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