26 completed, 11 recruiting, 7 terminated, 4 not yet recruiting. 24 Not applicable, 7 Phase 3, 6 Phase 4, 4 Phase 1, 4 Phase 2.
Follow Apnea of Prematurity: new trials by email Literature Review of Apnea of Prematurity trials Research Report on Apnea of Prematurity
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| MICropsampling for CAffeine in PREMature Newborns collection of an extra drop of capillary blood - Apnea of Prematurity | Not applicable | Not yet recruiting | University Hospital, Limoges | 40 | 2026-10-01 | 2026-08-21 |
| Fentanyl and Rocuronium for Tracheal Intubation in Newborns Rocuronium Bromide 10 MG/ML, Fentanyl 1 mcg/kg IV, single dose, administered before non-emergent tracheal intubation. - Infant, Premature, Intubation, Intratracheal | Phase 4 | Not yet recruiting | UEA - Universidade Do Estado Do Amazonas | 102 | 2026-09-01 | 2026-07-01 |
| The Effect of Caffeine Therapy in Cardiovascular Stability in Preterm Neonates at Assiut University Children Hospital NICU Preterm Neonates, Apnea of Prematurity | Not yet recruiting | Assiut University | 40 | 2026-06-30 | 2025-12-10 | |
| Wireless MicroPremVitals Button Sensor in the NICU Wireless MicroPremVitals Button Sensor System - Premature Birth, Fragility | Not applicable | Recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 10 | 2026-06-19 | 2026-07-28 |
| Caffeine Citrate in Preterm Infants at Risk of Apnea in Zambia Caffeine citrate 20mg/kg/day, Placebo-Sterile water 1ml/kg/day - Premature Infant Disease, Apnea of Prematurity | Phase 4 | Recruiting | University of Alabama at Birmingham | 340 | 2026-06-17 | 2026-06-23 |
| Pharmacokinetics and Placental Transfer of Caffeine Caffeine citrate - Preterm Labor With Preterm Delivery, Premature Birth | Phase 1 | Recruiting | Indiana University | 30 | 2026-06-01 | 2026-06-04 |
| Detection of Respiratory Events Using Acoustic Monitoring in Extremely Preterm Infants Wireless acoustic sensor, Semi-structured interview, Nox T3s portable sleep monitoring device - Apnea of Prematurity, Preterm Infant | Recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 50 | 2026-05-28 | 2026-08-19 | |
| The Role of Electroencephalography in Caffeine Discontinuation Timing in Premature Infants Apnea Neonatal, Apnea of Prematurity | Recruiting | Uludag University | 100 | 2026-01-02 | 2026-05-01 | |
| Caffeine Citrate to Improve Neonatal Outcomes. Caffeine citrate - Apnea of Prematurity | Not applicable | Not yet recruiting | University of Melbourne | 3900 | 2025-10-01 | 2025-05-15 |
| "Prapela® SVS Incubator Pad for Apnea of Prematurity SVS mattress - Apnea of Prematurity | Not applicable | Recruiting | Tufts Medical Center | 140 | 2025-02-06 | 2025-03-07 |
| Efficacy of PIMUN by Reducing Intermittent Hypoxia Events Brain NIRS, Polysomnogram, Reactive oxydative species - Preterm, Apnea of Prematurity | Not applicable | Recruiting | Pontificia Universidad Catolica de Chile | 20 | 2024-09-01 | 2026-02-09 |
| Apnea of Prematurity Results in Respiratory Distress and Cyanosis. Caffeine Citrate Can Treat It. High-Dose, Low Dose - Apnea of Prematurity | Phase 1 | Active not recruiting | Nishtar Medical University | 114 | 2024-06-03 | 2025-04-01 |
| The PARS Study: Paediatric Advanced Respiratory Service Study - An Observational Diagnostic Feasibility Study Pneumowave - Sleep Disordered Breathing, Apnea of Prematurity | Recruiting | NHS Greater Clyde and Glasgow | 225 | 2024-03-01 | 2026-04-14 | |
| Caffeine Use in the Management of Preterm Infants Caffeine, Sterile Water Placebo - Apnea of Prematurity | Phase 2 | Active not recruiting | University of California, Irvine | 80 | 2024-02-22 | 2025-11-10 |
| The Effect of an Additional Pre-extubational Loading Dose of Caffeine-citrate Caffeine citrate - Apnea of Prematurity, Premature Birth | Phase 4 | Recruiting | Semmelweis University | 226 | 2023-12-21 | 2024-05-06 |
| Non-Invasive Neurally Adjusted Ventilatory Assist (NAVA) Prone vs Supine in Premature Infants Body positioning - Neonatal Oxygen Desaturation, Premature | Not applicable | Completed | Milton S. Hershey Medical Center | 30 | 2023-09-11 | 2025-01-29 |
| Nasal Olfactory Stimulation and Its Effect on Respiratory Drive in Preterm Infants Aroma, Placebo - Apnea of Prematurity, Prematurity | Not applicable | Completed | University of Zurich | 80 | 2023-06-14 | 2025-04-04 |
| Detection of CardioRespiratory Events Using Acoustic Monitoring in Preterm Infants on CPAP Respiratory Acoustic Sensors, Nasal thermistor, Respiratory Inductive Plethysmography - Apnea of Prematurity | Active not recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 50 | 2022-12-05 | 2026-03-30 | |
| Maternal Odor as a Developmental Care Intervention for Apnea of Prematurity Maternal odor - Apnea of Prematurity, Prematurity | Not applicable | Completed | Ankara Yildirim Beyazıt University | 60 | 2022-11-01 | 2026-07-08 |
| Pilot Study to Evaluate Doses of Mechanical Stimulus on the Effectiveness of Preterm Breathing 20 per minute stimulus, 30 per minute stimulus, 40 per minute stimulus - Apnea of Prematurity, Intermittent Hypoxia | Not applicable | Completed | Pontificia Universidad Catolica de Chile | 12 | 2022-10-10 | 2024-10-15 |
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Apnea (55) · Premature Birth (25) · Bradycardia (6) · Bronchopulmonary Dysplasia (5) · Hypoxia (5) · Infant, Premature, Diseases (3) · Respiratory Distress Syndrome (3) · Respiratory Insufficiency (3) · Asphyxia Neonatorum (2) · Ductus Arteriosus, Patent (2) · Respiratory Distress Syndrome, Newborn (2) · Agnosia (1) · Bone Diseases, Metabolic (1) · Brain Injuries (1) · Cardiac Output, Low (1)
Pathological Conditions, Signs and Symptoms (55) · Respiration Disorders (55) · Respiratory Tract Diseases (55) · Signs and Symptoms (55) · Signs and Symptoms, Respiratory (55) · Female Urogenital Diseases and Pregnancy Complications (25) · Obstetric Labor Complications (25) · Pregnancy Complications (25) · Urogenital Diseases (25) · Obstetric Labor, Premature (24) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (13) · Infant, Newborn, Diseases (12) · Lung Diseases (10) · Pathologic Processes (8) · Infant, Premature, Diseases (7)
caffeine citrate (15) · Caffeine (5) · Absorptiometry, Photon (1) · Administration, Oral (1) · Continuous Positive Airway Pressure (1) · Contraceptives, Oral (1) · Doxapram (1) · Fentanyl (1) · Glucose (1) · Odorants (1) · Oxygen (1) · Posture (1) · Rocuronium (1) · Saline Solution (1) · Theophylline (1)
McGill University Health Centre/Research Institute of the McGill University Health Centre (3) · Ain Shams University (2) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (2) · McMaster University (2) · Pontificia Universidad Catolica de Chile (2) · The University of Texas Health Science Center, Houston (2) · University of Manitoba (2) · University of Zurich (2) · Ankara Yildirim Beyazıt University (1) · Assiut University (1) · Case Western Reserve University (1) · Children's Hospital of Chongqing Medical University (1) · Children's Hospital of Fudan University (1) · Complejo Hospitalario Universitario Insular Materno Infantil (1) · Daping Hospital and the Research Institute of Surgery of the Third Military Medical University (1)
United States (20) · Canada (9) · Switzerland (3) · Australia (2) · Chile (2) · China (2) · France (2) · Germany (2) · Italy (2) · Netherlands (2) · Turkey (Türkiye) (2) · United Kingdom (2) · Belgium (1) · Brazil (1) · Egypt (1)
Ruben E Alvaro, MD (2) · Alfonso Solimano, MD (1) · Anna Thomas, MD (1) · Anne Smits, MD, PhD (1) · Arne Ohlsson, MD (1) · Barbara K Schmidt, MD (1) · Brett Manley, MBChB PhD (1) · Brittany Duyka, MD (1) · Carole Marcus, M.B.B.Ch. (1) · Cherry Uy, MD (1) · Claire Beaullieu, MD (1) · Cynthia Bearer, MD (1) · David Paydarfar, MD (1) · Deborah Dewey, MD (1) · Deepak Jain, MD (1)
PMID 12524574, PMID 12892358, PMID 14660510, PMID 16203218, PMID 16455761, PMID 16707748, PMID 16932229, PMID 17989382, PMID 18344903, PMID 19081519, PMID 19593246, PMID 19926098, PMID 20304417, PMID 20452844, PMID 20843245, PMID 21173002, PMID 21896964, PMID 22137670, PMID 22185623, PMID 2222618, PMID 22253394, PMID 22475409, PMID 22481227, PMID 22908052, PMID 23037873, PMID 23589814, PMID 23716498, PMID 23733842, PMID 2386134, PMID 24496539, PMID 24840756, PMID 25126039, PMID 25171195, PMID 25538543, PMID 25633155, PMID 25641237, PMID 25784749, PMID 26262797, PMID 26598451, PMID 26635271, PMID 27304988, PMID 27384980, PMID 28437520, PMID 28587528, PMID 28707987, PMID 28929527, PMID 29746604, PMID 30006148, PMID 30136672, PMID 30375661
2019 (1), R01HD057098 (1), R01HL098045 (1), U10HD036790 (1), UG1HD021364 (1), UG1HD027851 (1), UG1HD027853 (1), UG1HD027880 (1), UG1HD027904 (1), UG1HD034216 (1), UG1HD040492 (1), UG1HD040689 (1), UG1HD053089 (1), UG1HD053109 (1), UG1HD068244 (1)