5 completed, 2 recruiting, 2 unknown, 1 not yet recruiting. 3 Phase 4, 2 Not applicable, 2 Phase 2, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 3 | Completed 2, Not yet recruiting 1 |
| Not applicable | 2 | Unknown 2 |
| Phase 2 | 2 | Completed 2 |
| Phase 1 | 1 | Completed 1 |
| Phase 3 | 1 | Recruiting 1 |
Follow Doxapram: new trials by email Literature Review of Doxapram trials Research Report on Doxapram
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| the Effect of Doxapram on Diaphragmatic Excursion(DE) During Weaning From Mechanical Ventilation. Doxapram - Mechanically Ventilated ICU Patients, Diaphragm Excursion | Phase 4 | Not yet recruiting | Kasr El Aini Hospital | 60 | 2026-06-01 | 2026-06-09 |
| Study to Investigate the Safety, Tolerability and Pharmacokinetics of QEV-817 Oral Suspension Hydrocodone Bitartrate, Hydrocodone Bitartrate + Doxapram Hydrochloride - Healthy, PK Drug-drug Interaction Study | Phase 1 | Completed | Quivive Pharma, Inc. | 8 | 2025-08-18 | 2026-08-05 |
| Doxapram Administration on Diaphragmatic Excursion in Mechanically Ventilated Patients With Chronic Obstructive Pulmonary Disease Undergoing Spontaneous Breathing Trial Doxapram - COPD, Mechanical Ventilation | Recruiting | Cairo University | 35 | 2025-06-22 | 2025-06-26 | |
| Doxapram Therapy in Preterm Infants (DOXA Trial) Doxapram, Placebo - Apnea of Prematurity, Respiratory Insufficiency | Phase 3 | Recruiting | Erasmus Medical Center | 396 | 2020-06-15 | 2024-04-04 |
| The Effect of Doxapram Versus Theophylline on Diaphragmatic Function Doxapram Hydrochloride, Theophylline - Weaning Failure | Not applicable | Unknown | Beni-Suef University | 70 | 2019-05-01 | 2019-03-28 |
| Doxapram as an Additive to Propofol Sedation in Sedation for ERCP Doxapram, Placebo - Sedation, Hypoxia | Phase 4 | Completed | Helsinki University Central Hospital | 50 | 2016-10-01 | 2016-12-05 |
| The Effect and Mechanism of Respiratory Stimulant Doxapram on Facilitating Emergence doxapram, saline - Anesthesia | Not applicable | Unknown | General Hospital of Ningxia Medical University | 40 | 2015-10-01 | 2017-01-18 |
| Aminophylline and Cognitive Function After Sevoflurane Anaesthesia Placebo [group P], 0.2 mL/kg of aminophylline 10 mg/mL [group A2], 0.2 mL/kg of aminophylline 15 mg/mL [group A3] - Anaesthesia | Phase 2 | Completed | King Faisal University | 180 | 2007-11-01 | 2010-11-19 |
| Staccato Alprazolam in Panic Attack Inhaled placebo, Inhaled alprazolam 1 mg, Inhaled alprazolam 2 mg - Treatment of Induced Panic Attack | Phase 2 | Completed | Alexza Pharmaceuticals, Inc. | 49 | 2007-05-01 | 2017-06-16 |
| Dosing Chart for Calculating the First Dose of Doxapram in Premature Infants Doxapram - Premature Infants, Apnea | Phase 4 | Completed | Jean Michel Hascoet | 85 | 2006-11-01 | 2017-02-27 |
Apnea (2) · Hypoxia (2) · Panic Disorder (1) · Premature Birth (1) · Pulmonary Disease, Chronic Obstructive (1) · Respiratory Insufficiency (1)
Alexza Pharmaceuticals, Inc. (1) · Beni-Suef University (1) · Cairo University (1) · Erasmus Medical Center (1) · General Hospital of Ningxia Medical University (1) · Helsinki University Central Hospital (1) · Jean Michel Hascoet (1) · Kasr El Aini Hospital (1) · King Faisal University (1) · Quivive Pharma, Inc. (1)
Egypt (2) · United States (2) · Belgium (1) · Canada (1) · China (1) · Finland (1) · France (1) · Netherlands (1) · Saudi Arabia (1)
Anne Smits, MD, PhD (1) · Frank Lee, MD (1) · Jarno Jokelainen, M.D. (1) · Jeremy Coplan, MD (1) · Karel Allegaert, MD, PhD (1) · Laszlo Papp, MD (1) · Mohamed R El Tahan, M.D. (1) · Sanjay Mathew, MD (1) · Zhihua Wang, M.D. (1)
PMID 1600786, PMID 21755342, PMID 24527224, PMID 26392767, PMID 27612991, PMID 31993819, PMID 33514664, PMID 33940248
2019 (1)