8 completed, 8 recruiting, 4 not yet recruiting, 1 enrolling by invitation. 11 Not applicable, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 11 | Not yet recruiting 4, Recruiting 4, Completed 2, Enrolling by invitation 1 |
| Phase 4 | 1 | Completed 1 |
Follow Aortic Valve Regurgitation: new trials by email Literature Review of Aortic Valve Regurgitation trials Research Report on Aortic Valve Regurgitation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| JOURNEY LVAD: JOURNEY Left Ventricular Assist Device J-Valve Transfemoral System - Aortic Valve Regurgitation, Aortic Valve Disease Mixed | Not applicable | Not yet recruiting | JC Medical, Inc., an affiliate of Edwards Lifesciences LLC | 50 | 2026-04-01 | 2026-03-05 |
| Clinical Investigation for the PoliaValve Aortic Heart Valve- India PoliaValve (Aortic) - AORTIC VALVE DISEASES, Aortic Valve Stenosis | Not applicable | Not yet recruiting | Suzhou Hearthill Medical Technology Co.,LTD | 50 | 2025-11-15 | 2025-08-14 |
| Evaluation of Safety and Effectiveness of the EMBLOK EPS Compared With No Cerebral Embolic Protection During TAVR EMBLOK™ Embolic Protection System ("EMBLOK EPS") - AORTIC VALVE DISEASES, Aortic Valve Stenosis and/or Insufficiency | Not applicable | Not yet recruiting | Emblok, Inc. | 560 | 2025-10-21 | 2025-08-19 |
| Cohort Observing Mechanisms, Progression and Sequelae of Valvular Heart Disease Heart Valve Disease, Mitral Valve (MV) Regurgitation | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 10000 | 2025-06-01 | 2025-12-05 | |
| Clinical Trial Evaluating the Safety and Efficacy of Artificial Polymer Heart Valve for the Treatment of Aortic Valve Disease Artificial polymer heart valves, Bovine pericardial aortic valve - Aortic Valve Stenosis, Aortic Valve Disease | Not applicable | Not yet recruiting | Suzhou Hearthill Medical Technology Co.,LTD | 198 | 2024-12-01 | 2024-12-30 |
| J-Valve Transfemoral Pivotal Study J-Valve Transfemoral (TF) System - Aortic Valve Regurgitation, Aortic Valve Disease Mixed | Not applicable | Recruiting | JC Medical, Inc., an affiliate of Edwards Lifesciences LLC | 194 | 2024-10-17 | 2026-05-04 |
| Evaluating the Safety and Efficacy of Prosthetic Polymer Heart Valves for the Treatment of Aortic Valve Disease PoliaValve (Aortic) - Aortic Valve Disease, Aortic Valve Stenosis | Not applicable | Enrolling by invitation | Suzhou Hearthill Medical Technology Co.,LTD | 10 | 2024-08-15 | 2024-12-16 |
| Left Ventricular Reverse Remodeling Evaluation After Surgical Correction of Aortic Regurgitation Not applicable - observational study - Aortic Valve Regurgitation, Mitral Valve Regurgitation | Recruiting | Petrovsky National Research Centre of Surgery | 120 | 2024-05-09 | 2025-06-11 | |
| TAVIS Registry - Trilogy Heart Valve System for Management of Patients With Aortic Valve Disease Transcatheter Aortic Valve Implantation (TAVI) - Aortic Valve Stenosis, Aortic Valve Regurgitation | Terminated | JenaValve Technology, Inc. | 24 | 2023-08-01 | 2026-08-21 | |
| Valve Hemodynamic Optimization Based on Doppler-Echocardiography vs Catheterization Measurements Following ViV TAVR Doppler-echocardiography, Invasive hemodynamic measurements - Aortic Valve Stenosis, Aortic Valve Regurgitation | Not applicable | Recruiting | Institut universitaire de cardiologie et de pneumologie de Québec, University Laval | 310 | 2023-01-11 | 2026-03-24 |
| Aortic or Mitral Valve Replacement With the Braile Biomédica® Bovine Pericardium Valvular Bioprosthesis Braile Biomédica® Bovine Pericardium Valvular Bioprosthesis. - Aortic Valve Insufficiency, Aortic Valve Regurgitation | Completed | Braile Biomedica Ind. Com. e Repr. Ltda. | 913 | 2023-01-01 | 2025-04-25 | |
| CT Scan Sizing for Perceval Sutureless Valve Aortic Valve Regurgitation | Completed | Maria Cecilia Hospital | 50 | 2022-12-01 | 2026-05-13 | |
| Early Aortic vaLve surgEry Versus wAtchful waitiNg Strategy in Severe Asymptomatic aOrtic reguRgitation State of art aortic valve surgery - Aortic Valve Regurgitation | Not applicable | Recruiting | Na Homolce Hospital | 217 | 2022-09-01 | 2026-02-17 |
| Clinical Evaluation of the Free Margin Cusp Sizer (CALIBRATE) Free Margin Cusp Sizer - Aortic Valve Regurgitation, Aortic Root Aneurysm | Not applicable | Recruiting | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | 120 | 2021-03-22 | 2025-05-16 |
| A 10-Minute Cardiovascular Magnetic Resonance Protocol for Cardiac Disease Coronary Artery Disease, Myocarditis | Recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 2130 | 2019-12-12 | 2024-10-24 | |
| Anticoagulation for Aortic Bioprosthesis (ANTIPRO) Warfarin, Aspirin - Aortic Valve Stenosis, Aortic Valve Disease | Phase 4 | Completed | Instituto Nacional de Cirugia Cardiaca, Uruguay | 140 | 2019-01-01 | 2022-03-08 |
| Transcatheter Aortic Valve Replacement for Pure Severe Aortic Valve Regurgitation Transcatheter aortic valve replacement - Aortic Valve Regurgitation | Recruiting | Xijing Hospital | 500 | 2018-10-30 | 2024-04-24 | |
| Hemodynamic Matched Comparison of the Balloon-Expandable Transcatheter Heart Valves Myval and Sapien-3 for the Treatment of Aortic Stenosis Sapien 3 Transcather Aortic Valve Implant, Myval Transcather Aortic Valve Implant - Aortic Valve Stenosis, Aortic Valve Regurgitation | Completed | Ignacio J. Amat Santos | 416 | 2018-06-01 | 2021-01-28 | |
| Protocoled Quantitative Assessment of Aortic Regurgitation Using Videodensitometry in a Multicontinental Trial in Rotterdam, Montreal, Yamaguchi, Segeberg, Amsterdam. Standardized protocol for assessing aortic regurgitation using videodensitometry - Aortic Valve Insufficiency, Aortic Valve Regurgitation | Completed | Imperial College London | 354 | 2017-09-01 | 2019-08-07 | |
| Physical and Functional Recovery From Cardiac Surgery in Hospitalized Patients: A Feasibility Pilot Study Ambulation orderly - Coronary Artery Disease, Mitral Valve Insufficiency | Not applicable | Completed | Baystate Medical Center | 36 | 2015-03-01 | 2017-11-06 |
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Aortic Valve Insufficiency (22) · Aortic Valve Stenosis (13) · Aortic Valve Disease (7) · Heart Valve Diseases (4) · Mitral Valve Insufficiency (4) · Mitral Valve Stenosis (4) · Coronary Artery Disease (2) · Ventricular Outflow Obstruction (2) · Aortic Root Aneurysm (1) · Cardiomyopathy, Dilated (1) · Cardiomyopathy, Hypertrophic (1) · Cardiovascular Diseases (1) · Constriction, Pathologic (1) · Gastroesophageal Reflux (1) · Heart Defects, Congenital (1)
Cardiovascular Diseases (21) · Heart Diseases (21) · Heart Valve Diseases (18) · Aortic Valve Disease (15) · Ventricular Outflow Obstruction (11) · Vascular Diseases (3) · Arterial Occlusive Diseases (2) · Arteriosclerosis (2) · Coronary Disease (2) · Myocardial Ischemia (2) · Pathological Conditions, Signs and Symptoms (2) · Aneurysm (1) · Aortic Aneurysm (1) · Aortic Aneurysm, Thoracic (1) · Aortic Diseases (1)
Transcatheter Aortic Valve Replacement (2) · Aspirin (1) · Drug Delivery Systems (1) · Observation (1) · Replantation (1) · Warfarin (1)
Suzhou Hearthill Medical Technology Co.,LTD (3) · Abbott Medical Devices (2) · JC Medical, Inc., an affiliate of Edwards Lifesciences LLC (2) · Baystate Medical Center (1) · Braile Biomedica Ind. Com. e Repr. Ltda. (1) · Cliniques universitaires Saint-Luc- Université Catholique de Louvain (1) · Emblok, Inc. (1) · Ignacio J. Amat Santos (1) · Imperial College London (1) · Institut universitaire de cardiologie et de pneumologie de Québec, University Laval (1) · Instituto Nacional de Cirugia Cardiaca, Uruguay (1) · JenaValve Technology, Inc. (1) · Maria Cecilia Hospital (1) · McGill University Health Centre/Research Institute of the McGill University Health Centre (1) · Na Homolce Hospital (1)
Canada (5) · United States (5) · China (3) · Belgium (2) · Germany (2) · Italy (2) · Japan (2) · United Kingdom (2) · Brazil (1) · Czechia (1) · France (1) · Netherlands (1) · Russia (1) · Serbia (1) · Spain (1)
Andrew Morse, MD (1) · Barathi Sethuraman (1) · Dean J Kereiakes, MD (1) · Diego Freire, MD (1) · Elisa Mikus, MD (1) · Fanglin Lu, MD (1) · Fernando Lucchese (1) · Hendrik Treede, MD (1) · Ling Tao, M.D, Ph.D (1) · Matthias G Friedrich, MD (1) · Michael Reardon, MD (1)
PMID 10199882, PMID 16872961, PMID 22879371, PMID 24958752, PMID 25283687, PMID 26984717, PMID 27855803, PMID 28314623, PMID 29718164, PMID 30660551, PMID 30687584, PMID 31147307, PMID 31240183, PMID 31510787, PMID 31614523, PMID 32817242, PMID 34453165, PMID 39966045, PMID 8227808, PMID 8563989