10 completed, 3 recruiting, 3 terminated, 2 not yet recruiting. 22 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 22 | Completed 10, Recruiting 3, Terminated 3, Not yet recruiting 2, Enrolling by invitation 1, Suspended 1, Unknown 1, Withdrawn 1 |
Follow Aneurysm: new trials by email Literature Review of Aneurysm trials Research Report on Aneurysm
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mechanistic Clinical Trial of PCSK9 Inhibition for AAA Evolocumab, Placebo - Abdominal Aortic Aneurysm | Early Phase 1 | Not yet recruiting | University of Pennsylvania | 44 | 2026-12-01 | 2026-04-20 |
| A Preliminary Exploratory Clinical Trial to Evaluate the Efficacy of NPDR-01 Eye Drops in the Treatment of Non-Proliferative Diabetic Retinopathy Investigational Eye Drops (NPDR-01) - Non-proliferative Diabetic Retinopathy (NPDR), Diabetic Retinal Microangiopathy | Early Phase 1 | Not yet recruiting | Sichuan Academy of Medical Sciences | 10 | 2025-12-01 | 2025-09-30 |
| PET Imaging of MMP Activation in AAA: Clinical Component Cu-64-RYM2, PET imaging using Cu-64 - Abdominal Aortic Aneurysm | Early Phase 1 | Recruiting | Washington University School of Medicine | 28 | 2025-11-03 | 2026-03-18 |
| Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia Placebo, Propranolol, Gemtesa - Aging, Menopause | Early Phase 1 | Recruiting | University of Missouri-Columbia | 75 | 2024-06-03 | 2026-09-10 |
| Sex-related Differences in Sympathetic Vascular Transduction in the Setting of Hypoxemia Propranolol Pill, Placebo - Vasodilation, Hypoxia | Early Phase 1 | Completed | University of Missouri-Columbia | 31 | 2023-04-26 | 2025-09-15 |
| Sex Disparities in Hypoxic Vasodilation and Impact of Obesity Propranolol Hydrochloride, Isoproterenol, Phentolamine Mesylate - Obesity, Vasodilation | Early Phase 1 | Recruiting | University of Missouri-Columbia | 72 | 2023-03-14 | 2026-07-28 |
| Safety and Tolerability of Nitro for Radial Artery Dilation Nitroglycerin ointment - Artery; Dilatation | Early Phase 1 | Unknown | Thomas Jefferson University | 20 | 2022-05-01 | 2022-04-06 |
| Pilot Study of BAO-G Technique in TAAA Endovascular Repair BAO-G - Aortic Aneurysm, Thoracoabdominal | Early Phase 1 | Enrolling by invitation | Peking Union Medical College Hospital | 20 | 2022-01-01 | 2024-08-02 |
| Impact of Intranasal Insulin on Sympathetic Activity and Cerebral Vasodilation Carbon dioxide breathing, Neurovascular Coupling, Human insulin - Healthy, Vasodilation | Early Phase 1 | Suspended | University of Missouri-Columbia | 65 | 2021-12-01 | 2025-12-19 |
| NIH CCR2 AAA Study AAA Group (Aim 3A), Non-AAA Group, Ex Vivo Human AAA Specimens (Aim 2A) - Abdominal Aortic Aneurysm (AAA), No Abdominal Aortic Aneurysm (Non-AAA) | Early Phase 1 | Completed | Washington University School of Medicine | 50 | 2021-02-17 | 2025-07-15 |
| Sex Disparities in Hypoxic Sympatholysis and Impact of Obesity Cold Pressor Test - Obesity, Healthy | Early Phase 1 | Completed | University of Missouri-Columbia | 73 | 2020-12-09 | 2026-07-28 |
| CCR2 AAA Pilot Study Aortoiliac Occlusive Disease Group - PET-CT imaging with injection of 64Cu-DOTA-ECL1i, AAA Group- PET-CT imaging with injection of 64Cu-DOTA-ECL1i - Abdominal Aortic Aneurysm (AAA) | Early Phase 1 | Terminated | Washington University School of Medicine | 1 | 2020-10-07 | 2022-04-15 |
| Targeting ER Stress in Vascular Dysfunction Acetylcholine, Sodium Nitroprusside, Ascorbic Acid - Vasodilation, Arterial Stiffness | Early Phase 1 | Terminated | Colorado State University | 17 | 2019-06-01 | 2025-04-08 |
| Role of Acetylcholine in Blood Flow Regulation in Healthy Adults: Effects of Age and Exercise Training Handgrip Exercise Training, Acetylcholine, Adenosine Triphosphate - Vasoconstriction, Vasodilation | Early Phase 1 | Withdrawn | Colorado State University | 2019-04-16 | 2021-08-02 | |
| Reflex Responses to Intermittent Hypoxia in Humans: Mechanisms and Consequences Hypoxic exposure, modified Oxford test, Oral Bosentan 62.5 mg - Sleep Apnea, Healthy | Early Phase 1 | Completed | University of Missouri-Columbia | 54 | 2016-12-20 | 2021-12-06 |
| An Investigation of the Dose-dependent Vascualr Effects of (-)-Epicatechin in Healthy Men Water, Epicatechin 0.1 mg/kg, Epicatechin 0.5 mg/kg - Vasodilation | Early Phase 1 | Completed | University of Reading | 21 | 2014-05-01 | 2016-05-30 |
| Screening Programme for Abdominal Aortic Aneurysm by Hand-Held-Ultrasonography in Primary Health Care Ultrasound (Trademark:VScan; Manufacturer:General Electric) - Abdominal Aortic Aneurysm | Early Phase 1 | Completed | Consorci d'Atenció Primària de Salut de l'Eixample | 1010 | 2013-06-01 | 2014-11-06 |
| Effects of Beta-blockade on Cardiopulmonary Exercise Testing Bisoprolol - Abdominal Aortic Aneurysm Patients Under Surveillance | Early Phase 1 | Completed | Michelle Mossa | 55 | 2011-02-01 | 2014-04-08 |
| Continuous Neurophysiological Monitoring Detection of Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage Subjects Neuro Monitoring - Cerebral Vasospasm, SAH | Early Phase 1 | Terminated | State University of New York - Upstate Medical University | 2 | 2010-12-01 | 2016-01-01 |
| Efficiency of Two Glucose Sampling Protocols for Maintenance of Euglycemia Insulin - Brain Neoplasms, Intracranial Aneurysm | Early Phase 1 | Completed | Northwestern University | 120 | 2009-10-01 | 2019-12-13 |
Showing 20 of 22. Sign in to see all of them.
Aortic Aneurysm, Abdominal (6) · Obesity (5) · Hypoxia (2) · Insulin Resistance (2) · Aortic Aneurysm, Thoracoabdominal (1) · Brain Neoplasms (1) · Diabetic Retinopathy (1) · Hypoglycemia (1) · Intracranial Aneurysm (1) · Microaneurysm (1) · Motor Activity (1) · Primary Dysautonomias (1) · Pulmonary Arterial Hypertension (1) · Sleep Apnea Syndromes (1)
Cardiovascular Diseases (22) · Vascular Diseases (22) · Aortic Aneurysm (7) · Aortic Diseases (7) · Pathological Conditions, Signs and Symptoms (7) · Signs and Symptoms (7) · Nutritional and Metabolic Diseases (6) · Body Weight (5) · Nutrition Disorders (5) · Overnutrition (5) · Overweight (5) · Nervous System Diseases (4) · Brain Diseases (2) · Central Nervous System Diseases (2)
Acetylcholine (3) · Nitroprusside (3) · Propranolol (3) · Bosentan (2) · Insulin (2) · Adenosine Triphosphate (1) · Ascorbic Acid (1) · Atropine (1) · Bisoprolol (1) · Bradykinin (1) · Catechin (1) · Endothelin-3 (1) · Insulin, Regular, Human (1) · Isoproterenol (1) · Neurovascular Coupling (1)
University of Missouri-Columbia (6) · Washington University School of Medicine (3) · Colorado State University (2) · Consorci d'Atenció Primària de Salut de l'Eixample (1) · Michelle Mossa (1) · Northwestern University (1) · Peking Union Medical College Hospital (1) · Sichuan Academy of Medical Sciences (1) · State University of New York - Upstate Medical University (1) · Stefan Soderberg (1) · Thomas Jefferson University (1) · University of Edinburgh (1) · University of Pennsylvania (1) · University of Reading (1)
United States (14) · United Kingdom (4) · China (1) · Spain (1) · Sweden (1)
Jacqueline K Limberg, Ph.D. (3) · Frank Dinenno, PhD (2) · Mohamed M. Zayed, MD (2) · Belchin Kostov, MSc (1) · Daniel Cararach Salami, MD (1) · David Fischman, M.D. (1) · Dhanesh Gupta, MD (1) · Eric M Deshaies, MD (1) · Jacqueline Limberg, Ph.D. (1) · Jeremy Spencer, PhD (1)
PMID 25716221, PMID 28409004, PMID 40066842, PMID 40465513
K99HL130339 (1), R00HL130339 (1), R01HL166991 (1)