17 completed, 1 enrolling by invitation, 1 recruiting, 1 unknown. 8 Not applicable, 6 Phase 1, 5 Phase 2, 1 Early Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 8 | Completed 6, Recruiting 1, Unknown 1 |
| Phase 1 | 6 | Completed 5, Withdrawn 1 |
| Phase 2 | 5 | Completed 5 |
| Early Phase 1 | 1 | Completed 1 |
| Phase 3 | 1 | Enrolling by invitation 1 |
Follow Catechin: new trials by email Literature Review of Catechin trials Research Report on Catechin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Oral or Topical Catechins for Radiation Dermatitis Epicatechin, Epigallocatechin Gallate (EGCG), Microcrystalline Cellulose NF (placebo) - Radiation Dermatitis Acute, Radiation Dermatitis | Phase 3 | Enrolling by invitation | CARLOS FRANCISCO SAAVEDRA GARCIA | 162 | 2026-10-01 | 2026-09-11 |
| The Effect of the Nutraceutical (-)- Epicatechin on Myosteatosis in Patients With Advanced CKD Epicatechin extract - Chronic Kidney Disease(CKD), Myosteatosis | Not applicable | Recruiting | Karolinska Institutet | 10 | 2025-01-17 | 2025-07-10 |
| The Influence of the Microbiome on the Pharmacokinetics of Flavan-3-ols (-)-Epicatechin - Diet Modification | Not applicable | Completed | University Ghent | 20 | 2021-11-01 | 2022-04-27 |
| Safety and Biomarker Response to (+)-Epicatechin in Becker Muscular Dystrophy (+)-Epicatechin - Becker Muscular Dystrophy | Phase 1 | Completed | Epirium Bio Inc. | 22 | 2020-07-13 | 2022-03-23 |
| Effects of COcoa Supplement in OBese Adolescent Subjects Cocoa Flavonols Supplement - Childhood Obesity, Adolescent Obesity | Not applicable | Completed | National Polytechnic Institute, Mexico | 104 | 2019-12-15 | 2026-04-03 |
| Candida Associated Cytokines in Oral Leukoplakia Fluconazole - Oral Leukoplakia | Completed | All India Institute of Medical Sciences | 90 | 2018-11-01 | 2021-01-20 | |
| Plus Epicatechin Duchenne Muscular Dystrophy in Non-ambulatory Adolescents (+)- Epicatechin - Duchenne Muscular Dystrophy | Phase 1 / Phase 2 | Completed | Craig McDonald, MD | 15 | 2016-11-01 | 2021-12-21 |
| (-)- Epicatechin Becker Muscular Dystrophy (-)-Epicatechin - Becker Muscular Dystrophy | Phase 2 | Completed | Craig McDonald, MD | 2 | 2016-11-01 | 2021-11-24 |
| (+) Epicatechin to Treat Friedreich's Ataxia (+)-Epicatechin - Friedreich's Ataxia | Phase 2 | Completed | Ralitza Gavrilova | 10 | 2016-09-01 | 2019-12-05 |
| Absorption, Metabolism and Excretion of Dietary Polyphenolic Bioactives in Humans Thearubigins, Theaflavins, Procyanidin Dimer B2 (DB2) - Healthy | Not applicable | Completed | University of California, Davis | 12 | 2016-08-01 | 2017-11-06 |
| Cross-over Double-blind Intervention to Investigate the Effects of Defined Antioxidant-containing Drinks on Time Course of Antioxidant Capacity Placebo, Vitamin C, epicatechin - The Impact of Vitamin c and Epicatechin Upon Antioxidant Capactity | Not applicable | Unknown | Newcastle University | 10 | 2016-07-01 | 2016-09-13 |
| Early Phase Pre-Clinical and Initial Clinical Research on Epicatechin (Part 2) epicatechin, Placebo - Pre-diabetes | Phase 1 | Completed | Veterans Medical Research Foundation | 15 | 2015-09-01 | 2016-04-28 |
| The Randomized Controlled Cocoa-Appetite Trial Lo-Flav, Hi-Flav, Epicatechin - Obesity | Not applicable | Completed | Brooklyn College of the City University of New York | 28 | 2015-03-01 | 2016-01-13 |
| Early Phase Pre-Clinical and Initial Clinical Research on Epicatechin (+)-Epicatechin - Pre-diabetes | Phase 1 | Completed | Veterans Medical Research Foundation | 12 | 2014-09-01 | 2017-04-17 |
| An Investigation of the Dose-dependent Vascualr Effects of (-)-Epicatechin in Healthy Men Water, Epicatechin 0.1 mg/kg, Epicatechin 0.5 mg/kg - Vasodilation | Early Phase 1 | Completed | University of Reading | 21 | 2014-05-01 | 2016-05-30 |
| (-)-Epicatechin and Pulmonary Arterial Hypertension (-)-Epicatechin - Pulmonary Arterial Hypertension | Phase 1 | Withdrawn | University of California, San Francisco | 2013-07-01 | 2014-09-10 | |
| Use of (-)-Epicatechin in the Treatment of Becker Muscular Dystrophy (Pilot Study) (-)-epicatechin - Becker Muscular Dystrophy | Phase 1 / Phase 2 | Completed | Craig McDonald, MD | 7 | 2013-05-01 | 2021-12-22 |
| Study on the Effects of Epicatechin and Quercetin Supplementation on Vascular Function and Blood Pressure (FLAVO) Epicatechin, Quercetin, Placebo - Hypertension, Endothelial Dysfunction | Not applicable | Completed | Wageningen University | 38 | 2012-09-01 | 2013-04-23 |
| Effect of an Apple Polyphenol Extract on Brachial Artery Flow-mediated Vasodilatory Function Epicatechin, Microcrystalline cellulose - Borderline Hypertension | Phase 2 | Completed | Danisco | 57 | 2012-08-01 | 2014-04-08 |
| Bioavailability and Vascular Effects of Apple Polyphenols Apple extract delivering 70 mg epicatechin, Apple extract delivering 140 mg epicatechin, Apple granules delivering 70 mg epicatechin - Healthy | Not applicable | Completed | Quadram Institute Bioscience | 12 | 2010-04-01 | 2013-03-06 |
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Muscular Dystrophy, Duchenne (4) · Glucose Intolerance (2) · Neuromuscular Diseases (2) · Obesity (2) · Aneurysm (1) · Cardiomyopathies (1) · Fibrosis (1) · Friedreich Ataxia (1) · Hypertension (1) · Leukoplakia, Oral (1) · Mitochondrial Diseases (1) · Muscular Diseases (1) · Overweight (1) · Pediatric Obesity (1) · Pulmonary Arterial Hypertension (1)
Craig McDonald, MD (3) · Veterans Medical Research Foundation (2) · All India Institute of Medical Sciences (1) · Brooklyn College of the City University of New York (1) · CARLOS FRANCISCO SAAVEDRA GARCIA (1) · Danisco (1) · Epirium Bio Inc. (1) · Karolinska Institutet (1) · National Polytechnic Institute, Mexico (1) · Newcastle University (1) · Provident Clinical Research (1) · Quadram Institute Bioscience (1) · Ralitza Gavrilova (1) · University Ghent (1) · University of California, Davis (1)
United States (11) · United Kingdom (3) · Mexico (2) · Belgium (1) · Finland (1) · India (1) · Netherlands (1) · Sweden (1)
Robert R Henry, MD (2) · Anne Lithonius (1) · Carl L Keen, PhD (1) · Carmen Palacios, MD; PhD; MMSc; genetics (1) · Christopher Barnett, MD, MPH (1) · Craig M McDonald, MD (1) · Erik K Henricson, MPH (1) · Ernst Rietzschel, PhD (1) · James Greenberg, Ph.D (1) · Jari Turunen, MSc (1) · Javier I Ottaviani, PhD (1) · Jeremy Spencer, PhD (1) · Kevin C Maki, PhD (1) · Kirsti Tiihonen, PhD (1)
PMID 22240243, PMID 22373658, PMID 22796902, PMID 23052543, PMID 24376420, PMID 24458104, PMID 25548896, PMID 25934864, PMID 25972527, PMID 26787421, PMID 26849546, PMID 27510533, PMID 27552564, PMID 27837784, PMID 28283258, PMID 28295797, PMID 28639319, PMID 28639320, PMID 29078780, PMID 30398646, PMID 32677106, PMID 33813637, PMID 39513382
R01AT008310 (2)