164 completed, 54 unknown, 52 recruiting, 16 terminated. 216 Not applicable, 11 Phase 2, 6 Phase 1, 6 Phase 4, 4 Phase 3.
Follow Amputation: new trials by email Literature Review of Amputation trials Research Report on Amputation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Measuring Plantar Pressures in Diabetic Patients With Lateral Forefoot Amputation Amputation, Diabetes Complications | Recruiting | Nanyang Technological University | 70 | 2026-11-27 | 2026-10-08 | |
| The Effect of Perioperative Intravenous Lidocaine Infusion on Post-amputation Pain in Amputee Patients Lidocaine Hydrochloride, Injectable, 0.9% normal saline - Amputation | Not applicable | Not yet recruiting | West China Hospital | 200 | 2026-10-01 | 2026-08-25 |
| Advancing Antimicrobial Photodynamic Therapy to Prevent Infection in Osseointegrated Prosthesis Patients 5-aminolevulinic acid (5-ALA), Photodynamic therapy (PDT) - Amputation, Osseointegration | Not yet recruiting | Dartmouth-Hitchcock Medical Center | 10 | 2026-10-01 | 2026-07-29 | |
| The Association Between Amputation Level and Chronic Low Back Pain After Combat-Related Amputation Low Back Pain, Amputation | Not yet recruiting | Ukrainian Society of Regional Anesthesia and Pain Therapy | 300 | 2026-09-15 | 2026-06-04 | |
| Training Independent Muscle Activation From a Common Source amputation or revision procedure with additional RPNI construction - Amputation | Not applicable | Recruiting | Brigham and Women's Hospital | 10 | 2026-09-01 | 2026-09-21 |
| Comparing the Attentional Demands and Functional Outcomes in People With Transradial Amputation Training with PRC, Training with DC, PRC Device use in community and home - Amputation, Prosthesis Use | Not applicable | Recruiting | Virginia Commonwealth University | 32 | 2026-07-02 | 2026-09-08 |
| Influence Of A Slope Adaptive Foot On Participation Of Veterans With Lower-Limb Amputations Fillauer Slope Adaptive Foot, Fillauer Motion Foot SLX - Amputation | Not applicable | Recruiting | VA Office of Research and Development | 30 | 2026-07-01 | 2026-07-30 |
| Bio Leg: Advancing Mobility (BAM) Bio Leg - Amputation of Lower Limb Above Knee, Amputee | Not applicable | Recruiting | University of Florida | 12 | 2026-06-01 | 2026-07-06 |
| Gait Training and Balance Using Artificial Intelligence Artificial Intelligence - Above Knee Amputation, Amputation | Not applicable | Recruiting | South Valley University | 40 | 2026-06-01 | 2026-08-18 |
| Assessing Ambulatory and Non-ambulatory Community Mobility in People With Lower Limb Amputation Clinical Descriptive Measures related to amputation collected, GPS device education/distributed, activPAL device education/distributed - Amputation | Not applicable | Recruiting | Virginia Commonwealth University | 50 | 2026-04-21 | 2026-07-27 |
| Prosthetic Socket Fit Testing System Prosthetic socket fit testing system - Amputation | Not applicable | Not yet recruiting | University of Washington | 18 | 2026-04-01 | 2026-03-24 |
| TOE Study: Treatment and Gait Analysis fOllowing an Excised Lesser Toe Otoform toe divider - Diabetes Mellitus, Amputation | Not applicable | Not yet recruiting | University of Huddersfield | 30 | 2026-04-01 | 2026-03-02 |
| Evacuation Time and Tourniquet Use as Risk Factors for PTSD in Combat-Related Amputation Amputation, PTSD | Not yet recruiting | Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans) | 300 | 2026-03-15 | 2026-04-03 | |
| Amputations in Childhood and Neuropathic Pain Pediatric, Neuropathic Pain | Recruiting | Hopitaux de Saint-Maurice | 50 | 2026-02-19 | 2026-02-23 | |
| Evaluation of Myoelectric Implantable Recording Array (MIRA) in Participants With Transradial Amputation Myoelectric Implantable Recording Array (MIRA) - Amputation, Amputation; Traumatic, Hand | Not applicable | Recruiting | Boninger, Michael, MD | 5 | 2026-01-16 | 2026-02-27 |
| Neuromusculoskeletal Interface for Bionic Arms eOPRA, OPRA, eOPRA with sensory feedback - Amputation, Amputation, Traumatic | Not applicable | Not yet recruiting | Shirley Ryan AbilityLab | 12 | 2026-01-01 | 2025-06-24 |
| Pilot Feasibility Trial of a Peer Support Program for Trauma Survivors Cross-continuum Peer Support Program - Traumatic Injury, Burns | Not applicable | Not yet recruiting | Sunnybrook Health Sciences Centre | 49 | 2026-01-01 | 2025-12-10 |
| Core Muscle Function and Postural Control in Lower Extremity Amputees Amputation, Ultrasonography | Recruiting | Hacettepe University | 32 | 2025-12-04 | 2026-10-15 | |
| Impact Evaluation of Breizh Fabribus Intervention for Personalized Assistive Technology Creation or Adaptation Amputation, Functional Limitation | Recruiting | Fondation Ildys | 70 | 2025-12-01 | 2026-01-02 | |
| Combined Local Anesthetic Blockade and Neuromodulation vs Local Anesthetic Blockade Only for Analgesia After Below-knee Amputation: RCT Ropivacaine 0.2% + nerve stimulator set, Ropivacaine 0.2% - Amputation | Not applicable | Not yet recruiting | Stanford University | 62 | 2025-12-01 | 2025-05-09 |
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Phantom Limb (32) · Wounds and Injuries (17) · Diabetes Mellitus (16) · Pain (16) · Amputation, Traumatic (15) · Diabetic Foot (13) · Peripheral Arterial Disease (10) · Motor Activity (9) · Spinal Cord Injuries (8) · Multiple Sclerosis (6) · Cerebral Palsy (5) · Chronic Pain (5) · Spinal Dysraphism (5) · Diabetic Neuropathies (4) · Leg Injuries (4)
Pathological Conditions, Signs and Symptoms (69) · Signs and Symptoms (56) · Nervous System Diseases (55) · Neurologic Manifestations (52) · Pathologic Processes (48) · Postoperative Complications (38) · Neurobehavioral Manifestations (33) · Perceptual Disorders (33) · Endocrine System Diseases (32) · Pain (31) · Pain, Postoperative (31) · Cardiovascular Diseases (28) · Vascular Diseases (27) · Wounds and Injuries (25) · Nutritional and Metabolic Diseases (21)
Standard of Care (3) · Surveys and Questionnaires (3) · Amputation, Surgical (2) · Antibodies, Monoclonal (2) · Hand Transplantation (2) · Health Resources (2) · Hyperbaric Oxygenation (2) · Lidocaine (2) · Saline Solution (2) · Self-Management (2) · Tacrolimus (2) · Acupuncture Therapy (1) · Aminolevulinic Acid (1) · Analgesia (1) · Anesthesia, Spinal (1)
VA Office of Research and Development (15) · Össur Iceland ehf (15) · Shirley Ryan AbilityLab (13) · Liberating Technologies, Inc. (11) · Hacettepe University (10) · University of Washington (8) · University of Michigan (7) · Brigham and Women's Hospital (5) · Gaziler Physical Medicine and Rehabilitation Education and Research Hospital (5) · Indiana University (4) · Infinite Biomedical Technologies (4) · Loma Linda University (4) · Sunnybrook Health Sciences Centre (4) · University of Colorado, Denver (4) · University of Nevada, Las Vegas (4)
United States (179) · Turkey (Türkiye) (30) · France (17) · Canada (14) · Italy (10) · Germany (5) · Netherlands (5) · United Kingdom (5) · Egypt (4) · Norway (4) · Pakistan (4) · Australia (3) · Finland (3) · Singapore (3) · Austria (2)
Levi Hargrove, PhD (5) · Matthew J Carty, MD (5) · Glenn K Klute, PhD (3) · Matthew J. Major, PhD (3) · Alena Grabowski, PhD BA (2) · Brian Ilfeld, M.D., M.S. (2) · Dana Anaby, PhD (2) · Deanna H Gates, PhD (2) · Helena Burger, MD, PhD (2) · Hugh M Herr, PhD (2) · Jennifer Johansson, MS (2) · Lee Fisher, PhD (2) · Sashwati Roy, PhD (2)
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1IK2RX003282-01A2 (1), 1UG3NS127063-01A1 (1), 2SB1AG050430-06 (1), DP2HD111709 (1), I21RX003290 (1), IK2RX001322 (1), K01HD091449 (1), K12TR004364 (1), P2CHD086844 (1), R01DK132569 (1), R01EB025819 (1), R01HD057916 (1), R01HD060585 (1), R01HD079428 (1), R01HD094861 (1)