19 not yet recruiting, 16 recruiting, 11 completed, 4 enrolling by invitation. 20 Not applicable, 8 Phase 2, 7 Phase 1, 2 Phase 3, 1 Early Phase 1.
Follow Alzheimer Disease (AD): new trials by email Literature Review of Alzheimer Disease (AD) trials Research Report on Alzheimer Disease (AD)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Predicting Pre-dementia Mild Cognitive Impairment (MCI), Alzheimer Dementia (AD) | Recruiting | Prevention Research Consortium Corp. | 100 | 2026-11-15 | 2026-09-22 | |
| Exercise in Alzheimer's Disease: Functional Biomarkers High load, Moderate load, Healthy adults - High load - Alzheimer's Dementia (AD), Alzheimer Disease (AD) | Not applicable | Not yet recruiting | European University Miguel de Cervantes | 48 | 2026-11-10 | 2026-11-05 |
| Remote Digital Assessments for Cognitive Disorders Mild Cognitive Impairment (MCI), Alzheimer Disease (AD) | Not yet recruiting | Centre for Addiction and Mental Health | 60 | 2026-11-01 | 2026-10-20 | |
| Intervention to Reduce Unwanted Loneliness in Family Caregivers of People With Alzheimer Multimodal intervention to Reduce Unwanted Loneliness in Family Caregivers of People With Alzheimer - Alzheimer Disease (AD), Unwanted Loneliness | Not applicable | Not yet recruiting | University of Valencia | 50 | 2026-10-01 | 2026-06-15 |
| DUVAX: A Phase 1 Alzheimer's Vaccine Study Targeting Amyloid-Beta and Tau DUVAX 200 µg, DUVAX 400 µg, Placebo (Adjuvant only) - Alzheimer Disease, Alzheimer Disease (AD) | Phase 1 | Recruiting | Nuravax, Inc. | 24 | 2026-09-25 | 2026-09-30 |
| Transcranial Alternating Current Stimulation (tACS) Combined With Cognitive Training in Alzheimer's Disease Transcranial Alternating Current Stimulation, Sham Transcranial Alternating Current Stimulation, Individualized Computerized Memory Training - Transcranial Alternating Current Stimulation, Alzheimer Disease (AD) | Not applicable | Recruiting | IRCCS Centro San Giovanni di Dio Fatebenefratelli | 30 | 2026-09-16 | 2026-11-05 |
| Assessment of Changes in Autonomy Through Analysis of Smartphone Usage Data in Patients With Alzheimer's Disease Data collection, Neuropsychological assesment, Autonomy questionnaire - Alzheimer Disease (AD) | Not yet recruiting | Poitiers University Hospital | 100 | 2026-09-01 | 2026-09-18 | |
| N-AD: Orally Administered Nicotinamide Riboside Over Two Years as a Potential Disease Modifying Treatment for Alzheimer's Disease Nicotinamide Riboside (NR), Palacebo - Alzheimer Disease (AD) | Phase 2 | Recruiting | Haukeland University Hospital | 270 | 2026-08-26 | 2026-08-20 |
| Digital Lifestyle Coaching for Alzheimer's Disease Prevention in APOE4 Carriers Education - Mild Cognitive Impairment (MCI), Alzheimer Disease (AD) | Not applicable | Enrolling by invitation | Scripps Translational Science Institute | 1200 | 2026-08-06 | 2026-10-14 |
| Use of a Mobile Brain-Body Imaging Approach to Evaluate the Effects of Rhythmic Auditory Stimulation on Gait and Brain Function in Alzheimer's Disease Metronome - Alzheimer Disease (AD), Mild Cognitive Impairment (MCI) | Not applicable | Recruiting | Boston University Charles River Campus | 40 | 2026-06-01 | 2026-08-13 |
| Tributyrin Treatment in Mild Alzheimer Disease: Assessment of Butyrate Effects Via the Gut-Brain tributyrin, Placebo - Alzheimer Disease (AD) | Phase 3 | Not yet recruiting | Universidad de Almeria | 156 | 2026-06-01 | 2025-12-18 |
| [18F]F-AraG PET Imaging in Alzheimer's Disease Drug: [18F]F-AraG (PET tracer) - Alzheimer Disease (AD) | Phase 2 | Not yet recruiting | CellSight Technologies, Inc. | 10 | 2026-05-16 | 2026-05-28 |
| A Study Testing Whether Low-Dose Radiation Could Help the Immune System and Possibly Improve Early-Onset Alzheimer's Disease. Low-Dose Whole-Brain Radiotherapy, Control Condition (No Radiotherapy) - Alzheimer Disease (AD), Early Onset Alzheimer Disease | Not applicable | Not yet recruiting | Heinrich-Heine University, Duesseldorf | 50 | 2026-05-15 | 2026-05-04 |
| The Co-Production and Evaluation of the Computerised Cognitive Assessment for Preclinical Alzheimer's Disease (CoCoA-PAD) Alzheimer Disease (AD) | Recruiting | University of Plymouth | 120 | 2026-05-05 | 2026-05-20 | |
| Improving Dementia Care in Primary Practice Improving Dementia Care, Enhanced Usual Care - Alzheimer Disease (AD), Mild Cognitive Impairment (MCI) | Not applicable | Not yet recruiting | Thomas Jefferson University | 80 | 2026-05-04 | 2026-04-17 |
| Study of Neural Stem Cell-Derived Exosomes in Moderate-to-Severe Early-Onset Alzheimer's Disease Neural Stem Cell-Derived Exosomes - Alzheimer Disease (AD) | Phase 1 | Not yet recruiting | Shanghai Mental Health Center | 9 | 2026-05-01 | 2026-05-15 |
| Efficacy of Lecanemab at Different Therapeutic Doses for Alzheimer's Disease (AD) in Real-World Practice Lecanemab 10 mg/kg, Lecanemab 5-10mg/kg - Alzheimer Disease (AD), Alzheimer Dementia | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 140 | 2026-04-30 | 2026-04-01 | |
| Brain NAD in Alzheimer's Disease Alzheimer Disease (AD) | Recruiting | Florida Atlantic University | 20 | 2026-03-18 | 2026-03-24 | |
| Cerebrospinal Fluid Mitochondrial Biomarkers in Ischemic Stroke and Alzheimer Disease Cerebrospinal Fluid Flow Cytometry - Ischemic Stroke, Alzheimer Disease (AD) | Completed | Capital Medical University | 40 | 2026-03-01 | 2026-09-09 | |
| Generation of Synthetic [18F]FDG PET From Early-Phase Amyloid PET in Alzheimer's Disease Alzheimer Disease (AD) | Not yet recruiting | IRCCS San Raffaele | 35 | 2026-03-01 | 2026-02-24 |
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Brain Diseases (56) · Central Nervous System Diseases (56) · Mental Disorders (56) · Nervous System Diseases (56) · Neurocognitive Disorders (56) · Neurodegenerative Diseases (56) · Tauopathies (55) · Dementia (43) · Cognition Disorders (26) · Pathological Conditions, Signs and Symptoms (11) · Nutritional and Metabolic Diseases (7) · Pathologic Processes (7) · Signs and Symptoms (7) · Basal Ganglia Diseases (6) · Metabolic Diseases (6)
Transcranial Direct Current Stimulation (2) · lecanemab (2) · ((18)F)PI-2620 (1) · (18F)GTP1 (1) · 4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene (1) · Amyloid beta-Protein Precursor (1) · Calcium (1) · Data Collection (1) · Dronabinol (1) · Educational Status (1) · Galantamine (1) · Genistein (1) · Ginkgo biloba extract (1) · Levetiracetam (1) · Pharmaceutical Preparations (1)
Nuravax, Inc. (2) · Second Affiliated Hospital, Zhejiang University, School of Medicine (2) · Abant Izzet Baysal University (1) · Amoneta Diagnostics SAS (1) · Anhui Provincial Hospital (1) · Ashvattha Therapeutics, Inc. (1) · Beijing Municipal Administration of Hospitals (1) · Boston University Charles River Campus (1) · Brigham and Women's Hospital (1) · Capital Medical University (1) · CellSight Technologies, Inc. (1) · Centre for Addiction and Mental Health (1) · Douglas Mental Health University Institute (1) · Eli Lilly and Company (1) · Erasme University Hospital (1)
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Roman Kniazev (2) · Adrian Ivanoiu, MD (1) · Anahit Ghochikyan, PhD (1) · Audrey Gabelle, MD (1) · Barry Rovner, MD (1) · Bruno Dubois, MD (1) · Caroline Williams-Gray, Dr. (1) · Corinne Lasmezas, PhD (1) · David Cribbs, PhD (1) · Eloi Magnin, MD (1) · Eric J Topol, MD (1)
PMID 33017671, PMID 35483736, PMID 37310119, PMID 38386949, PMID 39595863, PMID 41975901, PMID 42248874
R44AG091903 (1), U24AG084436 (1)