12 completed, 10 recruiting, 3 terminated, 3 unknown. 30 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 30 | Completed 12, Recruiting 10, Terminated 3, Unknown 3, Active not recruiting 1, Withdrawn 1 |
Follow ALS: new trials by email Literature Review of ALS trials Research Report on ALS
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| INdependence Through Endovascular Neuroprosthetic Technology (INTENT): an Early Feasibility Study Stentrode - Neurological Disorder, ALS (Amyotrophic Lateral Sclerosis) | Not applicable | Recruiting | Synchron, Inc. | 10 | 2026-05-07 | 2026-10-21 |
| Functional Outcomes and Control Using Synchron BCI - Canada Stentrode - Neurologic Disorder, ALS | Not applicable | Recruiting | Synchron, Inc. | 10 | 2026-03-18 | 2026-04-17 |
| Chinese-Specific Speech Imagery Coding Using High-Density ECoG Intraoperative high-density ECoG recording, Permanent high-density ECoG implantation - Aphasia, Dysarthria | Not applicable | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 50 | 2026-03-15 | 2026-03-10 |
| At-home Treatment With Cortico-spinal tDCS for Amyotrophic Lateral Sclerosis Real tDCS, Sham tDCS - ALS, ALS (Amyotrophic Lateral Sclerosis) | Not applicable | Recruiting | University of Trieste | 40 | 2025-05-19 | 2025-06-13 |
| Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Tablet-01) BrainGate Neural Interface System - Brainstem Stroke, ALS | Not applicable | Recruiting | Leigh R. Hochberg, MD, PhD. | 6 | 2024-07-22 | 2026-10-26 |
| Using the EHR to Advance Genomic Medicine Across a Diverse Health System Behavioral nudge - Genetic Predisposition, Paraganglioma | Not applicable | Recruiting | University of Pennsylvania | 1000 | 2024-06-10 | 2026-08-14 |
| Clinical Study of Induced Pluripotent Stem Cells Derived Motor Neuron Precursor Cell Therapy for Amyotrophic Lateral Sclerosis (ALS) iPSC-MNP - ALS | Not applicable | Recruiting | Shanghai East Hospital | 3 | 2024-03-13 | 2025-01-09 |
| Initiation of Noninvasive Ventilation in ALS Patients With Chronic Respiratory Insufficiency NIV initiation in patients with ALS - Ventilation Therapy, ALS | Not applicable | Active not recruiting | Tampere University | 120 | 2024-03-05 | 2026-08-11 |
| Customized Masks in Non-Invasive Mechanical Ventilation 3d printed mask - COPD, Severe Early-Onset, Ventilatory Failure | Not applicable | Unknown | Hospital Universitario 12 de Octubre | 10 | 2023-12-10 | 2024-01-22 |
| Combined Respiratory Training in Persons With ALS Respiratory Muscle Strength Training (LVR+EMST) - ALS, Respiratory Insufficiency | Not applicable | Recruiting | Nova Southeastern University | 34 | 2023-08-22 | 2025-12-23 |
| Satisfaction of Patients With Amyotrophic Lateral Sclerosis Regarding Home Assisted Teleconsultation Teleconsultation assisted by a physiotherapist or nurse - ALS, Charcot Disease | Not applicable | Terminated | AGIR à Dom | 38 | 2023-01-13 | 2026-02-06 |
| National Multicenter Interventional Study Aimed at Evaluating the Effect on the Intestinal Microbiota in Chronically Frail Patients Who Share Alterations in Intestinal Function. Prebiotic fiber, Dietary fiber, Probiotic - Adhd, ALS | Not applicable | Completed | Institute of Biomedical Technologies-National Research Council, Italy | 64 | 2021-10-01 | 2023-08-22 |
| Virtual Reality as an Adjunct to Management of Pain and Anxiety in Palliative Care Virtual Reality - Cancer, Heart Failure | Not applicable | Unknown | Riverview Health Centre | 8 | 2020-10-01 | 2021-03-10 |
| Remote Pulmonary Function Testing and Nurse Coaching in ALS remote pulmonary function testing, standard pulmonary function testing, Nurse Respiratory Health Coaching (NRHC) - ALS | Not applicable | Completed | Milton S. Hershey Medical Center | 34 | 2020-07-01 | 2024-07-24 |
| Respiratory Muscle Training (RMT) in ALS Respiratory Muscle Training - ALS | Not applicable | Completed | Duke University | 9 | 2020-01-14 | 2026-01-29 |
| ECoG BMI for Motor and Speech Control PMT/Blackrock Combination Device - ALS, SCI - Spinal Cord Injury | Not applicable | Recruiting | Karunesh Ganguly | 3 | 2018-11-09 | 2026-05-05 |
| rTMS in Treatment of Spasticity Mag Stim - ALS | Not applicable | Terminated | Hospital for Special Surgery, New York | 3 | 2018-09-01 | 2022-11-14 |
| Non-invasive Brain Stimulation for the Treatment of Depression Symptoms in ALS rTMS - ALS | Not applicable | Terminated | Hospital for Special Surgery, New York | 3 | 2017-11-29 | 2022-11-14 |
| Remote Pulmonary Function Testing in Amyotrophic Lateral Sclerosis (Pilot) remote pulmonary function testing, standard pulmonary function testing - ALS | Not applicable | Completed | Milton S. Hershey Medical Center | 49 | 2017-11-01 | 2020-08-07 |
| A Study of Protein Metabolism, Microbiome and Investigational Probiotic Use in Patients With ALS probiotic - Amyotrophic Lateral Sclerosis, ALS | Not applicable | Completed | Avera McKennan Hospital & University Health Center | 5 | 2017-06-01 | 2019-07-02 |
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Amyotrophic Lateral Sclerosis (6) · Motor Neuron Disease (3) · Nervous System Diseases (3) · Spinal Cord Injuries (3) · Stroke (3) · Alzheimer Disease (2) · Brain Stem Infarctions (2) · Deglutition Disorders (2) · Frontotemporal Dementia (2) · Multiple Sclerosis (2) · Muscular Dystrophies (2) · Parkinson Disease (2) · Quadriplegia (2) · Anxiety Disorders (1) · Aortic Aneurysm, Thoracic (1)
Neuromuscular Diseases (12) · Central Nervous System Diseases (11) · Nervous System Diseases (10) · Pathological Conditions, Signs and Symptoms (10) · Spinal Cord Diseases (9) · Neurodegenerative Diseases (8) · Cardiovascular Diseases (7) · Metabolic Diseases (7) · Nutritional and Metabolic Diseases (7) · Pathologic Processes (7) · Proteostasis Deficiencies (7) · Signs and Symptoms (7) · TDP-43 Proteinopathies (7) · Brain Diseases (6) · Vascular Diseases (6)
Probiotics (2) · Brain-Computer Interfaces (1) · Breathing Exercises (1) · Dietary Fiber (1) · Dietary Supplements (1) · Nurses (1) · Spinal Puncture (1) · Vitamin D (1) · caprylidene (1)
Hospital for Special Surgery, New York (2) · Milton S. Hershey Medical Center (2) · Synchron, Inc. (2) · University of Pittsburgh (2) · AGIR à Dom (1) · Assistance Publique - Hôpitaux de Paris (1) · Avera McKennan Hospital & University Health Center (1) · Duke University (1) · Hospital Universitario 12 de Octubre (1) · IRCCS San Camillo, Venezia, Italy (1) · Institut National de la Santé Et de la Recherche Médicale, France (1) · Institute of Biomedical Technologies-National Research Council, Italy (1) · Karunesh Ganguly (1) · Leigh R. Hochberg, MD, PhD. (1) · MD Stem Cells (1)
United States (16) · France (5) · Italy (3) · Canada (2) · China (2) · Finland (1) · Spain (1) · United Arab Emirates (1)
Alberto Benussi, MD (1) · Christel Saint-Raymond, PhD (1) · David Lacomis, MD (1) · Feng Yan (1) · Francine Arneson, MD (1) · Harrison Jones, PhD (1) · Jeffrey Weiss, MD (1) · Jennifer L Collinger, PhD (1) · Karunesh Ganguly, MD, PhD (1) · Katherine L Nathanson, MD (1) · Leigh R Hochberg, MD, Ph.D. (1) · Magalie Thomas, MBA (1) · Martin C McElhiney, Ph.D. (1)
PMID 29160240, PMID 31523813, PMID 34260835, PMID 34981890, PMID 36347863, PMID 39160614, PMID 39710171, PMID 40343020, PMID 40353311, PMID 40720979
U01DC017844 (1), U01DC018671 (1)