9 recruiting, 4 not yet recruiting, 1 completed, 1 unknown. 5 Not applicable, 4 Phase 3, 3 Phase 2, 1 Phase 1, 1 Phase 4.
Follow Acute Ischemic Stroke AIS: new trials by email Literature Review of Acute Ischemic Stroke AIS trials Research Report on Acute Ischemic Stroke AIS
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| PCSK9 Inhibitor for Intracranial Atherosclerosis Related Acute Ischemic Stroke Recaticimab plus standard therapy, Recaticimab's placebo in combination with standard therapy - Acute Ischemic Stroke AIS, Intracranial Atherosclerosis ICAS | Phase 4 | Not yet recruiting | Peking Union Medical College Hospital | 1212 | 2026-09-01 | 2026-07-15 |
| ACT-GLOBAL IA Thrombolysis(ACT-REACT-004)Domain Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632 Tenecteplase or Alteplase- depending upon availability at each treating centre, Control - Stroke, Acute Ischemic, Endovascular Thrombectomy | Phase 3 | Recruiting | University of Calgary | 1500 | 2026-08-11 | 2026-10-21 |
| The STem Cell-derived Extracellular Vesicle Therapy In Acute Ischemic Stroke (STEVIA) SNE-101 - Acute Ischemic Stroke AIS | Phase 1 | Recruiting | S&Ebio Co. Ltd. | 18 | 2026-06-22 | 2026-07-06 |
| Mobilisation After Endovascular Stroke Treatment Mobilisation - Stroke, Acute Ischemic Stroke | Recruiting | Karolinska Institutet | 400 | 2026-05-07 | 2026-10-06 | |
| CardioLogical Interventions and Acute strOke Treatment sTudy Acute Ischemic Stroke AIS, Stroke Treatment | Not yet recruiting | University of L'Aquila | 400 | 2026-01-01 | 2026-01-07 | |
| Bovis Calculus Stativus Treat Acute Cerebral Ischemic Stroke With Impaired Consciousness Bovis Calculus Stativus (BCS), Placebo - Acute Ischemic Stroke AIS, Impaired Consciousness | Phase 2 / Phase 3 | Not yet recruiting | Xiang Luo | 220 | 2025-12-15 | 2025-12-18 |
| One-Stop manaGemEnT For A Swift Initiation of Endovascular Therapy One Stop Management, Usual care management - Stroke Acute, Acute Ischemic Stroke AIS | Not applicable | Recruiting | Prof. Dr. Jan Liman | 390 | 2025-12-02 | 2026-01-20 |
| Exploration of the Efficacy and Mechanism of Galantamine (an Extract From Lycoris Aurea) in Treating Ischemic Stroke Galantamine, Standard treatment for acute ischemic stroke - Acute Ischemic Stroke AIS | Phase 2 / Phase 3 | Recruiting | Shanghai Yueyang Integrated Medicine Hospital | 66 | 2025-09-15 | 2025-09-16 |
| Balloon Guide Versus Conventional Guide Catheter in Stroke Thrombectomy Use of a Balloon Guide Catheter, Use of a Conventional (non-balloon) Guide Catheter - Acute Ischemic Stroke AIS | Not applicable | Recruiting | University of South Florida | 186 | 2025-08-27 | 2026-07-22 |
| A Phase IIa Clinical Trial to Evaluate the Efficacy and Safety of Intravenous Infusion of hUC-MSCs in Patients With AIS hUC-MSCs treatment (high dose), hUC-MSCs treatment (low dose), Placebo - Acute Ischemic Stroke AIS | Phase 2 | Recruiting | Shenzhen Wingor Biotechnology Co., Ltd. | 60 | 2025-08-27 | 2026-07-29 |
| Palmitoylethanolamide and Luteolin in Patients with Acute Ischemic Stroke co-ultramicronized Palmitoylethanolamide + Luteolin (770 mg), Placebo, Thrombectomy - Acute Ischemic Stroke AIS | Not applicable | Not yet recruiting | Ospedali Riuniti Trieste | 60 | 2025-01-01 | 2025-01-16 |
| ACT-GLOBAL THROMBOLYSIS (ACT-WHEN-001) Domain Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632 Tenecteplase - Acute Ischemic Stroke AIS, Stroke Acute | Phase 3 | Recruiting | University of Calgary | 4000 | 2024-09-26 | 2026-10-21 |
| Pulse Endovascular ReperFUSION for Acute Ischemic Stroke Pulse NanoMED System - Acute Ischemic Stroke AIS, Cerebral Arterial Disease | Not applicable | Recruiting | Euphrates Vascular, Inc. | 8 | 2023-10-01 | 2025-08-07 |
| Guiding Catheters in Endovascular Stroke Therapy - Are Balloon Guided Catheters Superior? Ballon guide catheter, Guide catheter without balloon - Acute Ischemic Stroke Patients, Acute Ischemic Stroke | Not applicable | Completed | University Hospital Heidelberg | 110 | 2023-03-15 | 2026-03-17 |
| Stroke Imaging Package Study of Intracranial Atherosclerosis ( SIPS-ICAS ) aggressive medical management - Acute Ischemic Stroke AIS, Intracranial Atherosclerosis ICAS | Unknown | Wei-Hai Xu | 550 | 2018-11-14 | 2020-03-31 |
Ischemic Stroke (9) · Stroke (6) · Cerebral Arterial Diseases (1) · Delirium (1) · Hemorrhagic Stroke (1) · Infections (1) · Intracranial Arteriosclerosis (1) · Neuroinflammatory Diseases (1) · Plaque, Atherosclerotic (1) · Venous Thromboembolism (1)
Brain Diseases (14) · Cardiovascular Diseases (14) · Central Nervous System Diseases (14) · Cerebrovascular Disorders (14) · Nervous System Diseases (14) · Vascular Diseases (14) · Stroke (6) · Pathological Conditions, Signs and Symptoms (3) · Intracranial Arterial Diseases (2) · Arterial Occlusive Diseases (1) · Arteriosclerosis (1) · Confusion (1) · Embolism and Thrombosis (1) · Inflammation (1) · Mental Disorders (1)
Tenecteplase (2) · Aspirin (1) · Clopidogrel (1) · Fibrinolytic Agents (1) · Galantamine (1) · Long-Term Synaptic Depression (1) · Luteolin (1) · Rosuvastatin Calcium (1) · Standard of Care (1) · Thrombectomy (1) · Tissue Plasminogen Activator (1)
University of Calgary (2) · Euphrates Vascular, Inc. (1) · Karolinska Institutet (1) · Ospedali Riuniti Trieste (1) · Peking Union Medical College Hospital (1) · Prof. Dr. Jan Liman (1) · S&Ebio Co. Ltd. (1) · Shanghai Yueyang Integrated Medicine Hospital (1) · Shenzhen Wingor Biotechnology Co., Ltd. (1) · University Hospital Heidelberg (1) · University of L'Aquila (1) · University of South Florida (1) · Wei-Hai Xu (1) · Xiang Luo (1)
China (4) · Australia (2) · Canada (2) · Germany (2) · Italy (2) · United States (2) · Finland (1) · South Korea (1) · Sweden (1) · Switzerland (1)
Bijoy K Menon, MD (1) · Bijoy K Menon, MD, MSc (1) · Chunxiang Chen (1) · Craig Anderson, MD (1) · Craig Anderson, MD, Ph.D. (1) · Dariush Dowlatshahi, MD, Ph.D. (1) · Eric Thelin, Ass. Professor (1) · Jan Liman, Dr (1) · Marcello Naccarato, MD, PhD (1) · Marios Psychogios, Dr. (1) · Michael O Breckwoldt, MD, PhD (1) · Mohammed Almekhlafi,, MD, MSc (1) · Weihai Xu, MD (1) · Xiang Luo, PhD MD (1)
PMID 28304224, PMID 30066942, PMID 31707788, PMID 32561535, PMID 32817184, PMID 35048716, PMID 35143758, PMID 38048667, PMID 38212060, PMID 38648030, PMID 38817546, PMID 39387764, PMID 39505412, PMID 39548030, PMID 39755915, PMID 39818872, PMID 40616232, PMID 40820974, PMID 41107765, PMID 41389830, PMID 41500725, PMID 41582814, PMID 42262770