39 completed, 21 unknown, 12 recruiting, 10 active not recruiting. 17 Not applicable, 17 Phase 4, 12 Phase 3, 4 Phase 1, 3 Phase 2.
Follow Plaque, Atherosclerotic: new trials by email Literature Review of Plaque, Atherosclerotic trials Research Report on Plaque, Atherosclerotic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Trial Assessing the Effectiveness of Evolocumab in Reducing the Plaque Burden in Participants With Subclinical Atheroma Evolocumab, Routine Lipid Management, Autoinjector - Coronary Artery Disease, Hypercholesterolemia | Phase 4 | Not yet recruiting | Amgen | 308 | 2027-01-31 | 2026-09-21 |
| PCSK9 Inhibitor for Intracranial Atherosclerosis Related Acute Ischemic Stroke Recaticimab plus standard therapy, Recaticimab's placebo in combination with standard therapy - Acute Ischemic Stroke AIS, Intracranial Atherosclerosis ICAS | Phase 4 | Not yet recruiting | Peking Union Medical College Hospital | 1212 | 2026-09-01 | 2026-07-15 |
| Multimodality Optical and Ultrasound Intravascular Imaging for Stent Optimization and Atheroma Assessment Conavi Medical Novasight Hybrid System intervention - Coronary Artery Disease, Coronary Stenosis | Not applicable | Withdrawn | Barts & The London NHS Trust | 2026-09-01 | 2025-09-17 | |
| Early Intensive Lipid-Lowering With Inclisiran for Plaque Stabilization in Acute Coronary Syndrome Inclisiran, Atorvastatin or Rosuvastatin, Ezetimibe - Acute Coronary Syndromes (ACS) | Phase 4 | Not yet recruiting | Seoul National University Bundang Hospital | 294 | 2026-09-01 | 2026-09-02 |
| Measuring Athlete's Risk of Cardiovascular Events 3 (MARC-3) Coronary Artery Disease, Atherosclerosis | Enrolling by invitation | Radboud University Medical Center | 250 | 2026-05-31 | 2026-08-13 | |
| Targeting Vascular INflammation in Patients With Community-Acquired Pneumonia Icosapent Ethyl 1000 MG Oral Capsule [Vascepa], Placebo - Inflammation, Community Acquired Pneumonia (CAP) | Phase 3 | Recruiting | Ottawa Heart Institute Research Corporation | 168 | 2026-04-08 | 2026-05-11 |
| Assessment of Platelet-derived GARP in Atherosclerotic Disease Tissue sample and data collection - Atheroma; Carotid Artery, Atheromatosis | Not yet recruiting | Université Catholique de Louvain | 200 | 2026-02-01 | 2026-01-27 | |
| Assessment of GARP Expression in Acute and Chronic Coronary Syndrome Arterial blood sample - Atheroma; Heart | Not applicable | Not yet recruiting | Université Catholique de Louvain | 600 | 2026-02-01 | 2026-02-17 |
| PCSK9 Inhibitor With Statin Therapy for Asymptomatic Intracranial Atherosclerosis Recaticimab and Statin, Statin - Intracranial Atherosclerosis, Intracranial Artery Stenosis | Phase 4 | Recruiting | Peking Union Medical College Hospital | 300 | 2025-11-07 | 2026-06-12 |
| Fish Oil, Metformin and Heart Health in PCOS Fish oil, Metformin, Fish Oil and Metformin - PCOS, Cardiovascular Disease | Phase 1 | Recruiting | University of Alberta | 146 | 2025-11-01 | 2025-12-12 |
| Evaluation of Atherectomy in the Management of Occlusive Lesions of the Common Femoral Arteries Atherectomy - Femoral Artery Occlusion, Atheromatous Plaques | Not yet recruiting | GCS Ramsay Santé pour l'Enseignement et la Recherche | 120 | 2025-09-01 | 2025-08-26 | |
| Multimodal Imaging Evaluation of Vulnerability of Atherosclerotic Plaques: A Comparison of HR-VWI, OCT, and RWS Intracranial Atherosclerotic Stenosis | Not yet recruiting | Shanghai Jiao Tong University Affiliated Sixth People's Hospital | 561 | 2025-08-10 | 2025-08-21 | |
| Changes in Plaque Characteristics After Short-term Statin Therapy as Assessed With Coronary CT Rosuvastatin 40mg, Placebo, Coronary Computed Tomography Angiography (Coronary CTA) - Coronary Artery Disease, Atherosclerotic Plaque | Not applicable | Recruiting | Prof. Maurovich-Horvat Pál | 140 | 2025-05-28 | 2026-05-13 |
| Comparison of Moderate-Intensity Statin Plus Ezetimibe vs. High-Intensity Statin for Coronary Plaque Stabilization Rosuvastatin, Rosuvastatin/ezetimibe - Coronary Artery Disease, Atherosclerosis of Coronary Artery | Phase 4 | Active not recruiting | Korea University Anam Hospital | 408 | 2025-05-12 | 2026-10-06 |
| Efficiency of AI Reporting (EAIR). Coronary Artery Disease | Withdrawn | London North West Healthcare NHS Trust | 2024-08-15 | 2025-05-23 | ||
| Intravascular Imaging Study of the Effect of Inclisiran on Plaque in Patients With Acute Myocardial Infarction atorvastatin, IVUS/OCT, inclisiran - Plaque, Atherosclerotic | Phase 4 | Active not recruiting | Novartis Pharmaceuticals | 318 | 2024-07-09 | 2026-07-28 |
| Can the BeatMove Device Help Patients With Obliterative Arterial Disease of the Lower Limbs? Music therapy walking program, Sham BeatMove - Atheromatous, Lower Limb Ischemia | Not applicable | Recruiting | Centre Hospitalier Universitaire de Nīmes | 54 | 2024-06-14 | 2025-12-19 |
| Carotid Plaque RADS vs CPVH: Diagnostic Accuracy Comparison Carotid Ultrasound with CPVH and Carotid Plaque RADS Assessment - Carotid Artery Stenosis Asymptomatic, Carotid Atherosclerosis | Completed | Limited Liability Company "European Institute of Family Health" | 150 | 2024-05-20 | 2026-10-13 | |
| A CCTA Imaging Trial to Evaluate the Effect of Obicetrapib/Ezetimibe on Coronary Plaque obicetrapib 10 mg + ezetimibe 10 mg FDC daily, Placebo - Lipidemia, Coronary Artery Disease | Phase 3 | Active not recruiting | NewAmsterdam Pharma | 300 | 2024-05-16 | 2026-04-09 |
| Prospective Multicenter Cohort Study to Validate Four Groups of Biomarkers for Assessing Lung Cancer Risk Among Patients With Atheromatous Cardiovascular Disease in a Screening Pathway blood sampling, stool collection, low dose CT scan - Smoking-related Pathology, Atheroma | Not applicable | Recruiting | Assistance Publique Hopitaux De Marseille | 750 | 2024-04-02 | 2024-04-26 |
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Atherosclerosis (33) · Coronary Artery Disease (29) · Carotid Artery Diseases (14) · Acute Coronary Syndrome (11) · Cardiovascular Diseases (10) · Carotid Stenosis (9) · Myocardial Infarction (9) · Inflammation (7) · Coronary Stenosis (6) · Stroke (6) · Arteriosclerosis (4) · Heart Diseases (4) · Hypercholesterolemia (4) · Intracranial Arteriosclerosis (4)
Pathological Conditions, Anatomical (100) · Pathological Conditions, Signs and Symptoms (100) · Vascular Diseases (77) · Cardiovascular Diseases (71) · Arterial Occlusive Diseases (60) · Arteriosclerosis (52) · Heart Diseases (42) · Myocardial Ischemia (41) · Coronary Disease (31) · Brain Diseases (29) · Central Nervous System Diseases (29) · Nervous System Diseases (29) · Cerebrovascular Disorders (28) · Pathologic Processes (22) · Infarction (12)
Atorvastatin (8) · Rosuvastatin Calcium (6) · Ezetimibe (4) · ALN-PCS (3) · Blood Specimen Collection (3) · High-Energy Shock Waves (3) · Niacin (3) · Tomography, Optical Coherence (3) · Ultrasonography, Carotid Arteries (3) · Angioplasty (2) · Hydroxymethylglutaryl-CoA Reductase Inhibitors (2) · Simvastatin (2) · Stents (2) · alirocumab (2) · 2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (1)
Cardio Med Medical Center (4) · Novartis Pharmaceuticals (3) · Radboud University Medical Center (3) · Assistance Publique Hopitaux De Marseille (2) · CHEOL WHAN LEE, M.D., Ph.D (2) · GlaxoSmithKline (2) · Maastricht University Medical Center (2) · Massachusetts General Hospital (2) · Peking Union Medical College Hospital (2) · Second Affiliated Hospital, Zhejiang University, School of Medicine (2) · University of Washington (2) · Université Catholique de Louvain (2) · Amgen (1) · Aristotle University Of Thessaloniki (1) · Assistance Publique - Hôpitaux de Paris (1)
United States (19) · South Korea (13) · China (12) · France (9) · Netherlands (9) · Canada (8) · Italy (6) · Belgium (5) · United Kingdom (5) · Argentina (4) · Brazil (4) · Japan (4) · Romania (4) · Russia (4) · Austria (3)
Christophe Beauloye, Medical Degree (2) · Sunwon Kim, MD, PhD (2) · Xue-Qiao Zhao, MD (2) · Addison M Taylor, MD, PhD (1) · Ahmed Tawakol, MD (1) · Alex N Haas, PhD (1) · Amer M Johri, MD (1) · Annetine C Gelijns, PhD (1) · Bon-Kwon Koo, MD, PhD (1) · Carisi Polanczyk, PhD (1) · Carlo Cavaliere, MD (1)
PMID 28304224, PMID 12468791, PMID 12706187, PMID 17548554, PMID 17548555, PMID 17643572, PMID 18765395, PMID 19477353, PMID 19557844, PMID 20194881, PMID 21291704, PMID 21493792, PMID 21774709, PMID 21899409, PMID 21920335, PMID 22019821, PMID 22149222, PMID 22198621, PMID 22330753, PMID 22421222, PMID 22421299, PMID 22541275, PMID 23168285, PMID 23333164, PMID 23395076, PMID 23871513, PMID 24010954, PMID 24102055, PMID 24126180, PMID 24239923, PMID 24316314, PMID 24463925, PMID 24489130, PMID 24631113, PMID 24769427, PMID 25084698, PMID 25182248, PMID 25216871, PMID 25245415, PMID 25256179, PMID 25410576, PMID 25687353, PMID 25773378, PMID 26147752, PMID 26330422, PMID 26493239, PMID 26655874, PMID 26681752, PMID 26708287, PMID 27162131
2016 (1), 2017 (1), 2025 (1), R01AG021570 (1), R01HL063895 (1), R01HL088214 (1), R01HL092944 (1), U01HL088942 (1)