76 completed, 39 unknown, 25 recruiting, 19 terminated. 39 Not applicable, 25 Phase 3, 25 Phase 4, 24 Phase 2, 3 Phase 1.
Follow Acute Heart Failure: new trials by email Literature Review of Acute Heart Failure trials Research Report on Acute Heart Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ketone Ester for Treatment Of Acute Heart Failure Ketone Ester (KetoneAid MonoEster), Placebo - Acute Heart Failure | Not applicable | Not yet recruiting | University of Alberta | 60 | 2027-01-01 | 2026-11-09 |
| Infusion of Furosemide to Improve Diuretic Efficiency in Acute Heart Failure Intravenous furosemide continuous infusion, Intravenous furosemide bolus injections - Acute Heart Failure, Volume Overload | Phase 4 | Recruiting | University of Aarhus | 436 | 2026-06-30 | 2026-07-06 |
| Efficacy and Safety With Early Treatment of Finerenone in Hospitalized Patients With Heart Failure Finerenone Oral Tablet, Finerenone Placebo - Acute Heart Failure | Phase 4 | Recruiting | Juntendo University | 550 | 2026-05-11 | 2026-08-10 |
| Pharmacological Optimization in Prevention in Heart Failure: A Sex-gap? Guideline-Directed Medical Therapy (GDMT) - Heart Failure, Acute Heart Failure | Phase 4 | Recruiting | IRCCS Policlinico S. Donato | 368 | 2026-03-31 | 2026-10-16 |
| Integrating Aerobic, Respiratory, and Cognitive Training in Acute Heart Failure Aerobic training, Inspiratory muscle training, Cognitive training - Acute Heart Failure | Not applicable | Not yet recruiting | Cairo University | 40 | 2026-03-07 | 2026-03-03 |
| a PRagmatic Observational Study of Congestion proFILes in patiEnts With Acute Heart Failure Acute Heart Failure | Recruiting | University Medical Center Groningen | 270 | 2025-05-01 | 2025-09-10 | |
| The Role of intraABDOminal Pressure and Point Of Care UltraSound to Guide Decongestive Therapy in Heart Failure Furosemide 20 Milligrams - Acute Heart Failure, Congestive Heart Failure | Phase 3 | Recruiting | Instituto de Investigación Sanitaria Aragón | 168 | 2025-03-10 | 2025-06-06 |
| Investigating aCute heArt failuRe Decongestion Guided by Lung UltraSonography LUS decongestive strategy, PE decongestive strategy - Acute Heart Failure | Not applicable | Recruiting | Antonio Leidi | 222 | 2024-10-22 | 2026-04-01 |
| Cardiac Assessment and Takotsubo-stunning Among COPD-exacerbations In-Hospital Chronic Obstructive Pulmonary Disease, Takotsubo Cardiomyopathy | Recruiting | Sahlgrenska University Hospital | 200 | 2024-09-23 | 2026-09-17 | |
| Optimal Diuretic Therapies for Acute Heart Failure With Volume Overload Acetazolamide, Metolazone 2.5 MG, Double-placebo - Acute Heart Failure | Phase 3 | Recruiting | Johannes Grand | 939 | 2024-09-05 | 2026-10-27 |
| Assessing the Clinical Outcomes of Dapagliflozin Versus Acetazolamide in Patients With Acute Heart Failure Dapagliflozin 10mg, Acetazolamide 500mg - Acute Heart Failure | Phase 2 / Phase 3 | Completed | Mansoura University | 108 | 2024-08-15 | 2026-10-26 |
| Liver Function Abnormalities in Patients With Acute Heart Failure Avoiding the risk factors - Acute Heart Failure | Unknown | Sohag University | 100 | 2024-07-01 | 2024-07-10 | |
| Predictors of Acute Kidney Injury in Patients With Acute Decompensated Heart Failure in Emergency Serum Creatinine - Acute Kidney Injury, Acute Heart Failure | Unknown | Sohag University | 100 | 2024-06-01 | 2024-06-18 | |
| Short Term Outcome of Acute Heart Failure in Diabetic and Non Diabetic Patients pro BNP - Acute Heart Failure, Diabetes Mellitus | Unknown | Sohag University | 100 | 2024-06-01 | 2024-06-20 | |
| Oxygen Targets in Acute Heart Failure With Pulmonary Congestion Oxygen - Acute Heart Failure, Pulmonary Congestion | Phase 2 / Phase 3 | Completed | Copenhagen University Hospital, Hvidovre | 135 | 2024-02-01 | 2026-10-26 |
| A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients Finerenone, Placebo - Heart Failure, Acute Heart Failure | Phase 3 | Recruiting | Colorado Prevention Center | 5200 | 2024-01-17 | 2026-09-10 |
| Natriuresis-Guided Diuretic Therapy in Patients With Acute Heart Failure With Reduced Ejection Fraction and Chronic Kidney Disease Furosemide 20 MG, diuretic therapy - Acute Heart Failure, Chronic Kidney Diseases | Phase 4 | Unknown | Assiut University | 300 | 2024-01-01 | 2024-01-12 |
| Naples Federico II Intensive Cardiac Care Unit Registry (Naples FED2-ICCU Registry) Acute Cardiovascular Disease, Acute Coronary Syndrome | Recruiting | Federico II University | 5000 | 2023-11-20 | 2025-03-03 | |
| Diuretic Strategies in Acute Heart Failure Patients at High Risk for Diuretic Resistance Furosemide, Metolazone, Acetazolamide - Acute Heart Failure, Diuretic Resistance | Phase 4 | Terminated | Stadtspital Zürich | 13 | 2023-10-10 | 2025-02-14 |
| DECONGEST-AHF: Vasodilatation or Loop Diuretics in Acute Heart Failure Furosemide Injection, Isosorbide Dinitrate, Furosemide and isosorbide dinitrate - Pulmonary Edema, Congestive Heart Failure | Phase 4 | Recruiting | Copenhagen University Hospital, Rigshospitalet | 1041 | 2023-09-14 | 2026-10-23 |
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Heart Failure (48) · Emergencies (9) · Dyspnea (7) · Edema (7) · Acute Kidney Injury (5) · Shock, Cardiogenic (5) · Heart Diseases (4) · Pulmonary Disease, Chronic Obstructive (4) · Renal Insufficiency, Chronic (4) · Cardiac Output, Low (3) · Cardio-Renal Syndrome (3) · Heart Failure, Diastolic (3) · Inflammation (3) · Pulmonary Edema (3) · Renal Insufficiency (3)
Cardiovascular Diseases (64) · Heart Diseases (60) · Pathological Conditions, Signs and Symptoms (49) · Pathologic Processes (34) · Disease Attributes (19) · Signs and Symptoms (17) · Female Urogenital Diseases (14) · Female Urogenital Diseases and Pregnancy Complications (14) · Kidney Diseases (14) · Male Urogenital Diseases (14) · Respiratory Tract Diseases (14) · Urogenital Diseases (14) · Urologic Diseases (14) · Vascular Diseases (12) · Renal Insufficiency (10)
Furosemide (8) · Standard of Care (6) · Acetazolamide (5) · empagliflozin (5) · dapagliflozin (4) · serelaxin protein, human (4) · Blood Specimen Collection (3) · Interviews as Topic (3) · Metolazone (3) · BAY 58-2667 (2) · Dobutamine (2) · Dopamine (2) · Exercise (2) · Glucose (2) · Hydrochlorothiazide (2)
University of Monastir (8) · Novartis Pharmaceuticals (7) · Central Hospital, Nancy, France (4) · Assistance Publique - Hôpitaux de Paris (3) · Indiana University (3) · Sohag University (3) · University Hospital, Basel, Switzerland (3) · University of Aarhus (3) · University of Alberta (3) · Adrian Hernandez (2) · Bayer (2) · Bristol-Myers Squibb (2) · Cairo University (2) · China-Japan Friendship Hospital (2) · Duke University (2)
United States (33) · France (20) · Germany (17) · Italy (17) · Switzerland (15) · Canada (10) · Spain (10) · China (9) · Denmark (9) · Egypt (9) · Tunisia (9) · Poland (8) · United Kingdom (8) · Argentina (7) · South Korea (7)
Adrian Hernandez, MD (3) · Eugene Braunwald, MD (3) · Nouira Semir, Professor (3) · Peter S Pang, MD (3) · Alberto Palazzuoli, MD (2) · Magdy M Amin, Professor (2) · Moheb Magdy Mouris, MD (2) · Mucio Tavares, MD (2) · Noha Mansour, PhD (2) · Yuya Matsue, MD (2) · Ahmed Mohamed Abdelmegeed ElFeky (1) · Aigul Baltabaeva, MBBS MD PhD (1)
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