10 completed, 6 recruiting, 6 unknown, 2 terminated. 25 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 25 | Completed 10, Recruiting 6, Unknown 6, Terminated 2, Withdrawn 1 |
Follow Acute Heart Failure: new trials by email Literature Review of Acute Heart Failure trials Research Report on Acute Heart Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Infusion of Furosemide to Improve Diuretic Efficiency in Acute Heart Failure Intravenous furosemide continuous infusion, Intravenous furosemide bolus injections - Acute Heart Failure, Volume Overload | Phase 4 | Recruiting | University of Aarhus | 436 | 2026-06-30 | 2026-07-06 |
| Efficacy and Safety With Early Treatment of Finerenone in Hospitalized Patients With Heart Failure Finerenone Oral Tablet, Finerenone Placebo - Acute Heart Failure | Phase 4 | Recruiting | Juntendo University | 550 | 2026-05-11 | 2026-08-10 |
| Pharmacological Optimization in Prevention in Heart Failure: A Sex-gap? Guideline-Directed Medical Therapy (GDMT) - Heart Failure, Acute Heart Failure | Phase 4 | Recruiting | IRCCS Policlinico S. Donato | 368 | 2026-03-31 | 2026-10-16 |
| Natriuresis-Guided Diuretic Therapy in Patients With Acute Heart Failure With Reduced Ejection Fraction and Chronic Kidney Disease Furosemide 20 MG, diuretic therapy - Acute Heart Failure, Chronic Kidney Diseases | Phase 4 | Unknown | Assiut University | 300 | 2024-01-01 | 2024-01-12 |
| Diuretic Strategies in Acute Heart Failure Patients at High Risk for Diuretic Resistance Furosemide, Metolazone, Acetazolamide - Acute Heart Failure, Diuretic Resistance | Phase 4 | Terminated | Stadtspital Zürich | 13 | 2023-10-10 | 2025-02-14 |
| DECONGEST-AHF: Vasodilatation or Loop Diuretics in Acute Heart Failure Furosemide Injection, Isosorbide Dinitrate, Furosemide and isosorbide dinitrate - Pulmonary Edema, Congestive Heart Failure | Phase 4 | Recruiting | Copenhagen University Hospital, Rigshospitalet | 1041 | 2023-09-14 | 2026-10-23 |
| Clinical Outcomes of Dapagliflozin in Acute Heart Failure With Reduced Ejection Fraction (CODA-HFrEF) Dapagliflozin 10mg Tab - Acute Heart Failure | Phase 4 | Completed | Cairo University | 117 | 2023-08-01 | 2024-02-28 |
| The Effects of Ferric Derisomaltose in Patients With Acute Heart Failure and Iron Deficiency on Exercise Capacity and Quality of Life(COREVIVE-HFrEF) Ferric derisomaltose, Placebo - Heart Failure With Reduced Ejection Fraction, Iron Deficiency | Phase 4 | Recruiting | China-Japan Friendship Hospital | 146 | 2023-08-01 | 2026-11-06 |
| The Effects of Ferric Derisomaltose in Patients With Acute Heart Failure and Iron Deficiency on Exercise Capacity and Quality of Life Ferric derisomaltose, Placebo - Heart Failure With Preserved Ejection Fraction, Iron Deficiencies | Phase 4 | Recruiting | China-Japan Friendship Hospital | 170 | 2023-08-01 | 2026-11-06 |
| Empagliflozin in Acute Heart Failure Empagliflozin 25 MG - Acute Heart Failure, Chronic Kidney Diseases | Phase 4 | Completed | McGill University Health Centre/Research Institute of the McGill University Health Centre | 25 | 2022-12-22 | 2026-03-16 |
| Diuretic Treatment in Acute Heart Failure With Volume Overload Guided by Serial Spot Urine Sodium Assessment UNa measurement after intravenous loop diuretic bolus, Intravenous acetazolamide 500 mg OD, Intravenous bumetanide TID - Acute Heart Failure, Diuretics Drug Reactions | Phase 4 | Completed | Vrije Universiteit Brussel | 107 | 2022-06-12 | 2026-09-11 |
| Dapagliflozin and Effect on Cardiovascular Events in Acute Heart Failure -Thrombolysis in Myocardial Infarction 68 (DAPA ACT HF-TIMI 68) Dapagliflozin, Placebo - Acute Heart Failure, Heart Failure | Phase 4 | Completed | The TIMI Study Group | 2401 | 2020-09-24 | 2026-06-16 |
| Safety and Efficacy of Early, seQUential Oral dIuretic Nephron blockAde In Acute Heart Failure Standard diuretic therapy, Early sequential nephron blockade - Acute Heart Failure | Phase 4 | Unknown | University of Parma | 206 | 2019-12-01 | 2019-08-20 |
| Protocol of Diuretics Use in Congestive Therapy in Heart Failure Furosemide, Hydrochlorothiazide - Heart Failure, Acute Heart Failure | Phase 4 | Completed | University Hospital, Clermont-Ferrand | 299 | 2019-05-17 | 2026-01-28 |
| Intravenous Vasodilator vs. Inotropic Therapy in Patients With Heart Failure Sodium nitroprusside, Dobutamine, Furosemide - Acute Heart Failure | Phase 4 | Withdrawn | Montefiore Medical Center | 2018-05-01 | 2018-10-31 | |
| Rivaroxaban Once Daily Versus Dose-adjusted Vitamin K Antagonist on the Biomarkers in Acute Decompensated Heart Failure and Atrial Fibrillation (ROAD HF-AF) Rivaroxaban, Warfarin + LMWH - Acute Heart Failure | Phase 4 | Unknown | Yonsei University | 150 | 2018-04-10 | 2019-01-10 |
| Early Management Strategies of Acute Heart Failure for Patients With NSTEMI Regular management+Levosimendan - Early Management, Acute Heart Failure | Phase 4 | Unknown | Qilu Hospital of Shandong University | 470 | 2017-07-01 | 2021-07-19 |
| Comparison of Sacubitril/Valsartan Versus Enalapril on Effect on NT-proBNP in Patients Stabilized From an Acute Heart Failure Episode. sacubitril/valsartan (LCZ696), Enalapril, sacubitril/valsartan (LCZ696) matching placebo - Acute Heart Failure | Phase 4 | Completed | Novartis Pharmaceuticals | 887 | 2016-04-29 | 2021-01-05 |
| A Study to Evaluate the Efficacy and Safety of Shenfu Zhusheye in Patients With Acute Heart Failure Shenfu Zhusheye, 5% glucose injection - Acute Heart Failure | Phase 4 | Completed | China Resources Sanjiu Medical & Pharmaceutical Co., Ltd. | 365 | 2014-09-03 | 2018-03-01 |
| Loop Diuretics Administration and Acute Heart Failure furosemide infusion - Acute Heart Failure | Phase 4 | Completed | University of Siena | 57 | 2010-04-01 | 2018-01-23 |
Showing 20 of 25. Sign in to see all of them.
Heart Failure (8) · Edema (4) · Iron Deficiencies (2) · Renal Insufficiency, Chronic (2) · Cardiovascular Diseases (1) · Dyspnea (1) · Fatigue (1) · Heart Diseases (1) · Heart Failure, Diastolic (1) · Hypokalemia (1) · Non-ST Elevated Myocardial Infarction (1) · Pulmonary Edema (1)
Cardiovascular Diseases (8) · Heart Diseases (8) · Pathological Conditions, Signs and Symptoms (7) · Signs and Symptoms (4) · Metabolic Diseases (3) · Nutritional and Metabolic Diseases (3) · Pathologic Processes (3) · Chronic Disease (2) · Disease Attributes (2) · Female Urogenital Diseases (2) · Female Urogenital Diseases and Pregnancy Complications (2) · Iron Metabolism Disorders (2) · Kidney Diseases (2) · Male Urogenital Diseases (2) · Renal Insufficiency (2)
Furosemide (6) · Acetazolamide (2) · Iron (2) · Saline Solution (2) · dapagliflozin (2) · ferric derisomaltose (2) · Bumetanide (1) · Canrenoic Acid (1) · Chlorthalidone (1) · Dobutamine (1) · Dopamine (1) · Eicosapentaenoic Acid (1) · Enalapril (1) · Glucose (1) · Heparin, Low-Molecular-Weight (1)
China-Japan Friendship Hospital (2) · Assiut University (1) · Cairo University (1) · China Resources Sanjiu Medical & Pharmaceutical Co., Ltd. (1) · Copenhagen University Hospital, Rigshospitalet (1) · IRCCS Policlinico S. Donato (1) · Juntendo University (1) · Larissa University Hospital (1) · M.D. Anderson Cancer Center (1) · McGill University Health Centre/Research Institute of the McGill University Health Centre (1) · Montefiore Medical Center (1) · Novartis Pharmaceuticals (1) · Osaka General Medical Center (1) · Qilu Hospital of Shandong University (1) · Stadtspital Zürich (1)
China (4) · Italy (4) · United States (3) · Denmark (2) · Switzerland (2) · Belgium (1) · Brazil (1) · Bulgaria (1) · Canada (1) · Egypt (1) · France (1) · Germany (1) · Greece (1) · Japan (1) · South Korea (1)
Alberto Palazzuoli, MD (1) · Christian B Poulsen, MD PhD (1) · Christian Mueller, MD (1) · David D Berg, MD, MPH (1) · Enrico Fiaccadori, MD, PhD (1) · Esben Merrild, MD (1) · Filippos Triposkiadis, MD (1) · Frederik H Verbrugge, M.D.; Ph.D.; M.Sc. (1) · Giuseppe Regolisti, MD (1) · Gregory Giamouzis, MD (1) · Heba Mahmoud Abdel-Mohsen El-Naggar, Supervisor (1) · Henrik Birn, MD PhD DMSc (1) · Jean-Bernard Durand, MD (1)
PMID 21111980, PMID 21366472, PMID 21900289, PMID 24974232, PMID 29086392, PMID 30540645, PMID 31684094, PMID 31825471, PMID 31846016, PMID 32800511, PMID 32854838, PMID 32919915, PMID 37871997, PMID 38447632, PMID 40335233, PMID 40884036, PMID 42044762, PMID 42669075
2025 (2)