51 completed, 16 unknown, 15 recruiting, 11 terminated. 44 Not applicable, 11 Phase 2, 11 Phase 3, 11 Phase 4, 3 Phase 1.
Follow Acute Decompensated Heart Failure: new trials by email Literature Review of Acute Decompensated Heart Failure trials Research Report on Acute Decompensated Heart Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Therapy Adjustment and IndividuaLized Response With Biomarker Observation in ReaL-world Heart Failure Chronic Heart Failure, Acute Decompensated Heart Failure | Not yet recruiting | Maastricht University Medical Center | 600 | 2026-09-01 | 2026-06-15 | |
| A Study Of Acute Decompensated Heart Failure Lung Ultrasound - Acute Decompensated Heart Failure | Not applicable | Recruiting | Mayo Clinic | 500 | 2026-08-26 | 2026-09-08 |
| Early Discharge With Subcutaneous Furosemide Versus Standard Care in Acute Heart Failure Early Discharge with Lasix® ONYU (furosemide injection, for subcutaneous use) using SQIN-Infusor - Heart Failure, Acute Decompensated Heart Failure | Phase 3 | Not yet recruiting | University of Texas Southwestern Medical Center | 250 | 2026-08-01 | 2026-05-04 |
| Add-on Diuretics in Acute Decompensated Heart Failure empagliflozin, Acetazolamide, metolazone - Acute Decompensated Heart Failure | Phase 2 | Recruiting | Tanta University | 66 | 2026-02-01 | 2026-02-04 |
| PREcision meDICine in Treatment in CardioVascular Disease ASSIST-HF AI- algorithm, Standard of Care (Investigator Choice) - Chronic Heart Failure, Acute Decompensated Heart Failure | Not applicable | Withdrawn | Maastricht University Medical Center | 2026-02-01 | 2026-04-17 | |
| Cardiac Perfusion and Metabolism With [11C] Acetate PET/CT is Associated With Hematopoietic System Activation in Acute Decompensated Heart Failure: An Imaging Sub-study Cardiac Perfusion and Metabolism with [11C] Acetate PET/CT - Acute Decompensated Heart Failure | Phase 1 | Withdrawn | University of Alabama at Birmingham | 2025-12-31 | 2023-04-07 | |
| Comparative Efficacy and Safety of Acetazolamide Versus Metolazone as an Adjunct to Standard Therapy in Patients With Acute Decompensated Heart Failure Acetazolamide, Metolazone - Acute Decompensated Heart Failure, Heart Failure, Diastolic | Not applicable | Recruiting | University of Health Sciences Lahore | 320 | 2025-10-11 | 2025-10-03 |
| BEAT-SHOCK Registry no internvention - Cardiogenic Shock, Myocardial Infarction (MI) | Recruiting | University Hospital, Basel, Switzerland | 8000 | 2025-10-01 | 2026-06-11 | |
| Effects of In-Hospital Cardiac Rehabilitation and Manual Lymphatic Drainage in Acute Decompensated Heart Failure Manual Lymphatic Drainage, Cardiac Rehabilitation - Acute Decompensated Heart Failure | Not applicable | Completed | Izmir Bakircay University | 40 | 2025-08-12 | 2025-12-23 |
| Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve System (FASTR-II) (IDE-G210258) Reprieve System, furosemide infusion - Acute Decompensated Heart Failure | Not applicable | Recruiting | Reprieve Cardiovascular, Inc | 400 | 2025-07-28 | 2026-10-13 |
| Using an Intervention Adapted to the Health Literacy Level to Improve Adherence to Medical Recommendations Interventional educational toolkit specific to low Health Literacy patients, designed with patients and health professionals. - Acute Decompensated Heart Failure, Acute Myocardial Infarction | Not applicable | Recruiting | Hospices Civils de Lyon | 300 | 2025-06-26 | 2025-07-14 |
| Clinical Evaluation of NIRSense Tissue Oximetry Sensor Monitoring to Early Detect Cardiogenic Shock NIRSense Tissue Oximetry Sensor System - Cardiogenic Shock, Acute Myocardial Infarction | Recruiting | NIRSense Inc. | 20 | 2025-06-17 | 2026-09-17 | |
| Naturally Controlled Decongestion Using Renal Independent System in ADHF Patients, a European Registry AquaPass - Chronic Heart Failure, Fluid Overload | Not applicable | Unknown | AquaPass Medical Ltd. | 30 | 2025-02-01 | 2024-05-06 |
| IC14 for Treatment of Acute Decompensated Heart Failure Atibuclimab (IC14) - Acute Decompensated Heart Failure | Phase 1 / Phase 2 | Active not recruiting | Implicit Bioscience | 10 | 2024-10-17 | 2026-03-27 |
| Venous Ultrasound Guided Organ Decongestion in Patients Hospitalized with Acute Decompensated Heart Failure VExUS guided decongestion - Cardiorenal Syndrome, Heart Failure | Not applicable | Recruiting | Oslo University Hospital | 180 | 2024-09-16 | 2024-12-03 |
| Acetazolamide Versus Dapagliflozin in Acute Decompensated Heart Failure Patients Acetazolamide, Dapagliflozin 10mg - Acute Decompensated Heart Failure | Phase 3 | Unknown | Helwan University | 60 | 2024-08-24 | 2024-08-05 |
| Feasibility Study to Support Cardiorenal Function in Acute Decompensated Heart Failure With Diuretic Resistance ModulHeart Support - Heart Failure, Acute Decompensated Heart Failure | Not applicable | Unknown | Puzzle Medical Devices Inc. | 5 | 2024-08-01 | 2024-06-17 |
| DORAYA-HF OUS Assessment of the Doraya Catheter for the Treatment of ADHF Patients With Insufficient Response to Diuretics Doraya catheter - Acute Decompensated Heart Failure | Not applicable | Completed | Revamp Medical Ltd. | 25 | 2024-07-01 | 2026-03-09 |
| Efficacy and Safety of Combination Diuretic Therapy in Patients With Acute Decompensated Heart Failure and Volume Overload Acetazolamide, Metolazone, IV Loop Diuretics - Acute Decompensated Heart Failure, Volume Overload | Phase 4 | Unknown | Cairo University | 110 | 2024-07-01 | 2024-07-24 |
| Compression Therapy of the Lower Limbs in Patients With Decompensated Heart Failure UrgoK2 / UrgoK2 Lite, Controll - Acute Decompensated Heart Failure | Not applicable | Completed | Fundación para la Investigación del Hospital Clínico de Valencia | 106 | 2024-05-27 | 2026-09-15 |
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Heart Failure (34) · Edema (4) · Shock, Cardiogenic (4) · Cardio-Renal Syndrome (3) · Cardiovascular Diseases (3) · Heart Diseases (3) · Sleep Apnea Syndromes (3) · Acute Kidney Injury (2) · Dyspnea (2) · Emergencies (2) · Heart Failure, Systolic (2) · Sleep Apnea, Obstructive (2) · Cheyne-Stokes Respiration (1) · Cytokine Release Syndrome (1) · Frailty (1)
Cardiovascular Diseases (39) · Heart Diseases (38) · Pathological Conditions, Signs and Symptoms (18) · Pathologic Processes (9) · Signs and Symptoms (9) · Respiratory Tract Diseases (7) · Respiration Disorders (6) · Female Urogenital Diseases (5) · Female Urogenital Diseases and Pregnancy Complications (5) · Kidney Diseases (5) · Male Urogenital Diseases (5) · Nervous System Diseases (5) · Shock (5) · Urogenital Diseases (5) · Urologic Diseases (5)
Acetazolamide (7) · Furosemide (7) · Metolazone (5) · Standard of Care (5) · Ultrafiltration (4) · Diuretics (3) · Sodium Potassium Chloride Symporter Inhibitors (3) · empagliflozin (3) · Bumetanide (2) · Dopamine (2) · Torsemide (2) · dapagliflozin (2) · Carbonic Anhydrase Inhibitors (1) · Cardiac Rehabilitation (1) · Chlorothiazide (1)
Reprieve Cardiovascular, Inc (4) · Abiomed Inc. (3) · Alere San Diego (2) · Cairo University (2) · Cardionomic Inc. (2) · Guangdong Provincial People's Hospital (2) · Maastricht University Medical Center (2) · Nile Therapeutics (2) · Revamp Medical Ltd. (2) · Universitas Diponegoro (2) · University of Monastir (2) · University of North Carolina, Chapel Hill (2) · Universität des Saarlandes (2) · Ziekenhuis Oost-Limburg (2) · Aalborg University (1)
United States (47) · Germany (10) · Italy (10) · Poland (9) · Israel (7) · Netherlands (7) · Belgium (6) · Spain (6) · Switzerland (5) · Argentina (4) · Canada (4) · China (4) · Czechia (4) · Egypt (4) · France (4)
Alan Maisel, MD (2) · Christopher O'Connor, MD (2) · David D'Alessandro, MD (2) · Hsiao Lieu, MD (2) · Abraham G Kocheril, MD (1) · Ahmad Zeeshan, MD (1) · Ahmed Shehata, MD (1) · Anthony Lemaire, MD (1) · Antonio Abbate, MD (1) · Antonio Santoro, MD (1) · Art Wheeler, MD (1) · Bhagwan Dass, MD (1) · Birthe Dinesen, PhD (1) · Bradley Bart (1)
PMID 35061249, PMID 40295876, PMID 21123186, PMID 21362524, PMID 21576282, PMID 21791540, PMID 23478743, PMID 24485633, PMID 24593826, PMID 26806668, PMID 27659464, PMID 27862700, PMID 28285121, PMID 28335841, PMID 28402745, PMID 28960673, PMID 29044915, PMID 29079633, PMID 29096790, PMID 29143416, PMID 29535141, PMID 29598933, PMID 30059750, PMID 30209124, PMID 30334387, PMID 30571197, PMID 30755071, PMID 30845873, PMID 30891964, PMID 31267239, PMID 31538944, PMID 31797310, PMID 31975496, PMID 32034017, PMID 32341140, PMID 32359358, PMID 32588127, PMID 33258331, PMID 33960144, PMID 33999544, PMID 34246602, PMID 34255642, PMID 34259921, PMID 35000420, PMID 35656973, PMID 35766022, PMID 35928510, PMID 36027559, PMID 36164731, PMID 36262741
2009 (2), 2017 (1), 2019 (1), R01AG045551 (1)