20 completed, 4 terminated, 2 unknown, 1 active not recruiting. 14 Not applicable, 2 Phase 1, 2 Phase 2, 2 Phase 4, 1 Phase 3.
Follow Cheyne-Stokes Respiration: new trials by email Literature Review of Cheyne-Stokes Respiration trials Research Report on Cheyne-Stokes Respiration
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Central Apnea in Heart Failure: Physiological Mechanisms to Inform Treatment Trazodone + positive airway pressure (PAP) therapy, Oxygen + positive airway pressure (PAP) therapy - Sleep Disordered Breathing, Able Bodied | Phase 4 | Recruiting | VA Office of Research and Development | 200 | 2026-09-16 | 2026-10-13 |
| Impact of Patient Involvement in Alerts Management of Telemonitoring CPAP New telemonitoring approach using 2 connected devices : Scanwatch connected watch + Asten&masanté application - OSA | Not applicable | Active not recruiting | Asten Sante | 556 | 2023-09-29 | 2026-06-26 |
| Benefit of Cheyne-Stokes Respiration Remote Monitoring in CPAP-treated Patients With Obstructive Sleep Apnea to Detect Early Events of Heart Failure. CSR remote monitoring - Obstructive Sleep Apnea | Not applicable | Completed | Groupe Medical de Pneumologie, Polyclinique Saint-Laurent | 555 | 2018-07-30 | 2021-03-10 |
| A Prospective Multicenter Registry of Patients With Sleep Disordered Breathing Treated With DreamStation BiPAP autoSV. DreamStation BiPAP autoSV - Central Sleep Apnea, Mixed Sleep Apnea | Completed | Philips Respironics | 129 | 2018-01-25 | 2023-10-02 | |
| Treatment of Central Sleep Apnoea in Patients With Heart Failure With Nasal High Flow Therapy (nHFT) Nasal high flow oxygen therapy - Central Sleep Apnea, Cheyne-Stokes Respiration | Not applicable | Terminated | University Medical Center Groningen | 6 | 2017-06-15 | 2018-12-17 |
| Morphine in Moderate Obstructive Sleep Apnoea Morphine sulphate - Obstructive Sleep Apnoea | Phase 3 | Terminated | Papworth Hospital NHS Foundation Trust | 6 | 2016-05-20 | 2018-11-29 |
| Comparison of SomnaPatch With Polysomnography in Sleep Disordered Breathing SomnaPatch, Polysomnography - Obstructive Sleep Apnea, Central Sleep Apnea | Not applicable | Completed | Somnarus Inc | 190 | 2016-02-01 | 2019-10-03 |
| Leg Fluid Shift in Patients With Chronic Heart Failure and Obstructive or Central Sleep Apnea Multi Frequency Bioimpedance Analysis (mfBIA), Polysomnography/Polygraphy (PSG/PG), Capillary Blood Gas Analysis (CBGA) - Obstructive Sleep Apnoea, Central Sleep Apnoea | Not applicable | Completed | Heart and Diabetes Center North-Rhine Westfalia | 40 | 2015-02-01 | 2017-04-04 |
| Fluid Shift on Obstructive and Central Sleep Apnea no interventions - Apnea (Central and Obstructive) | Completed | Nanjing Medical University | 36 | 2015-01-01 | 2019-02-12 | |
| Cardiovascular Improvements With MV ASV Therapy in Heart Failure MV ASV, Optimized Medical Treatment - Acute Decompensated Heart Failure, Sleep Disordered Breathing | Not applicable | Terminated | ResMed | 126 | 2013-12-01 | 2018-02-28 |
| Substudy on the Mechanistic Plausibility of the Clinical Benefits of Adaptive Servo-ventilation adaptive servoventilation (ASV) - Heart Failure, Sleep Disorder | Phase 4 | Completed | ResMed | 312 | 2012-08-01 | 2015-08-07 |
| Monitoring of the Cerebral Tissue Oxygenation and Perfusion in the Adapting Climber During Sleep in High Altitude Environmental Sleep Disorder, Cheyne-Stokes Respiration | Completed | Goethe University | 6 | 2011-05-01 | 2012-04-06 | |
| Comparison of Breathing Event Detection by a Continuous Positive Airway Pressure Device to Clinical Polysomnography Manipulation of Positive Airway Pressure (PAP) - Sleep Apnea Central, Cheyne-Stokes Respiration | Not applicable | Completed | Philips Respironics | 45 | 2010-09-01 | 2018-10-31 |
| Effect of Heart Valve Replacement on Cheyne-Stokes Respiration heart valve replacement - Cheyne-Stokes Respiration, Heart Valve Disease | Not applicable | Completed | Nanjing Medical University | 26 | 2010-09-01 | 2020-02-26 |
| Bipap Automatic Servo Ventilation (autoSV) Advanced in Central Apnea Patients BiPAP autoSV Advanced - Cheyne-Stokes Respiration, Sleep Apnea, Central | Not applicable | Completed | Philips Respironics | 29 | 2010-09-01 | 2016-04-28 |
| Chronic Evaluation of Respicardia Therapy remedē (TM) system - Sleep Disordered Breathing, Cheyne Stokes Respiration | Phase 2 | Completed | Respicardia, Inc. | 57 | 2010-05-01 | 2016-05-16 |
| Baclofen and Hypoxia-induced Periodic Ventilation Baclofen, Placebo - CHEYNE Stokes Respiration | Phase 1 | Completed | Assistance Publique - Hôpitaux de Paris | 53 | 2010-03-01 | 2012-10-31 |
| Effects of Adaptive Servoventilation in Patients With Systolic Heart Failure and Sleep-Disordered Breathing Cheyne-Stokes respiration by adaptive servoventilation - Heart Failure, Congestive, Sleep Apnea Syndromes | Completed | Ruhr University of Bochum | 550 | 2009-05-01 | 2019-09-04 | |
| Sleep Disordered Breathing in Patients With Chronic Heart Failure Sleep-disordered Breathing, Chronic Heart Failure | Unknown | LudwLudwig Boltzmann Institute for COPD and Respiratory Epidemiology | 200 | 2008-09-01 | 2011-06-16 | |
| Comparison of Modified With Conventional Adaptive Servoventilation Processes Adaptive Servo-controlled Ventilation (ASV) - Periodic Breathing, Cheyne-Stokes Respiration | Not applicable | Completed | ResMed | 20 | 2008-06-01 | 2021-02-05 |
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Sleep Apnea Syndromes (14) · Sleep Apnea, Central (14) · Heart Failure (11) · Sleep Apnea, Obstructive (7) · Apnea (3) · Hypoxia (2) · Respiratory Aspiration (2) · Agnosia (1) · Altitude Sickness (1) · Disease (1) · Dyssomnias (1) · Heart Diseases (1) · Heart Valve Diseases (1) · Hypercapnia (1)
Pathological Conditions, Signs and Symptoms (28) · Respiration Disorders (28) · Respiratory Tract Diseases (28) · Signs and Symptoms (28) · Signs and Symptoms, Respiratory (28) · Nervous System Diseases (22) · Dyssomnias (21) · Sleep Disorders, Intrinsic (21) · Sleep Wake Disorders (21) · Apnea (19) · Cardiovascular Diseases (13) · Heart Diseases (12) · Sleep Apnea Syndromes (7) · Mental Disorders (2) · Neurologic Manifestations (2)
Oxygen (2) · Polysomnography (2) · Baclofen (1) · Cardiac Surgical Procedures (1) · Drug Delivery Systems (1) · Hemodynamic Monitoring (1) · Morphine (1) · Therapeutics (1) · Trazodone (1)
ResMed (5) · Philips Respironics (3) · Nanjing Medical University (2) · Respicardia, Inc. (2) · Assistance Publique - Hôpitaux de Paris (1) · Asten Sante (1) · Goethe University (1) · Groupe Medical de Pneumologie, Polyclinique Saint-Laurent (1) · Heart and Diabetes Center North-Rhine Westfalia (1) · LudwLudwig Boltzmann Institute for COPD and Respiratory Epidemiology (1) · Military Institute od Medicine National Research Institute (1) · Papworth Hospital NHS Foundation Trust (1) · Ruhr University of Bochum (1) · Sanofi (1) · Somnarus Inc (1)
Germany (10) · United States (7) · France (5) · Australia (3) · China (3) · Poland (3) · Netherlands (2) · United Kingdom (2) · Austria (1) · Czechia (1) · Finland (1) · Italy (1) · Norway (1) · Spain (1) · Sweden (1)
Holger Woehrle, MD (2) · Anna Kazimierczak (1) · Arild Hetland, cardiologist (1) · Arnaud Prigent, Dr (1) · Arnaud Prigent, MD (1) · Arschang Valipour, M.D. (1) · Christian Straus, MD, PhD (1) · Christopher O'Connor, MD (1) · Erland Erdmann, Prof (1) · Helmut Teschler, MD (1) · Helmut Teschler, Prof (1) · Ian Smith, MBBS (1) · Ian Wilcox, PhD (1) · Jodie Lattimore, PhD (1) · Karl A Franklin, MD, PhD (1)
PMID 14760162, PMID 21856678, PMID 22302299, PMID 24716484, PMID 25770408, PMID 25950507, PMID 26682790, PMID 26806668, PMID 28335841, PMID 29187390, PMID 30059750, PMID 30325462, PMID 34873795
I01RD001576 (1)