10 completed, 4 terminated, 3 unknown, 1 recruiting. 7 Phase 4, 4 Not applicable, 4 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 7 | Completed 6, Unknown 1 |
| Not applicable | 4 | Terminated 3, Unknown 1 |
| Phase 3 | 4 | Completed 2, Recruiting 1, Unknown 1 |
| Phase 2 | 2 | Completed 1, Terminated 1 |
Follow Sodium Potassium Chloride Symporter Inhibitors: new trials by email Literature Review of Sodium Potassium Chloride Symporter Inhibitors trials Research Report on Sodium Potassium Chloride Symporter Inhibitors
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Dapagliflozin in Reducing Epicardial Adipose Tissue in Heart Failure with Preserved Ejection Fraction Dapagliflozin 10 mg once daily, Loop diuretics, Treatments of associated co-morbidities (e.g Anti-hypertensive, oral hypoglycemic) - Heart Failure with Preserved Ejection Fraction | Not applicable | Unknown | Aswan University | 70 | 2024-08-01 | 2024-07-19 |
| Efficacy and Safety of Combination Diuretic Therapy in Patients With Acute Decompensated Heart Failure and Volume Overload Acetazolamide, Metolazone, IV Loop Diuretics - Acute Decompensated Heart Failure, Volume Overload | Phase 4 | Unknown | Cairo University | 110 | 2024-07-01 | 2024-07-24 |
| Intra-operative Loop Diuretics to Improve Same-day Discharge Rates After HoLEP Furosemide - BPH With Urinary Obstruction, BPH | Phase 3 | Recruiting | Northwestern University | 138 | 2023-03-01 | 2023-09-13 |
| Ultrafiltration Versus IV Diuretics in Worsening Heart Failure Aquadex Smartflow® System, IV Loop Diuretics - Heart Failure (for Example, Fluid Overload), Heart Failure | Not applicable | Terminated | Nuwellis, Inc. | 167 | 2022-06-28 | 2026-06-25 |
| Sodium-glucose Cotransporter Type 2 Inhibitors for Acute Cardiorenal Syndrome Prevention Standard list of drugs used for acute decompensation of CHF (loop diuretics, vasodilators, digoxin, inotropic agents, vasopressors), plus dapagliflozin (Forxiga; MP-002596) - Congestive Heart Failure | Phase 4 | Completed | I.M. Sechenov First Moscow State Medical University | 370 | 2021-01-01 | 2022-12-07 |
| Pilot Study of Loop Diuretics Among Individuals Receiving Hemodialysis Furosemide (loop diuretic) Tablets - Chronic Kidney Disease Requiring Chronic Dialysis | Phase 2 | Completed | University of North Carolina, Chapel Hill | 39 | 2020-10-07 | 2022-06-13 |
| Sequential Nephron Blockade in Acute Heart Failure Metolazone, Loop Diuretics - Acute Heart Failure | Phase 3 | Unknown | Policlinico Casilino ASL RMB | 310 | 2019-10-01 | 2019-11-19 |
| Nitroglycerin vs. Furosemide Using Lung Ultrasound Pilot Trial Nitrates, Loop Diuretics - Heart Failure, Heart Failure Acute | Phase 2 | Terminated | Indiana University | 52 | 2017-12-14 | 2024-08-20 |
| Replication of the TRANSCEND Antihypertensive Trial in Healthcare Claims Data Loop diuretics, thiazides, dihydropyridines, Telmisartan - Hypertension | Completed | Brigham and Women's Hospital | 40048 | 2017-09-22 | 2023-07-27 | |
| Loop Diuretic Dosage in Patients With Acute Heart Failure and Renal Failure: Conventional Versus Carbohydrate Antigen 125-guided Therapy (IMPROVE-HF) CA125 guided strategy, Conventional Strategy - Heart Failure | Phase 4 | Completed | Fundación para la Investigación del Hospital Clínico de Valencia | 170 | 2015-01-01 | 2018-02-13 |
| Acetazolamide and Spironolactone to Increase Natriuresis in Congestive Heart Failure Combination therapy with acetazolamide and low-dose loop diuretics, High-dose loop diuretics, Upfront therapy with oral spironolactone - Heart Failure | Phase 4 | Completed | Hasselt University | 34 | 2013-11-01 | 2019-05-21 |
| Diuretic Response in Advanced Heart Failure: Bolus Intermittent vs Continuous INfusion Loop Diuretics - Heart Failure NYHA Class III, Heart Failure NYHA Class IV | Phase 3 | Completed | University of Turin, Italy | 80 | 2013-05-01 | 2018-07-19 |
| Tolvaptan/Ultrafiltration in the Treatment of Acute Heart Failure loop diuretic, tolvaptan, ultrafiltration - Acute Decompensated Heart Failure | Phase 4 | Completed | The Christ Hospital | 45 | 2013-05-01 | 2016-01-28 |
| Study of Heart Failure Hospitalizations After Aquapheresis Therapy Compared to Intravenous (IV) Diuretic Treatment Isolated veno-venous ultrafiltration (AQ), IV Loop Diuretics (LD) - Heart Failure, Cardiac Failure | Not applicable | Terminated | Nuwellis, Inc. | 224 | 2012-01-01 | 2023-08-29 |
| Assessment of Coronary Flow Reserve in Heart Failure Patients After Ultrafiltration Versus Diuretics Loop diuretics (furosemide, torsemide, bumetanide), Ultrafiltration - Acute Decompensated Heart Failure | Not applicable | Terminated | University of Cincinnati | 4 | 2011-11-01 | 2016-12-05 |
| Determining Optimal Dose and Duration of Diuretic Treatment in People With Acute Heart Failure (The DOSE-AHF Study) Furosemide-Q12 hour bolus, Furosemide-Continuous Infusion, Furosemide-Low Intensification - Heart Failure | Phase 3 | Completed | Duke University | 308 | 2008-02-01 | 2018-03-06 |
| Hypertension Study: Multinational Torasemide Trial in Mild to Moderate Hypertension. Torasemide Prolonged Release (loop diuretic), Torasemide Immediate Release (loop diuretic) - Hypertension | Phase 4 | Completed | Ferrer Internacional S.A. | 388 | 2005-04-01 | 2015-03-06 |
| Extracorporeal Ultrafiltration (UF) vs. Usual and Customary Care for Patients With Severe Heart Failure (HF) IV loop diuretic, NxStage System One - Heart Failure, CHF | Phase 4 | Completed | NxStage Medical | 36 | 2003-10-01 | 2012-06-19 |
Heart Failure (8) · Edema (3) · Hypertension (2) · Cardio-Renal Syndrome (1) · Hematuria (1) · Kidney Failure, Chronic (1) · Pulmonary Edema (1) · Renal Insufficiency (1)
Nuwellis, Inc. (2) · Aswan University (1) · Brigham and Women's Hospital (1) · Cairo University (1) · Duke University (1) · Ferrer Internacional S.A. (1) · Fundación para la Investigación del Hospital Clínico de Valencia (1) · Hasselt University (1) · I.M. Sechenov First Moscow State Medical University (1) · Indiana University (1) · Northwestern University (1) · NxStage Medical (1) · Policlinico Casilino ASL RMB (1) · The Christ Hospital (1) · University of Cincinnati (1)
United States (10) · Italy (2) · Belgium (1) · Canada (1) · Egypt (1) · Russia (1) · Spain (1)
Alan Hull, MD (1) · Alex Roca, MD, PhD (1) · Alexander O Sherenkov, MD, PhD (1) · Alexander V Orlov-Morozov, MD, PhD (1) · Amy E Krambeck, MD (1) · Andrei Y Baranovsky, MD, PhD (1) · Angel Cano, MD (1) · Angela Felip, MD, PhD (1) · Antonio Coca, MD, PhD (1) · Blas Gil, MD (1) · Boris M Goloschekin, MD, PhD (1) · Carles Brotons, MD, PhD (1) · Carlos Calvo, MD, PhD (1) · Elena F Pavlysh, MD, PhD (1) · Emili Marco, MD (1)
PMID 21366472, PMID 22277179, PMID 23194486, PMID 23250981, PMID 25543972, PMID 26041600, PMID 26927285, PMID 27514750, PMID 29587582, PMID 31074184, PMID 31256261, PMID 32624444, PMID 35061249, PMID 36787124, PMID 38775253, PMID 42021144
2014 (1), R03DK124651 (1), U01HL084904 (1)