32 completed, 9 unknown, 5 terminated, 2 recruiting. 14 Not applicable, 13 Phase 3, 10 Phase 4, 4 Phase 2, 1 Phase 1.
Follow Diuretics: new trials by email Literature Review of Diuretics trials Research Report on Diuretics
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Effect of Dapagliflozin on Patients With Cardiomyopathy Dapagliflozin (DAPA), Diuretic - Acute Decompensated Heart Failure (ADHF) | Phase 4 | Completed | May Mohamed Abdalla | 100 | 2025-08-01 | 2026-09-15 |
| "Effect of Albumin Combined With Furosemide in Critically Ill Patients With Fluid Overload: Impact on Urine Output and Renal Function" Furosemide plus albumin, Furosemide (Diuretic) - Urine Output Decreased | Not applicable | Recruiting | Jose J Zaragoza, MD MSc | 56 | 2025-06-01 | 2026-06-16 |
| Early Identification and Treatment of Rare Cardiomyopathy Cohorts diuretics, ACEIs/ARBs, beta blockers, positive inotropic drugs, MRAs, SGLT2i, retinoids, Close follow-up, early rehabilitation guidance - Hypertrophic Cardiomyopathy (HCM), Dilated Cardiomyopathy (DCM) | Not applicable | Not yet recruiting | RenJi Hospital | 300 | 2025-02-01 | 2025-01-27 |
| EU Sites: Fluid Management of Acute Decompensated Heart Failure With Reprieve Decongestion Management System (FASTR-EU) Reprieve Decongestion Management System, Diuretic (furosemide, bumetanide, torsemide, hydrochlorothiazide, and/or acetazolamide) - Acute Decompensated Heart Failure | Not applicable | Completed | Reprieve Cardiovascular, Inc | 12 | 2024-05-17 | 2025-03-10 |
| Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study Furosemide (Diuretic), Hypertonic Saline Infusion - Salt-Sensitivity of Blood Pressure | Phase 4 | Recruiting | University of Delaware | 120 | 2024-03-05 | 2026-03-24 |
| A Study of Ultra High Dose Diuretics to Treat Heart Failure Bumetanide, Furosemide - Heart Failure; With Decompensation | Phase 2 | Completed | Mayo Clinic | 20 | 2023-11-27 | 2026-01-14 |
| The Addition of Inhaled Furosemide to Standard Treatment of COPD Exacerbation Furosemide, Normal saline - Chronic Obstructive Pulmonary Disease Exacerbation, COPD Exacerbation | Phase 3 | Unknown | American University of Beirut Medical Center | 200 | 2023-03-01 | 2023-03-15 |
| Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve Decongestion Management System (DMS) Reprieve Decongestion Management System, Diuretic - Acute Decompensated Heart Failure | Not applicable | Completed | Reprieve Cardiovascular, Inc | 100 | 2022-07-11 | 2026-06-23 |
| International Registry of Acute Kidney Injury in Cirrhosis: The GLOBAL AKI Project Crystalloids, albumin, vasoconstrictors, diuretics, renal replacement therapy - Liver Cirrhosis, Acute Kidney Injury | Completed | Azienda Ospedaliera di Padova | 1456 | 2022-07-01 | 2024-01-30 | |
| Long-term Use of CCB and Breast Cancer Risk Calcium channel blocker, Beta blocker, Diuretic - Hypertension,Essential, Breast Cancer | Unknown | Curtin University | 68500 | 2022-07-01 | 2024-08-21 | |
| Risk Factors and Machine Learning Model for Diuretics Related Acute Kidney Injury Diuretics - Diuretic Toxicity, Acute Kidney Injury | Unknown | Qianfoshan Hospital | 18000 | 2022-07-01 | 2024-04-03 | |
| Predictive Value of Venous Excess Ultrasound Score in Management of Cardiorenal Patients VExUS score, Diuretic Effect - Cardio-Renal Syndrome | Unknown | Assiut University | 60 | 2022-06-01 | 2022-05-10 | |
| Empagliflozin as a Novel Therapy in Refractory Ascites Empagliflozin 10 MG, Diuretics - Ascites Hepatic | Phase 2 / Phase 3 | Completed | Alexandria University | 42 | 2022-04-21 | 2022-11-29 |
| Quantifying Congestion by Ultrasound Diuretics - Heart Failure | Not applicable | Unknown | NHS Greater Glasgow and Clyde | 20 | 2021-11-01 | 2021-10-22 |
| Oral Combined Hydrochlorothiazide/Lisinopril Versus Oral Nifedipine for Postpartum Hypertension ACE Inhibitors and Diuretics, NIFEdipine ER - Hypertension in Pregnancy, Postpartum Preeclampsia | Phase 4 | Completed | The University of Texas Health Science Center, Houston | 70 | 2021-10-18 | 2025-11-10 |
| Aquapheresis Efficacy in Outpatients With Decompensated Heart Failure Aquapheresis, IV Diuretics - Heart Failure, Congestive Heart Failure | Not applicable | Withdrawn | Ramona Gelzer Bell | 2021-06-08 | 2021-08-30 | |
| Acute Renal Injury After Major Elective Non-Cardiac Surgery Crystalloid Solutions, Colloid Blood Volume Expanders, blood replacement - Acute Renal Injury | Completed | Istanbul University | 425 | 2019-06-01 | 2021-09-22 | |
| Surgical Idiopathic Intracranial Hypertension Treatment Trial Acetazolamide, Optic Nerve Sheath Fenestration, Ventriculoperitoneal CSF Shunting - Idiopathic Intracranial Hypertension | Phase 3 | Terminated | Jaeb Center for Health Research | 7 | 2019-02-06 | 2022-06-16 |
| The Use of TrIple Fixed-dose Combination in the Treatment of Arterial Hypertension amlodipine / indapamide / perindopril arginine FDC - Arterial Hypertension | Completed | Servier Russia | 1247 | 2018-10-01 | 2021-06-10 | |
| To Study the Safety and Efficacy of Midodrine With Albumin Versus Albumin Alone in Hepatic Hydrothorax Midodrine, Albumin, Diuretics - Hepatic Hydrothorax | Not applicable | Completed | Institute of Liver and Biliary Sciences, India | 8 | 2018-09-30 | 2020-06-25 |
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Heart Failure (13) · Hypertension (10) · Cardiovascular Diseases (5) · Acute Kidney Injury (3) · Edema (3) · Heart Diseases (3) · Coronary Disease (2) · Fibrosis (2) · Liver Cirrhosis (2) · Ascites (1) · Atherosclerosis (1) · Body Weight (1) · Breast Neoplasms (1) · Cardio-Renal Syndrome (1) · Cardiomyopathies (1)
Hospital de Clinicas de Porto Alegre (3) · Boehringer Ingelheim (2) · Reprieve Cardiovascular, Inc (2) · Alere San Diego (1) · Alexandria University (1) · American University of Beirut Medical Center (1) · Assistance Publique - Hôpitaux de Paris (1) · Assiut University (1) · AstraZeneca (1) · Azienda Ospedaliera di Padova (1) · Catharina Ziekenhuis Eindhoven (1) · Central Hospital, Nancy, France (1) · Curtin University (1) · Emory University (1) · Farma de Colombia SA (1)
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Abdallah I. Kelany, MD (1) · Alan Maisel, MD (1) · Bjorn Eriksson, MD (1) · C. Hawkins (1) · Decio Mion Jr, MD (1) · Denise Fischer, Psychologist (1) · Divya Gupta, MD (1) · El Mehdi Siaghy (1) · Elvira Fernandez, MD,PhD (1) · Fabio T Cichelero, MD (1) · Fabrizio Oliva, MD (1) · Flavio D Fuchs, MD, PhD (1) · Hans Persson, MD, PhD (1)
PMID 40295876, PMID 17010806, PMID 17291932, PMID 18504339, PMID 19407805, PMID 20863950, PMID 21440872, PMID 21617110, PMID 21884956, PMID 22431406, PMID 22980301, PMID 23982888, PMID 24058183, PMID 24382030, PMID 24768965, PMID 25638527, PMID 26181335, PMID 26399404, PMID 26938814, PMID 27965209, PMID 29227377, PMID 29861076, PMID 30202211, PMID 30732732, PMID 31389723, PMID 33047257, PMID 34915839, PMID 36810101, PMID 37118703, PMID 37354146, PMID 37710178, PMID 37932787, PMID 38458796, PMID 38781664, PMID 39048932, PMID 39323439, PMID 40058397, PMID 42068320, PMID 9704688
2008 (1), 2009 (1), R01HL043232 (1), R01HL163906 (1), U10EY025990 (1)