24 completed, 10 recruiting, 6 not yet recruiting, 5 unknown. 24 Not applicable, 2 Phase 2, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 24 | Completed 9, Recruiting 6, Unknown 4, Not yet recruiting 2, Terminated 2, Active not recruiting 1 |
| Phase 2 | 2 | Completed 1, Recruiting 1 |
| Phase 3 | 2 | Completed 1, Recruiting 1 |
Follow Acute Brain Injury: new trials by email Literature Review of Acute Brain Injury trials Research Report on Acute Brain Injury
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Bedside Cranial Ultrasound for Risk-Stratified Imaging in Pediatric Acute Brain Injury Acute Brain Injury, Traumatic Brain Injury | Not yet recruiting | Virginia Commonwealth University | 220 | 2026-11-30 | 2026-08-19 | |
| Nucleosome Monitoring Relevance for Outcome Prediction in Critically Ill Patients Plasma H3.1 nucleosome measurement - Sepsis, Septic Shock | Not yet recruiting | Erasme University Hospital | 1000 | 2026-10-01 | 2026-09-22 | |
| Non-Invasive Triage for Intracranial Hypertension in Prehospital Care Brain4care non-invasive intracranial pressure monitor, Optic nerve sheath diameter ultrasound - Intracranial Hypertension, Acute Brain Injury | Not applicable | Not yet recruiting | Juliana Caldas | 180 | 2026-09-01 | 2026-08-05 |
| Portable MRI for Pediatric Hypoxic Ischemic Brain Injury Portable MRI, Scavenged Sample Collection - Acute Brain Injury, Hypoxia, Brain | Not applicable | Recruiting | Children's Mercy Hospital Kansas City | 200 | 2026-07-06 | 2026-09-24 |
| Effect of Central Venous Catheterization on Brain Pressure in Acute Brain Injury Patients Acute Brain Injury, Traumatic Brain Injury | Active not recruiting | Beijing Tiantan Hospital | 120 | 2026-03-01 | 2026-07-15 | |
| Regional Ventilation Evaluation During Neuro-injury Weaning Study Internal Thoracic Impedance - Acute Brain Injury, Mechanical Ventilation | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 60 | 2026-03-01 | 2026-02-19 | |
| The Role of Transcutaneous Vagus Nerve Stimulation in Treatment of Acute Brain Injury transcutaneous vagus nerve stimulation (tVNS), Sham (No Treatment) - Acute Brain Injury, Transcutaneous Vagus Nerve Stimulation | Not applicable | Not yet recruiting | Clinical Hospital Centre Zagreb | 60 | 2026-02-01 | 2026-02-03 |
| Contribution of Transthoracic and Transcranial Ultrasonography to the Titration of PEEP in Patients With ARDS and ABI Stepwise Positive End-Expiratory Pressure (PEEP) Increase Protocol - Acute Respiratory Distress Syndrome (ARDS), Acute Brain Injury | Not applicable | Recruiting | Theodoros Schizodimos | 30 | 2025-12-01 | 2025-12-31 |
| PRophylaxis Against Early VENTilator-associated Infections in Acute Brain Injury Ceftriaxone 2g diluted in >200ml 0.9%sodium chloride, Placebo comparator - no ceftriaxone - All-cause Mortality, Quality of Life | Phase 3 | Recruiting | The George Institute | 3300 | 2025-10-30 | 2026-08-28 |
| Physical Mobilisation to Acquired Brain Injury Patients in Intensive Care Units: a Prospective Cohort Study Acute Brain Injury | Recruiting | Copenhagen University Hospital, Rigshospitalet | 198 | 2025-08-25 | 2026-04-23 | |
| Feasibility and Safety of Targeting Neutral vs Liberal Fluid Balance in Traumatic Brain Injured Patients- LIMIT-TBI Trial Neutral Fluid Balance Strategy - Traumatic Brain Injury, Severe Traumatic Brain Injury | Phase 2 | Recruiting | Erasme University Hospital | 88 | 2025-07-01 | 2026-06-04 |
| VentricuLostomy AssoCiaTed InfeCtions (LACTIC): Focus on CSF Lactate and Sampling Site Sampling of blood and cerebrospinal fluid - Acute Brain Injury, Hydrocephalus | Recruiting | Copenhagen University Hospital, Rigshospitalet | 148 | 2025-01-15 | 2026-02-02 | |
| High-Flow Nasal Cannula After Extubation in Acute Brain Injury Acute Brain Injury, Post-neurosurgical Status | Completed | Bach Mai Hospital | 285 | 2025-01-01 | 2026-09-10 | |
| Clinical Application of Low-Field Magnetic Resonance Imaging in Patients on Extracorporeal Cardiopulmonary Resuscitation Cardiac Arrest (CA), Extracorporeal Cardiopulmonary Resuscitation | Completed | Capital Medical University | 36 | 2024-11-01 | 2026-04-13 | |
| Weaning From Mechanical Ventilation in Patients With Acute Brain Injury Ventilator Lung, Acute Brain Injury | Completed | Southeast University, China | 605 | 2024-08-06 | 2026-09-09 | |
| Multimodal Brain Monitoring as an Early Warning and Prognostic Tool for Acute Brain Injury no intervention - Acute Brain Injury | Not yet recruiting | Xiangya Hospital of Central South University | 490 | 2024-07-30 | 2024-07-17 | |
| ECMO ABI Detection With Hyperfine Hyperfine - Acute Brain Injury, Extracorporeal Membrane Oxygenation Complication | Not applicable | Recruiting | Children's Mercy Hospital Kansas City | 40 | 2024-07-23 | 2026-09-24 |
| Microdialysis and Jugular Bulb Glucose Profiles During Hyperglycaemic Clamping in Patients With Severe Acute Brain Injury Hyperglycaemic clamp - Acute Brain Injury | Not applicable | Completed | Copenhagen University Hospital, Rigshospitalet | 14 | 2024-05-08 | 2026-02-25 |
| Spleen Volume Change Predicts 45-Day Mortality in Neurocritical Care: A Prospective Cohort Study POCUS-based Splenic Volume Measurement - Intracerebral Hemorrhage (ICH), Hemorrhagic Stroke, Intracerebral | Completed | Ankara City Hospital Bilkent | 42 | 2024-03-15 | 2025-08-20 | |
| Brain Monitoring During PEEP-Based Respiratory Therapy in Critically Ill Patients Recruitment Maneuver, Positive End-Expiratory Pressure Adjustment - Acute Brain Injury, Mechanical Ventilation | Not applicable | Recruiting | Shengli Oilfield Hospital | 50 | 2024-02-01 | 2026-07-21 |
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Brain Injuries (50) · Brain Injuries, Traumatic (11) · Stroke (8) · Cerebral Hemorrhage (5) · Hypoxia-Ischemia, Brain (5) · Subarachnoid Hemorrhage (5) · Heart Arrest (4) · Intracranial Hypertension (4) · Brain Neoplasms (3) · Consciousness Disorders (3) · Ischemic Stroke (3) · Seizures (3) · Brain Concussion (2) · Brain Ischemia (2) · Delirium (2)
Brain Diseases (50) · Central Nervous System Diseases (50) · Craniocerebral Trauma (50) · Trauma, Nervous System (50) · Nervous System Diseases (49) · Wounds and Injuries (48) · Pathological Conditions, Signs and Symptoms (19) · Cardiovascular Diseases (15) · Signs and Symptoms (14) · Vascular Diseases (14) · Cerebrovascular Disorders (13) · Pathologic Processes (12) · Hemorrhage (9) · Intracranial Hemorrhages (8) · Neurologic Manifestations (8)
Airway Extubation (1) · Ceftriaxone (1) · Exercise (1) · Muscle Stretching Exercises (1) · Oxygen (1) · Positive-Pressure Respiration (1) · Respiration, Artificial (1) · Sleep (1) · Sodium Chloride (1)
Copenhagen University Hospital, Rigshospitalet (6) · Children's Mercy Hospital Kansas City (3) · Erasme University Hospital (3) · Capital Medical University (2) · Children's Hospital of Philadelphia (2) · Sunnybrook Health Sciences Centre (2) · University of Milano Bicocca (2) · Ankara City Hospital Bilkent (1) · Assistance Publique - Hôpitaux de Paris (1) · Bach Mai Hospital (1) · Bayside Health (1) · Beijing Tiantan Hospital (1) · Centre Hospitalier St Anne (1) · Clinical Hospital Centre Zagreb (1) · Colin Grissom (1)
United States (12) · China (6) · Denmark (6) · France (5) · Belgium (4) · Canada (4) · Italy (3) · Greece (2) · Norway (2) · Spain (2) · Australia (1) · Croatia (1) · Germany (1) · New Zealand (1) · Switzerland (1)
Damon Scales, MD, PhD (2) · Jessica Wallisch, MD (2) · Aarti Sarwal, MD (1) · Alia Marie O'Meara, MD (1) · Andrew Udy, Prof (1) · Anthony Delaney, Prof (1) · Asad Ikram, MD (1) · Atif Zafar, MD (1) · Cagdas Yildirim, Assistant Professor (1) · Camille Bouisse (1) · Camille CM Maury, MD (1) · Carole Ichai (1) · Catherine Hassett, DO (1) · Chiara Robba, MD (1) · Christian Gunge Riberholt, PhD (1)
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