118 completed, 35 terminated, 15 withdrawn, 14 recruiting. 196 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 196 | Completed 118, Terminated 35, Withdrawn 15, Recruiting 14, Not yet recruiting 9, Active not recruiting 4, Unknown 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Combating Related Epidemics in HCV Cepheid GeneXpert HCV Test, Abbott Determine HIV - 1/2 Ag/Ab, Abbott Determine HbsAg 2 - HIV - Human Immunodeficiency Virus, Hepatitis B Virus (HBV) | Phase 4 | Not yet recruiting | Duke University | 1280 | 2027-01-20 | 2026-10-15 |
| Study of QL Analgesic Response and Extent Quadratus Lumborum with 1.5% Lidocaine - Acute Pain, Postoperative Pain | Phase 4 | Not yet recruiting | Duke University | 25 | 2027-01-01 | 2026-07-08 |
| Targeted Nerve Injection to the Knee (Nerve to Vastus Medialis): Comparing Two Adductor Canal Block Approaches Traditional adductor canal block, NVM (nerve to vastus medialis) targeted adductor canal block, Chloroprocaine Injection - Anesthesia, Local | Phase 4 | Not yet recruiting | Duke University | 25 | 2027-01-01 | 2026-08-27 |
| SPARK Study - Sympathetic Periarterial Radial Block in Healthy Volunteers Lidocaine 2% - Healthy Volunteers, Sympathetic Activity | Phase 4 | Not yet recruiting | Duke University | 20 | 2027-01-01 | 2026-11-06 |
| Upneeq vs. Lumify Ptosis Oxymetazoline 0.1% (Upneeq), Brimonidine 0.025% (Lumify) - Acquired Ptosis | Phase 4 | Not yet recruiting | Duke University | 50 | 2026-12-01 | 2026-05-22 |
| NOTRE: Optimizing Long-Acting Pre-Exposure Prophylaxis and Medications for Opioid Use Disorder Interventions in Carceral Settings Cabotegravir Injection, Cabotegravir Pill, Buprenorphine injection - HIV Infections, Opioid Use Disorder | Phase 4 | Not yet recruiting | Duke University | 450 | 2026-12-01 | 2026-11-06 |
| Exparel and Dexamethasone Liposomal Bupivacaine with Bupivacaine, Dexamethasone - Postoperative Pain, Shoulder Arthroscopic Surgeries | Phase 4 | Not yet recruiting | Duke University | 80 | 2026-11-01 | 2026-10-19 |
| Suzetrigine Added to Multimodal Analgesia for Women Undergoing Minimally Invasive Hysterectomy Suzetrigine - Postoperative Pain | Phase 4 | Not yet recruiting | Duke University | 123 | 2026-11-01 | 2026-09-23 |
| IV Iron Therapy for Older Adults With Heart Failure With Preserved Ejection Fraction and Iron Deficiency Ferric derisomaltose, Placebo (normal saline) - Heart Failure With Preserved Ejection Fraction, Iron Deficiency | Phase 4 | Not yet recruiting | Duke University | 300 | 2026-11-01 | 2026-10-15 |
| ESP Blocks for Posterior Spinal Fusion ESP Block with Bupivacaine, ESP Block with Bupivacaine + Liposomal Bupivacaine - Postoperative Pain | Phase 4 | Recruiting | Duke University | 75 | 2026-09-17 | 2026-11-06 |
| Tirzepatide in Idiopathic Intracranial Hypertension Trial Tirzepatide, Tirzepatide Placebo - Idiopathic Intracranial Hypertension (IIH) | Phase 4 | Recruiting | Duke University | 60 | 2026-08-25 | 2026-09-15 |
| Flex Appeal: Evaluating the Efficacy of Anesthetic Techniques for Manipulation of Knees Under Anesthesia Spinal Anesthesia, General Anesthesia, Propofol - Knee Stiffness After Total Knee Arthroplasty | Phase 4 | Recruiting | Duke University | 128 | 2026-06-01 | 2026-06-03 |
| Project DEDUCE: Digital Envirotyping to Develop Understanding of Cigarette Smoking and the Environment transdermal nicotine replacement therapy - Smoking | Phase 4 | Recruiting | Duke University | 600 | 2026-05-06 | 2026-07-23 |
| Extended Oral Tranexamic Acid After Anterior Cruciate Ligament Reconstruction Tranexamic Acid (TXA), Placebo - ACL Injury, ACL Tears | Phase 4 | Withdrawn | Campbell Clinic | 2026-04-01 | 2026-03-03 | |
| Enhancing PrEP Uptake and Retention Among Latine TGW and GBM in the South Using Long-Acting Injectable PrEP Lenacapavir long-acting - HIV Prevention, HIV Pre-exposure Prophylaxis | Phase 4 | Recruiting | Duke University | 100 | 2026-01-13 | 2026-10-19 |
| Safety of RSV Preventive Monoclonal Antibody Respiratory Syncytial Virus (RSV) Preventive Monoclonal Antibody - Fever, Adverse Event Following Immunisation | Phase 4 | Recruiting | Duke University | 524 | 2025-10-02 | 2026-03-16 |
| MAPS PrEP Van Study Pre-Exposure Prophylaxis (PrEP) - HIV Infection | Phase 4 | Completed | Duke University | 7 | 2025-09-17 | 2026-07-24 |
| Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention Inclisiran sodium 300 mg (equivalent to 284 mg inclisiran) in 1.5 mL, Normal Saline (Placebo) - Percutaneous Coronary Intervention, Peripheral Endovascular Intervention | Phase 4 | Recruiting | Duke University | 6000 | 2025-07-23 | 2026-10-29 |
| Dispersion Following ESP Versus ITP Blocks Using Lidocaine Study Intertransverse Process Block with 1.5% Lidocaine, Erector Spinae Plane Block with 1.5% Lidocaine, 1.5% Lidocaine - Acute Pain, Postoperative, Regional Anesthesia Block | Phase 4 | Completed | Duke University | 13 | 2025-06-10 | 2025-08-28 |
| Optimizing Perioperative Analgesia to Lower Pain Following Cleft Palate Surgery Methadone hydrochloride, Fentanyl/Hydromorphone - Cleft Palate, Pain | Phase 4 | Recruiting | Duke University | 60 | 2025-06-04 | 2026-04-14 |
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Pain (13) · Pain, Postoperative (11) · Influenza, Human (10) · Cardiovascular Diseases (7) · Schizophrenia (7) · Agnosia (5) · Asthma (5) · Depression (5) · Psychotic Disorders (5) · Sleep Initiation and Maintenance Disorders (5) · Smoking Cessation (5) · Cigarette Smoking (4) · Fever (4) · Heart Failure (4) · Hypercholesterolemia (4)
Influenza Vaccines (11) · Sodium Chloride (10) · Ropivacaine (9) · Bupivacaine (8) · Dexamethasone (6) · Fentanyl (6) · Lidocaine (5) · Hydromorphone (4) · Nicotine Replacement Therapy (4) · Propofol (4) · Acetaminophen (3) · Bupropion (3) · Dental Occlusion (3) · Iopamidol (3) · Metformin (3)
United States (167) · Canada (3) · Brazil (2) · Denmark (2) · Kenya (2) · Australia (1) · Belgium (1) · Democratic Republic of the Congo (1) · France (1) · Germany (1) · India (1) · Ireland (1) · Israel (1) · Italy (1) · Netherlands (1)
Ashraf S Habib, MD (4) · Emmanuel B Walter, MD, MPH (3) · Joseph P McEvoy, MD (3) · Karen Broder, MD (3) · Amanda Kumar, MD (2) · Andrew D Krystal, MD (2) · Andrew Krystal, MD (2) · Ashraf Habib (2) · Ashwin A Patkar, M.D. (2) · Brenna Hughes, MD (2) · Brian Mendelson, MD (2) · Elizabeth Barnett, MD (2) · Elizabeth Schlaudecker, MD, MPH (2) · Emily Hall (2) · Emmanuel B Walter, MD (2)
PMID 17888856, PMID 18332269, PMID 18559695, PMID 19158975, PMID 19664750, PMID 20001518, PMID 20339536, PMID 20413733, PMID 21081776, PMID 21346609, PMID 21742089, PMID 21878431, PMID 22131611, PMID 22465214, PMID 22500572, PMID 22808006, PMID 23410543, PMID 23695483, PMID 24163385, PMID 24392250, PMID 24463669, PMID 24631512, PMID 24846035, PMID 24882900, PMID 25323254, PMID 25664215, PMID 27152422, PMID 27247177, PMID 29209926, PMID 30549494, PMID 31238203, PMID 31537089, PMID 31923061, PMID 31923074, PMID 32029684, PMID 32217365, PMID 32227754, PMID 32227756, PMID 32329435, PMID 32588430, PMID 32641226, PMID 32918323, PMID 33431616, PMID 33443580, PMID 33649343, PMID 33884617, PMID 33989711, PMID 34002866, PMID 34017999, PMID 34261807
K01DA043413 (1), K23DK062116 (1), K23MH081285 (1), P30AI064518 (1), P30MH066386 (1), R01AG059417 (1), R01AG097715 (1), R01DA038442 (1), R01DA042985 (1), R01DA053342 (1), R01DA062639 (1), R01DK139484 (1), R01HD114678 (1), R01HL085704 (1), R01HL134211 (1)