66 completed, 19 unknown, 11 recruiting, 7 terminated. 107 Phase 3, 16 Phase 2.
Follow Wound Infection: new trials by email Literature Review of Wound Infection trials Research Report on Wound Infection
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Integrating Next Generation Sequencing for Treatment of Surgical Site Infection After Fracture Fixation: NGS diagnostic findings - Next Generation Sequencing (NGS), Surgical Site Infection (SSI) | Phase 3 | Not yet recruiting | Johns Hopkins Bloomberg School of Public Health | 250 | 2026-11-01 | 2026-10-08 |
| Evaluation of the Effect of Antibiotic Prophylaxis During Lumpectomy for Breast Cancer: Prospective Randomised Double-blind Noninferiority Study of Placebo vs Cefazolin Cefazolin 2 g Infusion, Placebo infusion of .9 normal saline - Breast Cancer, Breast Surgery | Phase 3 | Not yet recruiting | University Hospital, Clermont-Ferrand | 1600 | 2026-11-01 | 2026-10-27 |
| Prophylactic Antibiotic Duration in Head and Neck Cancer Surgery (PROTECT-HN Trial) Ampicillin/Sulbactam 24-Hour Postoperative Prophylaxis, Ampicillin/Sulbactam 7-Day Postoperative Prophylaxis - Surgical Wound Infection, Head and Neck Neoplasms | Phase 3 | Recruiting | AC Camargo Cancer Center | 80 | 2025-05-29 | 2026-10-05 |
| Incisional Negative Pressure Wound Therapy to Reduce Infection and Complications in High-Risk Fractures Incisional Negative Pressure Wound Therapy (NPWT) - Fracture of Tibia, Wound Heal | Phase 3 | Recruiting | Major Extremity Trauma Research Consortium | 352 | 2025-01-01 | 2026-05-12 |
| Light-Activated Antimicrobial Therapy to Prevent Surgical Site Infections nasal antimicrobial photodisinfection therapy - Surgical Site Infections, Surgical Wound Infection | Phase 3 | Completed | Ondine Biomedical Inc. | 4787 | 2024-12-27 | 2026-09-15 |
| The MANTRA Trial (MANdibular TRauma and Antibiotic Use) Different post-operative antibiotic regimens following surgical treatment of mandible fractures - Mandible Fracture, Post-operative Antibiotics | Phase 3 | Recruiting | East Lancashire Hospitals NHS Trust | 2841 | 2024-12-06 | 2026-01-22 |
| Prophylactic Antibiotic in Subtalar Fusion Surgery Ceftriaxone 2000 mg - Surgical Site Infection | Phase 2 / Phase 3 | Unknown | Assiut University | 102 | 2024-09-01 | 2024-07-30 |
| The Role of Antibiotic Prophylaxis in Lowering Wound Infection Rates Post-Open Repair of Primary Elective Groin Hernias in High-Risk Patients Cefazolin 1000 MG - Antibiotic Prophylaxis, Wound Infection | Phase 3 | Unknown | University of Aleppo | 200 | 2024-08-01 | 2024-08-28 |
| Diluted Aqueous Povidone-Iodine Compared to Saline to Decrease Surgical Site Infections Povidone-Iodine, Normal Saline - Surgical Site Infection | Phase 3 | Recruiting | Loma Linda University | 1100 | 2024-06-03 | 2025-11-19 |
| Multicenter Study Protocol: Research on Evaluation and Detection of Surgical Wound Complications with AI-based Recognition. (REDSCAR-trial) RedScar App - Surgical Wound Infection | Phase 2 / Phase 3 | Recruiting | Universitat de les Illes Balears | 168 | 2024-01-01 | 2025-01-20 |
| Efficacy of Intrawound Vancomycin in Spine Surgery vancomycin, Standard surgical closure - Surgical Site Infection (SSI), Spine Diseases | Phase 3 | Completed | Ain Shams University | 416 | 2023-12-02 | 2026-10-15 |
| Small Bites Vs Large Bites Abdominal Midline Incisional Closure Small bite closure, Large bite closure - Suture Techniques, Wound Closure Techniques | Phase 2 / Phase 3 | Active not recruiting | Dow University of Health Sciences | 200 | 2023-11-23 | 2025-09-04 |
| PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation Standard of Care PO (oral) antibiotics, Standard of Care Intravenous (IV) antibiotics - Infections, Infected Wound | Phase 3 | Recruiting | Major Extremity Trauma Research Consortium | 250 | 2023-05-30 | 2026-09-11 |
| Outcomes of High-volume Saline Irrigation VS Povidone-Iodine Solution Cleaning of IOWI in Preventing SSIs in Emergency Laparotomies 0.9% saline solution, Povidone-iodine Swab - Surgical Site Infection, Surgical Wound | Phase 2 / Phase 3 | Recruiting | Dow University of Health Sciences | 200 | 2023-04-29 | 2025-06-18 |
| Prevention of Incisional Hernia With Mesh-suture at Umbilical Trocar Site. duramesh suture - Incisional Hernia of Anterior Abdominal Wall, Dehiscence Wound | Phase 3 | Unknown | Miguel A ngel Garci-a Urena | 124 | 2023-03-22 | 2024-02-09 |
| The Effect of Bacterial Decolonization Before Skin Cancer Surgery on Infection Rate of Lower Extremity Wounds Left Open to Heal Chlorhexidine gluconate (4%), Mupirocin 2% Ointment - Surgical Wound Infection | Phase 3 | Recruiting | The Cooper Health System | 848 | 2023-03-13 | 2025-08-26 |
| Povidone-iodine vs Saline Solution in Colorectal Surgeries and Its Effects on the Surgical Site Infection Povidone-iodine, Saline solution - Surgical Site Infection | Phase 3 | Recruiting | Hospital de Clinicas de Porto Alegre | 228 | 2023-01-02 | 2024-03-08 |
| Cefepime and Unictam on Preventing Post-Cesarean Surgical Site Infections Cefepime 1000 MG, Ampicillin-sulbactam - Cesarean Section; Infection | Phase 3 | Unknown | Beni-Suef University | 213 | 2023-01-01 | 2023-09-21 |
| Honey Dressing - A Preventive Procedure for Post-Surgical Site Infection. Honey Dressing, Iodine Dressing - Wound Infection, Wound Dehiscence | Phase 2 / Phase 3 | Completed | HITEC-Institute of Medical Sciences | 80 | 2022-12-02 | 2024-01-25 |
| Tranexamic Acid to Reduce Delirium After Gastrointestinal Surgery: the TRIGS-D Trial Tranexamic Acid 100Mg/ml Inj Vial 10ml, Placebo - Surgical Site Infection, Dementia | Phase 3 | Active not recruiting | Bayside Health | 826 | 2022-11-01 | 2025-12-31 |
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Surgical Wound Infection (87) · Infections (14) · Cellulitis (10) · Abscess (9) · Bacterial Infections (5) · Postoperative Complications (5) · Staphylococcal Infections (4) · Sepsis (3) · Surgical Wound (3) · Abdominal Abscess (2) · Acute Kidney Injury (2) · Breast Neoplasms (2) · Communicable Diseases (2) · Cross Infection (2)
Pathological Conditions, Signs and Symptoms (99) · Pathologic Processes (98) · Infections (93) · Postoperative Complications (84) · Inflammation (15) · Skin and Connective Tissue Diseases (14) · Suppuration (13) · Connective Tissue Diseases (10) · Skin Diseases, Infectious (10) · Wounds and Injuries (8) · Bacterial Infections and Mycoses (7) · Cardiovascular Diseases (7) · Neoplasms (6) · Neoplasms by Site (6)
Vancomycin (12) · Povidone-Iodine (9) · Saline Solution (9) · Cefazolin (5) · Sodium Chloride (5) · chlorhexidine gluconate (5) · Anti-Bacterial Agents (4) · Aztreonam (4) · Ceftaroline (4) · Chlorhexidine (4) · Metronidazole (4) · Standard of Care (4) · Amoxicillin-Potassium Clavulanate Combination (3) · Ethanol (3) · Linezolid (3)
Hospital General Universitario Elche (6) · Assiut University (3) · Durata Therapeutics Inc., an affiliate of Allergan plc (3) · Pfizer (3) · PolyPid Ltd. (3) · University of Birmingham (3) · Assistance Publique - Hôpitaux de Paris (2) · Balgrist University Hospital (2) · Columbia University (2) · Dow University of Health Sciences (2) · Forest Laboratories (2) · Major Extremity Trauma Research Consortium (2) · Melinta Therapeutics, Inc. (2) · University Hospital, Clermont-Ferrand (2) · University of Washington (2)
United States (37) · Spain (11) · Romania (9) · Brazil (8) · Germany (8) · Israel (8) · Poland (8) · France (7) · Italy (7) · Russia (7) · Ukraine (7) · Bulgaria (6) · Hungary (6) · South Africa (6) · Croatia (5)
David Melnick, MSD (2) · G. Ralph Corey, MD (2) · Jaime Ruiz-Tovar, MD, PhD (2) · Michael Dunne, MD (2) · Abida K. Sattar, MD, FACS (1) · Ammarin Thakkinstian, PhD (1) · Andres Garcia-Marin (1) · Angelo Nespoli, MD (1) · Antonio Arroyo, MD, PhD (1) · Arun Aneja, MD, PhD (1) · Avery B Nathens, MD PhD MPH (1) · Bart-Jan Kullberg, prof. Dr (1)
PMID 30597021, PMID 30716446, PMID 34741280, PMID 34905144, PMID 34922058, PMID 20695801, PMID 21115456, PMID 24897082, PMID 27370913, PMID 27585969, PMID 29358292, PMID 32335895, PMID 36748942, PMID 16980879, PMID 17076839, PMID 17119142, PMID 17638804, PMID 18461895, PMID 20054046, PMID 20825316, PMID 21115454, PMID 21115455, PMID 21444695, PMID 21896561, PMID 22265220, PMID 22581209, PMID 22621779, PMID 23052809, PMID 23180507, PMID 23623487, PMID 23887247, PMID 24080082, PMID 24866067, PMID 24897083, PMID 24907853, PMID 25005651, PMID 25151205, PMID 25294250, PMID 25631195, PMID 25737375, PMID 25900659, PMID 25946647, PMID 26229155, PMID 26611777, PMID 27879993, PMID 29349539, PMID 29654027, PMID 29946346, PMID 30380060, PMID 30554184
2014 (1), 2015 (1), 2018 (1), 2025 (1), P50HL073996 (1), T32AI078875 (1)