13 completed, 5 terminated, 4 recruiting, 1 unknown. 23 Phase 2, 2 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 23 | Completed 13, Terminated 5, Recruiting 4, Unknown 1 |
| Phase 1 | 2 | Completed 1, Terminated 1 |
| Phase 3 | 2 | Completed 1, Recruiting 1 |
Follow Weight Gain: new trials by email Literature Review of Weight Gain trials Research Report on Weight Gain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Early Metabolic Effects of Antiretroviral Drugs in Healthy volUnteers: a Phase 2 Randomized Study Dolutegravir (DTG) AND Tenofovir alafenamide (TAF), Tenofovir Disoproxil Fumarate, Dolutegravir - Healthy Volunteer, Weight Gain | Phase 2 | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 120 | 2026-09-24 | 2026-09-29 |
| No Guts No Glory Probiotics Probiotic Formula, Placebo - Patients Using Olanzapine, Quetiapine, Risperidone or Clozapine | Phase 2 / Phase 3 | Recruiting | University Medical Center Groningen | 112 | 2026-06-01 | 2026-05-26 |
| Incretin Microdosing for Cardiometabolic Health in People With HIV Dose escalation to 2 mg semaglutide weekly then semaglutide microdosing at 0.5 mg weekly, Dose escalation to 2 mg semaglutide weekly then no semaglutide - Weight Gain | Phase 2 | Recruiting | The University of Texas Health Science Center, Houston | 30 | 2026-02-12 | 2026-02-18 |
| Metreleptin in Anorexia Nervosa Metreleptin, Sodium chloride - Anorexia Nervosa | Phase 2 | Recruiting | Gabriella Milos | 50 | 2024-05-31 | 2026-07-29 |
| Empagliflozin vs Metformin on Metabolic Dysfunction in Polycystic Ovary Syndrome With or Without Comorbidity or Multimorbidity Empagliflozin 10 MG, MetFORMIN 500 Mg Oral Tablet - Polycystic Ovary Syndrome, Weight Gain | Phase 2 / Phase 3 | Completed | SINA Health Education and Welfare Trust | 70 | 2023-12-15 | 2025-05-14 |
| Exenatide for Smoking Cessation and Prevention of Weight Gain Exenatide 2 milligram (mg) Injection, Placebo, Nicotine patch - Smoking Cessation, Weight Gain | Phase 2 | Completed | The University of Texas Health Science Center, Houston | 140 | 2022-12-07 | 2026-03-23 |
| Study to Evaluate ARD-101 in Adults Receiving Bariatric Surgery ARD-101 - Bariatric Surgery, Obesity | Phase 2 | Completed | Aardvark Therapeutics, Inc. | 12 | 2022-03-01 | 2025-02-11 |
| A Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Miricorilant in Obese Adult Patients With Schizophrenia While Taking Antipsychotic Medications (GRATITUDE II) Miricorlilant, Placebo - Antipsychotic-induced Weight Gain (AIWG) | Phase 2 | Completed | Corcept Therapeutics | 150 | 2020-09-09 | 2024-06-13 |
| A Study to Assess the Safety, Efficacy, and Pharmacokinetics of Miricorilant (CORT118335) in Obese Adults With Schizophrenia or Bipolar Disorder Treated With Antipsychotic Medications Miricorilant, Placebo - Antipsychotic-induced Weight Gain (AIWG) | Phase 2 | Completed | Corcept Therapeutics | 71 | 2019-12-04 | 2024-09-19 |
| Oxytocin and Eating Syntocinon, Placebos - Weight Gain | Phase 2 | Unknown | Yale-NUS College | 60 | 2017-09-01 | 2017-07-21 |
| Prevention of Metabolic Syndrome and Increased Weight Using Metformin Concurrent to Androgen Deprivation Therapy and Radiotherapy for Locally Advanced Adenocarcinoma of the Prostate Metformin, Placebo - Prostatic Neoplasm | Phase 2 | Terminated | AHS Cancer Control Alberta | 83 | 2014-09-01 | 2024-01-30 |
| Lorcaserin for Preventing Weight Gain Among Smokers Varenicline, Lorcaserin - Tobacco Use Disorder, Weight Gain | Phase 1 / Phase 2 | Completed | Mayo Clinic | 20 | 2013-09-01 | 2017-06-06 |
| Melatonin for Prevention of Metabolic Side Effects of Olanzapine Melatonin, Placebo - Schizophrenia | Phase 2 | Completed | Guilan University of Medical Sciences | 36 | 2012-05-01 | 2013-04-09 |
| Comparison of a Drug and Placebo in the Prevention of Migraine Headaches ethosuximide, placebo comparator - Headache, Migraine | Phase 1 / Phase 2 | Terminated | US Department of Veterans Affairs | 5 | 2011-12-01 | 2015-08-19 |
| RCT of High- vs. Standard-Calorie Formula for Methadone-Exposed Infants High Calorie Infant formula, Standard Calorie Infant Formula - Neonatal Abstinence Syndrome | Phase 2 | Completed | University of Pittsburgh | 85 | 2010-04-01 | 2014-06-30 |
| Getting Physical on Cigarettes - Smoking Cessation & Relapse Prevention Exercise Behaviour Maintenance, Smoking Relapse prevention booklets, Contact control - Cancer | Phase 2 | Completed | University of Western Ontario, Canada | 413 | 2009-10-01 | 2014-12-16 |
| Predicting Weight Gain and Weight Loss Associated With Overeating or Fasting Weight Loss, Overfeeding, Overfeeding Low Pro - Obesity, Diet Therapy | Phase 2 | Completed | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 83 | 2008-09-18 | 2026-10-26 |
| Chromium Piccolinate in the Prevention of Weight Gain Induced by Serotonergic Medications Initiated on Psychiatric Inpatient Units. chromium piccolinate, placebo for chromium piccolinate - Weight Gain, Obesity | Phase 2 | Terminated | State University of New York - Upstate Medical University | 60 | 2008-09-01 | 2012-09-07 |
| Preventing Excessive Weight Gain in Adolescent Girls at High-Risk for Adult Obesity Interpersonal Psychotherapy, Health Education - Obesity, Overweight | Phase 2 | Completed | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 166 | 2008-05-15 | 2019-10-01 |
| Study to Examine the Effect of Betahistine on Body Weight Gain Due to Olanzapine Treatment Betahistine - Weight Gain | Phase 2 | Terminated | OBEcure Ltd. | 36 | 2007-03-01 | 2015-10-15 |
Showing 20 of 23. Sign in to see all of them.
Obesity (10) · Schizophrenia (5) · Depression (2) · Mental Disorders (2) · Metabolic Syndrome (2) · Psychotic Disorders (2) · Smoking Cessation (2) · Anorexia Nervosa (1) · Bipolar Disorder (1) · Bulimia (1) · Cigarette Smoking (1) · Diabetes Mellitus (1) · Hyperglycemia (1) · Hyperlipidemias (1)
Body Weight (23) · Body Weight Changes (23) · Pathological Conditions, Signs and Symptoms (23) · Signs and Symptoms (23) · Nutritional and Metabolic Diseases (13) · Nutrition Disorders (10) · Overnutrition (10) · Overweight (9) · Mental Disorders (6) · Behavior (5) · Schizophrenia Spectrum and Other Psychotic Disorders (5) · Glucose Metabolism Disorders (3) · Metabolic Diseases (3) · Behavioral Symptoms (2) · Chemically-Induced Disorders (2)
Metformin (4) · CORT118335 (2) · Betahistine (1) · Diet (1) · Ethosuximide (1) · Exenatide (1) · Exercise (1) · Injections (1) · Interpersonal Psychotherapy (1) · Melatonin (1) · Oxytocin (1) · Secondary Prevention (1) · Sodium Chloride (1) · Tablets (1) · Tenofovir (1)
Corcept Therapeutics (2) · The University of Texas Health Science Center, Houston (2) · University of North Carolina, Chapel Hill (2) · AHS Cancer Control Alberta (1) · Aardvark Therapeutics, Inc. (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Gabriella Milos (1) · Guilan University of Medical Sciences (1) · Mayo Clinic (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (1) · OBEcure Ltd. (1) · SINA Health Education and Welfare Trust (1) · State University of New York - Upstate Medical University (1) · US Department of Veterans Affairs (1)
United States (13) · Canada (3) · Iran (1) · Israel (1) · Netherlands (1) · Pakistan (1) · Singapore (1) · Switzerland (1)
Kavita Juneja, MD (2) · Linmarie Sikich, MD (2) · Brian P Epling, M.D. (1) · Debra L Bogen, MD (1) · Evert G Schouten, PhD (1) · Harry Prapavessis, Ph.D. (1) · Hina Sharif, PharmD,MSPH (1) · Iris E.C. Sommer, Prof. Dr. (1) · Jack A Yanovski, M.D. (1) · James Megna, MD (1) · Jordan Lake, MD, MSc (1) · Kathy L Gardner, MD (1) · Luba Yammine, PhD (1) · Mohammad Jafar Modabbernia, MD (1) · Nawaid Usmani, MD (1)
PMID 20205704, PMID 24607293, PMID 25240070, PMID 25964395, PMID 26210388, PMID 27808536, PMID 27852796, PMID 29607525, PMID 29777235, PMID 29902683, PMID 30651576, PMID 31012296, PMID 31172178, PMID 32002540, PMID 32118268, PMID 33029899, PMID 34611902, PMID 37316311, PMID 38172345, PMID 38663460, PMID 41257673
R01DK142171 (1), R21DA029257 (1)