13 completed, 3 terminated, 3 unknown, 2 not yet recruiting. 10 Phase 2, 5 Phase 1, 4 Not applicable, 3 Phase 4, 1 Phase 3.
Follow Betahistine: new trials by email Literature Review of Betahistine trials Research Report on Betahistine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| DMSO Dual-Route Therapy for Refractory Tinnitus in Long-COVID and Post-COVID-19 Vaccine Injury DMSO-based otic solution with betahistine, dexamethasone, and lidocaine, DMSO-based transdermal cream with levocarnitine and N-acetylcysteine - Tinnitus | Phase 2 | Enrolling by invitation | Leading Edge Clinic | 20 | 2026-05-15 | 2026-05-13 |
| Efficacy and Safety of Rimegepant for Acute Dizziness Rimegepant 75mg Orally Disintegrating Tablets (ODT), Betahistine Mesylate tablet - Dizziness | Phase 2 / Phase 3 | Not yet recruiting | Shi Tianming | 370 | 2026-03-20 | 2026-02-27 |
| The Effects of Conventional Therapy on Tinnitus, Disability, and Quality of Life in Patients With Tinnitus Neural Therapy of Huneke, Betahistine 24 mg bid (Betaserc) - Tinnitus, Neural Therapy of Huneke | Not applicable | Not yet recruiting | Sisli Hamidiye Etfal Training and Research Hospital | 30 | 2026-03-01 | 2026-03-23 |
| Comparing Oral Lumbrokinase DLBS1033 and Betahistine Mesylate in Benign Paroxysmal Positional Vertigo DLBS1033, Betahistine Mesylate tablet - Benign Paroxysmal Positional Vertigo (Disorder) | Phase 4 | Completed | Universitas Sebelas Maret | 44 | 2024-04-01 | 2025-07-20 |
| Modulating Auditory Symptoms and Vertigo of Meniere's Disease by Non-invasive Mastoid Electric Stimulation YPS-201b, betahistine - Meniere's Disease | Phase 1 / Phase 2 | Unknown | Seoul National University Hospital | 120 | 2023-09-18 | 2024-12-05 |
| Pharmacokinetic Profile of Betahistine With and Without Selegiline in Healthy Volunteers Betahistine dihydrochloride, Selegiline-hydrochloride - Ménière's Disease | Phase 1 | Completed | Ludwig-Maximilians - University of Munich | 15 | 2021-06-02 | 2023-07-12 |
| Laser Acupuncture for Meniere Disease Multiwave Locked System (MLS) laser (Mphi laser, ASA Srl, Vicenza, Italy), Betahistine Mesylate tablet - Meniere Disease | Phase 2 | Unknown | Beijing Tongren Hospital | 324 | 2021-05-01 | 2024-08-09 |
| Paroxysmal Positional Vertigo & Repositioning Maneuvers Modified eply & Semont maneuver, betahistine & Modified eply & Semont maneuver - Benign Paroxysmal Positional Vertigo | Not applicable | Completed | Neuro Counsel Hospital, Pakistan | 90 | 2021-01-02 | 2022-04-04 |
| Transcutaneous Auricular Vagus Nerve Stimulation for Meniere Disease Transcutaneous Auricular Vagus Nerve Stimulation with Betahistine - Meniere Disease | Not applicable | Completed | Beijing Tongren Hospital | 92 | 2020-10-01 | 2022-10-31 |
| Transcutaneous Auricular Vagus Nerve Stimulation for Meniere Disease taVNS, Betahistine Mesylate tablet - Meniere Disease | Completed | Beijing Tongren Hospital | 77 | 2019-01-01 | 2024-08-09 | |
| Interventions for Residual Dizziness After Successful Repositioning Maneuvers in Patients With BPPV Betahistine, Exercise-based vestibular rehabilitation - Vestibular Disorder | Not applicable | Unknown | Eye & ENT Hospital of Fudan University | 183 | 2018-09-01 | 2018-08-14 |
| The CBF Study Evaluating the Effect of Betahistine on the Cerebral Blood Flow betahistine dihydrochloride, placebo - Gait or Balance Disorder Problems | Phase 4 | Completed | Abbott Products | 27 | 2012-02-01 | 2017-10-26 |
| Evaluation of Safety, Drug-Drug Interactions and Pharmacokinetic Profiles of Co-Administration of Betahistine With Olanzapine in Healthy Female Subjects Betahistine - Healthy | Phase 1 | Completed | OBEcure Ltd. | 50 | 2009-02-01 | 2009-05-05 |
| Effects of Using Betahistine to Treat Adults With Attention Deficit Hyperactivity Disorder Betahistine Hydrochloride, Placebo Capsule - Attention Deficit Disorder With Hyperactivity | Phase 1 | Completed | P2D, Inc. | 16 | 2009-01-01 | 2013-09-26 |
| Efficacy Study of Betahistine on Body Weight in Obese Female Subjects betahistine dihydrochloride, placebo - Obesity | Phase 2 | Completed | OBEcure Ltd. | 187 | 2008-09-01 | 2009-05-07 |
| Efficacy and Tolerability Study of Betahistine to Ameliorate Antipsychotic Associated Weight Gain Betahistine, Placebo Oral Tablet - Schizophrenia, Schizoaffective Disorder | Phase 2 | Completed | Nathan Kline Institute for Psychiatric Research | 48 | 2008-07-01 | 2019-01-25 |
| Pilot Study of Betahistine Dihydrochloride in the Treatment of Major Depression With Atypical Features betahistine dihydrochloride - Recurrent Major Depressive Disorder With Atypical Features | Phase 2 | Terminated | University of Cincinnati | 1 | 2007-07-01 | 2017-07-25 |
| A Randomized, Double-Blind, Placebo-Controlled Study to Examine the Effect of Betahistine on Plasma Lipids in Patients Treated With Simvastatin Betahistine - Hypercholesterolemia | Phase 2 | Terminated | OBEcure Ltd. | 30 | 2007-05-01 | 2007-09-26 |
| Effects of Betahistine Hydrochloride in Overweight Women Betahistine Hydrochloride - Obesity, Overweight | Phase 1 | Completed | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 150 | 2007-04-10 | 2019-12-16 |
| Study to Examine the Effect of Betahistine on Body Weight Gain Due to Olanzapine Treatment Betahistine - Weight Gain | Phase 2 | Terminated | OBEcure Ltd. | 36 | 2007-03-01 | 2015-10-15 |
Showing 20 of 22. Sign in to see all of them.
Meniere Disease (6) · Obesity (4) · Benign Paroxysmal Positional Vertigo (2) · Dizziness (2) · Schizophrenia (2) · Tinnitus (2) · Weight Gain (2) · Attention Deficit Disorder with Hyperactivity (1) · Autism Spectrum Disorder (1) · Depression (1) · Hypercholesterolemia (1) · Inflammation (1) · Overnutrition (1) · Overweight (1) · Post-Acute COVID-19 Syndrome (1)
OBEcure Ltd. (5) · Beijing Tongren Hospital (3) · Abbott Products (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Eye & ENT Hospital of Fudan University (1) · Leading Edge Clinic (1) · Ludwig-Maximilians - University of Munich (1) · Nathan Kline Institute for Psychiatric Research (1) · Neuro Counsel Hospital, Pakistan (1) · P2D, Inc. (1) · Seoul National University Hospital (1) · Shi Tianming (1) · Sisli Hamidiye Etfal Training and Research Hospital (1) · Solvay Pharmaceuticals (1) · Universitas Sebelas Maret (1)
United States (6) · China (4) · Germany (2) · Israel (2) · Belgium (1) · Canada (1) · France (1) · Indonesia (1) · Netherlands (1) · Pakistan (1) · Romania (1) · Singapore (1) · South Korea (1)
Nir Barak, MD (2) · Ami Eyal, MD (1) · Andrew Ahmann, MD (1) · Charles H. Pierce, MD, PhD (1) · Dean Kereiakes, MD (1) · Diane Krieger, MD (1) · Diane Smith, MD (1) · Dmitri Kazei, MD (1) · Erik Nelson, MD (1) · Frank Greenway, MD (1) · Harold Bays, MD (1) · Jack A Yanovski, M.D. (1) · James Zavoral, MD (1) · Jeffrey Geohas, MD (1)
PMID 20881066, PMID 30542300, PMID 31217316, PMID 34519823, PMID 37838094, PMID 37920833, PMID 41905546
2008 (1), R43MH082461 (1)