10 completed, 4 terminated, 4 unknown, 2 recruiting. 22 Phase 3, 6 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 22 | Completed 10, Terminated 4, Unknown 4, Recruiting 2, Not yet recruiting 1, Withdrawn 1 |
| Phase 2 | 6 | Completed 2, Unknown 2, Not yet recruiting 1, Terminated 1 |
Follow Ventilator Associated Pneumonia: new trials by email Literature Review of Ventilator Associated Pneumonia trials Research Report on Ventilator Associated Pneumonia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nebulised Colistimethate Sodium to Prevent Pediatric Ventilator-associated Pneumonia colistimethate sodium, 0.9% Saline - Ventilator Associated Pneumonia | Phase 2 / Phase 3 | Not yet recruiting | University Hospital Fattouma Bourguiba | 400 | 2027-01-01 | 2026-10-08 |
| Acyclovir in Ventilated Patients With Pneumonia and HSV-1 in BAL Acyclovir - Pneumonia, Viral, Ventilator Associated Pneumonia | Phase 3 | Recruiting | Jena University Hospital | 616 | 2024-02-20 | 2026-07-23 |
| Efficacy of Cotrimoxazole as a De-escalation Treatment of Ventilator-Associated Pneumonia in Intensive Care Unit cotrimoxazole, standard antibiotic therapy - Ventilator Associated Pneumonia | Phase 3 | Recruiting | Assistance Publique - Hôpitaux de Paris | 628 | 2023-10-19 | 2025-05-20 |
| Oro-nasal Decontamination to Prevent Ventilator-associated Pneumonia Povidone-Iodine, Saline spray - Ventilator Associated Pneumonia | Phase 2 / Phase 3 | Completed | Menoufia University | 78 | 2023-06-24 | 2023-11-27 |
| A Human Monoclonal Antibody Against Staphylococcus Aureus Alpha Toxin in Mechanically Ventilated Adult Subjects - 2 Suvratoxumab, Placebo - Ventilator Associated Pneumonia, Staphylococcus Aureus | Phase 3 | Terminated | Aridis Pharmaceuticals, Inc. | 24 | 2022-09-02 | 2025-03-24 |
| Daily Chlorexidine Bath for Health Care Associated Infection Prevention 2% chlorhexidine digluconate solution with surface-active agents, Usual Baths - Health Care Associated Infection, Ventilator Associated Pneumonia | Phase 3 | Completed | Hospital do Coracao | 15730 | 2022-08-03 | 2024-06-13 |
| Nebulized Aztreonam for Prevention of Gram Negative Ventilator-associated Pneumonia Aztreonam lysine, Aerogen Solo, CombiHaler - Ventilator Associated Pneumonia, Prevention | Phase 2 / Phase 3 | Terminated | Hospital Universitari Joan XXIII de Tarragona. | 9 | 2019-03-19 | 2021-07-01 |
| Different Oral Colonization of Gram-negative Bacteria in ICU Patients When Using Chlorhexidine at 0.12% Versus Chlorhexidine at 2.0% Chlorhexidine gluconate at 2%, Chlorhexidine gluconate at 0.12% - Chlorhexidine, Ventilator Associated Pneumonia | Phase 3 | Unknown | Universidad de Guanajuato | 74 | 2019-02-01 | 2019-03-11 |
| A Study to Determine the Efficacy, Safety and Tolerability of Aztreonam-Avibactam (ATM-AVI) ± Metronidazole (MTZ) Versus Meropenem (MER) ± Colistin (COL) for the Treatment of Serious Infections Due to Gram Negative Bacteria. ATM-AVI, MTZ, MER - Complicated Intra-abdominal Infection, Hosptial Acquired Pneumonia | Phase 3 | Completed | Pfizer | 422 | 2018-04-05 | 2024-12-10 |
| Defining Antibiotic Treatment Duration for Ventilator - Associated Lung Infection Reducing Antibiotics treatment duration, Standard Antibiotics treatment duration - Ventilator Associated Pneumonia, Pneumonia, Bacterial | Phase 3 | Completed | University of Oxford | 460 | 2018-02-21 | 2024-01-18 |
| Selective Decontamination of the Digestive Tract in Intensive Care Unit Patients SDD Oral Paste, SDD Gastric Suspension, Intravenous Antibiotic - Critical Illness, Sepsis | Phase 3 | Completed | The George Institute | 20010 | 2017-05-01 | 2023-08-14 |
| The Effect of Colistin Inhalation on Ventilator Associated Pneumonia Colistin, Carbapenem + Aminoglycoside/ Quinolone - Ventilator Associated Pneumonia | Phase 2 / Phase 3 | Completed | Nourhan Hassan Osama Thuraya Mohamed | 40 | 2016-01-02 | 2018-08-09 |
| Air-impingement Manipulation to Clear Subglottic Secretion to Prevent VAP in Prolonged Intubated Patients Manual air-impingement operation, subglottic secretion drainage - Ventilator Associated Pneumonia | Phase 3 | Unknown | Beijing Chao Yang Hospital | 220 | 2016-01-01 | 2015-12-16 |
| Simplified Selective Digestive Tract Decontamination for the Prevention of Intensive Care Unit Acquired Infections Neomycin Colistin Nystatin Vancomycin - Bacteremia Associated With Intravascular Line, Ventilator Associated Pneumonia | Phase 2 / Phase 3 | Unknown | Rambam Health Care Campus | 2400 | 2013-06-01 | 2013-02-26 |
| The Gravity-VAP (Ventilator-Associated Pneumonia) Trial lateral-Trendelenburg position - Ventilator Associated Pneumonia | Phase 3 | Terminated | Policlinico Hospital | 800 | 2010-11-01 | 2017-06-16 |
| Pharmacokinetics of Nebulized Amikacin in Patients With Pneumonia Undergoing Mechanical Ventilation Nebulized amikacin, Intravenous amikacin, Placebo nebulization - Ventilator Associated Pneumonia | Phase 2 / Phase 3 | Unknown | Association Pour La Promotion A Tours De La Reanimation Medicale | 24 | 2009-01-01 | 2009-03-16 |
| Study of Povidone Iodine to Reduce Pulmonary Infection in Head Trauma and Cerebral Hemorrhage in Intensive Care Unit povidone iodine, Placebo - Ventilator Associated Pneumonia | Phase 3 | Terminated | Rennes University Hospital | 179 | 2008-04-01 | 2012-07-06 |
| Role of Oral Chlorhexidine Gel in Prevention of Ventilator Associated Pneumonia Chlorhexidine gel, Placebo gel - Ventilator Associated Pneumonia | Phase 3 | Completed | All India Institute of Medical Sciences | 86 | 2007-11-01 | 2011-03-23 |
| Bronchoscopy vs. Clinical Pulmonary Infection Score Guided Approach in Suspected Ventilator-Associated Pneumonia (VAP) Bronchoscopy, Clinical pulmonary infection score (CPIS) - Ventilator Associated Pneumonia | Phase 3 | Withdrawn | Mayo Clinic | 2007-01-01 | 2023-09-26 | |
| Oral Hygiene With Chlorhexidine and Incidence of Ventilator-Associated Pneumonia in Children Submitted to Heart Surgery oral hygiene, placebo - Ventilator Associated Pneumonia, Nosocomial Pneumonia | Phase 3 | Completed | University of Sao Paulo | 160 | 2006-02-01 | 2009-01-27 |
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Pneumonia, Ventilator-Associated (22) · Pneumonia (5) · Healthcare-Associated Pneumonia (2) · Bacteremia (1) · Community-Acquired Pneumonia (1) · Critical Illness (1) · Cross Infection (1) · Herpes Simplex (1) · Pneumonia, Bacterial (1) · Pneumonia, Viral (1) · Sepsis (1) · Shock, Septic (1) · Staphylococcal Infections (1)
Disease Attributes (22) · Iatrogenic Disease (22) · Infections (22) · Lung Diseases (22) · Pathologic Processes (22) · Pathological Conditions, Signs and Symptoms (22) · Respiratory Tract Diseases (22) · Respiratory Tract Infections (22) · Cross Infection (21) · Healthcare-Associated Pneumonia (20) · Pneumonia (17) · Bacterial Infections (3) · Bacterial Infections and Mycoses (3) · Inflammation (2) · Systemic Inflammatory Response Syndrome (2)
Colistin (4) · Bronchoscopy (2) · Povidone-Iodine (2) · Saline Solution (2) · Acyclovir (1) · Aminoglycosides (1) · Carbapenems (1) · Cefotaxime (1) · Ceftriaxone (1) · Ciprofloxacin (1) · Glycyrrhizic Acid (1) · Neomycin (1) · Nystatin (1) · Oral Hygiene (1) · Quinolones (1)
All India Institute of Medical Sciences (1) · Aridis Pharmaceuticals, Inc. (1) · Assistance Publique - Hôpitaux de Paris (1) · Association Pour La Promotion A Tours De La Reanimation Medicale (1) · Beijing Chao Yang Hospital (1) · Creighton University (1) · Hospital Universitari Joan XXIII de Tarragona. (1) · Hospital do Coracao (1) · Jena University Hospital (1) · Mayo Clinic (1) · Menoufia University (1) · Nourhan Hassan Osama Thuraya Mohamed (1) · Pfizer (1) · Policlinico Hospital (1) · Rambam Health Care Campus (1)
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