206 completed, 24 unknown, 18 terminated, 10 recruiting. 64 Phase 2, 52 Phase 3, 50 Phase 1, 41 Not applicable, 26 Phase 4.
Follow Herpes Simplex: new trials by email Literature Review of Herpes Simplex trials Research Report on Herpes Simplex
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Prevention of Recurrence of Herpes Simplex in Autoimmune Rheumatic Diseases Acyclovir (ACV), Placebo - Autoimmune Rheumatic Diseases, Recurrent Herpes Simplex | Phase 4 | Recruiting | University of Sao Paulo General Hospital | 62 | 2026-06-25 | 2026-08-05 |
| A Phase I Clinical Trial of Recombinant Herpes Zoster Vaccine (CHO Cell) Recombinant Herpes Zoster Vaccine, adjuvant placebo, Placebo - Herpes | Phase 1 | Enrolling by invitation | Changchun BCHT Biotechnology Co. | 120 | 2026-05-28 | 2026-06-08 |
| Evaluating Benzoyl Peroxide for Preventing Recurrence of HSV-1 Outbreaks With Rescue Crossover Option Benzoyl Peroxide 10% Bar, Placebo - HSV | Phase 2 | Not yet recruiting | Greg Bew | 100 | 2026-01-01 | 2025-08-05 |
| A Phase I Study to Evaluate the Safety, Tolerability, and Immunogenicity of an mRNA Vaccine Against Herpes Simplex Virus Type 2 (HSV-2) Post-Vaccination Low-Dose Cohort, Mid-Dose Cohort, High-Dose Cohort - Genital Herpes | Phase 1 | Enrolling by invitation | Changchun BCHT Biotechnology Co. | 144 | 2025-10-13 | 2026-01-09 |
| Clinical Study of Intrastromal Anti-VEGF Injection for Corneal Neovascularization. Intrastromal anti-VEGF injection and topical antiviral eye drops, Conventional antiviral topical ocular drops. - Herpes Simplex Keratitis, Corneal Neovascularization | Phase 1 / Phase 2 | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 100 | 2025-10-01 | 2026-01-09 |
| HSV G207 With a Single Radiation Dose in Children With Recurrent High-Grade Glioma Biological G207 - Neoplasms, High Grade Glioma | Phase 2 | Withdrawn | Pediatric Brain Tumor Consortium | 2025-09-01 | 2026-02-10 | |
| Esketamine Combined Pulsed Radiofrequency for Acute/Subacute Zoster-associated Trigeminal Neuralgia Esketamine group, PRF group - Zoster; Herpes, Trigeminal Neuralgia (Etiology) | Not applicable | Recruiting | Beijing Tiantan Hospital | 174 | 2025-04-01 | 2025-04-27 |
| A Study to Assess the Safety, Pharmacokinetics, and Tolerability of ABI-1179 in Healthy Subjects and in Subjects Seropositive for HSV-2 With Recurrent Genital Herpes ABI-1179, ABI-1179 Placebo - Recurrent Genital Herpes Simplex Type 2 | Phase 1 | Completed | Assembly Biosciences | 103 | 2024-12-08 | 2026-03-23 |
| Propolis in Primary Herpetic Gingivostomatitis 5% propolis gel, Placebo gel - Herpetic Gingivostomatitis | Not applicable | Completed | Fayoum University | 60 | 2024-10-10 | 2025-01-30 |
| Topical Ganciclovir Versus Systemic Aciclovir in the Treatment of Herpetic Keratitis Acyclovir 400 MG, Ganciclovir (GCV) - Herpetic Keratitis | Not applicable | Completed | Al-Azhar University | 20 | 2024-10-01 | 2025-01-03 |
| Quantification & Classification of Inflammatory Cells in Uveitis Using OCT Anterior Uveitis (AU), Birdshot Chorioretinitis | Recruiting | Oregon Health and Science University | 125 | 2024-09-01 | 2025-07-17 | |
| Efficacy and Safety of Acyclovir-penciclovir Cream Versus an Abreva in the Suppression of Herpes Simplex Virus Eruptions acyclovir-penciclovir cream, Abreva - Herpes Simplex Oral | Phase 2 | Completed | University of Utah | 40 | 2024-08-19 | 2026-01-05 |
| Using Artificial Intelligence to Help Doctors Identify Different Skin Conditions and Improve Patient Care AI-based medical device for aided diagnosis in Dermatology - Dermatitis, Melanoma (Skin Cancer) | Completed | AI Labs Group S.L | 16 | 2024-06-01 | 2026-02-24 | |
| A Study to Assess the Safety, Pharmacokinetics, and Antiviral Activity of ABI-5366 in Healthy Participants and Participants Seropositive for HSV-2 With Recurrent Genital Herpes ABI-5366, ABI-5366 Placebo - Recurrent Genital Herpes Simplex Type 2 | Phase 1 | Completed | Assembly Biosciences | 115 | 2024-05-30 | 2026-03-30 |
| Acyclovir in Ventilated Patients With Pneumonia and HSV-1 in BAL Acyclovir - Pneumonia, Viral, Ventilator Associated Pneumonia | Phase 3 | Recruiting | Jena University Hospital | 616 | 2024-02-20 | 2026-07-23 |
| A Study of mRNA-1647 Cytomegalovirus Vaccine in Liver Transplant Candidates and Recipients mRNA-1647, Placebo - Cytomegalovirus Infection | Phase 2 | Withdrawn | ModernaTX, Inc. | 2024-02-08 | 2024-03-15 | |
| Evaluating Safety and Efficacy of Repeat Doses of UB-621in Adult Patients With Recurrent Genital Herpes Placebo, UB-621 low-dose, UB-621 high-dose - Recurrent Genital Herpes | Phase 2 | Not yet recruiting | UBP Greater China (Shanghai) Co., Ltd | 200 | 2023-12-01 | 2022-10-03 |
| UB-621, a New Type of Anti-herpes Simplex Virus (HSV) Monoclonal Antibody for the Use in the Treatment of Adult Recurrent HSV-2 Infections of the Genitals UB-621 - Recurrent Genital Herpes | Phase 2 | Unknown | UBP Greater China (Shanghai) Co., Ltd | 44 | 2023-10-01 | 2022-05-18 |
| Trial Evaluating the Immunogenicity and Safety of an Adjuvanted Epstein-Barr Virus (EBV) Glycoprotein 350 Vaccine in EBV-seronegative Persons Matrix-M1 Adjuvant, EBV gp350-Ferritin Vaccine, Placebo Comparator - Epstein-Barr Virus Infection, Infectious Mononucleosis | Phase 1 / Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 25 | 2023-09-22 | 2026-04-22 |
| A Study of mRNA-1608, a Herpes Simplex Virus -2 (HSV-2) Therapeutic Candidate Vaccine, in Healthy Adults 18 to 55 Years of Age With Recurrent HSV-2 Genital Herpes mRNA-1608, BEXSERO - Genital Herpes | Phase 1 / Phase 2 | Completed | ModernaTX, Inc. | 303 | 2023-09-06 | 2026-05-08 |
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Herpes Genitalis (69) · Herpes Labialis (52) · HIV Infections (37) · Acquired Immunodeficiency Syndrome (15) · Virus Diseases (14) · Keratitis, Herpetic (13) · Herpes Zoster (11) · Herpesviridae Infections (10) · Kaposi Varicelliform Eruption (8) · Sexually Transmitted Diseases (8) · Stomatitis, Herpetic (8) · AIDS-Related Opportunistic Infections (7) · Dermatitis, Atopic (7) · Infections (5)
DNA Virus Infections (271) · Infections (268) · Herpesviridae Infections (263) · Virus Diseases (259) · Skin and Connective Tissue Diseases (207) · Skin Diseases, Viral (206) · Skin Diseases (205) · Skin Diseases, Infectious (205) · Urogenital Diseases (100) · Genital Diseases (96) · Communicable Diseases (94) · Sexually Transmitted Diseases, Viral (92) · Sexually Transmitted Diseases (86) · Female Urogenital Diseases and Pregnancy Complications (76)
Acyclovir (41) · Valacyclovir (40) · Famciclovir (12) · ASP2151 (9) · Foscarnet (5) · Adjuvants, Pharmaceutic (4) · Cidofovir (4) · ME 609 (4) · pritelivir (4) · squaric acid dibutyl ester (4) · 5-((2-(6-Amino-9H-purin-9-yl) ethyl) amino)-1-pentanol (3) · Ganciclovir (3) · Saline Solution (3) · Sodium Chloride (3) · Blood Specimen Collection (2)
National Institute of Allergy and Infectious Diseases (NIAID) (29) · GlaxoSmithKline (22) · University of Washington (14) · Novartis (7) · Genocea Biosciences, Inc. (6) · Maruho Europe Limited (5) · AiCuris Anti-infective Cures AG (4) · Glaxo Wellcome (4) · Medivir (4) · NanoBio Corporation (4) · National Center for Research Resources (NCRR) (4) · Roxane Laboratories (4) · Astra USA (3) · Centers for Disease Control and Prevention (3) · French National Agency for Research on AIDS and Viral Hepatitis (3)
United States (146) · Canada (22) · United Kingdom (19) · Germany (14) · Australia (10) · China (10) · France (10) · Belgium (9) · South Africa (9) · Brazil (7) · Spain (6) · Japan (5) · Netherlands (5) · Switzerland (5) · Kenya (4)
Anna Wald, MD, MPH (8) · Connie Celum, MD, MPH (6) · Jeffrey I Cohen, M.D. (3) · Alan Copa, PharmD (2) · Christine Johnston, MD, MPH (2) · Christopher M Hull, M.D. (2) · Christopher M Hull, MD (2) · Darrell HS Tan, MD FRCPC (2) · David W Kimberlin, MD (2) · David W. Kimberlin (2) · Jessica R Durkee-Shock, M.D. (2) · Kathleen Barnes, PhD (2)
PMID 22225814, PMID 21991950, PMID 26343451, PMID 35142535, PMID 16044019, PMID 16231970, PMID 17314338, PMID 18008230, PMID 18082566, PMID 18419342, PMID 18532873, PMID 18572080, PMID 18593294, PMID 18596069, PMID 18621575, PMID 18667923, PMID 18846389, PMID 18928378, PMID 19074928, PMID 19086814, PMID 19143902, PMID 19169140, PMID 19192993, PMID 19220138, PMID 19220143, PMID 19273678, PMID 19321868, PMID 19382840, PMID 19389002, PMID 19404392, PMID 19530940, PMID 19571722, PMID 19616720, PMID 19715417, PMID 19838129, PMID 19936044, PMID 20011596, PMID 20042848, PMID 20070143, PMID 20089951, PMID 20153888, PMID 20160046, PMID 20214474, PMID 20370481, PMID 20443734, PMID 20466416, PMID 20702659, PMID 20851499, PMID 21099672, PMID 21104007
N01AI30025 (3), P01AI030731 (3), 2005 (1), 2014 (1), 2016 (1), K23AI071257 (1), P30CA012197 (1), R01AI050132 (1), R01AI052054 (1), R03HD057773 (1), R21EY036563 (1), U01AI047981 (1), U01AI052054 (1), U19AI031448 (1), U19AI096398 (1)