44 completed, 15 recruiting, 15 terminated, 13 not yet recruiting. 27 Phase 2, 26 Phase 3, 24 Not applicable, 10 Phase 4, 9 Phase 1.
Follow Vaso-Occlusive Crises: new trials by email Literature Review of Vaso-Occlusive Crises trials Research Report on Vaso-Occlusive Crises
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Virtual Reality for SCD VOC Sham 2D Headset Control, Passive Immersive 3D Virtual Reality, Active Immersive Interactive 3D Virtual Reality - Sickle Cell Disease | Not applicable | Recruiting | University of Maryland, Baltimore | 50 | 2026-11-01 | 2026-10-16 |
| Buprenorphine for the Management of Pain in Children With Sickle Cell Disease Buprenorphine Buccal Film [Belbuca] - Sickle Cell Disease (SCD), Sickle Cell Disease Vaso-occlusive Crisis | Phase 1 | Not yet recruiting | Natasha Archer | 25 | 2026-10-01 | 2026-09-02 |
| Adaptive Platform Trial for Pain Management in Sickle Cell Vaso-Occlusive Crisis Group 02 Paracetamol + Morphine + Ketamine, Group 01 Control: Paracetamol + Morphine, Group 03 : Paracetamol + Morphine + Nefopam - Sickle Cell Disease, Vaso-occlusive Crisis | Phase 4 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 400 | 2026-10-01 | 2026-09-18 |
| Sub-dissociative Dose Ketamine in Treatment of Vaso-occlusive Pain Event in Children and Young Adults Sub-dissociative Ketamine Infusion, Normal Saline Placebo Infusion - Sickle Cell Disease, Vaso-Occlusive Pain Episode in Sickle Cell Disease | Phase 2 | Recruiting | Mohsen Saidinejad | 120 | 2026-09-10 | 2026-09-02 |
| Evaluation of the Efficacy of Iloprost in the Management of Vaso-occlusive Crises in Adult Patients With Sickle Cell Disease Iloprost, Placebo - Vaso-Occlusive Crises, Sickle Cell Disease | Phase 3 | Not yet recruiting | University Hospital, Rouen | 144 | 2026-09-01 | 2026-03-27 |
| Hypoxic Red Blood Cells in Sickle Cell Anemia Hemanext ONE System, Conventional RBCs - Sickle Cell Anaemia, Sickle Cell Anemia Crisis | Not applicable | Not yet recruiting | Hemanext | 48 | 2026-09-01 | 2026-08-17 |
| Standard of Care Comparative Arm of Phase 1/2 Gene Therapy Trial DREPAMIR" in Severe Sickle Cell Disease Patients standard of care - Sickle Cell Disease (SCD), Vaso-occlusive Events | Not applicable | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 30 | 2026-09-01 | 2026-08-07 |
| Pleuropulmonary Ultrasound Imaging in Patients With Sickle Cell Disease in a Vaso-occlusive Crisis. "ECHODREP" Pleuropulmonary ultrasound - Sickle Cell Disease (SCD), Vaso-Occlusive Crises | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 200 | 2026-09-01 | 2026-08-24 | |
| Lidocaine for Opioid Sparing in Vaso-occlusive Crisis of Sickle Cell Disease Lidocain, Placebo, Standard of care - Vaso-Occlusive Pain Episode in Sickle Cell Disease | Phase 3 | Recruiting | Nantes University Hospital | 104 | 2026-07-03 | 2026-09-09 |
| Analgesic Effect of Parecoxib Versus Morphine in SCD Patients Presenting to the Emergency Department Parecoxib, Morphine - Sickle-Cell Disease with Crisis | Phase 3 | Not yet recruiting | Oman Medical Speciality Board | 226 | 2026-05-01 | 2025-03-20 |
| Morphine Clearance and Glomerular Filtration in Sickle Cell Patients in Crisis in Intensive Care Injection of iohexol for glomerular filtration rate (GFR) measurement - Sickle Cell Disease, Glomerular Hyperfiltration | Not applicable | Recruiting | University Hospital, Tours | 100 | 2026-03-05 | 2026-03-10 |
| Efficacy Safety Study of Gene Therapy for Sickle Cell DiseaseSCD Using Autologous CD34+ Cells Transduced ex Vivo, Carrying a Corrected Globin Gene and a Silencing RNA. DREAM01 drug product, anti-inflammatory therapy - Sickle Cell Disease | Phase 1 / Phase 2 | Recruiting | Assistance Publique - Hôpitaux de Paris | 15 | 2026-02-25 | 2026-03-04 |
| Safety of Anumigilimab (CSL324) in Adults With Sickle Cell Disease (SCD) Anumigilimab, Placebo - Sickle Cell Disease | Phase 2 | Recruiting | CSL Behring | 63 | 2026-02-02 | 2026-08-05 |
| Optimal Timing of Ketamine Initiation for SCD Pain Ketamine hydrochloride injection, Placebo - Sickle Cell Disease, Sickle Cell Crisis | Phase 3 | Not yet recruiting | Boston Children's Hospital | 90 | 2026-02-01 | 2026-03-09 |
| Efficacy of Liberal Versus Restricted IV Fluid Approach in the Management of Sickle Cell Vaso-Occlusive Crisis Sodium Chloride (NaCl) 0.9 % - SCD, Vaso Occlussive Crisis | Not applicable | Recruiting | Imam Abdulrahman Bin Faisal University | 394 | 2025-10-05 | 2026-03-18 |
| Outcomes of Vaso-occlusive Crisis in Pediatric Sickle Cell Disease No intervention - Sickle Cell Disease, Vaso-occlusive Crisis | Not yet recruiting | Assiut University | 25 | 2025-10-01 | 2025-10-01 | |
| A Study of Intravenous L-Citrulline in Patients Aged 6-21 Years Old With Sickle Cell Disease Presenting to Emergency Departments in Acute Vaso-Occlusive Crisis L-citrulline, Placebo - Sickle Cell Disease | Phase 3 | Not yet recruiting | Asklepion Pharmaceuticals, LLC | 120 | 2025-07-25 | 2025-05-29 |
| Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis CSL889, Placebo - Sickle Cell Disease Vaso-occlusive Crisis | Phase 2 | Recruiting | CSL Behring | 70 | 2025-07-10 | 2026-10-08 |
| Impact of Regional Anesthesia on Inflammatory Mechanisms During Vaso-occlusive Crisis in Sickle Cell Patients Sickle Cell, Sickle Cell Disease | Recruiting | Centre Hospitalier Universitaire de la Guadeloupe | 34 | 2025-02-05 | 2025-06-03 | |
| Pilot Study on the Value of Bedside Pleuropulmonary Ultrasound in Patients With Sickle Cell Disease Presenting With Vaso-occlusive Crisis Pleuropulmonary ultrasound - Sickle Cell Disease | Not yet recruiting | University Hospital, Grenoble | 25 | 2025-01-01 | 2025-01-01 |
Showing 20 of 103. Sign in to see all of them.
Anemia, Sickle Cell (88) · Acute Chest Syndrome (11) · Agnosia (7) · Hematologic Diseases (7) · Hemoglobin SC Disease (7) · Sickle Cell Trait (7) · Emergencies (6) · Pain (6) · Anemia (5) · Acute Pain (4) · Genetic Diseases, Inborn (4) · Anemia, Hemolytic (2) · Hemoglobinopathies (2) · Hemolysis (2)
Anemia, Hemolytic, Congenital (103) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (103) · Hemic and Lymphatic Diseases (103) · Anemia, Hemolytic (101) · Hemoglobinopathies (101) · Genetic Diseases, Inborn (99) · Anemia (98) · Hematologic Diseases (96) · Pathological Conditions, Signs and Symptoms (25) · Neurologic Manifestations (17) · Signs and Symptoms (17) · Anemia, Sickle Cell (15) · Respiratory Tract Diseases (14) · Respiration Disorders (13) · Lung Diseases (12)
Ketamine (7) · Saline Solution (7) · Morphine (6) · Sodium Chloride (5) · crizanlizumab (5) · Blood Specimen Collection (3) · Hydroxyurea (3) · Nitric Oxide (3) · PEGylated carboxyhemoglobin bovine (3) · Standard of Care (3) · inclacumab (3) · rivipansel (3) · Fentanyl (2) · Hydromorphone (2) · Hyperbaric Oxygenation (2)
Assistance Publique - Hôpitaux de Paris (12) · Novartis Pharmaceuticals (5) · Pfizer (4) · Boston Children's Hospital (3) · Centre Hospitalier Universitaire de la Guadeloupe (3) · Duke University (3) · Anthera Pharmaceuticals (2) · AstraZeneca (2) · CSL Behring (2) · Forma Therapeutics, Inc. (2) · GlycoMimetics Incorporated (2) · Imam Abdulrahman Bin Faisal University (2) · Mast Therapeutics, Inc. (2) · National Heart, Lung, and Blood Institute (NHLBI) (2) · Sangart (2)
United States (59) · France (26) · Lebanon (11) · Brazil (10) · Turkey (Türkiye) (10) · United Kingdom (9) · Belgium (7) · Colombia (7) · Italy (7) · Oman (7) · Saudi Arabia (7) · Canada (6) · Egypt (6) · Kenya (6) · Guadeloupe (5)
Anders Berggren, MD, PhD (2) · Nirmish Shah, MD (2) · Tania Small, MD (2) · Ahmed F Mahmoud Hussein, MS.c (1) · Alicia Chang, MD (1) · Amelie Rolle, MD (1) · Anoosha Habibi, MD (1) · Arun S Shet, M.D. (1) · Biree Andemariam, MD (1)
PMID 35120836, PMID 35981565, PMID 37254256, PMID 38775255, PMID 10100293, PMID 10861320, PMID 16267411, PMID 1710777, PMID 20001619, PMID 2082307, PMID 21131035, PMID 21275961, PMID 21364138, PMID 22129980, PMID 23813607, PMID 23874164, PMID 24916507, PMID 25701866, PMID 25733584, PMID 26589907, PMID 2666928, PMID 2689472, PMID 27993418, PMID 28174191, PMID 28238158, PMID 29794277, PMID 30021096, PMID 31133061, PMID 31446143, PMID 33025690, PMID 33877274, PMID 34630163, PMID 35019238, PMID 35849650, PMID 36355805, PMID 36529836, PMID 37722599, PMID 39428602, PMID 39497751, PMID 39787687, PMID 40088922, PMID 40862241, PMID 41315052, PMID 41410575, PMID 42649491, PMID 9620101
2019 (3), 2025 (3), U54HL070587 (2), 2017 (1)