11 completed, 6 recruiting, 3 terminated, 2 not yet recruiting. 24 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 24 | Completed 11, Recruiting 6, Terminated 3, Not yet recruiting 2, Active not recruiting 1, Unknown 1 |
Follow Vaso-Occlusive Crises: new trials by email Literature Review of Vaso-Occlusive Crises trials Research Report on Vaso-Occlusive Crises
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hypoxic Red Blood Cells in Sickle Cell Anemia Hemanext ONE System, Conventional RBCs - Sickle Cell Anaemia, Sickle Cell Anemia Crisis | Not applicable | Not yet recruiting | Hemanext | 48 | 2026-11-30 | 2026-11-02 |
| Virtual Reality for SCD VOC Sham 2D Headset Control, Passive Immersive 3D Virtual Reality, Active Immersive Interactive 3D Virtual Reality - Sickle Cell Disease | Not applicable | Recruiting | University of Maryland, Baltimore | 50 | 2026-11-01 | 2026-10-16 |
| Standard of Care Comparative Arm of Phase 1/2 Gene Therapy Trial DREPAMIR" in Severe Sickle Cell Disease Patients standard of care - Sickle Cell Disease (SCD), Vaso-occlusive Events | Not applicable | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 30 | 2026-09-01 | 2026-08-07 |
| Morphine Clearance and Glomerular Filtration in Sickle Cell Patients in Crisis in Intensive Care Injection of iohexol for glomerular filtration rate (GFR) measurement - Sickle Cell Disease, Glomerular Hyperfiltration | Not applicable | Recruiting | University Hospital, Tours | 100 | 2026-03-05 | 2026-03-10 |
| Efficacy of Liberal Versus Restricted IV Fluid Approach in the Management of Sickle Cell Vaso-Occlusive Crisis Sodium Chloride (NaCl) 0.9 % - SCD, Vaso Occlussive Crisis | Not applicable | Recruiting | Imam Abdulrahman Bin Faisal University | 394 | 2025-10-05 | 2026-03-18 |
| Effect of EMDR for Reduction of Pain Interference in Children With Sickle Cell Disease Eye Movement Desensitization and Reprocessing (EMDR) - Sickle Cell Disease, Pain | Not applicable | Recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 40 | 2024-09-20 | 2025-06-03 |
| Virtual Reality as an Adjuvant Therapy for Sickle Cell Vaso-Occlusive Crisis in the Pediatric Emergency Department Virtual Reality Goggles - Sickle Cell Crisis | Not applicable | Completed | University of Mississippi Medical Center | 101 | 2023-08-01 | 2024-06-28 |
| Lipid Balance in Adult Sickle Cell Patients HDL2 - Sickle Cell Disease, Dyslipidemia | Not applicable | Active not recruiting | Centre Hospitalier Universitaire de la Guadeloupe | 116 | 2022-11-30 | 2025-12-10 |
| Mindfulness and Yoga Therapy for Acute Pain in Sickle Cell Disease Mindfulness meditation, breathing exercises (including incentive spirometry), and yoga therapy - Sickle Cell Crisis, Sickle Cell Disease | Not applicable | Completed | University of Texas Southwestern Medical Center | 39 | 2022-11-10 | 2023-02-13 |
| Hyperbaric Oxygen Therapy in Sickle Cell Pain hyperbaric oxygen therapy - Vaso-occlusive Crisis, Sickle Cell Anemia Crisis | Not applicable | Completed | University of Nebraska | 8 | 2022-09-01 | 2026-07-28 |
| Sickle Cell Improvement: Enhancing Care in the Emergency Department Care pathway - Sickle Cell Crisis | Not applicable | Recruiting | Medical College of Wisconsin | 5328 | 2021-09-01 | 2023-08-14 |
| Observational Prospective Study Measuring the Impact of the Use of a Hypnotic Script Associated With Virtual Reality on the Pain of the Child's Sickle Cell During a Vaso-occlusive Crisis Virtual Reality - Sickle Cell Disease | Not applicable | Completed | Assistance Publique - Hôpitaux de Paris | 12 | 2021-07-13 | 2025-09-16 |
| Evaluation of Virtual Reality to Save Morphinic in the Treatment of Vaso-occlusive Seizures of Sickle Cell Patients Consulting in the Emergency Room Virtual Reality, Usual Care - Vaso-occlusive Crisis, Sickle Cell Disease | Not applicable | Completed | Assistance Publique - Hôpitaux de Paris | 97 | 2021-03-04 | 2021-10-18 |
| Music Therapy in Sickle Cell Disease Vaso-occlusive Crisis Music therapy program MUSIC CARE® + standard care, standard care of vaso-occlusive crises - Vaso-occlusive Crisis | Not applicable | Unknown | Assistance Publique - Hôpitaux de Paris | 40 | 2018-09-28 | 2019-10-21 |
| Sleep Apnea in Sickle Cell Disease polysomnography and oxygen saturation exam, calculation of VOC frequency between the first polysomnography and the end of the first year of continuous positive airway pressure treatment, Blood samples - Sickle Cell Disease | Not applicable | Terminated | Hospices Civils de Lyon | 30 | 2018-05-28 | 2022-12-28 |
| Transillumination Device for Peripheral Intravenous Placement in Patients With Sickle Cell Disease (PERFID) Accuvein V400 device, Routine procedure - Sickle Cell Crisis | Not applicable | Completed | Assistance Publique - Hôpitaux de Paris | 126 | 2018-03-30 | 2023-01-13 |
| Effect of Virtual Reality Technology for Pain Management of Vaso-Occlusive Crisis in Patients With Sickle Cell Disease Virtual Reality Therapy - Sickle Cell Disease, Vaso-occlusive Crisis | Not applicable | Recruiting | St. Jude Children's Research Hospital | 76 | 2018-02-05 | 2026-05-18 |
| Ketamine for Acute Painful Crisis in Sickle Cell Disease Patients Morphine Group, Ketamine Group, standard IV hydration - Sickle Cell Crisis | Not applicable | Completed | Imam Abdulrahman Bin Faisal University | 278 | 2018-01-01 | 2025-05-28 |
| A Comprehensive Care Plan for Pediatric Patients With Vaso-Occlusive Crises Comprehensive Care Plan - Sickle Cell Disease, Sickle Cell Crisis | Not applicable | Terminated | Valley Anesthesiology Consultants | 3 | 2016-04-01 | 2018-05-03 |
| Sleep Study in Adult Patients With Major Sickle Cell Disease With Paroxysmal Nocturnal Events Polysomnography and blood sample - Sickle Cell Disease | Not applicable | Completed | Assistance Publique - Hôpitaux de Paris | 114 | 2014-09-17 | 2023-05-19 |
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Anemia, Sickle Cell (18) · Pain (4) · Acute Chest Syndrome (2) · Emergencies (2) · Priapism (2) · Sleep Apnea, Obstructive (2) · Chronic Disease (1) · Dyslipidemias (1) · Genetic Diseases, Inborn (1) · Pulmonary Arterial Hypertension (1) · Stress Disorders, Post-Traumatic (1)
Anemia (24) · Anemia, Hemolytic (24) · Anemia, Hemolytic, Congenital (24) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (24) · Hematologic Diseases (24) · Hemic and Lymphatic Diseases (24) · Hemoglobinopathies (24) · Genetic Diseases, Inborn (23) · Anemia, Sickle Cell (6) · Pathological Conditions, Signs and Symptoms (5) · Respiratory Tract Diseases (5) · Neurologic Manifestations (4) · Respiration Disorders (4) · Signs and Symptoms (4) · Disease Attributes (3)
Blood Specimen Collection (2) · Standard of Care (2) · Breathing Exercises (1) · Cell Count (1) · Continuous Positive Airway Pressure (1) · Control Groups (1) · Critical Pathways (1) · Eye Movement Desensitization Reprocessing (1) · Glomerular Filtration Rate (1) · Hyperbaric Oxygenation (1) · Mindfulness (1) · Polysomnography (1) · Sodium Chloride (1) · Spirometry (1) · Virtual Reality Exposure Therapy (1)
Assistance Publique - Hôpitaux de Paris (7) · Centre Hospitalier Universitaire de la Guadeloupe (2) · Imam Abdulrahman Bin Faisal University (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Hemanext (1) · Hospices Civils de Lyon (1) · Medical College of Wisconsin (1) · Nationwide Children's Hospital (1) · St. Jude Children's Research Hospital (1) · University Hospital, Tours (1) · University of Maryland, Baltimore (1) · University of Mississippi Medical Center (1) · University of Nebraska (1) · University of Texas Southwestern Medical Center (1) · Valley Anesthesiology Consultants (1)
France (9) · United States (9) · Guadeloupe (2) · Saudi Arabia (2) · Netherlands (1)
Anoosha Habibi, MD (1) · Biree Andemariam, MD (1) · Claire Heilbronner, MD, PhD (1) · David Brousseau, MD, MS (1) · Eric Fischer (1) · Jean-Benoit Arlet, MD,PhD (1) · Jeff S Cooper, MD (1) · Jonathon Lindner, MD (1) · Joshua J Field, MD, MS (1) · Karin Fijnvandraat, prof. dr. (1) · Laurel Omert, MD, FACS (1)
PMID 28174191, PMID 31133061, PMID 34630163, PMID 39787687, PMID 42649491