rivipansel: Clinical Trials

8 completed, 1 terminated. 6 Phase 1, 2 Phase 2, 2 Phase 3.

By phase and status

Phase	Trials	Status
Phase 1	6	Completed 6
Phase 2	2	Completed 2
Phase 3	2	Completed 1, Terminated 1

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
A Study to Evaluate the Effect of Age on the Pharmacokinetics, Safety and Tolerability of IV Rivipansel. Rivipansel - Healthy	Phase 1	Completed	GlycoMimetics Incorporated	16	2017-01-01	2020-06-18
A Study to Evaluate the Effect of IV Doses of Rivipansel in Subjects With Moderate Hepatic Impairment and in Healthy Subjects With Normal Hepatic Function Rivipansel - Moderate Hepatic Impairment, Normal Hepatic Function	Phase 1	Completed	GlycoMimetics Incorporated	16	2016-09-01	2020-07-09
A Study to Evaluate the Effect of IV Doses of Rivipansel on Subjects With Renal Impairment and in Healthy Subjects Rivipansel - Renal Impairment, Healthy	Phase 1	Completed	GlycoMimetics Incorporated	28	2016-06-01	2020-06-18
Safety of Rivipansel (GMI-1070) in the Treatment of One or More Vaso-Occlusive Crises in Hospitalized Subjects With Sickle Cell Disease Rivipansel - Sickle Cell Anemia, Sickle Cell Disease	Phase 3	Terminated	GlycoMimetics Incorporated	154	2015-12-16	2021-02-10
Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Subcutaneous Rivipansel With rHuPH20 in Healthy Subjects Rivipansel, Placebo - Healthy	Phase 1	Completed	GlycoMimetics Incorporated	27	2015-10-01	2020-06-18
Efficacy and Safety of Rivipansel (GMI-1070) in the Treatment of Vaso-Occlusive Crisis in Hospitalized Subjects With Sickle Cell Disease Rivipansel, Placebo - Anemia, Sickle Cell	Phase 3	Completed	Biossil Inc.	345	2015-06-17	2025-03-11
A Study to Evaluate the Effect of IV Doses of GMI-1070 on Qtc Intervals in Healthy African-American Adult Subjects Rivipansel - Healthy	Phase 1	Completed	GlycoMimetics Incorporated	48	2013-08-01	2020-06-18
Study of GMI-1070 for the Treatment of Sickle Cell Pain Crisis GMI-1070, Placebo - Sickle Cell Disease, Vaso-occlusive Crisis	Phase 2	Completed	GlycoMimetics Incorporated	81	2010-05-01	2020-05-13
Study of Intravenous GMI-1070 in Adults With Sickle Cell Disease GMI-1070 - Sickle Cell Disease	Phase 1 / Phase 2	Completed	GlycoMimetics Incorporated	15	2009-05-01	2020-05-11

Conditions studied

Anemia, Sickle Cell (4)  ·  Vaso-Occlusive Crises (3)  ·  Renal Insufficiency (1)

Sponsors

GlycoMimetics Incorporated (8)  ·  Biossil Inc. (1)

Countries

United States (8)  ·  Canada (3)  ·  Belgium (1)

Top investigators

Helen Thackray, MD (2)  ·  Marilyn J Telen, MD (1)

Results publications

PMID 32579796, PMID 35120836, PMID 35981565, PMID 22129980, PMID 24988449, PMID 25733584

NIH funding

2014 (1)