992 completed, 247 recruiting, 196 unknown, 168 terminated. 506 Phase 2, 366 Not applicable, 280 Phase 1, 229 Phase 3, 87 Phase 4.
Follow Anemia, Hemolytic: new trials by email Literature Review of Anemia, Hemolytic trials Research Report on Anemia, Hemolytic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of NM8074 in Patients With aHUS With Evidence of Ongoing Thrombotic Microangiopathy NM8074 - aHUS - Atypical Hemolytic Uremic Syndrome | Phase 2 | Not yet recruiting | NovelMed Therapeutics | 12 | 2027-11-01 | 2026-04-13 |
| Self-administered Acupressure in Patients With Sickle Cell Disease Verum Acupressure (using AcuWand), Sham Acupressure (using AcuWand) - Sickle Cell Disease (SCD) | Not applicable | Not yet recruiting | University of Cincinnati | 300 | 2027-10-01 | 2026-10-15 |
| Development of a Provider-Focused Intervention to Improve Health Outcomes in Pediatric Sickle Cell Disease Individuation and Perspective-Taking (IPT), pediatric SCD pain management education session - Sickle Cell Disease, Sickle Cell Anemia in Children | Not applicable | Not yet recruiting | Connecticut Children's Medical Center | 30 | 2027-09-01 | 2026-04-29 |
| Evaluation of Efficacy and Safety of a Single Dose of Exa-cel in Participants With Severe Sickle Cell Disease, βS/ βC Genotype Exa-cel - Sickle Cell Disease | Phase 3 | Withdrawn | Vertex Pharmaceuticals Incorporated | 2027-07-31 | 2026-03-25 | |
| MBI for Pain and Sleep in Adolescents and Young Adults With Sickle Cell Disease Mindfulness-based intervention - Chronic Pain, Sickle Cell Disease | Not applicable | Not yet recruiting | University of Illinois at Chicago | 48 | 2027-02-01 | 2026-09-21 |
| Heterologous Cord Blood-Derived Red Blood Cell for Transfusion in Extremely Preterm Infants Cord Blood Red Blood Cells, Standard Adult Donor Red Blood Cells - Extremely Premature Infant, Anemia Neonatal | Not applicable | Not yet recruiting | Hospital Clinic of Barcelona | 176 | 2027-01-01 | 2026-03-31 |
| Study of NM8074 in Adult PNH Patients With Inadequate Response to Soliris NM8074, Soliris - Paroxysmal Nocturnal Hemoglobinuria | Phase 2 | Not yet recruiting | NovelMed Therapeutics | 12 | 2027-01-01 | 2026-04-13 |
| Gene Therapy of Beta Thalassemia Using a Self-inactivating Lentiviral Vector Gene-modified autologous hematopoeitic stem cells - Beta-Thalassemia | Not applicable | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 20 | 2026-12-31 | 2026-08-27 |
| A Study of the Efficacy and Safety of FXS6837 Capsules Compared to Eculizumab for 24 Weeks in Patients With PNH. FXS6837 Capsule, Eculizumab infusion - Paroxysmal Nocturnal Hemoglobinuria | Phase 3 | Not yet recruiting | Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd. | 90 | 2026-12-10 | 2026-08-05 |
| A Phase 1b/2a Study of Velinotamig in Adults With Relapsed/Refractory ITP and wAIHA Velinotamig specified dose on specified days. - Immune Thrombocytopenia (ITP), Warm Autoimmune Hemolytic Anemia (WAIHA) | Phase 1 / Phase 2 | Not yet recruiting | Cullinan Therapeutics Inc. | 72 | 2026-12-01 | 2026-07-31 |
| Omega-3-Fatty Acids in Children With Sickle Cell Disease Flaxseed - Sickle Cell Disease (SCD) | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 20 | 2026-12-01 | 2026-08-21 |
| Minocycline In Neurocognitive Outcomes - Sickle Cell Disease Minocycline, Placebo - Sickle Cell Disease, Cognitive Impairment | Phase 1 | Not yet recruiting | University of Cincinnati | 30 | 2026-12-01 | 2026-05-14 |
| Research on YTS109 Cell in Patients With Recurrent/Refractory Autoimmune Hemolytic Anemia YTS109 cell - Autoimmune Hemolytic Anemia | Phase 1 | Not yet recruiting | China Immunotech (Beijing) Biotechnology Co., Ltd. | 13 | 2026-11-18 | 2026-10-22 |
| The Effect of Motivational Interviewing on Treatment Adherence and Self-Efficacy Among Omani Adults With Thalassemia Motivational Interviewing - Beta-Thalassemia Major, Transfusion-Dependent Thalassemia | Not applicable | Not yet recruiting | Oman Ministry of Health | 45 | 2026-11-01 | 2026-06-22 |
| Virtual Reality for SCD VOC Sham 2D Headset Control, Passive Immersive 3D Virtual Reality, Active Immersive Interactive 3D Virtual Reality - Sickle Cell Disease | Not applicable | Recruiting | University of Maryland, Baltimore | 50 | 2026-11-01 | 2026-10-16 |
| Feasibility and Acceptability of Amani Amani - Sickle Cell Disease | Phase 1 / Phase 2 | Not yet recruiting | Massachusetts General Hospital | 40 | 2026-11-01 | 2026-08-07 |
| Inflammatory Markers and Pain in Sickle Cell Disease Sickle Cell Disease | Not yet recruiting | Assiut University | 75 | 2026-11-01 | 2026-10-08 | |
| Transcranial Photobiomodulation Treatment in Patients With Sickle Cell Disease Active Transcranial Photobiomodulation (TPBM), Sham Transcranial photobiomodulation (TPBM) - Sickle Cell Disease | Not applicable | Not yet recruiting | St. Jude Children's Research Hospital | 60 | 2026-11-01 | 2026-09-10 |
| Study of SGB-9768 in Patients With Paroxysmal Nocturnal Hemoglobinuria SGB-9768 - PNH - Paroxysmal Nocturnal Hemoglobinuria | Phase 2 | Not yet recruiting | Suzhou Sanegene Bio Inc. | 24 | 2026-10-31 | 2026-09-04 |
| A Multicenter, Randomized, Open-Label, Positive Controlled Phase III Study to Evaluate the Efficacy and Safety of VSA012 Injection in Participants With Paroxysmal Nocturnal Hemoglobinuria Who Are Naive to Complement Inhibitor Therapy VSA012, Eculizumab (Soliris®) - Paroxysmal Nocturnal Hemoglobinuria, PNH | Phase 3 | Not yet recruiting | Bisirna Therapeutics (Suzhou) Co., Ltd. | 70 | 2026-10-29 | 2026-09-11 |
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Anemia, Sickle Cell (1118) · beta-Thalassemia (264) · Thalassemia (220) · Hemoglobinuria, Paroxysmal (189) · Vaso-Occlusive Crises (103) · Hematologic Diseases (84) · Anemia, Hemolytic, Autoimmune (83) · Anemia (80) · Hemoglobinopathies (70) · Iron Overload (65) · Pain (57) · Myelodysplastic Syndromes (46) · Atypical Hemolytic Uremic Syndrome (45) · Hemolysis (43)
Hemic and Lymphatic Diseases (1890) · Anemia (1811) · Hematologic Diseases (1807) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1549) · Anemia, Hemolytic, Congenital (1524) · Genetic Diseases, Inborn (1512) · Hemoglobinopathies (1412) · Pathological Conditions, Signs and Symptoms (328) · Bone Marrow Diseases (255) · Thalassemia (229) · Pathologic Processes (210) · Nutritional and Metabolic Diseases (192) · Immune System Diseases (190) · Metabolic Diseases (178)
Hydroxyurea (88) · eculizumab (49) · Cyclophosphamide (43) · Alemtuzumab (40) · Deferasirox (39) · fludarabine (37) · fludarabine phosphate (34) · Sirolimus (32) · Blood Specimen Collection (31) · Busulfan (28) · Whole-Body Irradiation (28) · Mycophenolic Acid (26) · Deferoxamine (23) · voxelotor (23) · Tacrolimus (22)
National Heart, Lung, and Blood Institute (NHLBI) (71) · Novartis Pharmaceuticals (63) · Assistance Publique - Hôpitaux de Paris (54) · St. Jude Children's Research Hospital (50) · Alexion Pharmaceuticals, Inc. (48) · Children's Hospital Medical Center, Cincinnati (33) · Assiut University (30) · Duke University (28) · Emory University (28) · Pfizer (27) · Institute of Hematology & Blood Diseases Hospital, China (24) · HaEmek Medical Center, Israel (19) · UCSF Benioff Children's Hospital Oakland (17) · Ain Shams University (15) · University of Illinois at Chicago (14)
United States (951) · France (213) · United Kingdom (171) · Italy (164) · China (155) · Canada (122) · Germany (89) · Egypt (80) · Turkey (Türkiye) (76) · Spain (72) · Netherlands (69) · Belgium (58) · Brazil (58) · Lebanon (58) · Greece (53)
John F Tisdale, M.D. (16) · Ariel Koren, MD (12) · Swee Lay Thein, M.D. (12) · Lakshmanan Krishnamurti, MD (9) · Janet Kwiatkowski, MD (7) · Russell Ware, MD, PhD (7) · Carina Levin, MD (6)
PMID 37975597, PMID 33783815, PMID 36240296, PMID 37254256, PMID 38775255, PMID 40277027, PMID 40569673, PMID 41026975, PMID 42133908, PMID 23738544, PMID 26589907, PMID 34175041, PMID 34219224, PMID 20175775, PMID 24916507, PMID 31974203, PMID 33661274, PMID 34922648, PMID 36594181, PMID 36860093, PMID 36975201, PMID 38866240, PMID 39079163, PMID 39382077, PMID 39428602, PMID 39535306, PMID 39659429, PMID 40694294, PMID 41809202, PMID 42705233, PMID 17634466, PMID 19721013, PMID 23416852, PMID 29931453, PMID 30617198, PMID 30655275, PMID 30952488, PMID 31799940, PMID 32384147, PMID 33283989, PMID 33570654, PMID 34000072, PMID 34526067, PMID 35019238, PMID 35075288, PMID 35120836, PMID 35869170, PMID 35981565, PMID 36123234, PMID 36355805
2019 (19), 2023 (17), 2017 (14), 2014 (12), 2016 (11), 2018 (8), U01HL065238 (8), U54HL070587 (8), 2015 (4), U01HL133996 (4), 2009 (3), 2025 (3), P30CA033572 (3), 2004 (2), K23HL094376 (2)