6 completed, 2 not yet recruiting, 1 recruiting, 1 withdrawn. 10 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 10 | Completed 6, Not yet recruiting 2, Recruiting 1, Withdrawn 1 |
Follow Vaso-Occlusive Crises: new trials by email Literature Review of Vaso-Occlusive Crises trials Research Report on Vaso-Occlusive Crises
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adaptive Platform Trial for Pain Management in Sickle Cell Vaso-Occlusive Crisis Group 02 Paracetamol + Morphine + Ketamine, Group 01 Control: Paracetamol + Morphine, Group 03 : Paracetamol + Morphine + Nefopam - Sickle Cell Disease, Vaso-occlusive Crisis | Phase 4 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 400 | 2026-10-01 | 2026-09-18 |
| Ketorolac for Acute Vaso-Occlusive Crisis in Pediatric Sickle Cell Disease Ketorolac - Sickle Cell Disease, Sickle Cell Crisis | Phase 4 | Not yet recruiting | Children's Blood and Cancer Center at Dell Children's Medical Center | 102 | 2024-09-30 | 2024-08-30 |
| Ketamine Infusion for Sickle Cell Pain Crisis Ketamine, Pain management - Anemia; Sickle-Cell, With Crisis, Acute Pain | Phase 4 | Withdrawn | Duke University | 2022-01-01 | 2022-01-14 | |
| An Indian Multi-centric Phase IV Study to Assess the Safety of Crizanlizumab in Sickle Cell Disease Patients crizanlizumab - Sickle Cell Disease (SCD) | Phase 4 | Completed | Novartis Pharmaceuticals | 140 | 2021-07-14 | 2025-09-26 |
| Rollover Study for Patients With Sickle Cell Disease Who Have Completed a Prior Novartis-Sponsored Crizanlizumab Study Crizanlizumab - Sickle Cell Disease | Phase 4 | Recruiting | Novartis Pharmaceuticals | 130 | 2021-06-10 | 2026-06-08 |
| Low Dose Ketamine and Acute Pain Crisis Ketamine, Normal Saline - Sickle Cell Crisis | Phase 4 | Completed | Rhode Island Hospital | 20 | 2020-07-01 | 2021-12-23 |
| Does IV Acetaminophen Reduce Opioid Requirement in Pediatric Patients With Acute Sickle Cell Crises? Acetaminophen, Normal saline - Sickle Cell Anemia Crisis | Phase 4 | Completed | Newark Beth Israel Medical Center | 71 | 2018-02-20 | 2021-04-02 |
| Low-dose Ketamine vs Morphine for Vaso-occlusive Crisis in Sicklers Low dose ketamine, Morphine - Sickle Cell Crisis, Acute Pain | Phase 4 | Completed | Makerere University | 240 | 2015-06-01 | 2016-08-03 |
| Comparing Acute Pain Management Protocols for Patients With Sickle Cell Disease Hydromorphone (Standardized, weight-based dosing), Morphine Sulfate (Standardized, weight-based dosing), Hydromorphone (Patient Specific dosing) - Sickle Cell Disease | Phase 4 | Completed | Duke University | 106 | 2015-03-15 | 2017-08-04 |
| Intranasal Fentanyl for Initial Treatment of a Vaso-occlusive Crisis Fentanyl Citrate, Normal Saline - Anemia, Sickle Cell, Pain | Phase 4 | Completed | Montefiore Medical Center | 124 | 2011-12-01 | 2016-08-19 |
Anemia, Sickle Cell (6) · Acute Pain (2) · Agnosia (2) · Emergencies (2) · Hemoglobin SC Disease (1) · Pain (1)
Anemia (10) · Anemia, Hemolytic (10) · Anemia, Hemolytic, Congenital (10) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (10) · Genetic Diseases, Inborn (10) · Hematologic Diseases (10) · Hemic and Lymphatic Diseases (10) · Hemoglobinopathies (10) · Pathological Conditions, Signs and Symptoms (6) · Neurologic Manifestations (5) · Signs and Symptoms (5) · Anemia, Sickle Cell (4) · Disease Attributes (2) · Nervous System Diseases (2) · Neurobehavioral Manifestations (2)
Ketamine (4) · Morphine (3) · Saline Solution (3) · crizanlizumab (2) · Acetaminophen (1) · Fentanyl (1) · Hydromorphone (1) · Ketoprofen (1) · Ketorolac (1) · Ketorolac Tromethamine (1) · Nefopam (1) · Pain Management (1) · Sodium Chloride (1) · Tramadol (1)
Duke University (2) · Novartis Pharmaceuticals (2) · Assistance Publique - Hôpitaux de Paris (1) · Children's Blood and Cancer Center at Dell Children's Medical Center (1) · Makerere University (1) · Montefiore Medical Center (1) · Newark Beth Israel Medical Center (1) · Rhode Island Hospital (1)
United States (6) · Belgium (1) · Brazil (1) · Colombia (1) · France (1) · Germany (1) · India (1) · Italy (1) · Lebanon (1) · Oman (1) · Spain (1) · Turkey (Türkiye) (1) · Uganda (1)
Alicia Chang, MD (1) · Cena Tejani, MD (1) · Daniel M Fein, MD (1) · Deogratias Munube, MMed (1) · Felix A. Lubega, MBChB (1) · Fred Bulamba, MBChB (1) · Mithrika S De Silva, MD (1) · Taneisha Wison, MD, ScM (1) · Tonny S. Luggya, MMed (1)
PMID 10100293, PMID 2082307, PMID 2666928, PMID 2689472, PMID 27993418, PMID 28238158, PMID 29794277, PMID 33025690, PMID 39428602, PMID 9620101