5 completed, 2 recruiting, 1 not yet recruiting, 1 terminated. 9 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 9 | Completed 5, Recruiting 2, Not yet recruiting 1, Terminated 1 |
| Phase 2 | 4 | Recruiting 2, Completed 1, Terminated 1 |
Follow Vaso-Occlusive Crises: new trials by email Literature Review of Vaso-Occlusive Crises trials Research Report on Vaso-Occlusive Crises
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Buprenorphine for the Management of Pain in Children With Sickle Cell Disease Buprenorphine Buccal Film [Belbuca] - Sickle Cell Disease (SCD), Sickle Cell Disease Vaso-occlusive Crisis | Phase 1 | Not yet recruiting | Natasha Archer | 25 | 2026-10-01 | 2026-09-02 |
| Efficacy Safety Study of Gene Therapy for Sickle Cell DiseaseSCD Using Autologous CD34+ Cells Transduced ex Vivo, Carrying a Corrected Globin Gene and a Silencing RNA. DREAM01 drug product, anti-inflammatory therapy - Sickle Cell Disease | Phase 1 / Phase 2 | Recruiting | Assistance Publique - Hôpitaux de Paris | 15 | 2026-02-25 | 2026-03-04 |
| Investigation Into the Use of BAH243 Lentiviral Vector for Gene Therapy in Treating Sickle Cell Disease Drug Product is administered by IV infusion following myeloablative conditioning with busulfan - Sickle Cell Disease, Sickle-Cell Disease With Crisis | Phase 1 / Phase 2 | Recruiting | Essen Biotech | 85 | 2024-08-01 | 2024-11-05 |
| Oral Ketamine for Treatment of Vaso-Occlusive Pain Ketamine Hydrochloride - Vaso-occlusive Crisis | Phase 1 | Completed | Boston Children's Hospital | 10 | 2023-05-26 | 2026-09-28 |
| Safety Study of MP4CO in Adult Sickle Cell Patients MP4CO, Sodium chloride solution - Anemia, Sickle Cell, Sickle Cell Anemia | Phase 1 | Completed | Sangart | 32 | 2012-01-01 | 2013-08-19 |
| Intermittent Preventive Treatment for Malaria in Patient With Sickle Cell Disease Proguanil, mefloquine plus artesunate, Sulfadoxine-pyrimethamine plus amodiaquine - Malaria, Sickle Cell Crisis | Phase 1 / Phase 2 | Completed | London School of Hygiene and Tropical Medicine | 270 | 2011-09-01 | 2014-03-21 |
| Safety and Efficacy of Sodium Nitrite in Sickle Cell Disease sodium nitrite injection, usp - Sickle Cell Disease | Phase 1 / Phase 2 | Terminated | Children's Hospital Los Angeles | 5 | 2009-12-01 | 2017-10-17 |
| Nitric Oxide and Transfusion Therapy for Sickle Cell Patients With Pulmonary Hypertension Nitric Oxide, INO Pulse - NO Delivery System - Sickle Cell Anemia, Pulmonary Hypertension | Phase 1 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 59 | 2001-07-27 | 2019-12-17 |
| A Phase I/II Trial of Recombinant-Methionyl Human Stem Cell Factor (SCF) in Adult Patients With Sickling Disorders Recombinant-methionyl human stem cell factor - Hemoglobin SC Disease, Sickle Cell Anemia | Phase 1 | Completed | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 50 | 2000-03-01 | 2008-03-04 |
Anemia, Sickle Cell (9) · Hemoglobin SC Disease (3) · Acute Chest Syndrome (1) · Acute Pain (1) · Agnosia (1) · Hypertension, Pulmonary (1) · Malaria (1) · beta-Thalassemia (1)
Anemia (9) · Anemia, Hemolytic (9) · Anemia, Hemolytic, Congenital (9) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (9) · Genetic Diseases, Inborn (9) · Hematologic Diseases (9) · Hemic and Lymphatic Diseases (9) · Hemoglobinopathies (9) · Neurologic Manifestations (2) · Pathological Conditions, Signs and Symptoms (2) · Signs and Symptoms (2) · Cardiovascular Diseases (1) · Hypertension (1) · Infections (1) · Lung Diseases (1)
Amodiaquine (1) · Artesunate (1) · Buprenorphine (1) · Busulfan (1) · Ketamine (1) · Mefloquine (1) · Nitric Oxide (1) · PEGylated carboxyhemoglobin bovine (1) · Proguanil (1) · Saline Solution (1) · Sodium Chloride (1) · Sodium Nitrite (1) · ancestim (1) · fanasil, pyrimethamine drug combination (1)
Assistance Publique - Hôpitaux de Paris (1) · Boston Children's Hospital (1) · Children's Hospital Los Angeles (1) · Essen Biotech (1) · London School of Hygiene and Tropical Medicine (1) · Natasha Archer (1) · National Heart, Lung, and Blood Institute (NHLBI) (1) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (1) · Sangart (1)
United States (5) · France (2) · China (1) · Jamaica (1) · Lebanon (1) · Nigeria (1) · United Kingdom (1)
John F Tisdale, M.D. (1) · Kalifa Bojang, PhD (1) · Natasha Archer, MD (1) · Paul J Milligan, PhD (1) · Rasaq Olaosebikan, MD (1) · Tania Small, MD (1) · Thomas Coates, MD (1)
PMID 24916507, PMID 25701866, PMID 26589907
2025 (1)