11 completed, 5 unknown, 3 recruiting, 1 active not recruiting. 8 Not applicable, 8 Phase 4, 2 Phase 2, 2 Phase 3, 1 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Novel Biomarkers of Non-IgE Immediate Hypersensitivity Drug Reactions Vancomycin (IV) - Healthy Volunteer, Hypersensitivity Reactions | Phase 1 / Phase 2 | Active not recruiting | Johns Hopkins University | 25 | 2026-05-21 | 2026-10-27 |
| STOP-CDI: Efficacy of Fecal Microbiota Transplantation vs Fidaxomicin vs Vancomycin in Treating and Preventing Relapse of Clostridioides Difficile Infection FMT (fecal microbiota transplantation), Fidaxomicin, Vancomycin (VAN) treatment - Clostridioides Difficile Infection, Clostridioides Difficile Infection Recurrence | Not applicable | Not yet recruiting | Medical University of Warsaw | 424 | 2025-10-01 | 2025-08-13 |
| Vancomycin Reduction Practices (VRP) in the NICU External Facilitation - Antibiotic Stewardship, Neonatal Sepsis, Late-Onset | Not applicable | Recruiting | Children's Hospital of Philadelphia | 13 | 2025-06-02 | 2026-09-24 |
| Effect of Direct-from-blood Bacterial Testing on Antibiotic Administration and Clinical Outcomes T2Bacteria® Panel (direct-from-blood testing), Usual Care - Bloodstream Infection, Sepsis Bacterial | Not applicable | Completed | Vanderbilt University Medical Center | 500 | 2023-12-13 | 2026-02-27 |
| First Time Right of Vancomycin Vancomycin - Vancomycin, Pharmacokinetics | Not applicable | Unknown | Erasmus Medical Center | 134 | 2023-10-01 | 2023-07-27 |
| Continuous vs. Intermittent Infusion Vancomycin Vancomycin Continuous Infusion, Vancomycin Intermittent Infusion - Vancomycin | Phase 4 | Completed | Aaron Cook | 37 | 2023-05-22 | 2025-12-15 |
| Intracameral Antibiotic Safety Study Vancomycin, Moxifloxacin, Placebo - Intracameral Antibiotics, Cataract Surgery | Phase 3 | Suspended | Panhandle Eye Group, LLP | 500 | 2023-01-01 | 2022-04-27 |
| Clinical Decision Support Tool for Vancomycin Dosing in Children Computer Decision Support Tool Intervention Group, Matched Historical Controls - Gram-Positive Bacterial Infections, Vancomycin | Not applicable | Completed | University of Maryland, Baltimore | 75 | 2022-05-09 | 2025-05-14 |
| The Clinical Validation of a Dried Blood Spot Method for Vancomycin and Creatinine fingerprick - Vancomycin | Completed | Erasmus Medical Center | 60 | 2022-03-21 | 2025-03-11 | |
| Model-informed Precision Dosing of Vancomycin in Adults Vancomycin model-informed precision dosing, Vancomycin - Vancomycin | Phase 4 | Completed | University Hospital, Ghent | 155 | 2021-11-12 | 2023-12-01 |
| Vancomycin Dose Adjustments Comparing Trough Levels to The AUC/MIC Method Using a Bayesian Approach in a Hospitalized Adult Population Vancomycin dose adjustment using the Bayesian method, Vancomycin dose adjustment using the trough level method - Vancomycin, Adult | Not applicable | Completed | CR-CSSS Champlain-Charles-Le Moyne | 45 | 2021-03-01 | 2021-09-10 |
| Optimal Dosing of Vancomycin in an Adult Population of Hemato-oncology Additional blood sample - Vancomycin, Hematologic Malignancies | Not applicable | Unknown | Ciusss de L'Est de l'Île de Montréal | 40 | 2021-02-01 | 2021-02-17 |
| Precision Dosing of Vancomycin in Critically Ill Children vancomycin model-informed precision dosing, Vancomycin - Vancomycin | Phase 4 | Completed | University Hospital, Ghent | 314 | 2020-12-28 | 2026-01-16 |
| Intraosseous Vancomycin in Primary Total Hip Arthroplasty - Designing a Protocol Experimental Intraosseous vancomycin 500mg in 250 mL NS, Standard IV administration of vancomycin - Prosthetic Joint Infection, Vancomycin | Phase 4 | Completed | The Methodist Hospital Research Institute | 23 | 2019-12-31 | 2025-03-13 |
| Vancomycin-Associated Acute Kidney Injury: A Cross-Sectional Study From a Multi- Center in China Vancomycin - Vancomycin, Staphylococcal Infections | Unknown | Peking University First Hospital | 10000 | 2018-10-31 | 2019-08-28 | |
| Intrawound Vancomycin Prophylaxis for Neural Stimulator Vancomycin Hydrochloride, Saline Solution - Vancomycin, Implantable Neural Stimulator | Phase 2 / Phase 3 | Unknown | University of British Columbia | 900 | 2017-09-15 | 2020-10-30 |
| Oral Vancomyin for Primary Clostridium Difficile Infection Prophylaxis in Patients Receiving High-Risk Antibiotics Vancomycin Oral - Clostridium Difficile Infection, Prophylaxis | Phase 4 | Completed | St. Luke's Hospital, Chesterfield, Missouri | 51 | 2016-11-01 | 2017-12-27 |
| Pediatric Antibiotic Dosing in Extracorporal Membrane Oxygenation (PADECMO) Amoxicillin-clavulanate, Piperacillin-tazobactam, Meropenem - Pharmacokinetics, Amoxicillin-clavulanate | Not applicable | Recruiting | University Hospital, Ghent | 300 | 2016-08-19 | 2026-09-21 |
| Vancomycin in the Target Site Treatment of Intracranial Infection Vancomycin - Vancomycin | Phase 4 | Unknown | Xijing Hospital | 2 | 2016-03-01 | 2018-07-13 |
| Optimal Treatment for Recurrent Clostridium Difficile Fidaxomicin, Vancomycin with Taper/Pulse, Vancomycin - Clostridium, Difficile | Phase 4 | Terminated | VA Office of Research and Development | 308 | 2016-02-19 | 2026-08-21 |
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Acute Kidney Injury (2) · Clostridium Infections (2) · Sepsis (2) · Surgical Wound Infection (2) · Endophthalmitis (1) · Febrile Neutropenia (1) · Gram-Positive Bacterial Infections (1) · Hematologic Neoplasms (1) · Hypersensitivity (1) · Joint Diseases (1) · Neonatal Sepsis (1) · Recurrence (1) · Reinfection (1) · Staphylococcal Infections (1)
Infections (9) · Pathologic Processes (7) · Pathological Conditions, Signs and Symptoms (7) · Bacterial Infections (4) · Bacterial Infections and Mycoses (4) · Gram-Positive Bacterial Infections (3) · Inflammation (3) · Systemic Inflammatory Response Syndrome (3) · Disease Attributes (2) · Female Urogenital Diseases (2) · Female Urogenital Diseases and Pregnancy Complications (2) · Kidney Diseases (2) · Male Urogenital Diseases (2) · Postoperative Complications (2) · Renal Insufficiency (2)
Vancomycin (15) · Blood Specimen Collection (2) · Fidaxomicin (2) · Amikacin (1) · Amoxicillin-Potassium Clavulanate Combination (1) · Cefazolin (1) · Ciprofloxacin (1) · Fecal Microbiota Transplantation (1) · Meropenem (1) · Moxifloxacin (1) · Piperacillin, Tazobactam Drug Combination (1) · Pulse (1) · Saline Solution (1) · Standard of Care (1) · Teicoplanin (1)
University Hospital, Ghent (4) · Erasmus Medical Center (2) · Aaron Cook (1) · CR-CSSS Champlain-Charles-Le Moyne (1) · Children's Hospital of Philadelphia (1) · Ciusss de L'Est de l'Île de Montréal (1) · Johns Hopkins University (1) · Medical University of Warsaw (1) · Panhandle Eye Group, LLP (1) · Peking University First Hospital (1) · Southeast University, China (1) · St. Luke's Hospital, Chesterfield, Missouri (1) · The Methodist Hospital Research Institute (1) · University of British Columbia (1) · University of Colorado, Denver (1)
United States (9) · Belgium (4) · Canada (3) · China (1) · Netherlands (1) · Puerto Rico (1)
Pieter De Cock, Prof (2) · Aaron M Cook, PharmD (1) · Annick de Jaeger, MD (1) · Brenda de Winter, PharmD (1) · Dale N Gerding, MD (1) · Jingyuan Xu, PHD. (1) · Matthew Semler, MD, MSc (1) · Melanie Dispenza, MD, PhD (1) · Melissa Brooks-Peterson, MD (1) · Pieter De Cock (1) · Ryan E Medas, PharmD (1) · Sagori Mukhopadhyay, MD, MMSc (1) · Stuart B. Johnson, MD BA (1) · Terry A Clyburn, MD (1)
PMID 26349821, PMID 27999035, PMID 33030704, PMID 35426861, PMID 39800394, PMID 40239747, PMID 41974145
R21AI176298 (1), R21AI182531 (1), T32HD087969 (1)