4 completed, 2 terminated, 2 withdrawn, 1 unknown. 9 Phase 2, 3 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 9 | Completed 4, Terminated 2, Withdrawn 2, Unknown 1 |
| Phase 1 | 3 | Withdrawn 2, Unknown 1 |
Follow Toxemia: new trials by email Literature Review of Toxemia trials Research Report on Toxemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Treatment of Septic Shock by Inhibiting Autodigestion and Preserving Gut Integrity With Enteric LB1148 LB1148, Placebo - Septic Shock | Phase 2 | Terminated | Leading BioSciences, Inc | 8 | 2015-04-01 | 2020-06-01 |
| Effect of Citrulline on the Clinical and Biochemical Evolution of Patients With Sepsis. Citrulline malate - Sepsis | Phase 1 / Phase 2 | Unknown | Instituto Mexicano del Seguro Social | 160 | 2014-11-01 | 2015-08-28 |
| The Effect of a Bifidobacterium and Polydextrose on Body Fat Mass Bifidobacterium animalis ssp. lactis 420, Polydextrose, Placebo - Obesity, Hyperglycemia | Phase 2 | Completed | Danisco | 225 | 2013-11-01 | 2016-02-02 |
| A Study on the Tolerability and Early Efficacy of hLF1-11 in Patients With Bacteremia Due to S. Epidermidis human lactoferrin peptide 1-11 - Staphylococcal Infections, Bacteremia | Phase 1 / Phase 2 | Withdrawn | AM-Pharma | 2009-02-01 | 2014-05-28 | |
| Evaluation of Corticosteroid Therapy in Childhood Severe Sepsis - a Randomised Pilot Study hydrocortisone - Sepsis | Phase 2 | Completed | University Hospital Southampton NHS Foundation Trust | 21 | 2008-04-01 | 2016-05-06 |
| Lipid Infusion in Dialysis Patients With Endotoxemia Lipidose, Placebo - Fatigue, End Stage Renal Disease (ESRD) | Phase 2 | Completed | Sepsicure | 22 | 2007-08-01 | 2011-09-20 |
| CTI-01 (Ethyl Pyruvate) Safety and Complication Prevention in Cardiac Surgery Patients on Cardiopulmonary Bypass (CPB) CTI-01 (ethyl pyruvate) - Coronary Disease, Heart Valve Diseases | Phase 2 | Terminated | Critical Therapeutics | 150 | 2005-04-01 | 2006-03-17 |
| Treatment Targets for Chronic Hypertension in Pregnancy methyldopa, labetalol, nifedipine - Pregnancy Toxemia, Hypertension | Phase 1 / Phase 2 | Withdrawn | Weill Medical College of Cornell University | 2004-07-01 | 2017-01-30 | |
| A Safety and Efficacy Study of Intravenous E5564 in Patients With Severe Sepsis E5564 - Sepsis, Shock, Septic | Phase 2 | Completed | Eisai Inc. | 300 | 2001-10-01 | 2005-12-12 |
Endotoxemia (4) · Sepsis (4) · Infections (2) · Shock (2) · Shock, Septic (2) · Systemic Inflammatory Response Syndrome (2) · Bacteremia (1) · Coronary Disease (1) · Fatigue (1) · Heart Valve Diseases (1) · Hyperglycemia (1) · Hyperlactatemia (1) · Hypertension (1) · Inflammation (1)
Pathological Conditions, Signs and Symptoms (9) · Pathologic Processes (8) · Infections (7) · Inflammation (7) · Systemic Inflammatory Response Syndrome (6) · Bacteremia (4) · Sepsis (4) · Signs and Symptoms (4) · Cardiovascular Diseases (2) · Female Urogenital Diseases (2) · Female Urogenital Diseases and Pregnancy Complications (2) · Male Urogenital Diseases (2) · Metabolic Diseases (2) · Nutritional and Metabolic Diseases (2)
20-aldehyde leukotriene B4 (1) · Citrulline (1) · Clonidine (1) · E5564 (1) · Hydrocortisone (1) · Labetalol (1) · Methyldopa (1) · Nifedipine (1) · Tranexamic Acid (1) · citrulline malate (1) · ethyl pyruvate (1) · hydrocortisone hemisuccinate (1) · lactoferrin (1-11), human (1) · microcrystalline cellulose (1) · polydextrose (1)
AM-Pharma (1) · Critical Therapeutics (1) · Danisco (1) · Eisai Inc. (1) · Instituto Mexicano del Seguro Social (1) · Leading BioSciences, Inc (1) · Sepsicure (1) · University Hospital Southampton NHS Foundation Trust (1) · Weill Medical College of Cornell University (1)
United States (5) · Canada (1) · Finland (1) · Mexico (1) · Netherlands (1) · United Kingdom (1)
Aila Rissanen, MD (1) · Alec Wittek, M.D. (1) · Andrew Wolf, MBBChir MD (1) · Carrol Gamble, PhD (1) · Diana M Gibb, MBChB MD (1) · Eduardo Almeida Gutierrez, MSc (1) · John V Pappachan, MB BChir (1) · Michael Levin, MBBCH PhD (1) · Phyllis August, MD MPH (1) · Professor P.E. Verweij, MD, PhD (1) · Robert S Heyderman, MBBS PhD (1) · Roxana Bologa, MD (1) · Sarah Walker, MA PhD (1) · Saul N Faust, MBBS PhD (1) · Simon Nadel, MB BS (1)
PMID 17662768, PMID 19056593, PMID 19105791, PMID 20084502, PMID 22666356, PMID 23327349, PMID 23509945, PMID 23612995, PMID 23782971, PMID 27810310, PMID 30525950