9 completed, 5 unknown, 3 withdrawn, 1 recruiting. 7 Phase 4, 5 Not applicable, 3 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 7 | Unknown 4, Completed 2, Recruiting 1 |
| Not applicable | 5 | Completed 3, Unknown 1, Withdrawn 1 |
| Phase 1 | 3 | Completed 2, Withdrawn 1 |
| Phase 2 | 3 | Withdrawn 2, Completed 1 |
Follow Methyldopa: new trials by email Literature Review of Methyldopa trials Research Report on Methyldopa
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| NICardipine for Fast Achievement of Systolic BP Targets in ICH Nicardipine, Glyceryl trinitrate - Intracerebral Haemorrhage | Phase 4 | Recruiting | Aarhus University Hospital | 88 | 2025-10-01 | 2026-06-24 |
| Effect of Pilates Exercise Versus Circuit Exercise Training on Gestational Hypertension Anti-hypertensive drug (Methyldopa 250 mg), Pilates exercise, Circuit exercise training - Gestational Hypertension | Not applicable | Completed | Cairo University | 69 | 2024-09-30 | 2025-12-19 |
| Effect of Foot Reflexology on Preeclampsia methyldopa tablets 250mg, methyldopa tablets 250mg + foot reflexology - Mild Pre-eclampsia | Not applicable | Unknown | Cairo University | 60 | 2023-06-09 | 2023-09-21 |
| Management of Hypertension in the Early Postpartum: a Randomized Controlled Trial Methyldopa 250 MG - Pregnancy-Induced Hypertension in Postpartum, Postpartum Pre-Eclampsia | Phase 4 | Completed | Federal University of Paraíba | 180 | 2021-05-01 | 2023-12-28 |
| Methyldopa for Reduction of DQ8 Antigen Presentation in At-Risk Subjects for Type 1 Diabetes Methyldopa, Placebo - Type1 Diabetes Mellitus | Phase 2 | Withdrawn | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 2020-09-01 | 2020-06-30 | |
| ACEI or ARB and COVID-19 Severity and Mortality in US Veterans ACEI/ARB, Non-ACEI/ARB, ACEI - Hypertension, COVID | Completed | University of Utah | 22213 | 2020-01-19 | 2021-04-28 | |
| Clinical Bioequivalence Study on Two Methyldopa Tablet 250mg Formulations BF-Methyldopa 250mg Tablet, Metopa Tab 250mg - Healthy | Phase 1 | Completed | Bright Future Pharmaceuticals Factory O/B Bright Future Pharmaceutical Laboratories Limited | 17 | 2017-09-20 | 2018-01-18 |
| Oral Antihypertensive Regimens for Management of Hypertension in Pregnancy Nifedipine, Labetalol, Methyldopa - Hypertension in Pregnancy, Preeclampsia | Phase 4 | Completed | Gynuity Health Projects | 894 | 2015-04-01 | 2018-11-08 |
| Early Vascular Adjustments During Hypertensive Pregnancy Labetalol, Nifedipine, Methyldopa - Hypertension, Pregnancy-Induced, Pre-Eclampsia | Phase 4 | Unknown | Maastricht University Medical Center | 368 | 2015-01-01 | 2021-03-24 |
| Community Level Interventions for Pre-eclampsia Community Engagement, PIERS on the Move mHealth decision aid, Magnesium Sulfate - Pre-eclampsia, Hypertension, Pregnancy Induced | Not applicable | Completed | University of British Columbia | 87500 | 2013-09-01 | 2019-06-27 |
| Effect of Methyldopa on MHC Class II Antigen Presentation in Type 1 Diabetes Methyldopa - Diabetes Mellitus, Type 1 | Not applicable | Completed | University of Colorado, Denver | 30 | 2013-06-01 | 2022-01-18 |
| Effect of Renin-angiotensin System Blockers on Glomerular Filtration Rate in Patients With Hypertension, Type 2 Diabetes With Normoalbuminuria Renin-angiotensin system blockers, non-renin angiotensin system blockers - Diabetes, Hypertensive Disease | Phase 4 | Unknown | Hospital Authority, Hong Kong | 1400 | 2011-11-01 | 2016-09-05 |
| Effect of Methyldopa on Uterine Artery Diameter in Pregnant Women With Mild Preeclampsia Methyldopa, Placebo - Pregnant Women With Mild Preeclampsia | Phase 2 | Completed | Isfahan University of Medical Sciences | 50 | 2011-08-01 | 2012-08-28 |
| Anti-Hypertensive Treatment In Stable Pregnant Women With Severe Pre-Eclampsia (Metildopape) methildopa, placebo - Preeclampsia | Phase 4 | Unknown | Professor Fernando Figueira Integral Medicine Institute | 200 | 2011-05-01 | 2011-05-30 |
| Autonomic Nervous System and Chronic Fatigue Syndrome Autonomic Function Testing, Saline infusions, L-NMMA trimethaphan - Chronic Fatigue Syndrome, Orthostatic Intolerance | Phase 1 | Completed | Vanderbilt University | 170 | 2007-04-01 | 2017-01-18 |
| Cardiovascular and Autonomic Reactivity in Women With a History of Pre-eclampsia alpha methyldopa - Preeclampsia | Phase 4 | Unknown | Radboud University Medical Center | 35 | 2005-09-01 | 2010-06-08 |
| A Comparison of Compliance Between Clonidine Patch and Methyldopa for the Treatment of Chronic Hypertension in Pregnancy methyldopa vs. clonidine, clonidine patch - Hypertension | Not applicable | Withdrawn | Afshan B. Hameed, M.D. | 2004-09-01 | 2018-01-30 | |
| Treatment Targets for Chronic Hypertension in Pregnancy methyldopa, labetalol, nifedipine - Pregnancy Toxemia, Hypertension | Phase 1 / Phase 2 | Withdrawn | Weill Medical College of Cornell University | 2004-07-01 | 2017-01-30 |
Hypertension (7) · Pre-Eclampsia (6) · Hypertension, Pregnancy-Induced (4) · Diabetes Mellitus (2) · Cerebral Hemorrhage (1) · Diabetes Mellitus, Type 1 (1) · Eclampsia (1) · Fatigue Syndrome, Chronic (1) · Maternal Death (1) · Orthostatic Intolerance (1) · Patient Compliance (1) · Postural Orthostatic Tachycardia Syndrome (1) · Proteinuria (1) · Toxemia (1)
Cairo University (2) · Aarhus University Hospital (1) · Afshan B. Hameed, M.D. (1) · Bright Future Pharmaceuticals Factory O/B Bright Future Pharmaceutical Laboratories Limited (1) · Federal University of Paraíba (1) · Gynuity Health Projects (1) · Hospital Authority, Hong Kong (1) · Isfahan University of Medical Sciences (1) · Maastricht University Medical Center (1) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (1) · Professor Fernando Figueira Integral Medicine Institute (1) · Radboud University Medical Center (1) · University of British Columbia (1) · University of Colorado, Denver (1) · University of Utah (1)
United States (5) · Brazil (2) · Egypt (2) · India (2) · Netherlands (2) · China (1) · Denmark (1) · Hong Kong (1) · Mozambique (1) · Nigeria (1) · Pakistan (1)
Aaron Michels, MD (1) · Abeer Mohamed Eldeeb, PhD (1) · Adam P Bress, PharmD, MS (1) · Afshan B Hameed, MD (1) · Andre Telis Araujo, PhD (1) · Brian Tomlinsion (1) · Carla Greenbaum, MD (1) · Doaa A. Osman, PhD (1) · Hillary Bracken, PhD (1) · Hossam E. Hussein, PhD (1) · Ineke Krabbendam, MD (1) · Italo Biaggioni, MD (1) · Luiz Aparecido Bortolotto, PhD (1) · Marc Spaanderman, professor (1) · Melania M Amorim, PHD (1)
PMID 21906029, PMID 26007682, PMID 27356502, PMID 27356754, PMID 27356863, PMID 27356968, PMID 27357579, PMID 27357695, PMID 27357840, PMID 27358068, PMID 27719673, PMID 27719677, PMID 27719678, PMID 27719680, PMID 27719681, PMID 28107350, PMID 28351355, PMID 29438107, PMID 30694829, PMID 30782892, PMID 30978179, PMID 31378394, PMID 32013994, PMID 33308198, PMID 33891615, PMID 34031134, PMID 34237265, PMID 34326995, PMID 36600428, PMID 37872504, PMID 42234864
UC4DK106993 (1), UC4DK117009 (1)