78 completed, 14 recruiting, 12 unknown, 8 terminated. 59 Not applicable, 30 Phase 2, 23 Phase 1, 14 Phase 3, 11 Phase 4.
Follow microcrystalline cellulose: new trials by email Literature Review of microcrystalline cellulose trials Research Report on microcrystalline cellulose
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pycnogenol (French Maritime Pine Bark) for the Treatment of Gulf War Illness Placebo, Pycnogenol, 100mg, Pycnogenol, 200mg - Gulf War Syndrome | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 20 | 2026-11-01 | 2026-09-21 |
| Creatine and Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation Plus Home-Based Exercise for Sarcopenia in Huntington's Disease Creatine monohydrate, Beta-hydroxy-beta-methylbutyrate (HMB), Placebo (microcrystalline cellulose) - Huntington Disease, Sarcopenia | Not applicable | Not yet recruiting | Universidad de Burgos | 88 | 2026-11-01 | 2026-10-28 |
| ProGo Menopause Wellbeing Study Salmon protein hydrolysate (SPH) powder formulated into a tablet format, Microcrystalline Cellulose - Menopause Related Conditions | Not applicable | Not yet recruiting | Hofseth Biocare ASA | 100 | 2026-10-01 | 2026-09-03 |
| Creatine Supplementation in Pediatric Brain Injury Creatine monohydrate, Microcrystalline Cellulose - Brain Injury, Traumatic Brain Injury | Not applicable | Not yet recruiting | Spaulding Rehabilitation Hospital | 46 | 2026-10-01 | 2026-08-10 |
| Magnesium Supplementation in Advanced Non-small Cell Lung Cancer (NSCLC) Magnesiocard, Magnesium Diasporal, Microcrystalline cellulose - Metastatic NSCLC - Non-Small Cell Lung Cancer | Phase 2 / Phase 3 | Recruiting | Swiss Cancer Institute | 230 | 2026-09-29 | 2026-10-28 |
| Low Dose Naltrexone Use in Patients With POTS Low Dose Naltrexone, Microcrystalline cellulose - Postural Orthostatic Tachycardia Syndrome | Phase 4 | Not yet recruiting | University of Calgary | 80 | 2026-07-01 | 2026-05-01 |
| Magnesium Bisglycinate in Major Depressive Disorder Magnesium Bisglycinate, Microcrystalline cellulose - Major Depressive Disorder | Not applicable | Recruiting | All India Institute of Medical Sciences, Bhubaneswar | 84 | 2026-06-12 | 2026-06-15 |
| Mitigating Delirium With Fluvoxamine Treatment for Non-Cardiac Surgery Fluvoxamine, Placebo - Delirium, Surgery-Complications | Phase 3 | Recruiting | Washington University School of Medicine | 46 | 2026-04-06 | 2026-04-29 |
| Acute Effects of Alpha-glycerylphosphorylcholine (A-GPC) on Lower Body Muscular Performance. L-Alpha glycerylphosphorylcholine, Microcrystalline Cellulose - Healthy Adult Participants | Not applicable | Not yet recruiting | Northern Illinois University | 20 | 2026-03-16 | 2026-02-09 |
| Glucose Tolerance Study TRPTI 150mg, TRPTI 300mg, Placebo - Healthy Volunteers, Glucose Tolerance | Phase 2 | Completed | RDC Clinical Pty Ltd | 19 | 2026-03-11 | 2026-04-28 |
| Effect of Daily Humiome® Post LB Intake on Wellbeing in Older Individuals With Moderate Stress Levels Humiome Post LB, Microcrystalline Cellulose - Stress | Not applicable | Recruiting | dsm-firmenich Switzerland AG | 200 | 2026-01-01 | 2026-09-02 |
| Effects of Vitamin B12 and Natural Orange Extract, and Their Combination on Physical and Mental Performance Vitamin B 12, Natural orange extract, Vitamina B12 + natural orange extract - Vitamin b12, Supplementation During Endurance Performance | Not applicable | Enrolling by invitation | Francisco Javier Martínez Noguera | 20 | 2025-12-01 | 2026-01-14 |
| Short-Chain Fatty Acids in Lypopolysaccharide-Induced Inflammation and Executive Function Short-Chain Fatty Acid Colon-Delivery Capsules, Placebo capsules, Lipopolysaccharide (LPS) - Endotoxemia, Inflammation | Not applicable | Recruiting | Universitaire Ziekenhuizen KU Leuven | 56 | 2025-10-24 | 2026-07-20 |
| The Effect of α-GPC on Cognitive Function and Sports Performance Alpha-Glycerophosphocholine（α-GPC）, Microcrystalline Cellulose (placebo) - Healthy Participants | Not applicable | Recruiting | Nanjing Nutrabuilding Bio-tech Co., Ltd. | 80 | 2025-10-21 | 2025-12-09 |
| Oral Supplementation With 1 mg of KGA-10 Daily (a Novel Environmentally-derived Mycolicibacterium) for Stress, Sleep, and Inflammation Mycolicibacterium petrae KGA-10 (heat-killed), Placebo (microcrystalline cellulose) - Stress Resilience, Systemic Inflammation | Not applicable | Completed | Kioga Inc. | 107 | 2025-08-14 | 2026-05-26 |
| Study Evaluating the Effect of Humiome® Post LB on Stress, Anxiety, and Cognition in Aging Adults Humiome Post LB (Postbiotic), Placebo - Healthy Aging | Not applicable | Recruiting | dsm-firmenich Switzerland AG | 236 | 2025-08-01 | 2026-03-11 |
| Colon-delivered Riboflavin and Gut Microbiota Composition Colon-delivered riboflavin, Conventional riboflavin, Microcrystalline Cellulose - Microbiome Dysbiosis, Gut Health | Not applicable | Recruiting | dsm-firmenich Switzerland AG | 90 | 2025-07-18 | 2026-03-19 |
| Safety and Tolerability of Oral Supplementation With 1 mg of KGA-10 Daily (a Novel Environmentally-derived Mycolicibacterium) - a Pilot Study Heat-killed Mycolicibacterium petrae KGA-10 (NeuroAlly), Placebo (microcrystalline cellulose) - Safety, Tolerability | Not applicable | Completed | Kioga Inc. | 8 | 2025-07-07 | 2026-06-22 |
| A Study to Assess the Effect Probiotic Supplement on Immune Health in Teachers Prone to Upper Respiratory Tract Infection Propionibacterium freudenreichii P.UF1, Microcrystalline cellulose, calciumcarbonate, Mg Stearate, Sylysia - URTI - Viral Upper Respiratory Tract Infection | Not applicable | Not yet recruiting | Vedic Lifesciences Pvt. Ltd. | 100 | 2025-06-25 | 2025-06-24 |
| Personalized Anti-Inflammatory Fibres in Ulcerative Colitis Acacia Gum, Microcrystalline Cellulose, Placebo - Ulcerative Colitis | Not applicable | Recruiting | University of Alberta | 69 | 2025-06-03 | 2026-06-05 |
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Inflammation (7) · COVID-19 (6) · Diabetes Mellitus, Type 2 (5) · Insulin Resistance (5) · Diabetes Mellitus (4) · Obesity (4) · Osteoarthritis, Knee (4) · Sarcopenia (4) · Brain Injuries, Traumatic (3) · Depression (3) · Depressive Disorder, Major (3) · Hypertension (3) · Stroke (3) · Anemia, Sickle Cell (2) · Bone Diseases, Metabolic (2)
Vedic Lifesciences Pvt. Ltd. (13) · Tufts University (5) · RDC Clinical Pty Ltd (4) · dsm-firmenich Switzerland AG (4) · Danisco (3) · Washington University School of Medicine (3) · Brightseed (2) · Columbia University (2) · Coordinación de Investigación en Salud, Mexico (2) · Deborah Yurgelun-Todd (2) · Dent Neuroscience Research Center (2) · Kioga Inc. (2) · Temple University (2) · University of Alberta (2) · University of British Columbia (2)
United States (52) · India (15) · Canada (7) · United Kingdom (6) · Germany (5) · Australia (4) · Finland (4) · South Korea (4) · Mexico (3) · Spain (3) · Brazil (2) · Denmark (2) · France (2) · Ireland (2) · Netherlands (2)
Amanda Rao, PhD (3) · Bess Dawson-Hughes, MD (3) · Dr Shalini Srivastava, MD medicine (3) · Craig A Buchman, MD, FACS (2) · Lixin Zhang, MD, PhD (2) · Adele Costabile (1) · Aila Rissanen, MD (1) · Aline M de Abreu, MSc (1) · Alison Oliveto, PhD (1) · Anne Lithonius (1) · Anneli Tarpila, PhD (1) · Arya Mani, MD (1) · Ben Palanca, MD (1) · Boushra Dalile, PhD (1)
PMID 11522739, PMID 1428296, PMID 15139502, PMID 15920188, PMID 18319309, PMID 18465717, PMID 18940881, PMID 19727904, PMID 19856249, PMID 20339920, PMID 21046483, PMID 21896936, PMID 21969011, PMID 22025377, PMID 22238745, PMID 23034474, PMID 23199039, PMID 23227981, PMID 24067405, PMID 24277765, PMID 25027582, PMID 25533534, PMID 25755837, PMID 26312614, PMID 26437709, PMID 26543027, PMID 27363506, PMID 27466607, PMID 27810310, PMID 28791566, PMID 2884855, PMID 29078780, PMID 29229209, PMID 29234916, PMID 29659956, PMID 29856651, PMID 30525950, PMID 30593980, PMID 30649227, PMID 30967436, PMID 31071719, PMID 31529056, PMID 32283645, PMID 32410951, PMID 32532654, PMID 32564244, PMID 33001556, PMID 33281447, PMID 33627334, PMID 33870484
2017 (2), P30AG028740 (2), 3UH3DK114920-04S2 (1), P50NS049060 (1), R01AG055443 (1), R01AR052322 (1), R01CA225716 (1), R21AG050850 (1), R21AG086855 (1), R21AR074138 (1), R21DA035325 (1), R44AA024905 (1), R44DA018515 (1), U01DA048517 (1), UL1TR001412 (1)