10 completed, 2 recruiting, 2 withdrawn, 1 unknown. 15 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 15 | Completed 10, Recruiting 2, Withdrawn 2, Unknown 1 |
| Phase 2 | 3 | Withdrawn 2, Unknown 1 |
Follow Toxemia: new trials by email Literature Review of Toxemia trials Research Report on Toxemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Investigate the Safety, Pharmacodynamic and Pharmacokinetic Characteristics of CBP-4888 in Hospitalized Participants With Preterm Preeclampsia and Their Children up to 24 Months CBP-4888 - sFlt1 Mediated Preterm Preeclampsia, Preeclampsia | Phase 1 | Recruiting | Comanche Biopharma | 60 | 2025-02-26 | 2026-05-18 |
| NADPH Oxidase Correction in mRNA-transfected Granulocyte-enriched Cells in Chronic Granulomatous Disease (CGD) gp91 Grans - Chronic Granulomatous Disease, Infection | Phase 1 | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 25 | 2022-07-22 | 2026-11-09 |
| Prevention of Sepsis-related Organ Dysfunction With Allocetra-OTS Allocetra-OTS - Organ Dysfunction Syndrome Sepsis | Phase 1 | Completed | Enlivex Therapeutics Ltd. | 10 | 2019-01-27 | 2020-05-19 |
| PK/PD of EA-230 During Endotoxemia EA-230, Endotoxin, Placebo - Endotoxemia, Systemic Inflammatory Response | Phase 1 | Completed | Radboud University Medical Center | 60 | 2015-02-01 | 2016-06-23 |
| Effect of Citrulline on the Clinical and Biochemical Evolution of Patients With Sepsis. Citrulline malate - Sepsis | Phase 1 / Phase 2 | Unknown | Instituto Mexicano del Seguro Social | 160 | 2014-11-01 | 2015-08-28 |
| Safety and Tolerability of Ceftazidime-Avibactam for Pediatric Patients With Suspected or Confirmed Infections CAZ-AVI - Systemic Infections | Phase 1 | Completed | Pfizer | 35 | 2013-07-01 | 2017-09-06 |
| Pharmacokinetics (PK) of Antistaphylococcal Antibiotics in Infants (NICHD-2012-02-Staph Trio) Antibiotic - Systemic Infection | Phase 1 | Completed | Phillip Brian Smith | 63 | 2013-01-01 | 2023-07-27 |
| A Study on the Tolerability and Early Efficacy of hLF1-11 in Patients With Bacteremia Due to S. Epidermidis human lactoferrin peptide 1-11 - Staphylococcal Infections, Bacteremia | Phase 1 / Phase 2 | Withdrawn | AM-Pharma | 2009-02-01 | 2014-05-28 | |
| A Possible Therapeutic Role for Adenosine During Inflammation AMPD1 polymorphism, Caffeine infusion, placebo - Endotoxemia | Phase 1 | Completed | Radboud University Medical Center | 33 | 2007-08-01 | 2009-10-01 |
| Anti-Inflammatory Effect of Statins in the Human Endotoxin Model LPS 2ng/kg intravenous bolus, Simvastatin 80mg; administered daily p.o. over 5 days, Rosuvastatin 40mg; administered daily p.o. over 5 days - Endotoxemia | Phase 1 | Completed | Medical University of Vienna | 6 | 2006-03-01 | 2007-01-05 |
| Ethnic Differences in the Inflammatory Response in Systemic Inflammation LPS - Endotoxemia | Phase 1 | Completed | Medical University of Vienna | 32 | 2006-01-01 | 2006-09-13 |
| Pathophysiology and Clinical Relevance of Endotoxin Tolerance in Humans repeated injections of endotoxin during 5 days - Endotoxemia | Phase 1 | Completed | Radboud University Medical Center | 16 | 2005-10-01 | 2008-04-15 |
| Effect of Selective iNOS Inhibition During Human Endotoxemia Aminoguanidine, endotoxin - Endotoxemia | Phase 1 | Completed | Radboud University Medical Center | 7 | 2005-01-01 | 2008-04-15 |
| Treatment Targets for Chronic Hypertension in Pregnancy methyldopa, labetalol, nifedipine - Pregnancy Toxemia, Hypertension | Phase 1 / Phase 2 | Withdrawn | Weill Medical College of Cornell University | 2004-07-01 | 2017-01-30 | |
| Blockade of Vascular Potassium Channels During Human Endotoxemia endotoxin, Potassium channel blockers: TEA, Quinin, Tolbutamide, L-NMMA - Endotoxemia | Phase 1 | Completed | Radboud University Medical Center | 36 | 2003-01-01 | 2008-10-17 |
Endotoxemia (7) · Pre-Eclampsia (2) · Bacteremia (1) · Granulomatous Disease, Chronic (1) · Hypertension (1) · Infections (1) · Inflammation (1) · Primary Immunodeficiency Diseases (1) · Proteinuria (1) · Sepsis (1) · Staphylococcal Infections (1)
Infections (14) · Pathological Conditions, Signs and Symptoms (11) · Pathologic Processes (10) · Systemic Inflammatory Response Syndrome (9) · Inflammation (8) · Sepsis (8) · Bacteremia (7) · Female Urogenital Diseases and Pregnancy Complications (2) · Hypertension, Pregnancy-Induced (2) · Pregnancy Complications (2) · Urogenital Diseases (2) · Bacterial Infections (1) · Bacterial Infections and Mycoses (1) · Cardiovascular Diseases (1)
Endotoxins (3) · Lipopolysaccharides (2) · Anti-Bacterial Agents (1) · Citrulline (1) · Clonidine (1) · Labetalol (1) · Methyldopa (1) · Nifedipine (1) · Tolbutamide (1) · alanyl-glutaminyl-glycyl-valine (1) · citrulline malate (1) · lactoferrin (1-11), human (1) · omega-N-Methylarginine (1) · pimagedine (1)
Radboud University Medical Center (5) · Medical University of Vienna (2) · AM-Pharma (1) · Comanche Biopharma (1) · Enlivex Therapeutics Ltd. (1) · Instituto Mexicano del Seguro Social (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Pfizer (1) · Phillip Brian Smith (1) · Weill Medical College of Cornell University (1)
Netherlands (5) · United States (4) · Austria (2) · Australia (1) · Israel (1) · Mexico (1)
Christa Firbas, MD (1) · Dror Mevorach, Prof (1) · Eduardo Almeida Gutierrez, MSc (1) · John Bradley, MD (1) · Michael Wolzt, MD (1) · P Pickkers, MD, Prof. (1) · Paul Newell, MBBS, MRCP (1) · Peter Pickkers, MD PhD (1) · Peter Pickkers, MD, PhD (1) · Peter Pickkers, MD,PhD (1) · Peter Pickkers, PhD (1) · Philip B Smith, MD (1) · Phyllis August, MD MPH (1) · Professor P.E. Verweij, MD, PhD (1) · Suk S De Ravin, M.D. (1)
PMID 16864730, PMID 17662768, PMID 18433844, PMID 19056593, PMID 19105791, PMID 20084502, PMID 20444270, PMID 21211004, PMID 22666356, PMID 23327349, PMID 23509945, PMID 23612995, PMID 23782971, PMID 26926644, PMID 27503642, PMID 28137820, PMID 30710387, PMID 30910891, PMID 30919998, PMID 34659208, PMID 34687548, PMID 42418275