15 completed, 5 recruiting, 4 terminated, 3 active not recruiting. 13 Phase 2, 9 Not applicable, 7 Phase 1, 3 Phase 3, 1 Early Phase 1.
Follow Systemic Scleroderma: new trials by email Literature Review of Systemic Scleroderma trials Research Report on Systemic Scleroderma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Using AI-Assisted Cameras to Track Hand Exercises in Scleroderma Patients AI-powered, camera-based, exercise-focused telerehabilitation, Physiotherapist-supervised, exercise-focused rehabilitation - Systemic Scleroderma | Not applicable | Not yet recruiting | Istanbul University - Cerrahpasa | 40 | 2026-11-01 | 2026-10-14 |
| A Study to Test CRT-402 in Refractory Autoimmune Disease CRT-402 - Autoimmune Diseases, Systemic Lupus Erythematosus | Phase 1 / Phase 2 | Recruiting | Myeloid Therapeutics | 34 | 2026-08-26 | 2026-10-22 |
| Efficacy and Safety of Firsekibart in the Treatment of Systemic Sclerosis Firsekibart injection - Systemic Scleroderma | Not applicable | Not yet recruiting | Tongji Hospital | 30 | 2026-05-01 | 2026-04-20 |
| Characterization of Autoreactive b Lymphocytes in Autoimmune Diseases and Immune Deficiencies blood draw - Systemic Lupus Erythematosus, Systemic Scleroderma | Recruiting | University Hospital, Strasbourg, France | 200 | 2026-01-20 | 2026-08-20 | |
| Efficacy and Safety of Allogenic Cultured Adipose-derived Mesenchymal Stromal Cell Injections on MoUth Fibrosis and Handicap in Patients With Systemic sclEroderma AdMSC, Placebo - Systemic Scleroderma | Phase 2 | Not yet recruiting | University Hospital, Toulouse | 50 | 2026-01-01 | 2026-01-08 |
| Diffuse Cutaneous Scleroderma (DSSc) SFDI Study Spatial-frequency domain imaging (SFDI) - Systemic Scleroderma, Diffuse Cutaneous Scleroderma | Not applicable | Recruiting | Boston University | 65 | 2025-11-06 | 2026-07-23 |
| Familial Systemic Scleroderma Systemic Scleroderma | Recruiting | University Hospital, Strasbourg, France | 20 | 2025-09-02 | 2026-01-15 | |
| Safety and Efficacy of CD19 Targeted CAR-T Therapy for Refractory Autoimmune Disease CD19 targeted CAR-T cells - SLE (Systemic Lupus), Sjogren's Syndrome | Phase 1 | Unknown | Chongqing Precision Biotech Co., Ltd | 24 | 2023-08-31 | 2023-09-28 |
| Longitudinal Spatial Frequency Domain Imaging Study Spatial-frequency domain imaging (SFDI) - Systemic Scleroderma | Not applicable | Active not recruiting | Boston University | 78 | 2023-02-10 | 2026-01-14 |
| Clinical Study of Divozilimab in Patients With Systemic Scleroderma Divozilimab, Placebo - Systemic Scleroderma | Phase 3 | Active not recruiting | Biocad | 152 | 2022-12-26 | 2026-06-10 |
| TBI Using IMRT and Cyclophosphamide Prior to Stem Cell Transplant for the Treatment of Severe Systemic Sclerosis Allogeneic Hematopoietic Stem Cell Transplantation, Cyclophosphamide, Intensity-Modulated Radiation Therapy - Systemic Scleroderma | Early Phase 1 | Active not recruiting | City of Hope Medical Center | 15 | 2022-02-24 | 2026-08-27 |
| Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO Biospecimen Collection, Cabozantinib, Fluoropyrimidine - Autoimmune Disease, Crohn Disease | Phase 1 | Recruiting | National Cancer Institute (NCI) | 300 | 2019-07-16 | 2026-10-05 |
| Role of Eosinophil in Fibrogenesis of Systemic Sclerosis Blood test, Skin biopsies - Systemic Sclerosis, Systemic Scleroderma | Completed | University Hospital, Lille | 70 | 2018-10-03 | 2025-12-23 | |
| Microparticles's Role in the Pathophysiology of Systemic Lupus Erythematosus and Systemic Sclerosis blood sample, urine sample - Systemic Lupus Erythematosus, Systemic Scleroderma | Not applicable | Completed | University Hospital, Bordeaux | 208 | 2018-09-20 | 2026-05-14 |
| BIOLOGICAL EXPLORATION OF THE VASCULAR FRACTION FROM THE ADIPOSE TISSUE OF PATIENTS WITH SCLERODERMIA Study of the gene expression profile - Systemic Scleroderma | Unknown | Assistance Publique Hopitaux De Marseille | 30 | 2018-09-01 | 2018-08-14 | |
| Evaluation of the Serum Soluble Fractalkine as a Biomarker of Pulmonary Fibrosis in Systemic Sclerosis blood samples - Systemic Scleroderma | Not applicable | Unknown | Assistance Publique Hopitaux De Marseille | 75 | 2018-05-15 | 2019-06-19 |
| Clinical and Paraclinical Characteristics of the Systemic Scleroderma Cohort According to the Criteria ACR 2013 and the History of Professional Exposure or of Agricultural Environment Systemic Scleroderma | Completed | Rennes University Hospital | 327 | 2016-07-29 | 2022-04-04 | |
| Trial of Topical C-82 in Systemic Sclerosis - A Phase I/II Biomarker and Safety Trial C-82 Topical Gel, 1%, C-82 Topical Gel, Placebo - Systemic Scleroderma | Phase 1 / Phase 2 | Completed | Prism Pharma Co., Ltd. | 17 | 2015-06-01 | 2017-08-17 |
| Treatment of Refractory Sever Systemic Scleroderma by Injection of Allogeneic Mesenchymal Stem Cells INJECTION OF ALLOGENEIC MESENCHYMAL STEM CELLS - SYSTEMIC SCLERODERMA, ALLOGENEIC MESENCHYMAL STEM CELLS | Phase 1 / Phase 2 | Completed | Assistance Publique - Hôpitaux de Paris | 20 | 2014-05-06 | 2024-05-01 |
| Study of Pomalidomide (CC-4047) to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Effectiveness for Patients With Systemic Sclerosis With Interstitial Lung Disease Pomalidomide (CC-4047), Placebo - Scleroderma, Systemic, Sclerosis, Systemic | Phase 2 | Terminated | Celgene | 23 | 2012-08-09 | 2023-12-01 |
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Scleroderma, Systemic (34) · Scleroderma, Diffuse (7) · Lupus Erythematosus, Systemic (6) · Autoimmune Diseases (4) · Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (2) · Arthritis, Rheumatoid (2) · Dermatomyositis (2) · Sjogren's Syndrome (2) · Antiphospholipid Syndrome (1) · Arthritis, Psoriatic (1) · Blood Coagulation Disorders (1) · Colitis, Ulcerative (1) · Connective Tissue Diseases (1) · Crohn Disease (1) · Fibrosis (1)
Skin Diseases (34) · Skin and Connective Tissue Diseases (34) · Connective Tissue Diseases (33) · Immune System Diseases (8) · Musculoskeletal Diseases (4) · Arthritis (3) · Autoimmune Diseases (3) · Cardiovascular Diseases (3) · Joint Diseases (3) · Mouth Diseases (3) · Muscular Diseases (3) · Nervous System Diseases (3) · Neuromuscular Diseases (3) · Pathologic Processes (3) · Pathological Conditions, Signs and Symptoms (3)
Cyclophosphamide (4) · Blood Specimen Collection (3) · Mycophenolic Acid (3) · Stem Cell Transplantation (3) · Whole-Body Irradiation (3) · Bosentan (2) · Peripheral Blood Stem Cell Transplantation (2) · Rituximab (2) · Tacrolimus (2) · fludarabine phosphate (2) · Antilymphocyte Serum (1) · Biopsy (1) · Bone Marrow Transplantation (1) · CTLA-4 Antigen (1) · Filgrastim (1)
Assistance Publique - Hôpitaux de Paris (2) · Assistance Publique Hopitaux De Marseille (2) · Boston University (2) · Fred Hutchinson Cancer Center (2) · University Hospital, Lille (2) · University Hospital, Strasbourg, France (2) · Biocad (1) · Celgene (1) · Chongqing Precision Biotech Co., Ltd (1) · City of Hope Medical Center (1) · Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium (1) · GWT-TUD GmbH (1) · George Washington University (1) · Georgetown University (1) · Heinrich-Heine University, Duesseldorf (1)
France (13) · United States (13) · Germany (4) · Australia (2) · China (2) · Russia (2) · Canada (1) · Italy (1) · Poland (1) · Spain (1) · Switzerland (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Andreea Bujor, MD, PhD (2) · George Georges (2) · Adam Raff, MD, PhD (1) · Annegret Kuhn, MD (1) · Guillaume Lefevre, MD (1) · Hussein A Tawbi (1) · Jeffrey Y Wong (1) · Leona Holmberg (1) · Liyun Zhang, M.D (1) · Martin Aringer, Prof. (1) · Maureen Mayes (1) · Nicolas Hunzelmann (1)
PMID 16790698, PMID 17717203, PMID 17901414, PMID 18641099, PMID 19892673, PMID 21547897, PMID 21777972, PMID 22156609, PMID 24475856, PMID 25452309, PMID 25995322, PMID 26378033, PMID 26704522, PMID 26757749, PMID 27696703, PMID 28544580, PMID 29099620, PMID 29685482, PMID 30651141, PMID 31219594, PMID 33193304, PMID 34193612, PMID 35470301, PMID 35904231, PMID 36928395, PMID 39348419, PMID 39624016, PMID 41316297
P30CA015704 (2), 2005 (1), R01AI041721 (1), R01AR085317 (1), U01HL060839 (1), U54CA163438 (1), UM1CA186688 (1)