3 completed, 2 recruiting, 1 terminated, 1 unknown. 7 Phase 1, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 7 | Completed 3, Recruiting 2, Terminated 1, Unknown 1 |
| Phase 2 | 5 | Completed 3, Recruiting 1, Terminated 1 |
Follow Systemic Scleroderma: new trials by email Literature Review of Systemic Scleroderma trials Research Report on Systemic Scleroderma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Test CRT-402 in Refractory Autoimmune Disease CRT-402 - Autoimmune Diseases, Systemic Lupus Erythematosus | Phase 1 / Phase 2 | Recruiting | Myeloid Therapeutics | 34 | 2026-08-26 | 2026-10-22 |
| Safety and Efficacy of CD19 Targeted CAR-T Therapy for Refractory Autoimmune Disease CD19 targeted CAR-T cells - SLE (Systemic Lupus), Sjogren's Syndrome | Phase 1 | Unknown | Chongqing Precision Biotech Co., Ltd | 24 | 2023-08-31 | 2023-09-28 |
| Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO Biospecimen Collection, Cabozantinib, Fluoropyrimidine - Autoimmune Disease, Crohn Disease | Phase 1 | Recruiting | National Cancer Institute (NCI) | 300 | 2019-07-16 | 2026-11-12 |
| Trial of Topical C-82 in Systemic Sclerosis - A Phase I/II Biomarker and Safety Trial C-82 Topical Gel, 1%, C-82 Topical Gel, Placebo - Systemic Scleroderma | Phase 1 / Phase 2 | Completed | Prism Pharma Co., Ltd. | 17 | 2015-06-01 | 2017-08-17 |
| Treatment of Refractory Sever Systemic Scleroderma by Injection of Allogeneic Mesenchymal Stem Cells INJECTION OF ALLOGENEIC MESENCHYMAL STEM CELLS - SYSTEMIC SCLERODERMA, ALLOGENEIC MESENCHYMAL STEM CELLS | Phase 1 / Phase 2 | Completed | Assistance Publique - Hôpitaux de Paris | 20 | 2014-05-06 | 2024-05-01 |
| Effectiveness of UVA1-irradiation in the Treatment of Early Skin Fibrosis in Patients Suffering From Systemic Sclerosis UVA1 - Systemic Scleroderma, Systemic Sclerosis | Phase 1 / Phase 2 | Terminated | Nicolas Hunzelmann | 9 | 2008-02-01 | 2017-05-31 |
| Allogeneic Hematopoietic Cell Transplantation for Severe Systemic Sclerosis fludarabine phosphate, Mycophenolic Acid, tacrolimus - Systemic Scleroderma, Severe Systemic Sclerosis | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 3 | 2006-09-01 | 2018-06-04 |
Scleroderma, Systemic (7) · Lupus Erythematosus, Systemic (3) · Autoimmune Diseases (2) · Dermatomyositis (2) · Scleroderma, Diffuse (2) · Sjogren's Syndrome (2) · Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (1) · Arthritis, Psoriatic (1) · Arthritis, Rheumatoid (1) · Colitis, Ulcerative (1) · Crohn Disease (1) · Hematologic Neoplasms (1) · Inflammatory Bowel Diseases (1) · Multiple Sclerosis (1) · Myositis (1)
Connective Tissue Diseases (7) · Skin Diseases (7) · Skin and Connective Tissue Diseases (7) · Immune System Diseases (3) · Muscular Diseases (3) · Musculoskeletal Diseases (3) · Nervous System Diseases (3) · Neuromuscular Diseases (3) · Arthritis (2) · Dry Eye Syndromes (2) · Eye Diseases (2) · Joint Diseases (2) · Lacrimal Apparatus Diseases (2) · Mouth Diseases (2) · Myositis (2)
Biopsy (1) · Bone Marrow Transplantation (1) · CTLA-4 Antigen (1) · Flow Cytometry (1) · Ipilimumab (1) · Mycophenolic Acid (1) · Nivolumab (1) · Platinum Compounds (1) · Specimen Handling (1) · Stem Cell Transplantation (1) · Tacrolimus (1) · Transplantation (1) · Ultraviolet Rays (1) · Whole-Body Irradiation (1) · cabozantinib (1)
Assistance Publique - Hôpitaux de Paris (1) · Chongqing Precision Biotech Co., Ltd (1) · Fred Hutchinson Cancer Center (1) · Myeloid Therapeutics (1) · National Cancer Institute (NCI) (1) · Nicolas Hunzelmann (1) · Prism Pharma Co., Ltd. (1)
United States (3) · Australia (1) · Canada (1) · China (1) · France (1) · Germany (1)
Adam Raff, MD, PhD (1) · George Georges (1) · Hussein A Tawbi (1) · Liyun Zhang, M.D (1) · Nicolas Hunzelmann (1) · Robert Lafyatis, MD (1)
R01AI041721 (1), UM1CA186688 (1)