55 completed, 21 terminated, 5 active not recruiting, 5 recruiting. 62 Phase 2, 25 Phase 1, 14 Phase 3, 10 Not applicable, 1 Phase 4.
Follow Bone Marrow Transplantation: new trials by email Literature Review of Bone Marrow Transplantation trials Research Report on Bone Marrow Transplantation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ruxolitinib Based GVHD Prophylaxis Regimen Before, During, and After Hematopoietic Cell Transplantation in Older Adult Patients With Acquired Aplastic Anemia Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Aplastic Anemia | Phase 2 | Active not recruiting | Fred Hutchinson Cancer Center | 1 | 2025-09-25 | 2026-05-22 |
| A First-in-Human Study of HLA-Partially to Fully Matched Allogenic Cryopreserved Deceased Donor Bone Marrow Transplantation for Patients With Hematologic Malignancies Ossium HPC Marrow, Bone Marrow Transplant, Pre-transplant conditioning - Myeloablative (MAC), Pre-transplant conditioning - Reduced Intensity (RIC) - Acute Leukemia, Acute Lymphoblastic Leukemia | Phase 1 / Phase 2 | Active not recruiting | Ossium Health, Inc. | 12 | 2024-08-16 | 2026-09-10 |
| HPC Offered for PRESERVE Expansion Bone Marrow Transplant with Ossium's HPC, Marrow (bone marrow recovered from deceased organ and tissue donors) - Bone Marrow Transplant (BMT) | Recruiting | Ossium Health, Inc. | 10 | 2024-06-27 | 2025-08-28 | |
| Delayed Tolerance Through Mixed Chimerism Bone Marrow Transplant, Peripheral Blood Stem Cell Collection, Fludarabine - Kidney Failure, Kidney Transplant; Complications | Phase 1 / Phase 2 | Recruiting | Massachusetts General Hospital | 20 | 2023-10-01 | 2026-09-28 |
| CD34+ Enriched Transplants From HLA-Compatible Patients With Hematologic Malignancies CliniMACS, Bone Marrow Transplant, Hyperfractionated Total Body Irradiation - Hematologic Diseases, Hematologic Malignancy | Phase 2 | Withdrawn | Baptist Health South Florida | 2022-09-01 | 2022-09-27 | |
| Cryopreserved MMUD BM With PTCy for Hematologic Malignancies Cyclophosphamide, Fludarabine, Total Body Irradiation - Acute Leukemia, Myelodysplastic Syndromes | Phase 1 | Withdrawn | Ossium Health, Inc. | 2022-09-01 | 2026-02-24 | |
| Treosulfan-Based Conditioning Regimen Before a Blood or Bone Marrow Transplant for the Treatment of Bone Marrow Failure Diseases (BMT CTN 1904) Treosulfan, Fludarabine Phosphate, Tacrolimus - Bone Marrow Failure Syndrome, Congenital Amegakaryocytic Thrombocytopenia | Phase 2 | Completed | Fred Hutchinson Cancer Center | 40 | 2022-04-19 | 2026-03-09 |
| HIV Antigen-specific T-cells Targeting Conserved Epitopes (HST-NEETs) BMTCTN1903 HST-NEETs, Bone Marrow Transplant - HIV Associated Lymphoma | Phase 2 | Completed | Catherine Bollard | 12 | 2021-10-25 | 2026-06-29 |
| HLA-Mismatched Unrelated Donor Hematopoietic Cell Transplantation With Post-Transplantation Cyclophosphamide Busulfan, Fludarabine, Total-body irradiation - Acute Lymphoblastic Leukemia, Acute Myelogenous Leukemia | Phase 2 | Active not recruiting | Center for International Blood and Marrow Transplant Research | 300 | 2021-09-30 | 2026-03-18 |
| AflacLL1901 (CHOA-AML) Cytarabine, Daunorubicin, Erwinase - Acute Myeloid Leukemia, AML, Childhood | Phase 2 | Terminated | Emory University | 8 | 2020-01-24 | 2022-06-15 |
| Inotuzumab Ozogamicin and Chemotherapy in Treating Patients With Leukemia or Lymphoma Undergoing Stem Cell Transplantation Allogeneic Bone Marrow Transplantation, Bendamustine, Filgrastim-sndz - Acute Lymphoblastic Leukemia, B Acute Lymphoblastic Leukemia | Phase 2 | Terminated | M.D. Anderson Cancer Center | 15 | 2019-10-28 | 2026-04-15 |
| Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell Transplant Total-Body Irradiation, Thiotepa, Fludarabine - Acute Biphenotypic Leukemia, Acute Leukemia | Phase 2 | Active not recruiting | Fred Hutchinson Cancer Center | 45 | 2019-08-29 | 2026-09-25 |
| Transplantation for Patients With Sickle Cell Disease From Mismatched Family Donors of Bone Marrow Bone Marrow Transplant (BMT), Hydroxyurea, Thiotepa - Sickle Cell Disease | Phase 2 | Completed | Emory University | 10 | 2019-07-10 | 2023-10-12 |
| 211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome Astatine At 211 Anti-CD45 Monoclonal Antibody BC8-B10, Cyclophosphamide, Total-Body Irradiation - Acute Lymphoblastic Leukemia in Remission, Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome | Phase 1 / Phase 2 | Recruiting | Fred Hutchinson Cancer Center | 30 | 2019-07-10 | 2026-06-22 |
| Resiliency in Older Adults Undergoing Bone Marrow Transplant Bone Marrow Transplant (BMT) - Leukemia, Lymphoma | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 126 | 2018-09-28 | 2025-10-27 | |
| Autologous Stem Cell Transplant for Crohn's Disease Autologous stem cell transplant, Cyclophosphamide, Thymoglobulin - Crohn Disease | Phase 2 | Recruiting | Aaron Etra | 50 | 2018-02-22 | 2026-07-24 |
| HLA Haploidentical Bone Marrow Transplant in Patients With Severe Sickle Cell Disease bone marrow transplant - Sickle Cell Disease | Phase 2 | Completed | Centre Hospitalier Intercommunal Creteil | 25 | 2017-08-10 | 2025-09-02 |
| Reduced Intensity Conditioning Allogeneic Hematopoietic Stem Cell Transplant (HSCT) For Lymphoma Allogeneic stem cell transplantation, Fludarabine, Thiotepa - Lymphoma | Phase 1 / Phase 2 | Withdrawn | Massachusetts General Hospital | 2017-05-01 | 2017-03-22 | |
| Bone Marrow Transplantation vs Standard of Care in Patients With Severe Sickle Cell Disease (BMT CTN 1503) Busulfan, Fludarabine, r-ATG - Sickle Cell Disease | Phase 2 | Completed | Medical College of Wisconsin | 138 | 2017-03-16 | 2025-04-18 |
| Sex-Mismatched Allogeneic Bone Marrow Transplantation for Men With Metastatic Castration-Resistant Prostate Cancer Bone marrow transplantation, Cytoxan, testosterone cypionate - Prostate Cancer | Phase 1 | Terminated | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 3 | 2017-02-09 | 2024-02-13 |
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Leukemia, Myeloid, Acute (22) · Leukemia (21) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (18) · Myelodysplastic Syndromes (17) · Lymphoma (14) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (12) · Anemia, Sickle Cell (11) · Multiple Myeloma (10) · Hematologic Diseases (9) · Leukemia, Lymphocytic, Chronic, B-Cell (8) · Anemia, Aplastic (7) · Lymphoma, Non-Hodgkin (7) · Graft vs Host Disease (5) · Hematologic Neoplasms (5) · Hodgkin Disease (5)
Masonic Cancer Center, University of Minnesota (18) · M.D. Anderson Cancer Center (11) · Fred Hutchinson Cancer Center (9) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (6) · City of Hope Medical Center (4) · Emory University (3) · National Cancer Institute (NCI) (3) · National Institute of Allergy and Infectious Diseases (NIAID) (3) · Ossium Health, Inc. (3) · Massachusetts General Hospital (2) · Medical College of Wisconsin (2) · National Heart, Lung, and Blood Institute (NHLBI) (2) · OHSU Knight Cancer Institute (2) · St. Jude Children's Research Hospital (2) · Aaron Etra (1)
United States (83) · Brazil (2) · France (2) · Italy (2) · Argentina (1) · Australia (1) · Canada (1) · Denmark (1) · Egypt (1) · Germany (1) · Iran (1) · Israel (1) · Mexico (1) · Saudi Arabia (1) · Spain (1)
Margaret MacMillan, MD (4) · Paul Orchard, MD (4) · Richard E. Champlin, MD (3) · Daniel J. Weisdorf, MD (2) · Eneida Nemecek, MD (2) · Lakshmanan Krishnamurti, MD (2) · A Bacigalupo, Dr. (1) · A Bosi, Dr. (1) · A Ferrant, Dr (1) · A Gratwohl, Dr. (1) · A Nagler, Dr. (1) · A Zander, Dr (1) · A. Pagliuca, Dr. (1) · Aaron Etra, MD (1) · Adetola A Kassim, MD (1)
PMID 21586746, PMID 36240296, PMID 19179301, PMID 20117965, PMID 20233136, PMID 20383216, PMID 20818854, PMID 20946966, PMID 21403127, PMID 22430088, PMID 22829629, PMID 23656665, PMID 24370862, PMID 25778529, PMID 25824692, PMID 26416896, PMID 27482888, PMID 27625358, PMID 29353109, PMID 30637784, PMID 31401903, PMID 32343796, PMID 32499241, PMID 32683126, PMID 33049057, PMID 34312462, PMID 35820112, PMID 36402456, PMID 37877375, PMID 37883803, PMID 38493482, PMID 39471440, PMID 40523209, PMID 41671463, PMID 42049986, PMID 42448319, PMID 42616616
P01CA078902 (2), P30CA015704 (2), U10HL069294 (2), P01CA015396 (1), P01CA018029 (1), P01CA049639 (1), P01CA081403 (1), P01CA148600 (1), P30CA006973 (1), P30CA016672 (1), P30CA033572 (1), P50CA100632 (1), R01AI041721 (1), R34HL108761 (1), U01CA070095 (1)