26 completed, 7 unknown, 3 not yet recruiting, 3 recruiting. 20 Not applicable, 8 Phase 2, 4 Phase 3, 2 Phase 1, 1 Phase 4.
Follow Systemic Inflammation: new trials by email Literature Review of Systemic Inflammation trials Research Report on Systemic Inflammation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| REducing Systemic Inflammation With LOw-dose Colchicine to ImproVE Cardiovascular Calcification in Chronic Kidney Disease: A Pilot Randomized Open-Label Trial Low-dose Colchicine at 0.5mg daily, Usual Care - Chronic Kidney Disease Mineral and Bone Disorder, Cognitive Function | Phase 2 | Not yet recruiting | University of Texas Southwestern Medical Center | 60 | 2026-10-30 | 2026-11-04 |
| Inflammation and Diabetes: Evaluating Antioxidant Levels No Interventions - Diabete Mellitus, Diabete Type 2 | Not yet recruiting | Istanbul Bilgi University | 180 | 2026-07-15 | 2026-07-29 | |
| MIECC vs Conventional Cardiopulmonary Bypass and Systemic Inflammation in CABG Minimally Invasive Extracorporeal Circulation, Conventional Cardiopulmonary Bypass - Coronary Artery Disease, Systemic Inflammation | Completed | Bursa Yuksek Ihtisas Training and Research Hospital | 90 | 2026-02-07 | 2026-10-20 | |
| Effects of Dietary Supplementation With omega3-fatty Acids (Fish Oil) and Progressive Resistance Training on Skeletal Muscle Status in Gynaecological, Gastrointestinal and Urological Cancer Patients Omega 3 FA (Fish Oil), Training, Corn Oil Placebo, 4 capsules/day for 12 weeks - Cancer Cachexia, Omega 3 | Not applicable | Recruiting | University of Erlangen-Nürnberg Medical School | 288 | 2026-01-01 | 2026-06-11 |
| Assessing the Feasibility of Multi-modal Biosensing for Monitoring Mobility and Cognition in Older Adults Eutectogel Sensors and Microneedle Patches - Chronic Stress, Systemic Inflammation | Not yet recruiting | Tufts University | 20 | 2025-12-01 | 2025-10-20 | |
| Effects of the Dietary Inflammatory Index on Systemic Inflammation Markers and Gastrointestinal Symptoms in Individuals With Bariatric Surgery Observational Intervention, Observetional - Bariatric Surgery, Bariatric Sleeve Gastrectomy | Enrolling by invitation | Istanbul Bilgi University | 70 | 2025-12-01 | 2026-07-10 | |
| Effects of Spinal vs General Anesthesia on Systemic Inflammation in PCNL Anesthesia Techniques, Percutaneous Nephrolithotomy | Completed | Elazıg Fethi Sekin Sehir Hastanesi | 90 | 2025-11-07 | 2026-06-22 | |
| Oral Supplementation With 1 mg of KGA-10 Daily (a Novel Environmentally-derived Mycolicibacterium) for Stress, Sleep, and Inflammation Mycolicibacterium petrae KGA-10 (heat-killed), Placebo (microcrystalline cellulose) - Stress Resilience, Systemic Inflammation | Not applicable | Completed | Kioga Inc. | 107 | 2025-08-14 | 2026-05-26 |
| Fermented Milk Drink With Lacticaseibacillus Paracasei Strain Shirota Helps Triathletes With Cold-Like Symptoms Before and After a Race Intervention Name: Fermented milk containing Lacticaseibacillus paracasei strain Shirota. Intervention Name: Non-fermented milk (placebo), Non-fermented milk (placebo) - Respiratory Tract Infections (RTI), Mucosal Immunity | Not applicable | Completed | Federal University of São Paulo | 80 | 2025-08-13 | 2026-10-15 |
| Assessment of Metformin for Restoration of Immune Homeostasis in HIV+ and HIV- Individuals With a History of Injection Drug Use Metformin, Placebo, Jynneos - Systemic Inflammation, Immune Dysregulation | Phase 4 | Recruiting | University of Alabama at Birmingham | 100 | 2025-04-07 | 2026-04-22 |
| A Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation Ziltivekimab, Placebo - Heart Failure, Systemic Inflammation | Phase 3 | Active not recruiting | Novo Nordisk A/S | 673 | 2024-04-01 | 2026-10-01 |
| A Study to Understand the Real-world Awareness and Perceptions of Systemic inFLAMmation and rolE of hsCRP as a Biomarker in Patients With AtheroSclerotic CardioVascular Disease and Chronic Kidney Disease Among Nephrologists No treatment given - Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD) | Completed | Novo Nordisk A/S | 300 | 2024-03-26 | 2024-07-26 | |
| Timing of Oral Hygiene Improvement Relative to Subgingival Instrumentation Nonsurgical periodontal treatment - Periodontal Diseases Inflammation, Periodontal Disease | Not applicable | Completed | University of Ljubljana | 10 | 2023-12-01 | 2026-11-03 |
| Effects of Oral Supplement Containing L-Histidine and Antioxidants on the Skin Barrier Function and Systemic Inflammation in Rosacea Skin Barrier Oral Supplement - Rosacea, Systemic Inflammation | Not applicable | Unknown | Integrative Skin Science and Research | 24 | 2023-11-22 | 2024-08-27 |
| Immunotherapy for Neurological Post-Acute Sequelae of SARS-CoV-2 IV normal saline, IV immunoglobulin - Systemic Inflammation, Neuroinflammation | Phase 2 | Enrolling by invitation | National Institute of Neurological Disorders and Stroke (NINDS) | 45 | 2023-07-10 | 2026-11-10 |
| Anti-Inflammatory Effects of Time-Restricted Feeding Psoriasis, Systemic Inflammation | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 27 | 2021-06-09 | 2026-07-31 | |
| Yoghurt Supplementation In Critically Ill Adults Yoghurt - Critical Illness, Systemic Inflammation | Not applicable | Completed | All India Institute of Medical Sciences, Bhubaneswar | 12 | 2021-06-01 | 2026-09-10 |
| The Effect of Water With Anti-Inflammatory Capabilities on the Inflammatory Response to Heavy Resistance Exercise We made a water with berry essence volatiles (cranberry, blackberry, and blueberry). This was consumed for 6 weeks. - Systemic Inflammation, Hydration | Not applicable | Completed | University of Arkansas, Fayetteville | 40 | 2021-05-17 | 2026-03-06 |
| Individualized Medical Nutrition Therapy in Adults With Type 2 Diabetes Mellitus Intensive Medical Nutrition Therapy (MNT), Standard Dietary Counseling - Type 2 Diabetes Mellitus (T2DM), Systemic Inflammation | Not applicable | Completed | Serap Balaban Barta | 40 | 2020-12-15 | 2026-03-27 |
| Symbiotics and Systemic Inflammation in Chronic Kidney Disease probiotic Vivomixx®, prebiotic Orafti®Synergy1, Placebo - Chronic Renal Failure, Diabete Type 2 | Phase 2 | Unknown | Centre Hospitalier Universitaire de Besancon | 62 | 2020-11-21 | 2022-08-03 |
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Inflammation (11) · Diabetes Mellitus, Type 2 (3) · Sepsis (3) · Abscess (2) · Atherosclerosis (2) · Cellulitis (2) · Critical Illness (2) · Fatigue (2) · Obesity (2) · Periodontal Diseases (2) · Periodontitis (2) · Renal Insufficiency, Chronic (2) · Wound Infection (2) · Acute Coronary Syndrome (1) · Anxiety Disorders (1)
Pathological Conditions, Signs and Symptoms (24) · Pathologic Processes (21) · Infections (8) · Nutritional and Metabolic Diseases (7) · Cardiovascular Diseases (6) · Disease Attributes (6) · Inflammation (6) · Signs and Symptoms (6) · Skin and Connective Tissue Diseases (5) · Vascular Diseases (5) · Arterial Occlusive Diseases (4) · Arteriosclerosis (4) · Chronic Disease (4) · Endocrine System Diseases (4) · Metabolic Diseases (4)
Resveratrol (2) · Vancomycin (2) · Autopsy (1) · Blood Specimen Collection (1) · Bronchoscopy (1) · Docosahexaenoic Acids (1) · Endotoxins (1) · Fatty Acids, Omega-3 (1) · Fatty Acids, Omega-6 (1) · Fish Oils (1) · Immunoglobulins, Intravenous (1) · Linseed Oil (1) · Lipopolysaccharides (1) · Metformin (1) · Saline Solution (1)
Istanbul Bilgi University (2) · Melinta Therapeutics, Inc. (2) · Northumbria University (2) · Novo Nordisk A/S (2) · Simon Fraser University (2) · All India Institute of Medical Sciences, Bhubaneswar (1) · Alloksys Life Sciences B.V. (1) · Assistance Publique - Hôpitaux de Paris (1) · Baskent University (1) · Bursa Yuksek Ihtisas Training and Research Hospital (1) · Cardio Med Medical Center (1) · Centre Hospitalier Universitaire de Besancon (1) · Copenhagen University Hospital, Rigshospitalet (1) · Dr. Soetomo General Hospital (1) · Elazıg Fethi Sekin Sehir Hastanesi (1)
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G. Ralph Corey, MD (2) · Ryan Allen, PhD (2) · Amit Badhwar, PhD (1) · Ana Valdez, Dr (1) · Avindra Nath, M.D. (1) · Dominik Wiedemann, Prof.Dr. (1) · El-Wui Loh, PhD (1) · Emma L Wightman, Dr (1) · Emma Wightman, Dr (1) · Hande Seven Avuk, Ph.D. (1)
PMID 27370913, PMID 29358292, PMID 19173710, PMID 21257787, PMID 23742058, PMID 24667535, PMID 24897083, PMID 25294250, PMID 25896330, PMID 26511835, PMID 26538309, PMID 40815832, PMID 42459802
2023 (1), R01AG091766 (1), R01DA060692 (1)