20 completed. 20 Phase 2, 6 Phase 3, 4 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 20 | Completed 20 |
| Phase 3 | 6 | Completed 6 |
| Phase 1 | 4 | Completed 4 |
Follow Stroke, Acute: new trials by email Literature Review of Stroke, Acute trials Research Report on Stroke, Acute
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effectiveness and Biological Mechanism of Direct Ischemic Post-conditioning for Acute Stroke Patients Due to Large Vessel Occlusion Direct Ischemic Post-conditioning, Endovascular therapy - Stroke, Acute, Neuroprotection | Phase 2 | Completed | Tianjin Huanhu Hospital | 60 | 2024-09-12 | 2026-06-15 |
| Glucagon-like Peptide 1 Receptor Agonist in Acute Large Vessel Occlusion Stroke Treated by Reperfusion Therapies Semaglutide - Stroke, Stroke, Acute | Phase 2 | Completed | Chinese University of Hong Kong | 140 | 2023-08-01 | 2025-03-07 |
| PROpranolol for Cerebral Hemorrhage-ASsociated pnEumonia (PRO-CHASE) Propranolol Hydrochloride, control group - Stroke, Vascular Accident | Phase 2 / Phase 3 | Completed | Beijing Tiantan Hospital | 168 | 2023-02-21 | 2025-07-14 |
| Glenzocimab for REperfusion in the Setting of Endovascular Therapy for Brain infarctioN: GREEN Study Glenzocimab, Placebo - Stroke, Acute, Stroke, Ischemic | Phase 2 / Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 108 | 2023-01-03 | 2026-07-08 |
| Endovascular Treatment With Versus Without Intravenous rhTNK-tPA in Stroke rhTNK-tPA, Endovascular treatment - Stroke, Acute, Stroke, Ischemic | Phase 2 / Phase 3 | Completed | Xinqiao Hospital of Chongqing | 550 | 2022-05-09 | 2025-04-03 |
| Normobaric Hyperoxia Combined With Endovascular Treatment in Acute Ischemic Stroke (OPENS-2) Normobaric Hyperoxia, Sham Normobaric Hyperoxia, Endovascular Thrombectomy - Stroke, Acute, Neuroprotection | Phase 2 | Completed | Capital Medical University | 282 | 2021-04-22 | 2023-07-06 |
| Blood Pressure Management in Stroke Following Endovascular Treatment Labetalol, Hydralazine, Enalapril - Stroke, Acute, Vessels; Occlusion | Phase 2 | Completed | Hamilton Health Sciences Corporation | 30 | 2020-10-23 | 2023-11-07 |
| Desmopressin for Reversal of Antiplatelet Drugs in Stroke Due to Haemorrhage Desmopressin Injection, Normal saline - Stroke, Acute | Phase 2 | Completed | University of Nottingham | 54 | 2019-04-01 | 2022-11-15 |
| Intraarterial Alteplase Versus Placebo After Mechanical Thrombectomy Intraarterial alteplase, Placebo - Stroke, Acute | Phase 2 / Phase 3 | Completed | Hospital Clinic of Barcelona | 121 | 2018-12-05 | 2022-05-20 |
| Treatment Evaluation of Acute Stroke for Using in Regenerative Cell Elements HLCM051, Placebo - Stroke, Acute | Phase 2 / Phase 3 | Completed | Healios K.K. | 206 | 2017-11-15 | 2024-01-17 |
| Study of Allogeneic Umbilical Cord Blood Infusion for Adults With Ischemic Stroke Umbilical Cord Blood, Placebo - Stroke, Stroke, Acute | Phase 2 | Completed | Joanne Kurtzberg, MD | 79 | 2017-03-14 | 2022-12-06 |
| THR-18's Pharmacokinetics and Pharmacodynamics in Subjects With Acute Ischemic Stroke Treated With tPA THR-18, Placebo - Stroke, Acute | Phase 2 | Completed | D-Pharm Ltd. | 30 | 2013-10-01 | 2015-02-04 |
| Efficacy and Safety of FTY720 for Acute Stroke Fingolimod - Stroke, Vascular Accident | Phase 2 | Completed | Tianjin Medical University General Hospital | 22 | 2012-10-01 | 2018-10-17 |
| Perfusion and Antihypertensive Therapy in Acute Ischemic Stroke Nitroglycerin, Labetalol - Stroke, Acute | Phase 2 | Completed | University of Alberta | 65 | 2009-06-01 | 2017-10-26 |
| Autologous Bone Marrow Stem Cells in Middle Cerebral Artery Acute Stroke Treatment. Infusion on autologous CD34+ stem cells into middle cerebral artery - Stroke, Acute, Infarction, Middle Cerebral Artery | Phase 1 / Phase 2 | Completed | Hospital Universitario Central de Asturias | 20 | 2008-09-01 | 2011-11-29 |
| Study of a Neuroprotective Drug to Limit the Extent of Damage From an Ischemic Stroke Minocycline - Stroke, Acute | Phase 1 / Phase 2 | Completed | David Hess, MD | 60 | 2008-05-01 | 2012-01-13 |
| Autologous Bone Marrow Stem Cells in Ischemic Stroke. Infusion of autologous CD34+ stem cells into middle cerebral artery - Stroke, Acute, Infarction, Middle Cerebral Artery | Phase 1 / Phase 2 | Completed | Imperial College London | 5 | 2007-09-01 | 2019-07-08 |
| Treatments for Recovery of Hand Function in Acute Stroke Survivors Neuromuscular electrical stimulator - Stroke, Acute, Stroke | Phase 1 / Phase 2 | Completed | MetroHealth Medical Center | 21 | 2007-07-01 | 2018-12-19 |
| Intravenous Administration of Microplasmin for Treatment of Acute Ischemic Stroke Microplasmin - Stroke, Acute | Phase 2 | Completed | ThromboGenics | 40 | 2005-10-01 | 2014-11-07 |
| Multicenter Efficacy Study of Recombinant Human Erythropoietin in Acute Ischemic Stroke recombinant human erythropoietin alfa, 0.9% NaCl - Infarction, Middle Cerebral Artery, Middle Cerebral Artery Stroke | Phase 2 / Phase 3 | Completed | Max-Planck-Institute of Experimental Medicine | 522 | 2003-01-01 | 2008-10-22 |
Stroke (20) · Ischemic Stroke (7) · Infarction, Middle Cerebral Artery (3) · Cerebral Hemorrhage (2) · Intracranial Hemorrhages (2) · Ischemia (2) · Bites and Stings (1) · Brain Diseases (1) · Brain Injuries (1) · Hemiplegia (1) · Hemorrhagic Stroke (1) · Hypoxia (1) · Infections (1) · Paresis (1) · cyclopia sequence (1)
Cardiovascular Diseases (20) · Central Nervous System Diseases (20) · Cerebrovascular Disorders (20) · Nervous System Diseases (20) · Vascular Diseases (20) · Brain Diseases (19) · Pathological Conditions, Signs and Symptoms (8) · Pathologic Processes (7) · Brain Infarction (3) · Brain Ischemia (3) · Cerebral Arterial Diseases (3) · Cerebral Infarction (3) · Hemorrhage (3) · Infarction (3) · Intracranial Arterial Diseases (3)
Labetalol (2) · Saline Solution (2) · Control Groups (1) · Deamino Arginine Vasopressin (1) · Enalapril (1) · Fingolimod Hydrochloride (1) · Hydralazine (1) · Minocycline (1) · Nitroglycerin (1) · Propranolol (1) · TNK-tissue plasminogen activator (1) · Tenecteplase (1) · glenzocimab (1) · microplasmin (1) · semaglutide (1)
Assistance Publique - Hôpitaux de Paris (1) · Beijing Tiantan Hospital (1) · Capital Medical University (1) · Chinese University of Hong Kong (1) · D-Pharm Ltd. (1) · David Hess, MD (1) · Hamilton Health Sciences Corporation (1) · Healios K.K. (1) · Hospital Clinic of Barcelona (1) · Hospital Universitario Central de Asturias (1) · Imperial College London (1) · Joanne Kurtzberg, MD (1) · Max-Planck-Institute of Experimental Medicine (1) · MetroHealth Medical Center (1) · ThromboGenics (1)
China (6) · United States (3) · Canada (2) · Germany (2) · Spain (2) · United Kingdom (2) · Austria (1) · Belgium (1) · France (1) · Hong Kong (1) · Japan (1) · Ukraine (1)
Angel Chamorro, MD, PhD (1) · Anna Ramos, MD (1) · Aristeidis H Katsanos, MD (1) · Bonaventure Yiu Ming IP, MB ChB (1) · David C Hess, MD (1) · Elisa Cuadrado, MD, PhD (1) · Fu-Dong Shi, MD,PhD (1) · Jayme S Knutson, PhD (1) · Jeffrey L Saver, MD (1) · Joanne Kurtzberg, MD (1) · Nagy Habib, Professor (1)
PMID 22163120, PMID 19834012, PMID 20705929, PMID 21852153, PMID 22764211, PMID 25003359, PMID 25107583, PMID 26202811, PMID 29134924, PMID 33172941, PMID 33464335, PMID 35143603, PMID 35720286, PMID 37870112, PMID 38227308, PMID 39435713, PMID 39922675, PMID 40396577, PMID 40866207, PMID 41392086, PMID 42460477, PMID 42623571