32 completed, 11 unknown, 9 recruiting, 3 not yet recruiting. 35 Not applicable, 13 Phase 2, 5 Phase 4, 3 Phase 1, 1 Phase 3.
Follow Stress Disorders, Traumatic, Acute: new trials by email Literature Review of Stress Disorders, Traumatic, Acute trials Research Report on Stress Disorders, Traumatic, Acute
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Assessment of the Preventive Effect of Defusing on Traumatic Kindling Defusing, Psychological First Aid (PFA) - Acute Stress Disorder, Post Traumatic Stress Disorder PTSD | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 70 | 2026-11-01 | 2026-09-30 |
| Early Intervention to Prevent Development of PTSD in Burn Survivors and Their Caregivers Promotion of Emotional Disclosure for Burns (PoED-B), minimally Enhanced Usual Care control (mEUC) - Posttraumatic Stress Disorder, Burns | Not applicable | Not yet recruiting | University of Southern California | 44 | 2026-08-01 | 2026-06-18 |
| The Efficacy of Vitamin D Supplementation to Sustain Performance Outcomes Vitamin D3 (Cholecalciferol), Oral Placebo Tablet - Acute Stress Reaction | Not applicable | Recruiting | Walter Reed Army Institute of Research (WRAIR) | 52 | 2026-07-17 | 2026-09-10 |
| Impact of MetaCalm on Stress of Healthy People With Acute Stress 2 chewable tablets of MetaCalm, 4 chewable tablets of MetaCalm - Adults, Acute Stress Reaction | Not applicable | Not yet recruiting | Metagenics, Inc. | 280 | 2026-04-15 | 2026-04-13 |
| Breathwork and Stress: Investigating the Mechanisms of Action and Effectiveness of Breathing Interventions in Modulating the Psychophysiological Response to Acute Stress Test Coherent Breathing (6 bpm), Sham Breathing (15 bpm) - Healthy Adult Participants, Acute Stress Reaction | Not applicable | Completed | Medical University of Bialystok | 100 | 2026-04-07 | 2026-10-21 |
| Adolescent Stress and Substance Intervention Subsequent to Trauma ASSIST Video Intervention - PTSD, Substance Use Disorder (SUD) | Not applicable | Recruiting | Rhode Island Hospital | 92 | 2026-03-03 | 2026-07-09 |
| BXCL501 After Stress to Increase Recovery Success BXCL501 (dexmedetomidine HCl), Placebo - Acute Stress Reaction, Acute Stress Disorder | Phase 2 | Recruiting | University of North Carolina, Chapel Hill | 100 | 2026-02-23 | 2026-04-14 |
| Impact of Repeated Virtual Reality Training on Markers of Stress Active Shooter, Target Practice - Stress, Acute Stress Reaction | Not applicable | Completed | Texas State University | 50 | 2025-10-01 | 2026-08-18 |
| Safety & Efficacy of Intranasal Dexmedetomidine, Fentanyl & Midazolam in the Pediatric Emergency Room Intranasal Dexmedetomidine (4 mcg/kg), Intranasal Fentanyl (2 mcg/kg), Intranasal Midazolam (5 mg/kg) - Acute Stress Disorder, Anxiety | Phase 2 | Withdrawn | Nationwide Children's Hospital | 2025-09-01 | 2025-09-10 | |
| Cannabidiol (CBD) and Stress Response: Psychobiological Mechanisms Stress Intervention - CBD, Cannabidiol | Not applicable | Recruiting | University of Minnesota | 125 | 2025-06-16 | 2026-07-22 |
| The Effects of Propranolol and Hydrocortisone on Military-Relevant Performance Outcomes Propranolol, Hydrocortisone, Placebo (oral) - Fear of Spiders, Acute Stress Reaction | Phase 4 | Recruiting | Walter Reed Army Institute of Research (WRAIR) | 88 | 2025-05-27 | 2026-05-13 |
| Prevention/Reduction of ASRs and PTSD to Sustain Civilian Performance With Sublingual Cyclobenzaprine HCl (TNX-102 SL) Cyclobenzaprine HCl, Placebo - Acute Stress Reaction, Acute Stress Disorder | Phase 2 | Recruiting | University of North Carolina, Chapel Hill | 180 | 2025-03-25 | 2026-10-22 |
| Effect of Transcutaneous Auricular Neurostimulation on Cognitive Performance in a Laboratory Model of Acute Stress Reaction Sparrow Hawk (Active), Sparrow Hawk (Sham) - Acute Stress Reaction, Cognitive Performance | Not applicable | Completed | Spark Biomedical, Inc. | 43 | 2024-11-26 | 2025-08-01 |
| Internet-delivered Trauma-focused Cognitive-behavioral Therapy as an Early Intervention After Sexual Trauma Condensed Internet delivered prolonged exposure (CIPE) - Acute Stress Disorder, Post Traumatic Stress Disorder | Not applicable | Unknown | Karolinska Institutet | 30 | 2024-10-01 | 2024-07-16 |
| Condensed Digital Prolonged Exposure for Individuals Treated Within Somatic Trauma Care. Condensed Internet delivered prolonged exposure (CIPE) - Post Traumatic Stress Disorder, Acute Stress Disorder | Not applicable | Unknown | Karolinska Institutet | 250 | 2024-09-01 | 2024-07-10 |
| Promoting Improved Functioning Among People Experiencing Stressful Situations iCOVER, Physical Presence with Reassurance - Acute Stress Reaction | Not applicable | Recruiting | University of North Carolina, Chapel Hill | 450 | 2024-08-15 | 2025-12-09 |
| The Effect of Breathing on Cognitive Performance and Stress Box Breathing, Prolonged Exhalation, Normal Breathing - Stress, Acute Stress Reaction | Not applicable | Completed | Texas State University | 66 | 2024-08-01 | 2025-05-22 |
| Feasibility Study of the Self-Care Immediate Stabilization Procedure (ISP) ® After a Traumatic Experience Eye Movement Desensitization and Reprocessing (EMDR) - Post-traumatic Stress Disorder, Acute Stress Disorder | Not applicable | Unknown | Tel Aviv University | 200 | 2024-04-01 | 2024-03-27 |
| Integrative Medicine for Hospital Workers Exposed to War Integrative medicine - Anxiety | Not applicable | Recruiting | Bnai Zion Medical Center | 500 | 2023-10-21 | 2026-09-30 |
| Removing Surrogates' Uncertainty to Reduce Fear and Anxiety After Cardiac Events Educational Informational Platform - Cardiac Arrest | Not applicable | Completed | Columbia University | 53 | 2023-09-07 | 2025-11-18 |
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Stress Disorders, Post-Traumatic (31) · Anxiety Disorders (14) · Wounds and Injuries (8) · Depression (5) · Psychomotor Agitation (5) · Adjustment Disorders (3) · Substance-Related Disorders (3) · Trauma and Stressor Related Disorders (3) · Burns (2) · COVID-19 (2) · Depressive Disorder (2) · Stress Disorders, Traumatic (2) · Acne Vulgaris (1) · Aggression (1)
Mental Disorders (57) · Stress Disorders, Traumatic (56) · Trauma and Stressor Related Disorders (55) · Behavior (13) · Behavioral Symptoms (11) · Pathological Conditions, Signs and Symptoms (9) · Nervous System Diseases (8) · Signs and Symptoms (8) · Neurologic Manifestations (7) · Aberrant Motor Behavior in Dementia (6) · Chemically-Induced Disorders (5) · Dyskinesias (5) · Neurobehavioral Manifestations (5) · Psychomotor Disorders (5) · Infections (3)
Propranolol (4) · Dexmedetomidine (3) · neurexan (3) · Hydrocortisone (2) · Psychological First Aid (2) · Analgesics (1) · Antiemetics (1) · Atorvastatin (1) · Cholecalciferol (1) · Crisis Intervention (1) · Escitalopram (1) · Eye Movement Desensitization Reprocessing (1) · Fentanyl (1) · Interviews as Topic (1) · Mass Shooting Events (1)
Biologische Heilmittel Heel GmbH (3) · University of North Carolina, Chapel Hill (3) · Centre Hospitalier Universitaire Vaudois (2) · Douglas Mental Health University Institute (2) · Hospices Civils de Lyon (2) · Karolinska Institutet (2) · National Institute of Mental Health (NIMH) (2) · Texas State University (2) · Walter Reed Army Institute of Research (WRAIR) (2) · Ain Shams University (1) · Baylor College of Medicine (1) · Bnai Zion Medical Center (1) · Centre Hospitalier Universitaire de Besancon (1) · Centre de Recherche de l'Institut Universitaire en santé Mentale de Montréal (1) · Columbia University (1)
United States (26) · Israel (5) · Canada (4) · France (4) · Germany (3) · Switzerland (3) · Italy (2) · Spain (2) · Sweden (2) · Turkey (Türkiye) (2) · Argentina (1) · Brazil (1) · Chile (1) · China (1) · Colombia (1)
Manfred Schedlowski, PhD (2) · Samuel McLean, MD (2) · Alain Brunet, Ph.D. (1) · Alain Brunet, PhD. (1) · Ali Fuat Erdem, Professor (1) · Andre Atoian, MD (1) · Andrew McGovern, MD (1) · Antje Horsch, D.Clin.Psych. (1) · Antje Horsch, DClinPsych (1) · Arieh Y Shalev, M.D. (1) · Carrie Pettus-Davis, PhD (1) · Christopher Jones, MD (1) · Claudia S Robertson, MD (1) · Esther Sabban, PhD (1)
PMID 38767196, PMID 10966293, PMID 11442853, PMID 11588447, PMID 16344363, PMID 17267907, PMID 18778321, PMID 20705788, PMID 21763472, PMID 23245705, PMID 23417207, PMID 24035670, PMID 24062371, PMID 24079640, PMID 26332857, PMID 26772822, PMID 27830281, PMID 28006970, PMID 28229114, PMID 28453969, PMID 29486547, PMID 31525488, PMID 31892657, PMID 32123197, PMID 32971266, PMID 33175877, PMID 33676455, PMID 34627829, PMID 34729551, PMID 34912250, PMID 35049605, PMID 35141873, PMID 35213077, PMID 35275108, PMID 35438535, PMID 35589975, PMID 36434512, PMID 37603846, PMID 37628548, PMID 37759037, PMID 38154074, PMID 38418244, PMID 38709554, PMID 39447384, PMID 42275639
2015 (1), 2016 (1), 2017 (1), 2023 (1), K23MH141296 (1), P30AG064198 (1), R21DA062071 (1)