6 completed, 4 unknown, 2 terminated, 1 withdrawn. 13 Phase 2, 7 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 13 | Completed 6, Unknown 4, Terminated 2, Withdrawn 1 |
| Phase 1 | 7 | Completed 3, Unknown 3, Withdrawn 1 |
| Phase 3 | 1 | Unknown 1 |
Follow Spondylosis: new trials by email Literature Review of Spondylosis trials Research Report on Spondylosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety Evaluation of ART352-L in Subjects Undergoing Posterolateral Spinal Fusion ART352-L - Degenerative Spondylolisthesis | Phase 1 / Phase 2 | Unknown | Ankasa Regenerative Therapeutics, Inc. | 12 | 2020-09-30 | 2020-10-12 |
| Safety and Preliminary Effectiveness of NVD-001 for the Treatment of Low Grade Degenerative Lumbar Spondylolisthesis NVD-001, Standard of Care - Spondylolisthesis | Phase 1 / Phase 2 | Completed | Novadip Biosciences | 48 | 2017-01-01 | 2021-08-13 |
| Transverse Abdominis Plane Block for Anterior Approach Spine Surgery TAP block ropivacaine, TAP block placebo, General anesthesia - Spine Surgery, Low Back Pain | Phase 2 | Completed | Rennes University Hospital | 43 | 2016-11-07 | 2023-05-24 |
| Immune Effect of Dexmedetomidine in Patients Undergoing to Spinal Fusion Dexmedetomidine intervention, Placebo - Spine; Arthrosis, Spondylolysis | Phase 2 / Phase 3 | Unknown | Sarah Network of Rehabilitation Hospitals | 46 | 2016-08-01 | 2016-08-23 |
| Safety and Efficacy of Pre-incisional Intravenous Ibuprofen to Reduce Postoperative Pain and Opioid Dependence After Posterior Cervical or Lumbar Instrumented Spine Surgery Ibuprofen, normal saline - Cervical Spondylosis, Lumbar Spondylosis | Phase 2 | Terminated | St. Joseph's Hospital and Medical Center, Phoenix | 6 | 2015-03-01 | 2024-04-19 |
| Safety Study of Mesenchymal Stem Cells and Spinal Fusion XCEL-MT-OSTEO-ALPHA, Standard treatment - Lumbar Spondylolisthesis Involving L4-L5, and/or, Degenerative Discopathy Involving L4-L5 | Phase 1 / Phase 2 | Completed | Banc de Sang i Teixits | 69 | 2012-07-19 | 2020-01-21 |
| CopiOs Posterolateral Fusion Procedure Copios - Spondylolisthesis, Stenosis | Phase 2 | Terminated | Zimmer Biomet | 45 | 2010-06-01 | 2015-05-27 |
| Safety and Preliminary Efficacy Study of NeoFuse in Subjects Requiring Lumbar Interbody Fusion Lumbar Interbody Fusion with Autograft, Lumbar Interbody Fusion with NeoFuse - Degenerative Disc Disease, Degenerative Spondylolisthesis | Phase 2 | Completed | Mesoblast, Ltd. | 24 | 2009-09-01 | 2020-06-29 |
| Pilot Study to Assess Safety/Preliminary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery Prefix (AMPLEX) B2A Peptide Enhanced Ceramic Granules, Iliac crest autograft - Degenerative Disc Disease, Spondylolisthesis | Phase 1 / Phase 2 | Unknown | BioSurface Engineering Technologies, Inc | 22 | 2008-11-01 | 2012-03-09 |
| Pilot Study to Assess Safety/Prelimary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery Prefix (AMPLEX) B2A Peptide Enhanced Ceramic Granules, Iliac crest autograft - Degenerative Disc Disease, Spondylolisthesis | Phase 1 / Phase 2 | Unknown | BioSurface Engineering Technologies, Inc | 24 | 2008-11-01 | 2012-03-09 |
| Safety and Efficacy Study of NeoFuse in Subjects Requiring Posterolateral Lumbar Fusion PLF with autograft, PLF with NeoFuse - Degenerative Disc Disease, Degenerative Spondylolisthesis | Phase 1 / Phase 2 | Withdrawn | Mesoblast, Ltd. | 2008-11-01 | 2020-06-02 | |
| Study of 3 Doses of NeoFuse Combined With MasterGraft Granules in Subjects Requiring Posterolateral Lumbar Fusion (PLF) NeoFuse, posterolateral spinal fusion with instrumentation - Degenerative Disc Disease, Spondylolisthesis | Phase 1 / Phase 2 | Completed | Mesoblast, Ltd. | 6 | 2007-10-01 | 2020-06-29 |
| Effect of Cervical Collar in Cervical Radicular Pain. Soft or stiff cervical collar(device), neck school(behavior) - Cervical Radicular Pain | Phase 2 | Completed | Ullevaal University Hospital | 120 | 2004-01-01 | 2011-07-06 |
Spondylolisthesis (11) · Intervertebral Disc Degeneration (6) · Spinal Stenosis (3) · Ankylosis (1) · Back Pain (1) · Constriction, Pathologic (1) · Low Back Pain (1) · Osteoarthritis (1) · Radiculopathy (1) · Spondylolysis (1)
Bone Diseases (13) · Musculoskeletal Diseases (13) · Spinal Diseases (13) · Spondylolysis (10) · Pathological Conditions, Signs and Symptoms (3) · Neurologic Manifestations (2) · Pain (2) · Signs and Symptoms (2) · Arthritis (1) · Back Pain (1) · Joint Diseases (1) · Nervous System Diseases (1) · Neuromuscular Diseases (1) · Pathological Conditions, Anatomical (1)
Spinal Fusion (3) · Transplantation, Autologous (2) · Adrenergic alpha-2 Receptor Agonists (1) · Anesthesia, General (1) · Dexmedetomidine (1) · Ibuprofen (1) · Saline Solution (1) · Standard of Care (1)
Mesoblast, Ltd. (3) · BioSurface Engineering Technologies, Inc (2) · Ankasa Regenerative Therapeutics, Inc. (1) · Banc de Sang i Teixits (1) · Novadip Biosciences (1) · Rennes University Hospital (1) · Sarah Network of Rehabilitation Hospitals (1) · St. Joseph's Hospital and Medical Center, Phoenix (1) · Ullevaal University Hospital (1) · Zimmer Biomet (1)
United States (7) · Belgium (1) · Brazil (1) · Canada (1) · Czechia (1) · France (1) · Norway (1) · Poland (1) · Spain (1)
Donna Skerrett, MD (2) · Brent Atkinson, PhD (1) · Christian Raftopoulos, MD, PhD (1) · David M Hooper, PhD (1) · Denis Dufrane, MD, PhD (1) · Luciano P Miranda (1) · Nicholas Theodore, MD (1) · Roger Brown (1) · Vibeke Graver, PhD (1)
2016 (1)