7 completed, 5 unknown, 2 terminated, 1 not yet recruiting. 17 Phase 3, 7 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 17 | Completed 7, Unknown 5, Terminated 2, Not yet recruiting 1, Recruiting 1, Suspended 1 |
| Phase 2 | 7 | Unknown 4, Completed 2, Recruiting 1 |
Follow Speech Disorders: new trials by email Literature Review of Speech Disorders trials Research Report on Speech Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Superiority Trial of Aphasia-focused Rehabilitation With tDCS Stimulation tDCS - Aphasia, Broca's Aphasia | Phase 2 / Phase 3 | Recruiting | University of South Carolina | 130 | 2026-07-14 | 2026-07-21 |
| EFFECT OF ANODAL TRANSCRANIAL DIRECT CURRENT STIMULATION ON NAMING IN APHASIC PATIENTS WITH ACUTE ISCHEMIC STROKE Transcranial Direct Current Stimulation - Acute Ischemic Cerebrovascular Disease, Post Stroke Aphasia | Phase 3 | Not yet recruiting | Dr. Ram Manohar Lohia Hospital | 28 | 2026-03-31 | 2026-03-27 |
| Lateral Cord Magnetic Stimulation For Refractory Spastic Cerebral Palsy Magnetic Spinal Stimulation - Spastic Cerebral Palsy, Dysarthria | Phase 2 / Phase 3 | Unknown | Sociedad Argenttina de Neuromodulación | 20 | 2024-11-18 | 2023-11-21 |
| Brain Correlates of Multimodal Rehabilitation in Chronic Post-stroke Aphasia Donepezil, Intensive-Language Action Therapy, Transcranial direct current stimulation - Aphasia, Stroke | Phase 3 | Completed | University of Malaga | 20 | 2019-01-08 | 2020-11-05 |
| Efficacy and Tolerability of Ecopipam in Adults With Childhood Onset Fluency Disorder (Stuttering). Ecopipam 50mg, Ecopipam 100mg - Stuttering, Adult, Childhood-onset Fluency Disorder | Phase 2 / Phase 3 | Unknown | Gerald Maguire, MD | 10 | 2016-09-01 | 2016-10-26 |
| Efficacy and Safety of AM-111 as Acute Sudden Sensorineural Hearing Loss Treatment AM-111 0.4 mg/ml, AM-111 0.8 mg/ml, Placebo - Hearing Loss, Idiopathic Sudden Sensorineural | Phase 3 | Terminated | Auris Medical, Inc. | 56 | 2016-06-01 | 2020-08-07 |
| Use of Local Intraoperative Steroid in MIS TLIF Methylprednisolone, Dexamethasone - Dysphasia | Phase 3 | Completed | Rush University Medical Center | 105 | 2015-11-13 | 2020-11-20 |
| AM-111 in the Treatment of Acute Inner Ear Hearing Loss Placebo, AM-111 0.4 mg/ml, AM-111 0.8 mg/ml - Hearing Loss | Phase 3 | Completed | Auris Medical AG | 256 | 2015-11-01 | 2023-09-14 |
| Effects of MTS-r on Speech Production in Non-fluent Aphasia Post-ischemic Stroke Patients Transcranial Magnetic Stimulation (TMS-r), Placebo Transcranial Magnetic Stimulation - Aphasia, Broca | Phase 3 | Unknown | Fundación Cardiovascular de Colombia | 100 | 2014-08-01 | 2014-09-16 |
| A Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Tolerability of Asenapine With Flexible Dosing From 5mg to 20mg in Adults With Developmental Stuttering Asenapine - Stuttering | Phase 3 | Suspended | University of California, Irvine | 32 | 2012-09-01 | 2014-05-20 |
| Non-invasive Repetitive Paraorbital Alternating Current Stimulation Therapy for Aphasia rtACS stimulation (Verum condition), placebo condition - Aphasia | Phase 3 | Terminated | University of Magdeburg | 30 | 2010-12-01 | 2013-12-19 |
| A Study to Assess the Efficacy and Safety of Pagoclone for Adults With Stuttering pagoclone, placebo - Stuttering | Phase 2 / Phase 3 | Completed | Endo USA Inc., a Keenova Therapeutics Company | 321 | 2009-02-01 | 2012-08-28 |
| Improvement of Language Disturbances After Stroke by Intensive Training and Electrical Brain Stimulation anodal tDCS, cathodal tDCS, sham stimulation - Aphasia, Stroke | Phase 2 / Phase 3 | Unknown | University Hospital Muenster | 20 | 2009-01-01 | 2009-01-14 |
| Randomized Clinical Trial of Phonological Interventions Speech Production Intervention, Speech Perception Intervention, Articulation Parent Group - Speech Articulation Disorder, Developmental Articulation Disorder | Phase 2 / Phase 3 | Unknown | McGill University | 96 | 2008-11-01 | 2009-09-23 |
| Melodic-Intonation-Therapy and Speech-Repetition-Therapy for Patients With Non-fluent Aphasia Melodic Intonation Therapy, Speech-Repetition-Therapy - Aphasia, Stroke | Phase 3 | Completed | Beth Israel Deaconess Medical Center | 30 | 2008-02-01 | 2020-09-21 |
| Augmenting Language Therapy for Aphasia: Levodopa levodopa/carbidopa, Placebo comparator - Nonfluent Aphasia, Stroke | Phase 2 / Phase 3 | Completed | Shirley Ryan AbilityLab | 36 | 2007-10-01 | 2013-12-25 |
| Treatment of Childhood Social Phobia Social Effectiveness Therapy for Children (SET-C), Fluoxetine, Pill Placebo - Social Phobia | Phase 3 | Completed | University of Central Florida | 139 | 2001-04-01 | 2013-08-01 |
Aphasia (9) · Stroke (7) · Aphasia, Broca (3) · Stuttering (3) · Communication Disorders (2) · Deafness (2) · Ear Diseases (2) · Hearing Disorders (2) · Hearing Loss (2) · Hearing Loss, Sensorineural (2) · Hearing Loss, Unilateral (2) · Otorhinolaryngologic Diseases (2) · Sensation Disorders (2) · Signs and Symptoms (2)
Neurobehavioral Manifestations (17) · Pathological Conditions, Signs and Symptoms (17) · Language Disorders (16) · Nervous System Diseases (16) · Neurologic Manifestations (16) · Communication Disorders (15) · Signs and Symptoms (15) · Brain Diseases (8) · Central Nervous System Diseases (8) · Cardiovascular Diseases (7) · Vascular Diseases (7) · Cerebrovascular Disorders (6) · Mental Disorders (3) · Neurodevelopmental Disorders (3)
Transcranial Direct Current Stimulation (4) · D-JNKI-1 (2) · Dexamethasone (1) · Donepezil (1) · Fluoxetine (1) · Methylprednisolone (1) · Transcranial Magnetic Stimulation (1) · Transcutaneous Electric Nerve Stimulation (1) · asenapine (1) · carbidopa, levodopa drug combination (1) · ecopipam (1) · pagoclone (1)
Auris Medical AG (1) · Auris Medical, Inc. (1) · Beth Israel Deaconess Medical Center (1) · Dr. Ram Manohar Lohia Hospital (1) · Endo USA Inc., a Keenova Therapeutics Company (1) · Fundación Cardiovascular de Colombia (1) · Gerald Maguire, MD (1) · McGill University (1) · Rush University Medical Center (1) · Shirley Ryan AbilityLab (1) · Sociedad Argenttina de Neuromodulación (1) · University Hospital Muenster (1) · University of California, Irvine (1) · University of Central Florida (1) · University of Magdeburg (1)
United States (8) · Canada (2) · Germany (2) · Argentina (1) · Bulgaria (1) · Colombia (1) · India (1) · South Korea (1) · Spain (1)
Agnes Floel, MD (1) · Andrea Norton, BM (1) · Ashish Kumar Duggal, DM (Neurology) (1) · Bernhard A Sabel, Prof. Dr. (1) · Federico A Silva, MD,MSc (1) · Gerald Maguire, M.D. (1) · Gottfried Schlaug, MD, PhD (1) · Juan Carlos M Andreani, MD (1) · Kern Singh, MD (1) · Marcelo L Berthier, MD, PhD (1) · Susan Rvachew, Ph.D. (1) · Thomas Meier (1) · Tommaso Tufo, MD (1) · Werner Braunsdorf, MD (1) · Wojciech Maksymowicz, MD (1)
PMID 10917410, PMID 12849360, PMID 15026214, PMID 15212606, PMID 15328899, PMID 18030084, PMID 19673813, PMID 20013046, PMID 20075648, PMID 21197418, PMID 21391024, PMID 21636820, PMID 24434529, PMID 30497132, PMID 35433325
R01DC008796 (1), R01MH053703 (1), U01DC022447 (1)