57 completed, 7 terminated, 4 not yet recruiting, 4 recruiting. 24 Not applicable, 13 Phase 3, 10 Phase 4, 6 Phase 2, 4 Phase 1.
Follow Soft Tissue Infections: new trials by email Literature Review of Soft Tissue Infections trials Research Report on Soft Tissue Infections
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Naproxen Versus Placebo as Adjunct Treatment of Cellulitis enteric-coated naproxen, Cephalexin Tablets, Placebo - Cellulitis, Skin Disease, Infectious | Phase 3 | Not yet recruiting | Ottawa Hospital Research Institute | 884 | 2026-11-01 | 2026-10-20 |
| Automatic Versus As-Needed Follow-up After Hospitalization for Children With Medical Complexity Automatic follow-up recommendation, As-needed follow-up recommendation - Children With Medical Complexity, Respiratory Tract Infections (RTI) | Not applicable | Not yet recruiting | Seattle Children's Hospital | 160 | 2026-10-01 | 2026-10-08 |
| Delafloxacin Plasma and Tissue Concentration in Patients With Skin, Soft Tissue, and Bone and Joint Infections. delafloxacin - Soft Tissue Infections, Mediastinitis | Not yet recruiting | IRCCS San Raffaele | 20 | 2026-04-01 | 2026-02-23 | |
| Exploring if Patients Can Safely and Easily Swab Their Own Surgical Wounds at Home Self-swabbing of surgical wound - Cardiac Surgery, Infection, Soft Tissue | Not applicable | Completed | Guy's and St Thomas' NHS Foundation Trust | 43 | 2026-01-06 | 2026-06-10 |
| Necrotizing Soft Tissue Infections Necrotizing Soft Tissue Infection, Fournier Gangrene | Enrolling by invitation | European Society for Trauma and Emergency Surgery | 480 | 2026-01-01 | 2025-08-06 | |
| Randomized Controlled Study on the Safety and Efficacy of Phage Cocktail in the Treatment of Multidrug-Resistant Bacterial Skin Infections Bacteriophage Treatment, Placebo treatment using 0.9% normal saline - Phage Therapy, Bacteriophage Therapy | Early Phase 1 | Enrolling by invitation | First Affiliated Hospital Xi'an Jiaotong University | 150 | 2025-01-15 | 2026-06-02 |
| The Role of Circadian Clock Proteins in Innate and Adaptive Immunity Blue Light - Pneumonia, Necrotizing Soft Tissue Infection | Not applicable | Recruiting | Washington University School of Medicine | 144 | 2024-10-29 | 2026-02-11 |
| Anchoring Sequential Intermittent Long Acting Antimicrobials With Medication for Opioid Use Disorder (MOUD) for Invasive Infections Related to Opioid Use Oritavancin - Substance Use Disorders, Infection, Soft Tissue | Phase 4 | Terminated | University of Maryland, Baltimore | 1 | 2024-07-15 | 2026-07-24 |
| Staph Intervention for Effective Local Defense Mupirocin + Nozin + chlorhexidine gluconate, Education + Household supplies - Staphylococcus Aureus Infection | Phase 4 | Completed | Johns Hopkins Bloomberg School of Public Health | 78 | 2024-04-01 | 2026-06-12 |
| PATH Study: People With Injecting Related Infections: Assessing Treatment Outcomes for Those Who Are Hospitalised. Observational - Invasive Fungal Infections, Invasive Bacterial Infection | Not yet recruiting | Kirby Institute | 300 | 2024-03-01 | 2024-02-20 | |
| Comparing Oral Versus Parenteral Antimicrobial Therapy Amoxicillin, amoxicillin-clavulanate, cefadroxil, cefpodoxime, cefalexin, ciprofloxacin, delafloxacin, doxycycline, levofloxacin, linezolid, Ampicillin, ampicillin-sulbactam, cefazolin, cefepime, ceftaroline, ceftazidime, ceftazidime-avibactam, dalbavancin, daptomycin, ertapenem - Endovascular Infection, Bone and Joint Infection | Phase 4 | Terminated | West Virginia University | 94 | 2023-08-04 | 2025-08-26 |
| Clinical Effectiveness of Polymethoxy Flavones Solid Dispersion as a Dressing Material for Palatal Grafts Donor Sites hydroxylate flavones solid dispersion application, Placebo - Soft Tissue Infections, Gingival Recession | Not applicable | Unknown | Assiut University | 30 | 2023-04-20 | 2023-04-14 |
| Dalbavancin Outpatient Pilot Dalbavancin - Gram-Positive Bacterial Infections, Soft Tissue Infections | Phase 4 | Withdrawn | Wake Forest University Health Sciences | 2023-04-01 | 2023-05-03 | |
| ASAP: Access to Syringes at Pharmacies for the Prevention of Bloodborne Infections Among People Who Inject Drugs ASAP - Skin and Soft Tissue Infections, Hiv | Not applicable | Completed | University of Arizona | 18 | 2022-12-01 | 2023-12-19 |
| Sepsis Prognosis and Diagnosis in the Emergency Department (SPEED) IMX-BVN-4 and IMX-SEV-4 - Respiratory Tract Infections, Urinary Tract Infections | Withdrawn | Inflammatix | 2022-12-01 | 2023-12-27 | ||
| Safety, Immunogenicity and Efficacy of GSK S. Aureus Candidate Vaccine (GSK3878858A) When Administered to Healthy Adults (Dose-escalation) and to Adults 18 to 64 Years of Age With a Recent S. Aureus Skin and Soft Tissue Infection (SSTI) Sa-5Ag half dose non-adjuvanted, Sa-5Ag full dose non-adjuvanted, Sa-5Ag half dose adjuvanted - Infections, Soft Tissue | Phase 2 | Completed | GlaxoSmithKline | 226 | 2022-11-16 | 2025-05-08 |
| Antibiotic Therapy in Infections of the Diabetic Foot Syndrome Data collection in patients with diabetic foot syndrome and infections in the area of the foot - Diabetic Foot Infection | Completed | University Hospital, Basel, Switzerland | 80 | 2022-10-12 | 2024-07-03 | |
| Follow-up Automatically vs. As-Needed Comparison (FAAN-C) Trial As-needed follow up, Automatic follow-up - Pneumonia, Urinary Tract Infections | Not applicable | Recruiting | University of Utah | 2674 | 2022-08-22 | 2025-12-10 |
| Nurse-led Antimicrobial Stewardship Intervention to Increase Antibiotic Appropriateness in Residential Aged Care Facilities Antimicrobial stewardship - Antimicrobial Stewardship, Urinary Tract Infections | Not applicable | Unknown | Bayside Health | 700 | 2021-01-01 | 2022-01-13 |
| Discharge Stewardship in Children's Hospitals Discharge antibiotic stewardship intervention - Pneumonia, Bacterial, Pneumonia Childhood | Not applicable | Completed | Children's Hospital of Philadelphia | 1131 | 2020-06-10 | 2026-10-01 |
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Cellulitis (15) · Infections (15) · Bacterial Infections (11) · Abscess (10) · Urinary Tract Infections (10) · Skin Diseases, Infectious (9) · Sepsis (8) · Staphylococcal Infections (8) · Respiratory Tract Infections (7) · Fasciitis, Necrotizing (6) · Fournier Gangrene (6) · Intraabdominal Infections (6) · Osteomyelitis (5) · Bacteremia (4)
Infections (68) · Pathologic Processes (40) · Pathological Conditions, Signs and Symptoms (40) · Inflammation (31) · Skin and Connective Tissue Diseases (30) · Bacterial Infections and Mycoses (28) · Suppuration (22) · Urogenital Diseases (20) · Skin Diseases (19) · Skin Diseases, Infectious (19) · Bacterial Infections (17) · Male Urogenital Diseases (17) · Connective Tissue Diseases (15) · Respiratory Tract Diseases (15) · Musculoskeletal Diseases (14)
Vancomycin (10) · Daptomycin (7) · Linezolid (5) · Ceftaroline (4) · Amoxicillin (3) · Aztreonam (3) · Cephalexin (3) · Drainage (3) · Ertapenem (3) · chlorhexidine gluconate (3) · delafloxacin (3) · Cefazolin (2) · Moxifloxacin (2) · Oxacillin (2) · Piperacillin, Tazobactam Drug Combination (2)
Pfizer (5) · GBR Academy (3) · Inflammatix (3) · Merck Sharp & Dohme LLC (3) · Ole Hyldegaard (3) · Paratek Pharmaceuticals Inc (3) · Children's Hospital of Philadelphia (2) · Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (2) · GlaxoSmithKline (2) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (2) · Motif Bio (2) · Novartis Pharmaceuticals (2) · University of Maryland, Baltimore (2) · Wake Forest University Health Sciences (2) · Assiut University (1)
United States (33) · Italy (9) · Greece (7) · Argentina (6) · Bulgaria (6) · Romania (6) · Spain (6) · Germany (5) · Peru (5) · Brazil (4) · Canada (4) · Chile (4) · Croatia (4) · Denmark (4) · Hungary (4)
Ole Hyldegaard, MD, PhD (3) · David Melnick, MSD (2) · Marco Bo Hansen, MD (2) · Abel Wakai, MD FRCS FCEM (1) · Adolfo Pisanu, MD (1) · Ahmed Mortada, Professor (1) · Amy Manley (1) · Anders Sundoy, Chief Doc (1) · Andrew McRae, MD, FRCPC, PhD (1) · Anna Yuen, BSc. Pharm (1)
PMID 27585969, PMID 29783024, PMID 31367742, PMID 33326848, PMID 33458763, PMID 35776862, PMID 39461915, PMID 11751780, PMID 18662172, PMID 23758300, PMID 23772042, PMID 23772045, PMID 23772047, PMID 25419768, PMID 25805867, PMID 25967993, PMID 26112223, PMID 26880104, PMID 26888908, PMID 28630189, PMID 28982834, PMID 29281036, PMID 29518178, PMID 29530858, PMID 30349845, PMID 30380060, PMID 30597021, PMID 30716446, PMID 30726689, PMID 31474458, PMID 31916575, PMID 32082310, PMID 32607967, PMID 32770686, PMID 32868346, PMID 33017060, PMID 33242083, PMID 33653766, PMID 33908631, PMID 34263738, PMID 34741280, PMID 34920946, PMID 34922058, PMID 35623048, PMID 36427229, PMID 37946314, PMID 38850687, PMID 38979062, PMID 39040989, PMID 39106169
2009 (1), R01CI000373 (1), R01GM145674 (1), S06GM142120 (1)