15 completed, 5 unknown, 3 not yet recruiting, 3 recruiting. 9 Not applicable, 1 Phase 2, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 9 | Completed 4, Unknown 2, Not yet recruiting 1, Recruiting 1, Terminated 1 |
| Phase 2 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
| Phase 4 | 1 | Active not recruiting 1 |
Follow Fasciitis, Necrotizing: new trials by email Literature Review of Fasciitis, Necrotizing trials Research Report on Fasciitis, Necrotizing
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Validation of the Use of the Arteriovenous Tension Difference in CO2 Under Hyperbaric Conditions Echography - Necrotizing Fascitis, Cellulitis | Not yet recruiting | University Hospital, Lille | 74 | 2026-06-15 | 2026-05-14 | |
| Patients With Necrotizing Skin and Soft Tissue Infections Managed Within the SURFAST Care Pathway. Necrotizing Soft-tissue Infections | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 1000 | 2026-03-01 | 2026-02-18 | |
| Hyperbaric Oxygen Treatment for Necrotizing Fasciitis and Necrotizing Soft Tissue Infections Hyperbaric Oxygen Therapy - Necrotizing Fascitis | Not applicable | Not yet recruiting | Corewell Health West | 160 | 2025-11-14 | 2025-09-12 |
| Real-Time Diagnosis of Life-Threatening Necrotizing Soft Tissue Infections (NSTI) Using Indocyanine Green (ICG) Kinetic Modeling Administration of indocyanine green (ICG) and fluorescence imaging - Necrotizing Fascitis | Recruiting | Eric R. Henderson | 420 | 2025-09-26 | 2026-03-19 | |
| The Management of Necrotizing Soft Tissue Infection Wounds With Cytal® Wound Matrix and MicroMatrix® Cytal® Wound Matrix, MicroMatrix® - Necrotizing Fascitis, Necrotizing Soft Tissue Infection | Not applicable | Recruiting | Benjamin T. Miller | 50 | 2025-03-05 | 2026-10-21 |
| AFS Compared to AHC in Treatment of Necrotizing Fasciitis NF Acellular Fish Skin Graft (AFS) with Standard of Care Negative Pressure Wound Therapy (NPWT), Acellular Human Cadaver (AHC) with Standard of care Negative Pressure Wound Therapy (NPWT) - Necrotizing Fasciitis | Phase 4 | Active not recruiting | Kerecis Ltd. | 30 | 2023-08-01 | 2024-12-30 |
| VAC and Conventional Dressing in the Healing Process of Necrotizing Fasciitis VAC - Necrotizing Fascitis | Not applicable | Unknown | Assiut University | 30 | 2023-06-01 | 2023-05-31 |
| VACuum-Assisted Closure for Necrotizing Soft Tissue infecTIONs Negative pressure wound therapy (NPWT), Conventional dressing - Necrotising Soft Tissue Infections | Not applicable | Unknown | Assistance Publique - Hôpitaux de Paris | 130 | 2021-12-01 | 2021-10-08 |
| SKin and Soft Tissue Necrotizing INfections in the Intensive Care Unit: a Prospective Multi-national Cohort Study non interventional - Necrotizing Fasciitis, Fournier Gangrene | Unknown | Henri Mondor University Hospital | 1033 | 2021-11-08 | 2021-11-23 | |
| Detection and Delineation of Necrotizing Fasciitis Via a Vascular Perfusion Fluorophore Indocyanine green solution - Necrotising Fasciitis | Completed | Dartmouth-Hitchcock Medical Center | 18 | 2021-04-05 | 2025-05-23 | |
| RECELL® System Combined With Meshed Autograft for Reduction of Donor Skin Harvesting in Soft Tissue Reconstruction Control Intervention (Conventional Autograft), Investigational Intervention (RECELL + more widely meshed autograft) - Full-thickness Skin Defects, Degloving Injuries | Not applicable | Completed | Avita Medical | 65 | 2020-03-02 | 2024-07-30 |
| Compare Effects of Dressing With Honey and EUSOL Honey, EUSOL - Necrotizing Fascitis, Wound Infection | Not applicable | Completed | Dow University of Health Sciences | 326 | 2020-03-01 | 2022-11-15 |
| FATAL-NSTI Study (Factors Associated With In-hospital mortALity in NSTI). No Intervention: Observational Cohort - Necrotizing Fascitis, Fournier Gangrene | Recruiting | University of Cagliari | 300 | 2020-01-01 | 2026-01-22 | |
| A Single-stage Bilayered Skin Reconstruction With Glyaderm® Dermal subsitute Glyaderm + skin graft, Skin graft alone - Burns, Full Thickness Burn | Not applicable | Completed | University Hospital, Ghent | 82 | 2017-02-01 | 2024-02-08 |
| Phase III Efficacy and Safety Study of AB103 in the Treatment of Patients With Necrotizing Soft Tissue Infections AB103 0.5 mg/kg, NaCl 0.9% - Necrotizing Soft Tissue Infections, Necrotizing Fasciitis | Phase 3 | Completed | Atox Bio Ltd | 290 | 2015-12-01 | 2021-10-05 |
| Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled Trial IVIG (Privigen), Saline 0.9% - Necrotizing Soft Tissue Infection, Necrotizing Fasciitis | Phase 2 | Completed | Anders Perner | 100 | 2014-04-01 | 2016-09-30 |
| Severe Soft Tissue Infections: Perspectives of Patients and Significant Others Necrotizing Fasciitis | Unknown | Göteborg University | 30 | 2014-01-01 | 2018-08-14 | |
| Genetic Susceptibility to Severe Streptococcal Infections Invasive Streptococcal Infection, Invasive Group A Streptococcal Disease | Unknown | University of Oxford | 200 | 2013-12-01 | 2018-05-18 | |
| Biomarkers in Patients With Flesh-eating Bacterial Infections Necrotizing Soft Tissue Infection, Necrotizing Fasciitis | Completed | Ole Hyldegaard | 169 | 2013-02-01 | 2016-02-17 | |
| Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort Study Hyperbaric oxygen therapy - Necrotizing Soft Tissue Infection, Necrotizing Fascitis | Completed | Ole Hyldegaard | 260 | 2013-02-01 | 2019-06-24 |
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Fournier Gangrene (9) · Soft Tissue Infections (6) · Fasciitis (4) · Gas Gangrene (4) · Infections (4) · Cellulitis (3) · Staphylococcal Infections (3) · Bacterial Infections (2) · Disease (2) · Gangrene (2) · Necrosis (2) · Skin Diseases, Bacterial (2) · Wounds and Injuries (2) · Burns (1)
Musculoskeletal Diseases (28) · Fasciitis (24) · Bacterial Infections and Mycoses (10) · Infections (10) · Genital Diseases (9) · Genital Diseases, Male (9) · Male Urogenital Diseases (9) · Urogenital Diseases (9) · Bacterial Infections (8) · Pathologic Processes (6) · Pathological Conditions, Signs and Symptoms (6) · Gram-Positive Bacterial Infections (5) · Skin Diseases, Infectious (5) · Skin and Connective Tissue Diseases (5) · Clostridium Infections (4)
Hyperbaric Oxygenation (2) · Sodium Chloride (2) · AB103 (1) · Daptomycin (1) · Eusol (1) · High-Energy Shock Waves (1) · Honey (1) · Immunoglobulin G (1) · Immunoglobulins, Intravenous (1) · Negative-Pressure Wound Therapy (1) · Optical Imaging (1) · Saline Solution (1) · Skin Transplantation (1)
Ole Hyldegaard (3) · Assistance Publique - Hôpitaux de Paris (2) · Anders Perner (1) · Assiut University (1) · Atox Bio Ltd (1) · Avita Medical (1) · Benjamin T. Miller (1) · Corewell Health West (1) · Dartmouth-Hitchcock Medical Center (1) · Dow University of Health Sciences (1) · Eric R. Henderson (1) · Göteborg University (1) · Henri Mondor University Hospital (1) · Karolinska Institutet (1) · Kerecis Ltd. (1)
United States (9) · Denmark (6) · France (5) · Belgium (2) · Sweden (2) · United Kingdom (2) · Egypt (1) · Iran (1) · Italy (1) · Norway (1) · Pakistan (1) · Taiwan (1)
Ole Hyldegaard, MD, PhD (3) · Marco Bo Hansen, MD (2) · Adolfo Pisanu, MD (1) · Anders Perner, Professor (1) · Bounthavy Homsombath, MD (1) · Chi-Tai Fang, MD, PhD (1) · Eileen M Bulger, MD (1) · Eric R Henderson, MD (1) · George Murphy, MRCS (1) · Lillian S Kao, MD (1) · Manjari G Joshi, MD (1) · Nicolas de Prost, MD, PhD (1) · Peter V Polzik, MD (1) · Peter Verhamme, MD,PhD (1)
PMID 31916575, PMID 25967993, PMID 26880104, PMID 27399982, PMID 28421246, PMID 28982834, PMID 32082310, PMID 32657946, PMID 34263738, PMID 36427229, PMID 37946314, PMID 38098145, PMID 38745983, PMID 39810178, PMID 40613866
K23RR020020 (1), R01AI184513 (1)