8 completed, 4 terminated, 1 not yet recruiting. 5 Phase 3, 4 Phase 1, 2 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 5 | Completed 3, Terminated 2 |
| Phase 1 | 4 | Completed 3, Terminated 1 |
| Phase 2 | 2 | Completed 2 |
| Phase 4 | 1 | Terminated 1 |
Follow delafloxacin: new trials by email Literature Review of delafloxacin trials Research Report on delafloxacin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Delafloxacin Plasma and Tissue Concentration in Patients With Skin, Soft Tissue, and Bone and Joint Infections. delafloxacin - Soft Tissue Infections, Mediastinitis | Not yet recruiting | IRCCS San Raffaele | 20 | 2026-04-01 | 2026-02-23 | |
| A Study Comparing the Bioavailability of a Taste-masked Delafloxacin Powder for Oral Suspension With the Delafloxacin Tablet in Healthy Adults Delafloxacin, Delafloxacin Powder - Healthy | Phase 1 | Terminated | Melinta Therapeutics, Inc. | 16 | 2024-06-03 | 2026-09-11 |
| Comparing Oral Versus Parenteral Antimicrobial Therapy Amoxicillin, amoxicillin-clavulanate, cefadroxil, cefpodoxime, cefalexin, ciprofloxacin, delafloxacin, doxycycline, levofloxacin, linezolid, Ampicillin, ampicillin-sulbactam, cefazolin, cefepime, ceftaroline, ceftazidime, ceftazidime-avibactam, dalbavancin, daptomycin, ertapenem - Endovascular Infection, Bone and Joint Infection | Phase 4 | Terminated | West Virginia University | 94 | 2023-08-04 | 2025-08-26 |
| Delafloxacin IV and OS Administration Compared to Best Available Therapy in Patients With Surgical Site Infections Delafloxacin, Vancomycin, Linezolid - Surgical Site Infection | Phase 3 | Terminated | Menarini Group | 268 | 2019-09-25 | 2022-02-02 |
| Evaluate Safety and Pharmacokinetic To Assess Bronchopulmonary Disposition of Intravenous Delafloxacin in Healthy Adults Delafloxacin - Pneumonia | Phase 1 | Completed | Melinta Therapeutics, Inc. | 30 | 2018-04-30 | 2018-08-15 |
| Study to Compare Delafloxacin to Moxifloxacin for the Treatment of Adults With Community-acquired Bacterial Pneumonia Delafloxacin, Moxifloxacin, Linezolid - Community Acquired Bacterial Pneumonia | Phase 3 | Completed | Melinta Therapeutics, Inc. | 860 | 2016-12-14 | 2020-02-27 |
| Study to Evaluate the Effect of Delafloxacin on the Pharmacokinetics of Midazolam in Healthy Subjects Midazolam, Delafloxacin - VA Drug Interactions | Phase 1 | Completed | Melinta Therapeutics, Inc. | 22 | 2015-06-01 | 2016-12-16 |
| Pharmacokinetics of Delafloxacin in Subjects With and Without Hepatic Impairment Delafloxacin - Hepatic Impairment | Phase 1 | Completed | Melinta Therapeutics, Inc. | 40 | 2014-09-01 | 2015-04-30 |
| Delafloxacin vs Vancomycin and Aztreonam for the Treatment of Acute Bacterial Skin and Skin Structure Infections delafloxacin, vancomycin, aztreonam - Skin and Subcutaneous Tissue Bacterial Infections, Skin Structures and Soft Tissue Infections | Phase 3 | Completed | Melinta Therapeutics, Inc. | 850 | 2014-05-01 | 2017-11-17 |
| Comparison of Delafloxacin Versus Ceftriaxone for the Treatment of Uncomplicated Gonorrhea Delafloxacin, Ceftriaxone - Gonorrhea | Phase 3 | Terminated | Melinta Therapeutics, Inc. | 460 | 2014-01-23 | 2018-06-20 |
| Delafloxacin Versus Vancomycin and Aztreonam for the Treatment of Acute Bacterial Skin and Skin Structure Infections Delafloxacin, Vancomycin, Aztreonam - Skin and Subcutaneous Tissue Bacterial Infections | Phase 3 | Completed | Melinta Therapeutics, Inc. | 660 | 2013-04-01 | 2017-09-27 |
| A Study to Assess Objective Endpoint Measurements of Response in Bacterial Skin Infections Delafloxacin, Linezolid, Vancomycin - Skin and Subcutaneous Tissue Bacterial Infections | Phase 2 | Completed | Melinta Therapeutics, Inc. | 256 | 2011-01-01 | 2019-10-16 |
| Safety and Efficacy Study of a Fluoroquinolone to Treat Complicated Skin Infections delafloxacin, tigecycline - Skin Structure Infections, Bacterial Skin Diseases | Phase 2 | Completed | Melinta Therapeutics, Inc. | 150 | 2008-06-01 | 2014-07-14 |
Bacterial Infections (3) · Infections (3) · Skin Diseases, Bacterial (3) · Soft Tissue Infections (3) · Pneumonia (2) · Arthritis, Infectious (1) · Cellulitis (1) · Gonorrhea (1) · Mediastinitis (1) · Osteomyelitis (1) · Staphylococcal Skin Infections (1) · Surgical Wound Infection (1)
Melinta Therapeutics, Inc. (10) · IRCCS San Raffaele (1) · Menarini Group (1) · West Virginia University (1)
United States (10) · Latvia (3) · Argentina (2) · Bulgaria (2) · Georgia (2) · Hungary (2) · Peru (2) · Romania (2) · Russia (2) · Spain (2) · Ukraine (2) · Brazil (1) · Chile (1) · Colombia (1) · Croatia (1)
Sue Cammarata, MD (3) · Sue K Cammarata, MD (3) · Arif R. Sarwari, MD, MSc, MBA (1) · Jeanne Breen, MD (1) · Joy J. Juskowich, MD (1) · Marco Ripa, MD (1) · Scott Hopkins, MD (1) · Stefano Margaritora (1) · Sue K. Cammarata, MD (1)
PMID 28630189, PMID 30349845, PMID 25448332, PMID 26679243, PMID 27570245, PMID 28495029, PMID 29029278, PMID 29518178, PMID 30985632, PMID 31988972, PMID 40908975, PMID 41419216
2015 (1), 2018 (1)