16 completed, 11 recruiting, 5 unknown, 4 not yet recruiting. 21 Not applicable, 3 Phase 4, 1 Phase 2, 1 Phase 3.
Follow Severe Aortic Stenosis: new trials by email Literature Review of Severe Aortic Stenosis trials Research Report on Severe Aortic Stenosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Prospective, Multi-centre, Single Arm, Pivotal Clinical Study to Determine the Safety and Effectiveness of Crea Aortic Valve for Use as a Replacement Aortic Heart Valve Investigational Transcatheter Aortic Valve Replacement System - Aortic Valve Stenosis, Severe Aortic Stenosis | Not applicable | Not yet recruiting | Onecrea Medical Inc. | 30 | 2026-12-04 | 2026-07-29 |
| Application of TAVI at Experienced Interventional Cardiac Centers Without On-site Cardiac Surgery (ATLAS Study) Transcatheter Aortic Valve Replacement (TAVR) with surgical oversight, Transcatheter Aortic Valve Replacement (TAVR) without surgical oversight - Aortic Stenosis, Severe Aortic Stenosis | Phase 4 | Not yet recruiting | University of Alberta | 600 | 2026-12-01 | 2026-10-27 |
| Coronary Access After Evolut FX Plus TAVI: Impact of Commissural Alignment and the Large-Cell Frame Design: ACCESS-FX+ Registry Severe Aortic Stenosis | Not yet recruiting | Yonsei University | 122 | 2026-09-29 | 2026-09-10 | |
| Angiotensin Receptor Blocker After TAVR in Severe Aortic Stenosis With Left Ventricular Hypertrophy (ARBITAR) Angiotensin Receptor Blocker (ARB) - Transcatheter Aortic Valve Replacement (TAVR), Left Ventricular Hypertrophy | Phase 4 | Not yet recruiting | Seoul National University Hospital | 632 | 2026-08-15 | 2026-07-29 |
| CLEAR-AS: CT-FFR-Guided Revascularization in Patients With Severe Aortic Stenosis CCTA plus CT-FFR-informed preoperative decision strategy, CCTA-guided preoperative decision strategy - Severe Aortic Stenosis | Not applicable | Recruiting | Yan'an Affiliated Hospital of Kunming Medical University | 300 | 2026-04-01 | 2026-04-16 |
| Safety and Efficacy of the RENATUS® Transcatheter Aortic Valve System for the Treatment of Severe Aortic Stenosis RENATUS® TAVR - Severe Aortic Stenosis | Not applicable | Recruiting | Beijing Balance Medical Technology Co., Ltd | 800 | 2026-02-01 | 2026-02-17 |
| Pre-Emptive LAVA-ECMO for Complex High-Risk TAVR Left Atrial Veno-Arterial Extracorporeal Membrane Oxygenation (LAVA-ECMO) - Severe Aortic Stenosis, Cardiogenic Shock | Recruiting | Atlantic Health System | 30 | 2026-01-01 | 2025-12-30 | |
| Navitor Japan Study Navitor Transcatheter Aortic Valve Implantation - Severe Aortic Stenosis | Recruiting | Abbott Medical Devices | 100 | 2025-10-30 | 2026-05-26 | |
| A Clinical Trial Assessing the Safety and Effectiveness of the DurAVR® THV System TAVR with DurAVR® THV, TAVR with SAPIEN THV series or the Evolut THV series - Severe Aortic Stenosis, Valve-in-valve Procedures | Not applicable | Recruiting | Anteris Technologies Ltd. | 1650 | 2025-10-21 | 2026-07-15 |
| Transfemoral TAVI With or Without Coronary Angiogram in Patients With Severe Aortic Stenosis (PURE TAVI) Transcatheter aortic valve implantation - Severe Aortic Stenosis | Not applicable | Enrolling by invitation | Rede Optimus Hospitalar SA | 620 | 2025-08-08 | 2026-08-25 |
| Alwide Plus China Post-market Clinical Investigation Severe Aortic Stenosis, Transcatheter Aortic Valve Replacemen | Completed | Shanghai MicroPort CardioFlow Medtech Co., Ltd. | 75 | 2025-01-03 | 2025-12-26 | |
| Act on Quality of Life in Patients With aortIc Stenosis Kansas City Cardiomyopathy Questionnaire (KCCQ-12) score - Severe Aortic Stenosis | Recruiting | Hospices Civils de Lyon | 240 | 2024-12-19 | 2025-01-17 | |
| Observational Study Relating to the Long-term Follow-up of Patients with Severe Aortic Stenosis Evaluated for Percutaneous Aortic Valve Replacement (TAVI). TAVI - Severe Aortic Stenosis, TAVI(Transcatheter Aortic Valve Implantation) | Enrolling by invitation | University Hospital of Ferrara | 600 | 2024-11-30 | 2025-03-27 | |
| Comparison of a Single Versus Double Perclose Technique for TAVR Perclose Proglide system - Severe Aortic Stenosis | Not applicable | Completed | Second Affiliated Hospital, Zhejiang University, School of Medicine | 876 | 2024-01-23 | 2026-10-02 |
| VARC-TAVI VALVE IMPLANTATION) Secondary TAVI access - Severe Aortic Stenosis, TAVI\(Transcatheter Aortic Valve Implantation\) | Not applicable | Unknown | Hospital Universitario La Paz | 600 | 2024-01-08 | 2024-01-05 |
| A Prospective, Multicenter, Single-arm Study to Evaluate a Transcatheter Aortic Valve System Safety and Efficacy for the Treatment of Patients With Severe Aortic Stenosis Transcatheter aortic valve replacement - Severe Aortic Stenosis | Not applicable | Recruiting | Pan Xiangbin | 120 | 2023-10-18 | 2023-11-18 |
| Prevalence of ATTR Cardiac Amyloidosis in Patients Undergoing TAVR ATTR Amyloidosis Wild Type, Severe Aortic Stenosis | Unknown | Jordan Collaborating Cardiology Group | 100 | 2023-10-01 | 2023-08-29 | |
| Prevalence of Cusp Asymmetry, Coronary Ostial Eccentricity in Patients Undergoing Trans Catheter Aortic Valve Implantation and Their Impact on Coronary Ostia Overlap Risk Assessment Severe Aortic Stenosis, Trans-catheter Aortic Valve Implantation | Completed | Ain Shams University | 64 | 2023-06-01 | 2025-02-19 | |
| Aspirin vs Clopidogrel After TAVR Aspirin single antiplatelet therapy, Clopidogrel single antiplatelet therapy - Severe Aortic Stenosis | Not applicable | Recruiting | Yonsei University | 270 | 2023-02-02 | 2026-06-30 |
| SAvvyWire™ EFficacy and SafEty in Transcatheter Aortic Valve Implantation Procedures (SAFE-TAVI) TAVI - Severe Aortic Stenosis | Not applicable | Completed | Opsens, Inc. | 119 | 2022-10-25 | 2023-04-12 |
Showing 20 of 41. Sign in to see all of them.
Aortic Valve Stenosis (41) · Heart Valve Diseases (3) · Cardiovascular Diseases (2) · Anemia, Iron-Deficiency (1) · Aortic Valve Insufficiency (1) · Aortic Valve, Calcification of (1) · Atrial Fibrillation (1) · Chest Pain (1) · Coronary Artery Disease (1) · Hypertrophy, Left Ventricular (1) · Shock, Cardiogenic (1)
Aortic Valve Disease (41) · Heart Diseases (41) · Ventricular Outflow Obstruction (41) · Cardiovascular Diseases (39) · Heart Valve Diseases (38) · Pathological Conditions, Signs and Symptoms (4) · Myocardial Ischemia (2) · Pathologic Processes (2) · Vascular Diseases (2) · Anemia (1) · Anemia, Hypochromic (1) · Arrhythmias, Cardiac (1) · Arterial Occlusive Diseases (1) · Arteriosclerosis (1) · Cardiomegaly (1)
Transcatheter Aortic Valve Replacement (6) · Angiotensin Receptor Antagonists (1) · Deamino Arginine Vasopressin (1) · Heparin (1) · bivalirudin (1)
Medtronic Cardiovascular (4) · Abbott Medical Devices (2) · HLT Inc. (2) · Yonsei University (2) · Ain Shams University (1) · Anteris Technologies Ltd. (1) · Atlantic Health System (1) · BC Centre for Improved Cardiovascular Health (1) · Beijing Balance Medical Technology Co., Ltd (1) · Centro Hospitalar de Vila Nova de Gaia/Espinho, E.P.E. (1) · Colibri Heart Valve LLC (1) · Edwards Lifesciences (1) · Fondazione IRCCS Policlinico San Matteo di Pavia (1) · Hospices Civils de Lyon (1) · Hospital Universitario La Paz (1)
Germany (7) · Italy (7) · Canada (6) · France (6) · Switzerland (6) · United Kingdom (6) · China (5) · Netherlands (5) · United States (5) · Denmark (4) · Spain (4) · Belgium (3) · Czechia (3) · Poland (3) · Austria (2)
David H Adams, MD (2) · Axel Linke, MD (1) · Axel Linke, Prof Dr med (1) · Bernard Chevalier, MD (1) · Borut Jug, PhD (1) · Chengde Liao (1) · David H Adams (1) · David H. Adams, MD (1) · Dr. Emanuele Barbato, Professor (1) · Dr. Felix Mahfoud, Professor (1) · Dr. Gabor G Toth, Professor (1) · Dr. William Wijns, Professor (1) · Eberhardt Grube, MD (1) · Flavio Ribichini, Professor (1)
PMID 36515976, PMID 27601429, PMID 30341970, PMID 31665959, PMID 34529944, PMID 34581194, PMID 38710669, PMID 23702009, PMID 24657695, PMID 24678937, PMID 25152474, PMID 25287265, PMID 25700755, PMID 25946437, PMID 26055947, PMID 26184612, PMID 26292584, PMID 26383718, PMID 26384204, PMID 26477635, PMID 26508386, PMID 26762727, PMID 26764063, PMID 26892451, PMID 27012401, PMID 27050187, PMID 27208464, PMID 27296201, PMID 27313280, PMID 27369803, PMID 27443429, PMID 27491485, PMID 27541162, PMID 28304219, PMID 28484830, PMID 28633375, PMID 29102579, PMID 30172363, PMID 30249462, PMID 30360820, PMID 30929507, PMID 31215985, PMID 31476897, PMID 31607151, PMID 31902431, PMID 32715995, PMID 32723555, PMID 32763073, PMID 32997095, PMID 33217396
2019 (1)