2 not yet recruiting, 2 recruiting, 2 terminated, 1 active not recruiting. 3 Not applicable, 1 Early Phase 1, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 3 | Not yet recruiting 1, Recruiting 1, Terminated 1 |
| Early Phase 1 | 1 | Terminated 1 |
| Phase 1 | 1 | Not yet recruiting 1 |
Follow REM Behavior Disorder: new trials by email Literature Review of REM Behavior Disorder trials Research Report on REM Behavior Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| INSIGHT: Insomnia, Nightmares, and Sympathetic Hyperactivity Intervention NightWare smartwatch configured to detect physiological signs of sympathetic activation during sleep, such as heart-rate spikes and movement patterns., Sham (No Treatment) - Nightmare, Insomnia | Not applicable | Not yet recruiting | Uniformed Services University of the Health Sciences | 180 | 2026-06-01 | 2026-04-28 |
| The Role of METhanogens in the PROgression Of Parkinson's Disease and Related Neurological Conditions Probiotic Supplementation with L. reuteri - PARKINSON DISEASE (Disorder), Parkinson | Not applicable | Recruiting | University of Cambridge | 215 | 2025-11-01 | 2026-08-25 |
| Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia PROSOMNIA Sleep Therapy™ (PSTx), Anesthesia-Induced Sleep Therapy, Diprivan (propofol), Astra-Zeneca - Chronic Insomnia, Sleep Deprivation | Phase 1 | Not yet recruiting | Nyree Penn | 100 | 2025-11-01 | 2025-05-28 |
| Quantification of Phosphorylated Alpha-synuclein in Cutaneous Biopsies as a Prospective Biomarker in Parkinson's Disease REM Behavior Disorder, Parkinson Disease | Active not recruiting | CND Life Sciences | 100 | 2024-12-17 | 2026-10-20 | |
| Prodromal Model of Parkinson's Disease Confined to The Peripheral Nervous System Polyneuropathy, Alpha-Synucleinopathy | Enrolling by invitation | University of Aarhus | 100 | 2024-05-13 | 2025-01-08 | |
| The Effects of Tasimelteon in Participants With REM Behavior Disorder (RBD) Tasimelteon - REM Behavior Disorder | Early Phase 1 | Terminated | Brigham and Women's Hospital | 20 | 2023-09-30 | 2025-10-09 |
| Mainz Register of Patients With Sleep Disorders Implantation of vagus nerve stimulation according to clinical indication - Sleep Disorder, Sleep Disorder Parasomnia | Recruiting | Johannes Gutenberg University Mainz | 500 | 2022-02-01 | 2022-09-15 | |
| Subcortical Oscillations in Human Sleep Dysregulation Sleep, PD and DBS - Parkinson Disease, REM Behavior Disorder | Unknown | University of Colorado, Denver | 15 | 2018-02-27 | 2024-05-13 | |
| Efficacy and Tolerability of Ramelteon in Patients With Rapid Eye Movement (REM) Behavior Disorder and Parkinsonism Rozerem, Placebo - REM Behavior Disorder, Parkinsonism | Not applicable | Terminated | Northwestern University | 3 | 2008-06-01 | 2024-01-09 |
REM Sleep Behavior Disorder (9) · Parkinson Disease (5) · Sleep Initiation and Maintenance Disorders (3) · Alzheimer Disease (2) · Idiopathic Hypersomnia (2) · Lewy Body Disease (2) · Sleep Wake Disorders (2) · Stress Disorders, Post-Traumatic (2) · Anxiety Disorders (1) · Cancer Pain (1) · Chronobiology Disorders (1) · Cognitive Dysfunction (1) · Combat Disorders (1) · Constipation (1) · Dementia (1)
Mental Disorders (9) · Nervous System Diseases (9) · REM Sleep Parasomnias (9) · Parasomnias (8) · Sleep Wake Disorders (7) · Brain Diseases (6) · Central Nervous System Diseases (6) · Neurodegenerative Diseases (6) · Basal Ganglia Diseases (5) · Movement Disorders (5) · Neurocognitive Disorders (4) · Parkinsonian Disorders (4) · Pathological Conditions, Signs and Symptoms (4) · Signs and Symptoms (4) · Synucleinopathies (4)
Electroencephalography (1) · Propofol (1) · Sleep (1) · ramelteon (1) · tasimelteon (1)
Brigham and Women's Hospital (1) · CND Life Sciences (1) · Johannes Gutenberg University Mainz (1) · Northwestern University (1) · Nyree Penn (1) · Uniformed Services University of the Health Sciences (1) · University of Aarhus (1) · University of Cambridge (1) · University of Colorado, Denver (1)
United States (6) · Denmark (1) · Germany (1) · United Kingdom (1)
Aleksandar Videnovic, M.D. (1) · Astrid J. Terkelsen, MD, DrMedSc, PhD, Professor (1) · Caroline Williams-Gray, Dr. (1) · John A Thompson, Ph.D. (1) · Marta Camacho, Dr. (1) · Milena Pavlova, M.D. (1) · Nyree Penn, MHSc., CAA, Master of Health Science (1) · Tanya Simuni, M.D. (1) · Todd Levine (1)