27 completed, 6 unknown, 2 terminated, 1 not yet recruiting. 12 Not applicable, 10 Phase 3, 9 Phase 4, 5 Phase 2, 2 Phase 1.
Follow Mydriasis: new trials by email Literature Review of Mydriasis trials Research Report on Mydriasis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pharmacodynamics of a Fixed Dose Combination of 0.34% Tropicamide and 2.5% Phenylephrine Hydrochloride, Eye Drop, Solution IMP 08P2002F0, Mydriasert® insert - Mydriasis | Phase 1 / Phase 2 | Completed | Unither Pharmaceuticals, France | 20 | 2025-11-01 | 2026-06-17 |
| The Correlation Between Pupil Size and Retinal Nerve Fibers Changes in Pseudoexfoliation Syndrome. optical coherence tomography - Pseudoexfoliation Syndrome | Not yet recruiting | Assiut University | 33 | 2024-12-01 | 2024-09-19 | |
| Comparison of 4 Methods of Eye Drops for Pupil Dilation in Diabetic Patients 1 drop of a 0.8% tropicamide + 5% phenylephrine combination, 1 drop of 0.5% tetracaine and 1 drop of a 0.8% tropicamide + 5% phenylephrine combination, 3 drops of a 0.8% tropicamide + 5% phenylephrine combination - Diabetes (DM), Retinopathy, Diabetic | Not applicable | Completed | Burapha University | 84 | 2024-11-04 | 2026-03-27 |
| Comparing Efficacy and Safety of CTO0303 in Pediatric Subjects CTO0303-A, CTO0303-B, CTO0303-C - Pupillary Dilation Effect During Cycloplegic Refraction | Phase 2 / Phase 3 | Unknown | Taejoon Pharmaceutical Co., Ltd. | 156 | 2024-05-09 | 2024-09-24 |
| Comfort Level in Premature Infants Undergoing Retinopathy of Prematurity Screening standard phototherapy eye patches - Premature, Retinopathy of Prematurity | Not applicable | Completed | Istanbul Nisantasi University | 90 | 2024-01-01 | 2025-06-12 |
| Safety and Efficacy of Fixed Combination Phenylephrine-Tropicamide for Pupil Dilation MydCombi - Mydriasis | Phase 4 | Completed | Eyenovia Inc. | 30 | 2023-11-28 | 2024-04-18 |
| The Effect of Eyedrop Size on Pupillary Dilation Using the Nanodropper Bottle Adapter Nanodropper, Standard eye drop bottle - Medication Delivery, Eye Drop Delivery | Not applicable | Completed | Sutter Health | 54 | 2022-01-04 | 2024-11-15 |
| Nyxol (0.75% Phentolamine Ophthalmic Solution) to Reverse Pharmacologically-Induced Mydriasis in Pediatric Subjects Phentolamine Ophthalmic Solution 0.75%, Phentolamine Ophthalmic Solution Vehicle - Mydriasis, Dilation | Phase 3 | Completed | Opus Genetics, Inc | 23 | 2021-12-17 | 2026-10-30 |
| Cochlear Implanted Listening Effort and Hearing Attention Forced choice psychoacoustic task for the evaluation of modulation detection performance and selective auditory attention. (for both arm), Measurement of the pupil diameter for the evaluation of listening effort during speech perception - Sensorineural Hearing Loss | Not applicable | Recruiting | Assistance Publique - Hôpitaux de Paris | 170 | 2021-12-08 | 2025-01-13 |
| Safety and Efficacy of Nyxol (0.75% Phentolamine Ophthalmic Solution) to Reverse Pharmacologically-Induced Mydriasis (MIRA-3) Phentolamine Ophthalmic Solution 0.75%, Phentolamine Ophthalmic Solution Vehicle - Mydriasis, Dilation | Phase 3 | Completed | Opus Genetics, Inc | 368 | 2021-11-18 | 2026-10-30 |
| Efficacy and Safety of Mydriatic Microdrops for Retinopathy Of Prematurity Screening Microdrop administration of phenylephrine 1.67% and tropicamide 0.33%, Standard drop administration of phenylephrine 1.67% and tropicamide 0.33% - Retinopathy of Prematurity | Phase 4 | Completed | Aristotle University Of Thessaloniki | 83 | 2021-09-07 | 2025-03-18 |
| Evaluation of Pupil Dilation Speed With the MAP Dispenser tropicamide-phenylephrine fixed combination ophthalmic solution - Mydriasis | Phase 4 | Completed | Eyenovia Inc. | 61 | 2021-05-24 | 2025-01-09 |
| The Effects of Mydriatic Eye Drops in Retinopathy of Prematurity Examinations NIRS(INVOS 5100; Covidien Somanetics, Troy, MI - Retinopathy of Prematurity, Mydriasis | Completed | Istanbul Training and Research Hospital | 62 | 2021-05-01 | 2023-05-30 | |
| Efficacy Mydrane ® for Cataract Surgery in Patients With Concomitant Primary Open Angle Glaucoma. Efficacy of a Standardized Intracameral Combination of Mydriatics and Anesthetic (Mydrane ®) for Cataract Surgery in Patients With Concomitant Primary Open Angle Glaucoma - Cataract Surgery | Not applicable | Completed | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 60 | 2021-03-18 | 2023-07-06 |
| Safety and Efficacy of Nyxol (0.75% Phentolamine Ophthalmic Solution) to Reverse Pharmacologically-Induced Mydriasis Phentolamine Ophthalmic Solution 0.75%, Phentolamine Ophthalmic Solution Vehicle (Placebo) - Mydriasis, Dilation | Phase 3 | Completed | Opus Genetics, Inc | 185 | 2020-11-18 | 2026-10-30 |
| Efficacy and Safety of Mydriatic Microdrops Compared With Standard Drops for Retinopathy of Prematurity (ROP) Screening: a Pilot Randomized Clinical Trial Microdrop administration [phenylephrine 1.67% + tropicamide 0.33% (drop volume: 6-7 μL)], Standard drop administration [phenylephrine 1.67% + tropicamide 0.33% (drop volume: 28-34 μL)] - Retinopathy of Prematurity | Phase 4 | Completed | Aristotle University Of Thessaloniki | 25 | 2020-03-24 | 2022-04-04 |
| Sutureless Intrascleral Intraocular Lens Fixation and Modified Iris Cerclage Pupilloplasty Sutureless Intrascleral Intraocular Lens Fixation and Modified Iris Cerclage Pupilloplasty - Aphakia, Mydriasis | Not applicable | Unknown | Changzhou Second People's Hospital affiliated with Nanjing Medical University | 20 | 2020-01-01 | 2023-04-25 |
| Safety and Efficacy of Ophthalmic Phentolamine Mesylate to Reverse Pharmacologically Induced Mydriasis Phentolamine Mesylate Ophthalmic Solution 1%, Phentolamine Mesylate Ophthalmic Solution Vehicle (Placebo) - Mydriasis, Dilation | Phase 2 | Completed | Opus Genetics, Inc | 32 | 2019-08-13 | 2026-10-30 |
| Stimulation and Validation of the Pupillary Dilation for the Detection of Pain in Analgosedated Patients Under Mechanically Ventilation in Intensive Care Unit Pupillometer - Pain | Not applicable | Unknown | Basque Health Service | 82 | 2019-03-14 | 2022-03-11 |
| Effect of Intracameral Injection of Mydriatic Plus Anaesthetic Combination on Corneal Endothelial Count in Phaco Fydrane®: (Manufacturer DELPHARM TOURS, FRANCE). - Corneal Endothelial Cell Loss, Mydriasis | Phase 3 | Completed | Cairo University | 30 | 2019-02-01 | 2020-05-20 |
Showing 20 of 37. Sign in to see all of them.
Dilatation, Pathologic (6) · Cataract (5) · Retinopathy of Prematurity (4) · Pain (3) · Diabetes Mellitus (2) · Exfoliation Syndrome (2) · Premature Birth (2) · Aphakia (1) · Corneal Endothelial Cell Loss (1) · Diabetic Retinopathy (1) · Drug-Related Side Effects and Adverse Reactions (1) · Eye Diseases (1) · Hearing Loss, Sensorineural (1) · Infant, Newborn, Diseases (1)
Pupil Disorders (37) · Eye Diseases (36) · Pathological Conditions, Signs and Symptoms (11) · Lens Diseases (6) · Pathological Conditions, Anatomical (6) · Retinal Diseases (5) · Signs and Symptoms (5) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (4) · Infant, Premature, Diseases (4) · Neurologic Manifestations (4) · Infant, Newborn, Diseases (3) · Endocrine System Diseases (2) · Female Urogenital Diseases and Pregnancy Complications (2) · Glucose Metabolism Disorders (2) · Iris Diseases (2)
Phenylephrine (10) · Tropicamide (8) · Ophthalmic Solutions (2) · Anesthetics (1) · Atropine (1) · Brimonidine Tartrate (1) · Cyclopentolate (1) · Epinephrine (1) · Ketorolac (1) · Lidocaine (1) · Tetracaine (1) · Tomography, Optical Coherence (1)
Eyenovia Inc. (5) · Opus Genetics, Inc (4) · Khon Kaen University (3) · Aristotle University Of Thessaloniki (2) · Assistance Publique - Hôpitaux de Paris (2) · Assiut University (1) · Basque Health Service (1) · Burapha University (1) · Cairo University (1) · Carmel Medical Center (1) · Changzhou Second People's Hospital affiliated with Nanjing Medical University (1) · Clinica Oftamologica Zona Sul (1) · Dar El Oyoun Hospital (1) · Emory University (1) · Erasme University Hospital (1)
United States (12) · Thailand (4) · Greece (3) · Egypt (2) · France (2) · Turkey (Türkiye) (2) · Brazil (1) · Canada (1) · China (1) · Israel (1) · Italy (1) · Mexico (1) · South Korea (1) · Spain (1)
Tsontcho Ianchulev, MD, MPH (3) · Yosanan Yospaiboon, M.D. (3) · Alexandre P Costa, Pinto (1) · Charles Slonim, MD (1) · Erika M. Espino-Torres, MD (1) · Greg Bennett, MS (1) · Keith Walter, MD (1) · Nattawat Asawaworarit, M.D. (1) · Orna Geyer, Professor (1) · Stephen J Kim, MD (1)
PMID 41743463, PMID 17205877, PMID 18779478, PMID 20462091, PMID 22368443, PMID 29189318, PMID 32126990, PMID 33633016, PMID 34654903, PMID 35428316, PMID 37158245, PMID 37573155, PMID 39571502, PMID 39724200, PMID 41159095